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1.
Rev. esp. enferm. dig ; 116(3): 166-167, 2024.
Artigo em Inglês | IBECS | ID: ibc-231481

RESUMO

Macroenzymes are complexes formed by the binding of enzyme molecules to each other or to other plasma components. We report the clinical case of a woman with abnormal liver enzymes secondary to macro-AST. Macro-AST should be considered in the differential diagnosis as a cause of isolated AST elevation, thus avoiding unnecessary additional tests. (AU)


Assuntos
Humanos , Feminino , Idoso , Transaminases , Insuficiência Renal Crônica , Enzimas , Aspartato Aminotransferases
2.
Rev. ORL (Salamanca) ; 14(4)18 Dic. 2023. tab
Artigo em Espanhol | IBECS | ID: ibc-228776

RESUMO

Introducción y objetivo: El síndrome VEXAS (SV) es una entidad de descripción reciente que afecta fundamentalmente a varones, y se debe a una mutación somática en el gen UBA1. Puede cursar con múltiples manifestaciones sistémicas, siendo la afectación de cabeza y cuello muy frecuente. El objetivo de este estudio fue describir las manifestaciones otorrinolaringológicas del SV, que contribuyan a un diagnóstico y tratamiento temprano de la enfermedad. Método: Se realizó una revisión de la literatura médica, utilizando los criterios PRISMA adaptados al tipo de estudio, de las manifestaciones otorrinolaringológicas del SV, utilizando la base de datos PubMed. Resultados: Fueron incluidos en nuestro trabajo 81 artículos que cumplían los criterios de inclusión del mismo, los cuales describían 133 casos. Los resultados mostraron que el SV se produce, sobre todo, en varones mayores de 50 años de edad, presentando en más de la mitad de los casos, manifestaciones de cabeza y cuello, entre las que destacan la CA, la condritis nasal y el edema periorbitario. Conclusiones: Con frecuencia el SV es confundido, en los pacientes con manifestaciones otorrinolaringológicas, con la policondritis recurrente. El conocimiento por parte del otorrinolaringólogo de las manifestaciones de cabeza y cuello asociadas al mismo, puede contribuir a un diagnóstico y tratamiento temprano mejorando el pronóstico de la enfermedad. (AU)


Introduction and objectives: VEXAS syndrome (VS) is a recently described clinical entity that mainly affects males, and is due to a somatic mutation in the UBA1 gene. It can present with multiple systemic manifestations, especially hematological and dermatological, being the affectation of the head and neck very frequent, especially, auricular chondritis (AC). The objective of this study was to describe the otorhinolaryngological manifestations of VS, knowledge of which by the otolaryngologist could contribute to early diagnosis and treatment of the disease. Methods: A review of the medical literature was carried out, using the PRISMA criteria adapted to the type of study, of the otorhinolaryngological manifestations of VS, from its description in the year 2020 to December 2022, using the Pubmed database. Results: 81 articles that met the inclusion criteria were included in our work, which described 133 cases in detail. The results showed that VS occurs mainly in men over 50 years of age, presenting in more than half of the cases head and neck manifestations, among which AC, nasal chondritis and periorbital edema stand out. Conclusions: Since VS can affect any part of the body, mimicking the clinical pictures of other diseases, it has often been confused, in patients with otorhinolaryngological manifestations, especially with recurrent polychondritis. Knowledge by the otolaryngologist of the head and neck manifestations associated with it can contribute to early diagnosis and treatment, improving the prognosis of the disease. (AU)


Assuntos
Humanos , Otolaringologia , Perda Auditiva Neurossensorial , Vacúolos , Enzimas
3.
Int. microbiol ; 25(4): 831-838, Nov. 2022. graf
Artigo em Inglês | IBECS | ID: ibc-216249

RESUMO

Bjerkandera adusta can decompose polycyclic aromatic hydrocarbons including cellulose and lignin, but its roles in inhibiting plant pathogens are unclear. Here, the confrontation culture and greenhouse pot experiments were employed to study the control effect of B. adusta M1 on Fusarium graminearum and wheat scab. The results showed that B. adusta M1 fermentation broth (FB) inhibited the growth of F. graminearum, with an inhibition rate of 52.7–89.17%. FB had a significant control effect (72.14 ± 1.42%) on wheat scab, which was slightly lower than that of the chemical fungicide carbendazim (77.34 ± 1.76%). The growth rate was significantly higher in B. adusta M1 than in F. graminearum, indicating a strong competitiveness by B. adusta M1. The images from a scanning electron microscope showed substantial deformations of the hyphae of F. graminearum being penetrated by the hyphae of B. adusta M1, indicating a strong mycoparasitism by B. adusta M1. In addition, FB increased the activity of catalase, peroxidase, and phenylalanine ammonia-lyase in wheat leaves related to disease resistance and decreased the malondialdehyde production and cell membrane permeability. We conclude that B. adusta M1 is a promising fungal agent to control the detriment of F. graminearum to cereal growth in the field.(AU)


