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Background: Oral submucous fibrosis (OSF) and proliferative verrucous leukoplakia (PVL) are established as oralpotentially malignant disorders. Dual pathology of the two conditions is not commonly encountered in clinicalpractice. This study aims to present a case series of multifocal leukoplakia in patients with and without OSF tooutline the clinical behavior and challenges in the management of this high-risk group in clinical practice.Material and Methods: We retrospectively analyzed cases of six Indian patients (four with OSF) managed over aperiod of 5.5 to 13 years at the Government Dental College, Nagpur. Patient data consisting of age, gender, med-ical history, habits, clinical findings, and biopsy reports were recorded at the initial visit. During follow-up visits,the clinicopathological data were reassessed. When surgical intervention failed to arrest the disease or whensurgery was contraindicated metronomic therapy with Folitrax 15 mg once a week and Celecoxib 100mg twicedaily was initiated.Results: All patients developed PVL after the initial pathology diagnosis of OSF or oral leukoplakia. Initial lesionswere either homogenous or non-homogenous leukoplakia. All patients developed multiple recurrences, regional orsystemic metastasis. Despite thorough interventions, the patients died of, or with the disease.Conclusions: The occurrence of two or more oral potentially malignant disorders poses challenges in patient man-agement and possibly presents a higher risk of malignant transformation. More clinical trials are necessary to as-sess the benefits of metronomic therapy for patients diagnosed with aggressive PVL concurrently found with OSF.(AU)
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Humanos , Masculino , Feminino , Neoplasias Bucais , Leucoplasia Oral , Doenças da Boca , Procedimentos Cirúrgicos Operatórios , Estudos Retrospectivos , Odontologia , Medicina Bucal , Saúde BucalRESUMO
Background: The Spindle Assembly Checkpoint (SAC) is a surveillance mechanism essential to ensure the ac-curacy of chromosome segregation during mitosis. Our aim was to evaluate the expression of SAC proteins in oralcarcinogenesis, and to assess their potential in predicting malignant transformation of oral leukoplakia.Material and Methods: We analysed the immunoexpression of BubR1, Mad2, Bub3, and Spindly proteins in 64oral biopsies from 52 oral leukoplakias and 12 normal tissues. Univariate and multivariate analysis were per-formed to evaluate predictive factors for malignant transformation (MT).Results: We observed that BubR1 and Mad2 were more highly expressed in high dysplasia grade lesions than inlow grade or normal tissues (P<0.05). High expression of Spindly was significantly correlated with a high Ki-67score (P=0.004). Six (11.5%) oral leukoplakias underwent malignant transformation. In univariate analysis, thebinary dysplasia grade (high grade) (P<0.001) was associated with a higher risk of malignant transformation aswell as high BubR1 (P<0.001) and high Mad2 (P=0.013) expression. In multivariate analysis, high expression ofBubR1 and Mad2 when combined showed an increased risk for malignant transformation (P=0.013; HR of 4.6,95% CI of 1.4-15.1). Conclusions: Our findings reveal that BubR1 and Mad2 were associated with an increased risk for malignant trans-formation independently of histological grade and could be potential and useful predictive risk markers of malignanttransformation in oral leukoplakias.(AU)
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Humanos , Masculino , Feminino , Biomarcadores , Leucoplasia Oral , Transformação Celular Neoplásica , Pontos de Checagem da Fase M do Ciclo Celular , Proteínas Mad2 , Estudos de CoortesRESUMO
