RESUMO
Objective: To investigate the clinical efficacy of combining budesonide formoterol with tiotropium bromide for treating asthmachronic obstructive pulmonary disease overlap syndrome (AOCS). Methods: The data of 104 patients with AOCS admitted to our hospital from December 2019 to December 2020 were assessed, randomly and divided into an experimental group (comprising 52 patients, receiving drug combination therapy) and a conventional group (comprising 52 patients, receiving drug therapy alone). Patients clinical efficacy, pulmonary function, fractioned exhaled nitric oxide (FeNO), immune function, endothelial function, serum lipid peroxidation injury indexes, adverse reactions, and quality of life scores were compared. Results: Prior to treatment, no significant differences were observed in various pulmonary function indicators, FeNO, immune function, endothelial function, and lipid peroxidation injury indexes between the two groups (P > 0.05). However, after treatment, all observation indexes in both groups improved to different levels, with the experimental group -demonstrating -significantly superior improvement, compared to the conventional group (P < 0.05). We also observed that adverse reactions in the experimental group were significantly lower than in the conventional group (P < 0.05). Conclusion: The combination of budesonide formoterol to tiotropium bromide in treating asthmaCOPD overlap syndrome may significantly improve pulmonary function, endothelial function, and immune status of patients and encourage the recovery of serum lipid peroxidation injury; therefore, this may deserve widespread adoption and application (AU)
Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Combinação Budesonida e Fumarato de Formoterol/administração & dosagem , Antiasmáticos/administração & dosagem , Brometo de Tiotrópio/administração & dosagem , Broncodilatadores/administração & dosagem , Asma/tratamento farmacológico , Doença Pulmonar Obstrutiva Crônica/tratamento farmacológico , Quimioterapia Combinada , Resultado do Tratamento , SíndromeRESUMO
No disponible
Assuntos
Humanos , Feminino , Adulto , Doenças Pulmonares Intersticiais/diagnóstico , Doenças Pulmonares Intersticiais/tratamento farmacológico , Acetazolamida/administração & dosagem , Broncoconstrição , Natação/fisiologia , Espirometria , Combinação Budesonida e Fumarato de Formoterol/administração & dosagem , Tecido Parenquimatoso/diagnóstico por imagem , Edema Pulmonar/complicações , Exercício FísicoRESUMO
No disponible