Assuntos
Humanos , Triticum , Fusarium , Enzimas , Coriolaceae , Microbiologia , Microbiologia de Alimentos
4.
Clin. transl. oncol. (Print) ; 24(2): 288-296, febrero 2022.
Artigo em Inglês | IBECS | ID: ibc-203434

RESUMO

PurposeAnaplastic thyroid carcinoma (ATC) is one of the most aggressive cancers in the world. Stearoyl-CoA desaturase-1 (SCD-1) is one of major enzymes in the de novo synthesis of fatty acids and is related to cancer aggressiveness and poor patient prognosis. The study aimed to construct exosomes loaded SCD-1 interference, investigate its effects and mechanisms on the cell proliferation and apoptosis of ATC cells.MethodsThe expressions of SCD-1 in normal thyroid cell line and ATC cell lines were determined by qRT-PCR and western blotting, respectively. Exosomes were prepared and purification then loaded with SCD-1 siRNA by electroporation and observed by transmission electron microscopy. Higher SCD-1 mRNA and protein levels were found in ATC cell lines compared than normal thyroid cell line (P < 0.05), and both Hth-7 and FRO cells could uptake PKH67-labeled exosomes. The effects of exosomes loaded SCD-1 siRNA on ATC cells were measured by CCK8 assay and apoptosis detection kit.ResultsWhen compared with control group, the cell viability significantly decreased in both two ATC cell lines taken up exosomes loaded SCD-1 siRNA (P < 0.001), and apoptotic and necrotic cells obviously increased (P < 0.05). In order to explore the mechanism of exosomes loaded SCD-1 on ATC, the ROS level was detected by fluorescence reagent. It was found that exosomes loaded SCD-1 siRNA significantly increased intracellular ROS level of ATC cells (P < 0.05).ConclusionsExosomes loaded SCD-1 siRNA inhibited ATC cellular proliferation and promoted cellular apoptosis, and the mechanisms involved maybe the regulation of fatty acids metabolism and ROS level. Our study provides a promising therapeutic strategy for ATC.


Assuntos
Humanos , Ciências da Saúde , Carcinoma Anaplásico da Tireoide , Exossomos , Espécies Reativas de Oxigênio , Neoplasias da Glândula Tireoide , Enzimas , Proliferação de Células/efeitos da radiação
5.
Clin. transl. oncol. (Print) ; 24(2): 297-304, febrero 2022. graf
Artigo em Inglês | IBECS | ID: ibc-203435

RESUMO

PurposeDistal cholangiocarcinoma and pancreatic ductal adenocarcinoma are malignancies with poor prognoses that can be difficult to distinguish preoperatively. Thrombospondin-2 has been proposed as a novel diagnostic biomarker for early pancreatic ductal adenocarcinoma. The aim of the present study was to evaluate thrombospondin-2 as a diagnostic and prognostic biomarker in combination with current biomarker CA 19-9 for distal cholangiocarcinoma and pancreatic ductal adenocarcinoma.MethodsThrombospondin-2 was measured in prospectively collected serum samples from patients who underwent surgery with a histopathological diagnosis of distal cholangiocarcinoma (N = 51), pancreatic ductal adenocarcinoma (N = 52) and benign pancreatic diseases (N = 27) as well as healthy blood donors (N = 52) using an enzyme-linked immunosorbent assay.ResultsThrombospondin-2 levels (ng/ml) were similar in distal cholangiocarcinoma 55 (41–77) and pancreatic ductal adenocarcinoma 48 (35–80) (P = 0.221). Thrombospondin-2 + CA 19-9 had an area under the curve of 0.92 (95% CI 0.88–0.97) in differentiating distal cholangiocarcinoma and pancreatic ductal adenocarcinoma from healthy donors which was superior to CA 19-9 alone (P < 0.001). The diagnostic value of adding thrombospondin-2 to CA 19-9 was larger in early disease stages. Thrombospondin-2 did not provide additional value to CA 19-9 in differentiating the benign disease group; however, heterogeneity was notable in the benign cohort. Three of five patients with autoimmune pancreatitis patients had greatly elevated thrombospondin-2 levels. Thrombospondin-2 levels had no correlation with prognoses.ConclusionsSerum thrombospondin-2 in combination with CA 19-9 has potential as a biomarker for distal cholangiocarcinoma and pancreatic cancer.