Background: The aim of this study was to investigate the frequency of oral lesions in the floor of the mouth fromrepresentative oral pathology centres in Latin America.Material and Methods: This study was conducted on biopsies obtained from January of 1978 to December of 2018at nine Latin America oral and maxillofacial pathology centres. Gender, age and histopathological diagnosis wereevaluated. Data were analysed using descriptive methods. Chi-square test was used for pairwise comparisons.Results: From 114,893 samples, 4,016 lesions (3.49%) occurred in the floor of the mouth. Brazil showed 3,777 cases(94%), Mexico 182 cases (4.5%) and Argentina 57 cases (1.4%). Benign lesions represented 65.1% (2,617 cases),followed by 34.9% (1,404 cases) of malignant disorders. Lesions of epithelial origin were more frequent (1,964) cases; 48.9%), followed by salivary glands (1,245 cases; 31%) and soft tissue lesions (475 cases; 11.7%). The mostcommon histological subtypes were oral squamous cell carcinoma (1,347 cases; 33.5%), ranula (724 cases; 18%), oralleukoplakia (476 cases; 11.8%) and inflammatory fibrous hyperplasia (239 cases; 5.9%). The lesion affected males in2,129 cases and females in 1,897 cases.Conclusions: In the current study, lesions in the floor of the mouth represented 3.49% of biopsies submitted to oralpathology services and oral squamous cell carcinoma, ranula and leukoplakia were the most common lesions.(AU)
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Humanos , Boca/lesões , Úlceras Orais , Soalho Bucal/anormalidades , Soalho Bucal/lesões , Neoplasias Bucais/epidemiologia , Leucoplasia Oral , Epidemiologia Descritiva , Medicina Bucal , Cirurgia Bucal , Patologia Bucal , Saúde Bucal , América Latina , Estudos Retrospectivos , Doenças da BocaRESUMO
Background: There is a debate as to whether some types of oral leucoplakias (OL) are caused by Candida species,and whether they contribute to the malignant transformation, associated with a minority of such lesions. As nodetailed population analysis of yeast isolates from OL is available, we evaluated the virulence attributes, and geno-types of 35 C. albicans from OL, and compared their genotypes with 18 oral isolates from healthy individuals.Material and Methods: The virulence traits evaluated were esterase, phospholipase, proteinase, haemolysin andcoagulase production, and phenotypic switching activity, and yeast adherence and biofilm formation. DNA fromOL and control yeasts were evaluated for A, B or C genotype status.Results: Phospholipase, proteinase, and coagulase activity and biofilm formation was observed in 80%, 66%, 97% and 77 % of the isolates, respectively. Phenotypic switching was detected in 8.6%, while heamolytic, and ester-ase activity and adherence were noted in all isolates.Conclusions: The genotype A was predominant amongst both the OL and control groups. Due to the small samplesize of our study a larger investigation to define the role of candidal virulent attributes in the pathogenicity of OLis warranted, and the current data should serve as a basis until then.(AU)
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Humanos , Leucoplasia Oral , Boca , Fatores de Virulência , Candida albicans/genética , Virulência , EsterasesRESUMO
Background: Carcinogenesis is a dynamic process which traditional biopsying can not keep up with. Saliva asfluid in the vicinity of the tumor can offer better insights to this process. This study aimed to identify the accuracyof salivary DNA integrity index in differentiating between oral premalignant lesions and oral cancer.Material and Methods: This phase II diagnostic test accuracy study included 93 patients divided into three groups:30 oral cancer patients, 33 patients with oral premalignant lesions divided into 21 oral lichen planus patients and12 patients with leukoplakia and 30 normal individuals who acted as controls. Oral rinse was collected from allparticipants and they all underwent conventional visual and tactile examination, and patients with oral lesions hadthe diagnosis confirmed by histopathological examination of tissue biopsy. DNA integrity index was determinedas the ratio between ALU247 and ALU115 measured by qPCR.Results: There was no statistically significant difference regarding ALU115, ALU247 and DNA integrity indexbetween the three study groups. The index was significantly higher in the oral cancer group than the oral lichenplanus patients, while no significant difference was found between the oral cancer and the leukoplakia cases. TheDNA integrity index sensitivity, specificity, positive and negative predictive values were 73%, 45%, 55% and 65%respectively.Conclusions: Salivary DNA integrity index showed poor diagnostic abilities in differentiating between the oralcancer and premalignant lesions.(AU)
