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10.
Clin. transl. oncol. (Print) ; 23(10): 2133-2140, oct. 2021. graf
Artigo em Inglês | IBECS | ID: ibc-223384

RESUMO

Objectives Stereotactic body radiotherapy (SBRT) is a consolidate treatment for inoperable early-stage lung tumors, usually delivered in single or multi-fraction regimens. We aimed to compare these two approaches in terms of local effectiveness, safety and survival. Materials and methods Patients affected by medically inoperable early-stage lung tumor were treated at two Institutions with two different schedules: 70 Gy in ten fractions (TF) (BED10: 119 Gy) or 30 Gy in single fraction (SF) (BED10: 120 Gy). Results 73 patients were treated with SBRT delivered with two biological equivalent schedules: SF (44) and TF (29). The median follow-up was 34 months (range 3–81 months). Three-year Overall survival (OS) was 57.9%, 3-year cancer-specific survival (CSS) was 77.2%, with no difference between treatment groups. Three-year progression-free survival (LPFS) was 88.9% and did not differs between SF and TF. Overall, four cases (5.4%) of acute grade ≥ 3 pneumonitis occurred. No differences in acute and late toxicity between the two groups were detected. Conclusion SF and TF seems to be equally safe and effective in the treatment of primary inoperable lung tumors especially for smaller lesion. The SF may be preferentially offered to reduce patient access to hospital with no negative impact on tumor control and survival (AU)


Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Neoplasias Pulmonares/mortalidade , Neoplasias Pulmonares/radioterapia , Radiocirurgia/efeitos adversos , Radiocirurgia/métodos , Fracionamento da Dose de Radiação , Seguimentos , Neoplasias Pulmonares/patologia , Recidiva Local de Neoplasia , Intervalo Livre de Doença , Esofagite/etiologia
12.
Rev. patol. respir ; 23(4): 161-164, oct.-dic. 2020. ilus
Artigo em Espanhol | IBECS | ID: ibc-201110

RESUMO

La fístula traqueoesofágica consiste en una comunicación anómala entre el sistema respiratorio y el digestivo, que puede ser a causa de una enfermedad congénita, o bien secundaria a una patología tal como la infecciosa, la tumoral o postraumática. Entre las etiologías infecciosas, Candida o Aspergillus son dos hongos que provocan esofagitis fúngica, la cual podría complicarse con esta entidad, aunque son casos extremadamente raros. El diagnóstico de las fístulas se basa en la clínica, las pruebas de imagen como la TC y la endoscopia, donde se podrá apreciar la solución de continuidad. Este defecto debe ser tratado mediante cirugía o endoscópicamente


The tracheoesophageal fistula consists of an abnormal communication between the respiratory and digestive systems, which may be due to a congenital disease or secondary to a pathology such as infectious, tumorous or post-traumatic. Among the infectious etiologies, Candida or Aspergillus are two fungi that cause fungal esophagitis, which could be complicated by this entity, although they are extremely rare cases. The diagnosis of fistulas is based on the clinic, imaging tests such as CT and endoscopy, where the solution of continuity can be appreciated. This defect must be treated surgically or endoscopically, a technique that is currently on the rise due to its fewer complications


Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Fístula Traqueoesofágica/diagnóstico por imagem , Fístula Traqueoesofágica/microbiologia , Candida glabrata/patogenicidade , Candidíase/complicações , Esofagite/complicações , Doenças Raras , Tomografia Computadorizada por Raios X , Endoscopia Gastrointestinal , Esofagite/microbiologia
18.
Rev. esp. enferm. dig ; 111(11): 874-879, nov. 2019. tab, graf
Artigo em Inglês | IBECS | ID: ibc-190512

RESUMO

Background and objective: associations between gastroesophageal reflux disease (GERD) and atrial fibrillation (AF) are inconclusive. Some studies found that AF was a risk factor for GERD whereas other studies showed opposite results. The primary objective of this study was to systematically evaluate whether GERD and AF have a bidirectional association using a meta-analysis. Methods: a systematic review was conducted of studies on the association between GERD and AF, written in the English language and included in Cochrane CENTRAL, PubMed and EMBASE until February 2017. The search was limited to longitudinal, case-control, and cross-sectional studies. Results: among 548 studies found in the above-mentioned databases, seven fulfilled the inclusion criteria. Among these seven studies, two were longitudinal studies, two were case-control studies, and three were cross-sectional studies. The summary adjusted relative risks (RRs) for AF-induced GERD and GERD-induced AF were 1.54 (95% CI, 1.08-2.17) and 1.06 (95% CI, 0.86-1.31), respectively. The subgroup analysis showed that the associations were not significantly modified by sample size, study design, age, or geographic area. Conclusions: this meta-analysis supported the association of AF with increased risk of GERD


No disponible


Assuntos
Humanos , Refluxo Gastroesofágico/complicações , Fibrilação Atrial/complicações , Esofagite/complicações , Técnicas de Diagnóstico Cardiovascular , Técnicas de Diagnóstico do Sistema Digestório
19.
Rev. esp. enferm. dig ; 111(11): 884-886, nov. 2019. ilus
Artigo em Espanhol | IBECS | ID: ibc-190516

RESUMO

La esofagitis enfisematosa es una entidad extremadamente infrecuente sin prácticamente ningún caso descrito en la literatura. Presentamos el caso de una paciente con esofagitis y gastritis enfisematosa con afectación de toda la pared del esófago y el estómago al diagnóstico. Fue intervenida quirúrgicamente por perforación gástrica en dos ocasiones, realizándose cierre primario en ambas con evolución posterior favorable. Pese a la gran extensión de la esófago-gastritis enfisematosa al diagnóstico y la presencia de una perforación gástrica, es seguro realizar un manejo semejante a la gastritis enfisematosa siendo lo más conservadores posibles en caso de precisar cirugía


Emphysematous esophagitis is an extremely rare disease and there are very few previous reports in the literature. We report a case of emphysematous esophagitis and gastritis with complete affectation of the gastric and esophageal wall at diagnosis. Two surgical interventions were performed due to gastric perforation that was treated in both cases with primary closure. The post-operative recovery was satisfactory. Despite the large emphysematous esophago-gastritis affectation at diagnosis and the presence of gastric perforation, it is safe to perform the same management principles as with emphysematous gastritis. This should be as conservative as possible in case a surgical procedure is required


Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Esofagite/complicações , Enfisema/complicações , Ruptura Gástrica/complicações , Gastrite/patologia , Tomografia Computadorizada por Raios X/métodos , Esofagite/diagnóstico por imagem , Enfisema/diagnóstico por imagem , Ruptura Gástrica/diagnóstico por imagem , Laparoscopia/métodos
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