Assuntos
Humanos , Ciências da Saúde , Trombospondinas , Biomarcadores Tumorais , Carcinoma Ductal Pancreático , Neoplasias Pancreáticas , Neoplasias , Pancreatopatias , Enzimas
6.
Int. microbiol ; 25(1): 123-131, Ene. 2022. graf
Artigo em Inglês | IBECS | ID: ibc-216017

RESUMO

Naringin, considered as the main bitter component of grapefruit, requires the use of enzymes to reduce the level of this substance during juice processing. For this reason, it has been the focus of many studies. In this study, to increase the production of naringinase by Aspergillus niger cultivated in solid-state fermentation (SSF), a three-component simplex-centric mixing design along with a response surface methodology (RSM) was applied to generate statistical models and analyze the dataset. First, grapefruit peel, rice bran, and wheat bran were used for substrate selection for naringinase production and, finally, selected the best of the three inducers or their mixtures to remove the bitterness of grapefruit juice. Cultivation with 2.3 g of grapefruit peel, 2.5 g of rice bran, and 5.2 g of wheat bran and medium supplementation with a mixture of naringin, rutin, and hesperidin in the concentration of 2, 5, 4.5, and 3.0 g/L, respectively, resulted in a maximum activity of 28 U/mL. The results indicate that the sequencing procedure, which allowed the definition of an optimal mixture of components, is a new way for microorganisms to have a high naringinase yield, in particular by SSF, since our data showed a 96% increase in the production of naringinase. This dataset can help other researchers apply a mixing design to increase enzyme production.(AU)


Assuntos
Humanos , Aspergillus niger , Citrus , Resíduos Industriais , Misturas Complexas , Citrus paradisi , Enzimas , Microbiologia , Técnicas Microbiológicas
7.
Int. microbiol ; 25(1): 133-152, Ene. 2022. ilus
Artigo em Inglês | IBECS | ID: ibc-216018

RESUMO

In the present work, the extensive biological activities of marine endophytic Streptomyces strains isolated from marine soft coral Sarcophyton convolutum have been demonstrated. Within fifty-one Streptomyces isolates evaluated for their hydrolytic enzymes and enzyme inhibitors productivities, six isolates showed the hyperactivities. Pharmaceutical metabolites productivities evaluated include enzymes (alkaline protease, L-asparaginase, L-glutaminase, tyrosinase, and L-methioninase) and enzyme inhibitors (inhibitors of α-amylase, hyaluronidase, β-lactamase, α-glucosidase, and β-glucosidase). These isolates were identified based on their morphological, biochemical, and genetic characteristics as Streptomyces sp. MORSY 17, Streptomyces sp. MORSY 22, Streptomyces sp. MORSY 25, Streptomyces sp. MORSY 36, Streptomyces sp. MORSY 45, and Streptomyces sp. MORSY 50. Moreover, in further evaluation, these strains exhibited wide spectrum of antimicrobial (against bacteria and fungi), antiviral (against hepatitis C virus), antibiofilm against biofilm-forming bacteria (methicillin-resistant Staphylococcus aureus and multidrug-resistant Pseudomonas species), and anti-proliferative activities (against liver and colon carcinoma cell lines). The GC–MS analysis of the hyperactive strains MORSY 17 and MORSY 22 revealed the presence of different bioactive agents in the ethyl acetate extract of both strains.(AU)


Assuntos
Humanos , Endófitos , Anticorpos Anti-Hepatite C , Anti-Infecciosos , Enzimas , Streptomyces , Microbiologia
8.
Cient. dent. (Ed. impr.) ; 16(2): 99-104, mayo-ago. 2019. tab
Artigo em Espanhol | IBECS | ID: ibc-183719

RESUMO

El angioedema hereditario (AEH) es una enfermedad genética rara de transmisión autosómica dominante, en la que existe un déficit de la encima C1-INH. Cursa con episodios recurrentes y autolimitados de edema, causados por aumento de la permeabilidad vascular. Tiene unas importantes implicaciones para los profesionales de la salud bucodental, ya que determinados procedimientos odontológicos y quirúrgicos pueden desencadenar episodios de angioedema, potencialmente mortales al producirse edema en las vías respiratorias superiores. El objetivo de este trabajo es aportar información y recomendaciones a los odontólogos a la hora de tratar a estos pacientes con el fin de minimizar las complicaciones. Los resultados han aportado un total de 48 pacientes y se realizaron un total de 90 intervenciones, siendo el tratamiento más frecuente las extracciones dentales. El AEH tipo I es el más frecuente de los tres tipos con una incidencia de entorno al 85% y el tipo III es el menos común y conocido, ya que se ha identificado en los últimos años. La profilaxis a corto plazo es un método preventivo que ha de realizarse en todos los pacientes con AEH antes de cualquier intervención quirúrgica odontológica. El tratamiento de estos pacientes implica, en la mayoría de las ocasiones, una profilaxis a largo y corto plazo con el fin de disminuir los ataques. Siendo aconsejable realizar los procedimientos odontológicos-quirúrgicos en ambiente hospitalario