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Humanos , Leucoplasia Oral/diagnóstico , Neoplasias Bucais , Carcinogênese , DNA , Testes Diagnósticos de Rotina , Líquen Plano Bucal/diagnóstico , Medicina Bucal , Cirurgia Bucal , Patologia Bucal , Saúde Bucal , SalivaRESUMO
Background: Among the oral potentially malignant disorders, leukoplakia stands out as the most prevalent. Thepurpose of this study was to analyse the clinical-pathological features of oral leukoplakia in groups of patientsfrom three major pathology centers in two different regions of Brazil, in order to determine which factors wouldbe associated to the clinical risk of malignant transformation.Material and Methods: A total of 148 patients was analyzed, and data regarding gender, age, site, classification ofthe clinical subtype, harmful habits such as use of tobacco and alcohol, time of evolution and presence of dyspla-sia were collected. The association between risk factors and malignant transformation was investigated using thechi-square test and Fischer's exact test for correlation of variables. A significance level of 5% (p≤0.05) was used.Results: The mean age of the patients was 60 years, and 56% were female. Most of the lesions (34,5%) were lo-cated in the lateral and ventral regions of the tongue. Of the 148 patients, ninety had clinical follow-up. Malignanttransformation occurred in 13 patients (8.8%), with an average of 44 months of follow up.Conclusions: Non-smoker, nonhomogeneous clinical presentation, location at the tongue, and the presence of highdegree of dysplasia were statistically relevant factors associated with a higher risk of transformation transformation.(AU)
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Humanos , Masculino , Feminino , Leucoplasia Oral/complicações , Leucoplasia Oral/diagnóstico , Leucoplasia Oral/patologia , Carcinoma de Células Escamosas , Estudos Retrospectivos , Brasil , Saúde Bucal , Patologia Bucal , Medicina Bucal , Cirurgia Bucal , Fatores de RiscoRESUMO
La lengua negra vellosa es una patología benigna y autolimitada, rara en Pediatría, ocasionada por la colonización de bacterias y levaduras cromógenas y la presencia concomitante de factores exógenos. Clínicamente se caracteriza por la coloración pardo-negruzca del dorso lingual, asociada a hipertrofia, hiperqueratosis y elongación de papilas filiformes, dándole a la lengua un aspecto velloso. Su diagnóstico es fundamentalmente clínico, sin ser necesarios otros estudios complementarios. Presentamos un caso de un lactante de dos meses con lengua vellosa negra con buena respuesta a urea tópica
The black hairy tongue is a benign and self-limited pathology, rare in Pediatrics, caused by the colonization of chromogenic bacteria and yeasts and the concomitant presence of exogenous factors. Clinically it is characterized by brownish-black coloration of the lingual dorsum, associated with hypertrophy, hyperkeratosis and elongation of filiform papillae giving the tongue a villous appearance. Its diagnosis is fundamentally clinical, without other complementary studies being necessary. We present a case of a two-month-old baby with black hairy tongue with a good response to topical urea
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Humanos , Lactente , Língua Pilosa/diagnóstico , Ureia/uso terapêutico , Papilas Gustativas/microbiologia , Língua Pilosa/tratamento farmacológico , Leucoplasia Oral/diagnóstico , Diagnóstico DiferencialRESUMO
BACKGROUND: Oral potentially malignant disorders (OPMDs) comprise a range of clinical-pathological alterations that are frequently characterized as architectural and cytological derangements upon histological analysis. Epithelial-mesenchymal transition (EMT) has been proposed as a critical mechanism for the acquisition of the malignant phenotype in neoplastic epithelial processes. This study aims to systematically review the current findings on the immunohistochemical expression of epithelial-mesenchymal transition markers in oral potentially malignant disorders and to evaluate their possible application as biomarkers associated with the progression of oral