Hereditary angioedema (HAE) is a rare genetic disease of autosomal dominant transmission, in which there is a deficit of C1-INH enzyme. It runs with recurrent and self-limited episodes of edema to increase vascular permeability. There are some important complications for oral health professionals because many dental and surgical procedures can trigger angioedema episodes which can be a potentially life-threating condition due to edema in the upper respiratory tract. The objective of this research is to provide information and recommendations to dentists for treating these patients in order to minimize complications. 48 patients have been reported and a total of 90 interventions were performed, being extractions the most frequent treatment. HAE type 1 is the most frequent of the three types with an 85% of incidence, and type III is the least common and known, it has been identified in recent years. Shortterm prophylaxis is a preventive method that must be done in all HAE patients before any dental surgery. The treatment of these patients implies, in most cases, a long- and short-term prophylaxis in order to reduce attacks. It is recommended to realize dental-surgical procedures in a hospital environment


Assuntos
Humanos , Angioedemas Hereditários/diagnóstico , Angioedemas Hereditários/cirurgia , Profilaxia Dentária/métodos , Enzimas/deficiência , Permeabilidade Capilar , Angioedemas Hereditários/classificação
9.
Int. microbiol ; 22(1): 103-110, mar. 2019. graf, tab
Artigo em Inglês | IBECS | ID: ibc-184818

RESUMO

Two ascomycete strains were isolated from creosote-contaminated railway sleeper wood. By using a polyphasic approach combining morpho-physiological observations of colonies with molecular tools, the strains were identified as Fusarium oxysporum Schltdl. (IBPPM 543, MUT 4558; GenBank accession no. MG593980) and Lecanicillium aphanocladii Zare & W. Gams (IBPPM 542, MUT 242; GenBank accession no. MG593981). Both strains degraded hazardous pollutants, including polycyclic aromatic hydrocarbons, anthraquinone-type dyes, and oil. Oil was better degraded by F. oxysporum, but the aromatic compounds were better degraded by L. aphanocladii. With both strains, the degradation products of anthracene, phenanthrene, and fluorene were 9,10-anthraquinone, 9,10-phenanthrenequinone, and 9-fluorenone, respectively. During pollutant degradation, F. oxysporum and L. aphanocladii produced an emulsifying compound(s). Both fungi produced extracellular Mn-peroxidases, enzymes possibly involved in the fungal degradation of the pollutants. This is the first report on the ability of L. aphanocladii to degrade four-ring PAHs, anthraquinone-type dyes, and oil, with the simultaneous production of an extracellular Mn-peroxidase


No disponible


Assuntos
Ascomicetos/isolamento & purificação , Poluentes Ambientais/metabolismo , Hypocreales/isolamento & purificação , Óleos/metabolismo , Madeira/microbiologia , Microbiologia Ambiental , Hypocreales/metabolismo , Hidrocarbonetos Policíclicos Aromáticos/metabolismo , Biotransformação , Enzimas/análise , Hypocreales/classificação
11.
Fisioterapia (Madr., Ed. impr.) ; 39(6): 269-272, nov.-dic. 2017. graf, tab
Artigo em Espanhol | IBECS | ID: ibc-168087

RESUMO

Antecedentes y objetivo: La fibrosis quística (FQ) produce una afectación multisistémica, por lo que la hidroterapia puede aportar numerosos beneficios en su tratamiento. El objetivo de este estudio es la presentación de la efectividad de un programa de hidroterapia en una paciente pediátrica con FQ. Descripción del caso: Niña de 23 meses de edad con FQ que presenta dificultad respiratoria. Intervención: El programa de tratamiento consiste en la realización de 5 sesiones de hidroterapia de 30 min de duración cada una. Resultados: Se muestran mejoras en los signos vitales y las capacidades de la paciente (movilización de secreciones y expectoración), generando efectos positivos sobre su calidad de vida. Discusión: Otros autores han relacionado este tipo de tratamiento con trastornos respiratorios en edades pediátricas y en edad adulta, confirmando igualmente los beneficios que se han obtenido en el caso clínico planteado