epithelial dysplasias. MATERIAL AND METHODS: A systematic search was performed in the following databases: PubMed, EMBASE, Chinese BioMedical Literature Database, and Cochrane Library. Articles that evaluated the relationship between the expression of EMT markers and the degree of oral epithelial dysplasia were selected for the systematic review. The quality of each eligible study was evaluated by independent reviewers that used operationalized prognostic biomarker reporting guidelines (REMARK). RESULTS: Seventeen articles met all inclusion criteria and were selected. The EMT markers analyzed exhibited an important association with the prognosis of the cases evaluated. The results showed a progressive increase in the expression of nuclear transcription factors and markers of mesenchymal differentiation, as well as negative regulation of epithelial and cell adhesion markers, according to the stage of oral epithelial dysplasia. CONCLUSIONS: The dysregulation of expression of important EMT components in oral dysplastic epithelium is a potential prognostic marker in OPMDs
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Humanos , Transição Epitelial-Mesenquimal , Doenças da Boca/patologia , Leucoplasia Oral/patologia , Biomarcadores Tumorais/análise , Mucosa Bucal/patologia , Imuno-Histoquímica , Valor Preditivo dos Testes , Prognóstico , Lesões Pré-Cancerosas/patologia , Progressão da DoençaRESUMO
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Humanos , Feminino , Pessoa de Meia-Idade , Leucoplasia Oral/diagnóstico , Leucoplasia Oral/patologia , Cárie Dentária/complicações , Carcinoma in Situ/patologia , Leucoplasia Oral/cirurgia , Cárie Dentária/cirurgia , Carcinoma in Situ/cirurgia , Tabagismo/complicaçõesRESUMO
BACKGROUND: The objective of this study investigated the distribution of immature dendritic cells (DCs), Langer-hans cells and plasmacytoid DCs in oral submucous fibrosis (OSMF), OSMF associated with oral squamous cell carcinoma (OSMF-OSCC), oral leukoplakia (OL), and oral squamous cell carcinoma (OSCC). MATERIAL AND METHODS: Fourteen cases of OSMF, 9 of OSMF-OSCC, 8 of OL ̧ 45 of OSCC and 8 of normal epi-thelium were retrospectively retrieved and their diagnoses confirmed. Immunoreactions against CD1a, CD207 e CD303 were performed and the number of positive cells quantified. RESULTS: A significant decrease of CD1a+ was found in OSMF (p≤0.05), OSMF-OSCC (p ≤ 0.01), and OSCC (p ≤ 0.001) when compared to normal epithelium. For CD207+ the significance decrease was observed in OSMF-OSCC (p ≤ 0.05), and OSCC (p ≤ 0.01) when compared with normal epithelium, and in OSMF when compared with OL (p ≤ 0.05). There was no significant difference for CD303, but increased in CD303+ was observed in OSCC when compared with normal epithelium. CONCLUSION: The decrease in the number of CD1a+ and CD207+ cells may be associate to the development of oral OSCC, and in OPMDs they might be indicators of malignant transformation
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Humanos , Masculino , Feminino , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Idoso , Carcinoma de Células Escamosas/patologia , Neoplasias Bucais/patologia , Fibrose Oral Submucosa/patologia , Células Dendríticas/patologia , Leucoplasia Oral/patologia , Estudos Retrospectivos , Antígenos CD1/análise , Antígenos CD/análise , Lectinas Tipo C/análise , Imuno-Histoquímica , Estudos de Casos e Controles , Valores de ReferênciaRESUMO
BACKGROUND: The frequency and distribution of oral potentially malignant disorders (OPMD) may vary among dif-ferent populations. The aim of the present study was to evaluate the clinical-pathological characteristics of OPMD diagnosed in a Brazilian oral pathology laboratory over a period of 11 years. MATERIAL AND METHODS: All cases diagnosed as leukoplakia, speckled leukoplakia, erythroplakia, and actinic chei-litis from 2005 to 2015 were analyzed. Clinical information was obtained from laboratory forms and histological information was obtained from histological slides stained with hematoxylin and eosin. RESULTS: the final sample was comprised of 684 cases, of which 292 were males and 392 were females. The mean age was 58 years. The anatomical site most often involved was the lateral border of the tongue (23%), followed by the lower lip (20%), and by the buccal mucosa/vestibule (18%). Leukoplakia accounted for 82% of the sample (564 cases). The mean size of the leukoplakia and speckled leukoplakia lesions was 13 mm (ranging from 1 to 100 mm) and 15 mm (ranging from 5 to 30 mm), respectively (p = 0.460). Males reported smoking and drinking alcohol more frequently than females (p = 0.001 and p < 0.0001, respectively). In half of the cases, dysplasia was not histo-logically detected, while slight dysplasia was detected in 28% of the cases. The lesions from patients aged from 41 to 80 years presented moderate and severe dysplasia more often than lesions from patients in other age groups. CONCLUSIONS: OPMD were more common in females in their sixties. Females were more frequently affected in all anatomical sites, except for the lips. Leukoplakia lesions were the most common OPMD, followed by actinic cheili-tis. The lateral border of the tongue was the most affected anatomical site. OPMD located in the floor of the mouth/sublingual mucosa and lesions from older patients presented severe epithelial dysplasia with greater frequency
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Humanos , Masculino , Feminino , Criança , Adolescente , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Leucoplasia Oral/patologia , Queilite/patologia , Doenças da Boca/patologia , Lesões Pré-Cancerosas/patologia , Leucoplasia Oral/epidemiologia , Queilite/epidemiologia , Doenças da Boca/epidemiologia , Lesões Pré-Cancerosas/epidemiologia , Distribuição por Idade e Sexo , Índice de Gravidade de Doença , Fatores de Risco , Brasil/epidemiologiaRESUMO
There is a distinct lack of uniformity in the definitions and clinical terminologies related to oral leukoplakia and leukoplakialike lesions and disorders. Proposals have been put forward to subclassify leukoplakia into a homo-geneous and a non-homogeneous type based on color only, being either predominantly white or mixed white-and-red, respectively, irrespective of the texture of the lesion. In this proposal there is no need anymore to regard the poorly defined proliferative verrucous leukoplakia as a separate entity. Since keratosis is primarily a histo-pathological term, its clinical use is discouraged. Alternative terminology for these so-called keratotic lesions and disorders has been put forward. Finally, a suggestion has been made to rename the term hairy leukoplakia, being a well defined, not potentially malignant disorder particularly related to HIV-infection, into 'EBV-positive white lesion of the tongue' (EBVposWLT)
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Humanos , Leucoplasia Oral/classificação , Doenças da Língua/classificação , Terminologia como AssuntoRESUMO
Presentamos un caso de leucoplasia verrucosa proliferativa, que es una lesión multifocal y progresiva que se presenta en forma de placas blancas en la cavidad oral, de etiología desconocida, resistente a todo intento de tratamiento y con alta recurrencia. Su conocimiento y seguimiento es de especial relevancia por la alta tasa de malignización a carcinoma de células escamosas y a carcinoma verrucoso. Es decir, se trata de una lesión premaligna agresiva, sin claro consenso sobre su etiología, y sin tratamiento efectivo en el momento actual, por lo que requiere de su conocimiento, diagnóstico precoz y seguimiento estricto
We present a case of proliferative verrucous leukoplakia, a multifocal progressive lesion that occurs as white patches in the oral cavity, of unknown etiology, treatment resistant, and with a high recurrence rate. Knowledge and follow-up of this disease is particularly relevant due to its high risk of progressing to malignant squamous cell carcinoma and to verrucous carcinoma. That is, it is an aggressive premalignant lesion, lacking an agreed etiology and an effective treatment at the present time. Therefore it requires knowledge of it, an early diagnosis and a close follow-up
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Humanos , Feminino , Pessoa de Meia-Idade , Neoplasias da Língua/diagnóstico , Leucoplasia Oral/diagnóstico , Epidermodisplasia Verruciforme/diagnóstico , Lesões Pré-Cancerosas/diagnóstico , Detecção Precoce de Câncer/métodos , Candida albicans/isolamento & purificação , Candidíase Bucal/diagnóstico , Diagnóstico Diferencial , Tabagismo/complicaçõesRESUMO