Background and objective: Cystic Fibrosis (CF) leads to a multisystemic involvement. Hydrotherapy shows many positive effects. The aim of this study is to show the effectiveness of a hydrotherapy program in a patient with CF. Case description: The patient is a 23 month-old girl with CF and respiratory distress. Intervention: The treatment program consisted of the fulfilment of five 30-minute hydrotherapy sessions. Results: There was an improvement in in patient vital signs and capacities (mainly in terms of mobilisation of secretions and expectoration), generating positive effects on her quality of life. Discussion: Other authors have associated this type of treatment with respiratory disorders, and have confirmed its benefits in paediatric and adult patients, including those obtained in the case presented


Assuntos
Humanos , Feminino , Lactente , Fibrose Cística/terapia , Terapias Complementares/métodos , Hidroterapia/métodos , Qualidade de Vida , Hidroterapia/tendências , Transtornos Respiratórios/reabilitação , Transtornos Respiratórios/terapia , Vitaminas Lipossolúveis/uso terapêutico , Aerossóis/uso terapêutico , Enzimas/uso terapêutico
13.
Rev. esp. cardiol. (Ed. impr.) ; 70(9): 689-689, sept. 2017.
Artigo em Espanhol | IBECS | ID: ibc-166492

RESUMO

No disponible


Assuntos
Terminologia como Assunto , Enzimas
14.
Rev. osteoporos. metab. miner. (Internet) ; 9(2): 72-81, abr.-jun. 2017. ilus, tab, graf
Artigo em Espanhol | IBECS | ID: ibc-164167

RESUMO

Objetivos: Identificar putativas variantes funcionales en los genes CYP11A1 y CYP17A1 asociadas a efectos musculoesqueléticos (pérdida acelerada de la masa ósea y artralgias) derivados del tratamiento con inhibidores de la aromatasa (IA). Material y métodos: La cohorte B-ABLE es un estudio prospectivo de mujeres postmenopáusicas con cáncer de mama en tratamiento con IA. La densidad mineral ósea en columna lumbar y cuello femoral se midió mediante densitometría, y el dolor articular mediante escala analógica visual. A partir de polimorfismos de cambio de un nucleótido (SNPs) en los genes CYP11A1 (rs4077581, rs11632698 y rs900798) y CYP17A1 (rs4919686, rs4919683, rs4919687, rs3781287, rs10786712, rs6163, rs743572), asociados previamente con eventos musculoesqueléticos, se construyeron los haplotipos para cada paciente de la cohorte, y se seleccionaron aquellos que mostraron mayor diferencia fenotípica (p<0,05). Dentro de cada haplotipo, se eligieron aquellas pacientes con fenotipos extremos para la secuenciación de los respectivos genes y la identificación de variantes genéticas funcionales. Finalmente, se realizó un análisis de regresión lineal múltiple contemplando los modelos de herencia genética dominante, recesivo y aditivo. Resultados: No se encontró ninguna mutación en las regiones codificantes. En la región del promotor basal del gen CYP11A1 se encontró una variante genética (D15S520) asociada a la pérdida de masa ósea del cuello de fémur a los 24 meses de tratamiento con IA. Conclusiones: Variantes en regiones reguladoras del gen CYP11A1 podrían modular la expresión de este gen, explicando así parte de la variabilidad fenotípica encontrada en la pérdida de hueso de las pacientes en tratamiento con IA (AU)


Objetives: Identify putative functional variants in the CYP11A1 and CYP17A1 genes associated with musculoskeletal effects (accelerated bone mass loss and arthralgia) derived from treatment with aromatase inhibitors (AI). Material and methods: The B-ABLE cohort is a prospective study of postmenopausal women with breast cancer undergoing AI treatment. Bone mineral density in the lumbar spine and femoral neck was measured by densitometry and joint pain using visual analogue scale. From single-nucleotide polymorphisms (SNPs) in genes CYP11A1 (rs4077581, rs11632698 and rs900798) and CYP17A1 (rs4919686, rs4919683, rs4919687, rs3781287, rs10786712, rs6163, rs743572), previously associated with musculoskeletal events, haplotypes were constructed for each pacient from the cohort, and those haplotypes that showed greatest phenotypic differences were chosen (p<0.05). Within each haplotype, patients with extreme phenotypes were chosen for the sequencing of respective genes and identifying functional genetic variants. Finally, a multiple linear regression analysis was carried out considering the models of dominant, recessive and additive genetic inheritance. Results: No mutation was found in coding regions. A genetic variant (D15S520), in the basal promoter region of gene CYP11A1, was found associated with femoral neck bone loss at 24 month of AI treatment. Conclusions: Variants in regulatory regions of the CYP11A1 gene could modulate the expression of this gene, thus explaining part of the phenotypic variability found in bone loss of patients undergoing AI treatment (AU)


Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Inibidores da Aromatase/administração & dosagem , Inibidores da Aromatase/efeitos adversos , Inibidores da Aromatase/metabolismo , Artralgia/complicações , Artralgia/enzimologia , Artralgia/genética , Escala Visual Analógica , Estudos de Coortes , Estudos Prospectivos , Densidade Óssea/genética , Colo do Fêmur/enzimologia , Colo do Fêmur/patologia , Densitometria/métodos , Enzimas/análise
15.
Bol. pediatr ; 57(240): 91-96, 2017. tab
Artigo em Espanhol | IBECS | ID: ibc-169642

RESUMO

La mayoría de las enfermedades metabólicas se debe a una deficiencia enzimática en alguna de las numerosas vías metabólicas derivadas de los carbohidratos, las proteínas o los ácidos grasos, o del tráfico intracelular. Se manifiestan en cualquier momento de la vida, sobre todo en el periodo neonatal, pero también pueden hacerlo en la infancia o edad adulta. Aunque todavía no se diagnostican de forma suficiente, en los últimos años el campo de los errores innatos del metabolismo (EIM) ha evolucionado desde lo que constituía un grupo limitado de enfermedades raras (ER), poco frecuentes, desconocidas y a menudo fatales, hacia una serie de enfermedades graves pero tratables. Dadas la diversidad y la baja frecuencia de cada uno de los EIM, su seguimiento se realiza habitualmente en centros de referencia, pero en todos los demás escalones asistenciales deben poder iniciarse investigaciones y/o tratamientos antes de referir al paciente. Los responsables de la atención de pacientes afectos de un EIM deben conocer las características básicas de cada enfermedad, los alimentos permitidos y prohibidos, las posibles complicaciones y cómo actuar ante descompensaciones agudas a las que idealmente debieran anticiparse


Most metabolic diseases are due to an enzymatic deficiency in one of the numerous metabolic pathways derived from carbohydrates, proteins or fatty acids, or from intracellular trafficking. They manifest at any time in life, especially in the neonatal period, but they can also do so in childhood or adulthood. Although not yet sufficiently diagnosed, in recent years the field of inborn errors of metabolism (EIM) has evolved from what constituted a limited group of rare, unknown and often fatal diseases to a series of serious but treatable diseases. Given the diversity and low frequency of each of the EIM, their follow-up is usually done in reference centers, but in all other levels of care should be able to initiate research and / or treatments before referring the patient. Those responsible for the care of patients affected by an EIM must know the basic characteristics of each disease, the permitted and forbidden food, the possible complications and how to act in the face of acute descompensation to which they should ideally anticipate


Assuntos
Humanos , Criança , Doenças Metabólicas/complicações , Doenças Metabólicas/diagnóstico , Sistema de Alarme e Alerta , Enzimas/deficiência , Erros Inatos do Metabolismo/diagnóstico , Triagem Neonatal/métodos , Tratamento de Emergência/métodos , Erros Inatos do Metabolismo/complicações , Exame Físico/métodos , Tratamento de Emergência/tendências , Tratamento de Emergência
16.
Reumatol. clín. (Barc.) ; 12(6): 307-312, nov.-dic. 2016. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-157430

RESUMO

Objetivos. Estudiar si en la artritis psoriásica (APs) hay asociación entre la obesidad, el control de la actividad inflamatoria y el aumento de efectos adversos con los fármacos modificadores de la enfermedad (FAME). Métodos. Revisión sistemática de la literatura utilizando las bases de datos Medline y Embase según las guías del consenso MOOSE. Se incluyeron estudios en pacientes con APs, en los que la obesidad fuera factor predictor de efectos adversos y el desenlace fuera toxicidad, incluido fallo de eficacia. La calidad se evaluó mediante una escala de riesgo de sesgos ad hoc. Se realizó un análisis cualitativo por tipo de estudio y población estudiada, calidad y resultados específicos. Resultados. Se encontraron 1.043 artículos, la mayoría se descartaron por título y abstract. Se estudiaron en detalle 10, excluyéndose finalmente 3. La mayoría concluye con resultados estadísticamente significativos que la obesidad en pacientes con APs e inhibidores del TNF-α (iTNF-α) se asocia a una probabilidad menor de alcanzar y mantener la mínima actividad inflamatoria, con mayor tasa de interrupción del tratamiento y menor tasa de respuesta cutánea. En relación con los FAME sintéticos convencionales, se observó en obesos una tendencia a un aumento moderado de las transaminasas con metotrexato (MTX). Conclusiones. La obesidad es un factor predictivo negativo de la respuesta clínica en pacientes con APs e iTNF-α. Exceptuando la hepatotoxicidad por el MTX, no se encontraron otros efectos adversos ni por otros fármacos en relación con la obesidad (AU)