BACKGROUND: Oral leukoplakia is the most common potentially malignant disorder (PMD) of the oral cavity. The objectives of this study are to determine the clinicopathologic features in a group of patients with oral leukoplakia of Northern Spain (Galicia), determining the factors associated to clinical risk and analyzing the malignant transformation of these patients. MATERIAL AND METHODS: We included 85 patients. We recorded sex and age, habits like alcohol and tobacco, size, clinical appearance, site, number of lesions, and presence or absence of dysplasia. We assess the association between risk factors and transformation and developed a logistic regression analysis. Finally we used the Kaplan-Meier and log-rank test for the survival analysis. RESULTS: 7 patients (8.2%) had malignant transformation. The mean follow-up of the patients was 4.13 years versus 5.58 years of those who developed carcinoma. Only location and initial dysplasia have a statistically significant relationship with malignant transformation, but when applied the long rank test only the presence of dysplasia remains statistically significant (P<0,026). Oral Cancer Free Survival was 81.9% (0.150) at 11 years for the group without dysplasia. CONCLUSIONS: We found that the presence of dysplasia is the only risk factor that is statistically related to the development of a carcinoma
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Humanos , Masculino , Feminino , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Transformação Celular Neoplásica , Leucoplasia Oral/mortalidade , Leucoplasia Oral/patologia , Análise de Sobrevida , Fatores de Risco , EspanhaRESUMO
Background: Most of the studies dealing with Chronic Mechanical Irritation (CMI) and Oral Cancer (OC) only considered prosthetic and dental variables separately, and CMI functional factors are not registered. Thus, the aim of this study was to assess OC risk in individuals with dental, prosthetic and functional CMI. Also, we examined CMI presence in relation to tumor size. Material and methods: a case-control study was carried out from 2009 to 2013. Study group were squamous cell carcinoma cases; control group was patients seeking dental treatment in the same institution. Results: 153 patients were studied (Study group n=53, Control group n=100). CMI reproducibility displayed a correlation coefficient of 1 (p< 0.0001). Bivariate analysis showed statistically significant associations for all variables (age, gender, tobacco and alcohol consumption and CMI). Multivariate analysis exhibited statistical significance for age, alcohol, and CMI, but not for gender or tobacco. Relationship of CMI with tumor size showed no statistically significant differences. Conclusions: CMI could be regarded as a risk factor for oral cancer. In individuals with other OC risk factors, proper treatment of the mechanical injuring factors (dental, prosthetic and functional) could be an important measure to reduce the risk of oral cancer (AU)
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Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Neoplasias Bucais/complicações , Neoplasias Bucais/patologia , Mucosa Bucal/patologia , Estudos de Casos e Controles , Leucoplasia Oral/complicações , Leucoplasia Oral/cirurgia , Análise MultivariadaRESUMO
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Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias da Língua/diagnóstico , Neoplasias da Língua/cirurgia , Eritema/complicações , Biópsia , Radiocirurgia , Leucoplasia Oral/complicações , Leucoplasia Oral/cirurgiaRESUMO
Background: In view of the many white or predominantly white lesions of the oral mucosa it is a challenge for dentists to clinically identify a leukoplakia, being a potentially (pre)malignant lesion. Material and Methods: Based on the available literature and experience of the authors the parameters of a clinical diagnosis of oral leukoplakia have been studied. Results: A guide has been presented that should help dentists to establish a clinical diagnosis of leukoplakia as accurate as possible. Conclusions: Probably in most parts of the world dentists will need the help of a specialist for confirmation or exclusion of the clinical diagnosis of oral leukoplakia and for further management of the patient, including patient information (AU)