Objectives. To assess the association between obesity, control of inflammatory activity and increased adverse effects in psoriatic arthritis (PsA) with disease-modifying anti-inflammatory drugs (DMARD). Methods. A systematic literature review was performed using MEDLINE and EMBASE databases following the guidelines of the Meta-analysis Of Observational Studies in Epidemiology (MOOSE) consensus statement. Studies were selected if they included patients with PsA, obesity was studied as a predictive factor, and the outcome was adverse effects, including efficacy failure. Quality was assessed using an ad hoc risk of bias tool. A qualitative analysis was carried out by type of study and study population, quality and specific results. Results. We found 1043 articles, discarding most of them on the basis of title and abstract. Ten articles were studied in detail and finally excluded three. The majority concluded, with statistically significant results, that in patients with PsA and treated with TNFα inhibitors (TNFαi), obesity is associated with poorer chances of achieving and maintaining a minimal disease activity, higher treatment discontinuation rates, and lower skin response. Regarding conventional synthetic DMARD, a trend toward a moderate increase in transaminases with methotrexate (MTX) was observed in obese patients with PsA. Conclusions. Obesity is a negative predictor of clinical response in patients with PsA being treated with TNFαi. Except MTX hepatotoxicity, no other adverse effects, either with TNFαi or other drugs, were found in relation to obesity in PsA (AU)


Assuntos
Humanos , Masculino , Feminino , Artrite/complicações , Artrite/terapia , Psoríase/complicações , Obesidade/complicações , Antirreumáticos/administração & dosagem , Antirreumáticos/efeitos adversos , Metotrexato/uso terapêutico , Sobrepeso/complicações , Sobrepeso/diagnóstico , Anti-Inflamatórios não Esteroides/uso terapêutico , 25783/métodos , Índice de Massa Corporal , Fatores de Risco , Comorbidade , Artrite/diagnóstico , Ativação Enzimática/imunologia , Enzimas/imunologia , Fígado/enzimologia
17.
Arch. med. deporte ; 33(176): 404-412, nov.-dic. 2016.
Artigo em Espanhol | IBECS | ID: ibc-160574

RESUMO

Todas las sesiones de entrenamiento y competición suponen una oportunidad de mejora del rendimiento de los jugadores de futbol, por lo que es primordial afrontar cada sesión de entrenamiento o partido en el mejor estado posible. A fecha actual, y para nuestro conocimiento, todavía existen dudas sobre las causas y los mecanismos subyacentes al proceso de fatiga y recuperación en futbol, de ahí la complejidad de controlar este proceso. Existe una variedad de marcadores utilizados en la actualidad (de rendimiento, perceptivos y bioquímicos), algunos de los cuales pueden no ser adecuados debido a la posible fatiga adicional generada que influya en el seguimiento del proceso de la recuperación. Por ello, y a pesar de la dificultad de realizarse en algunas categorías en las que se disponga de los medios necesarios, la información que permiten obtener los marcadores bioquímicos debe ser considerada siempre que sea posible. Dado que su valoración permite optimizar el equilibro entre el estrés competitivo y la recuperación de los jugadores de futbol, el objetivo de esta revisión es analizar la importancia que puede tener el control, seguimiento y evaluación de diferentes marcadores bioquímicos dentro del proceso de recuperación en jugadores de fútbol. Teniendo en cuenta la alta variabilidad en su respuesta debido a las características individuales de los futbolistas y las diferencias metabólicas y fisiológicas que genera cada partido y/o entrenamiento, no podemos realizar un control adecuado del proceso de recuperación en fútbol utilizando únicamente un marcador bioquímico, pues es preciso valorar diferentes marcadores en conjunto. De hecho, deben considerarse como una opción que complemente la información obtenida a través de marcadores de rendimiento físico y/o perceptivo


Training and competition provide an opportunity to enhance the performance of football players, so is essential to face every training session or competition in the best possible condition. For our knowledge, there are still doubts about the causes and mechanisms underlying fatigue and recovery in football, hence the complexity of monitoring this process. A variety of biomarkers are used nowadays (performance, perceptual and biochemical), but some may not be suitable due to the probable fatigue caused that could influence the recovery process. Despite the difficulty of obtain them in some categories where is not plausible, the information of biochemical markers should be considered whenever was possible. Since its assessment let to optimize the balance between competitive stress and recovery of football players, the aim of this review is to analyze the importance of control, monitoring and evaluate different biochemical markers of recovery in soccer players. Even so, the high variability in their response due to the individual characteristics of players and the metabolic and physiological differences caused by a soccer match or training stop us from monitoring the recovery process in soccer using only one biochemical marker, it is necessary to assess several markers together. In fact, they should be considered as an option to complement the information obtained through physical performance and perceptive markers


Assuntos
Humanos , Futebol/fisiologia , Recuperação de Função Fisiológica/fisiologia , Enzimas/análise , Hormônios/análise , Desempenho Atlético/fisiologia , Biomarcadores/análise , Fadiga/fisiopatologia
18.
Cir. plást. ibero-latinoam ; 42(4): 339-346, oct.-dic. 2016. ilus, tab, graf
Artigo em Espanhol | IBECS | ID: ibc-159785

RESUMO

Introducción y Objetivo. El tratamiento clásico de las quemaduras se basa en la eliminación precoz de la escara; sin embargo, el desbridamiento tangencial de las quemaduras mixtas y profundas retira tejidos dérmicos viables, obligando a la cobertura con autoinjertos. El desbridamiento enzimático con enzimas proteolíticos enriquecidos con Bromelaína (Nexobrid®) mantiene restos dérmicos que pueden permitir la reepitelización por sí misma de la quemadura. Evaluamos el uso en nuestra unidad de Nexobrid® (MediWound Ltd., Israel) en quemaduras mixtas y dérmicas profundas, valorando la capacidad de reepitelización tras su uso, la tasa de injerto en los pacientes tratados, y la aparición de cicatrización hipertrófica. Pacientes y Método. Evaluamos retrospectivamente 36 pacientes tratados con Nexobrid® entre enero de 2015 y febrero de 2016, 11 mujeres y 25 varones con una media de edad de 42.89 años. La superficie corporal quemada media fue del 7.47% y la diagnosticada como profunda del 6.42%.Todos los pacientes presentaron quemaduras profundas con necesidad de cirugía para su desbridamiento y cobertura con injertos. Resultados. Tras el desbridamiento enzimático solo el 36.1% de los pacientes (13 de 36) requirió cobertura con injertos (p < 0.001).La superficie injertada fue tan solo del 2.67% frente al 4.98% que fue desbridada enzimáticamente (p < 0.001). A pesar de que el tiempo hasta la epitelización total de las quemaduras se alargó hasta los 25.69 días, tan solo un 11.1% de los pacientes desarrolló cicatriz hipertrófica. Conclusiones. Nexobrid® permite el desbridamiento completo de las quemaduras mixtas y dérmicas profundas disminuyendo el porcentaje de pacientes que requieren autoinjertos y la superficie injertada, con bajas tasas de cicatrización hipertrófica (AU)


Background and Objective. Early burn scar removal is the standard of care for burn patients; excisional debridement, however, often leads to excision of dermal remnants, making autografting unavoidable. Enzymatic debridement with proteolytic enzymes enriched in Bromelain (Nexobrid®) leaves these dermal remnants to allow spontaneous healing of partial thickness burns. This study evaluates if Nexobrid® (MediWound Ltd., Israel) reduces the need for surgery and autografting in intermediate and deepdermal burns, the reduction in the excised and grafted area, and the development of hypertrophic scarring. Patients and Methods. We conduct a prospective study between January 2015 and February 2016 evaluating 36 patients (11 females, 25 males) whose mean age was 42.89, with burns covering a mean of 7.47% of their total body surface area (6.42% deep burns). All patients would need excision and autografting as their previous standard of care. Results. After enzymatic debridement, only 13 patients (36.1%) needed surgery (p < 0.001). The area of burns excised and grafted was reduced (2.67% vs. 4.98% p < 0.001). Since wound closure was delayed until 25.69 days, only 11.1% of the patients developed hypertrophic scars. Conclusions. Nexobrid® allows scar removal in deep-dermal and intermediate burns, reducing the need of surgery and the grafted body surface area, while achieving good scars (AU)


Assuntos
Humanos , Masculino , Feminino , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Idoso , Desbridamento/métodos , Enzimas/uso terapêutico , Transplante Autólogo , Queimaduras/cirurgia , Retalhos Cirúrgicos , Resultado do Tratamento
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