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Humanos , Leucoplasia Oral/diagnóstico , Mucosa Bucal/lesões , Mucosa Bucal/patologia , Biópsia , Carcinoma in Situ/diagnóstico , Carcinoma in Situ/fisiopatologia , Candidíase/epidemiologia , Boca/lesões , Boca/patologiaRESUMO
Background: Oral leukoplakia (OL) is the most typical potentially malignant disorder of the oral mucosa. We aimed to evaluate the clinical outcome of oral leukoplakia treated with several types of lasers and with the use of quantic molecular resonance (QMR) lancet, in terms of recurrence rate. Material and Methods: Eighty-seven previously untreated OL (52 occurring in females and 35 in males, mean age of 59.4 ± 13.9 years) were consecutively submitted to surgical treatment at University Hospital of Parma, Italy, and Hospital de Valongo, Portugal, (1999 to 2012). Interventions were subclassified into 5 groups according to the instrument used for the surgical removal of OL (cold blade - 17; Nd:YAG 1064nm laser - 14; Er:YAG 2940nm laser - 33; CO2 10600nm laser - 15; and QMR scalpel - 8). The mean follow-up period after treatment was 21.6 months (range 1-151 months). The outcome of treatment was scored through the same clinical protocol in the two participating units. Statistical analysis were carried by univariate analysis using chi-square test (or Pearson's test when appropriate). Results: Recurrences were observed in 24 cases of OL (27.6%). Malignant transformation occurred in one patient (1.1%) after a period of 35 months. Statistical comparison of the 5 surgical treatment modalities showed no differ ences in clinical outcomes nor in the recurrence rate of OL. However, when Er:YAG laser group was compared with traditional scalpel, a significantly better outcome in cases treated with Er:YAG laser (P = 0.015) was highlighted. Conclusions: Our results suggests that Er:YAG laser could be a promising option for the treatment of OL (AU)
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Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Leucoplasia Oral/cirurgia , Procedimentos Cirúrgicos Bucais/métodos , Neoplasias Bucais/epidemiologia , Recidiva , Lasers de Estado Sólido/uso terapêutico , Terapia a Laser/estatística & dados numéricos , Lesões Pré-Cancerosas/cirurgia , Lasers de Gás/uso terapêutico , Estudos Retrospectivos , Estadiamento de Neoplasias , Resultado do TratamentoRESUMO
BACKGROUND: Retrospective studies to assess the distribution of oral diseases (ODs) are helpful in estimating the prevalence of oral diagnoses in the population, and thus help in preventive and curative services. Prevalence and frequency data for ODs are available from many countries, but information from Chile is scarce. MATERIAL AND METHODS: This study investigated the frequency of ODs in a Chilean population. For this, we included all patients treated at the University of Talca (UTALCA, Chile) between 2001 and 2014. Patient characteristics were retrieved from medical files. To contextualize our results, we conducted a systematic review (SystRev) using Publish or Perish software (PoP), Google Scholar and MEDLINE/PubMed. RESULTS: One hundred sixty-six ODs were diagnosed, and the most prevalent groups were soft tissue tumours, epithelial pathology and salivary gland pathology. Individually, irritation fibroma, oral lichen planus (OLP) and mucocele were the most common diagnoses. ODs frequently affected unspecified parts of the mouth (including cheek, vestibule and retromolar area), gum, lips, tongue and palate. In the SystRev, the more studied diagnoses were leukoplakia, OLP and recurrent aphthous stomatitis; prevalent lesions included Fordyce's spots, recurrent aphthous stomatitis and fissured tongue. Chilean patients and SistRev shared almost all ODs. CONCLUSIONS: The results reflect ODs diagnosed in a specialized service of oral pathology and medicine in Chile and will allow the establishment of preventive/curative policies, adequate health services and dentistry curriculum
