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2.
Clin. transl. oncol. (Print) ; 19(8): 921-930, ago. 2017. tab, ilus
Artigo em Inglês | IBECS | ID: ibc-164670

RESUMO

Pancreatic cancer is one of the most deadly cancers, with dismal prognosis due to its poor early detection rate and high metastatic rate. Thus, elucidation of the molecular mechanisms accounting for its metastasis and discovery of competent biomarkers is required. Exosomes are multivesicular body-derived small extracellular vesicles released by various cell types that serve as important message carriers during intercellular communication. They are also known to play critical roles during cancer-genesis, cancer-related immune reactions, and metastasis. They also possess promising potential as novel biomarkers for cancer early detection. Therefore, extensive studies on pancreatic cancer-derived exosomes are currently being performed because they hold the promising potential of elevating the overall survival rate of patients with pancreatic cancer. In the present review, we focus on the role of exosomes in pancreatic cancer-related immune reactions, metastasis, and complications, and on their potential application as pancreatic cancer biomarkers (AU)


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Assuntos
Humanos , Neoplasias Pancreáticas/diagnóstico , Biomarcadores Tumorais/análise , Exossomos , Exossomos , Complexo Multienzimático de Ribonucleases do Exossomo/análise , Prognóstico , Tetraspanina 29/análise , Tetraspanina 30/análise , Tetraspanina 28/análise
3.
Rev. esp. patol ; 49(2): 106-111, abr.-jun. 2016. ilus
Artigo em Inglês | IBECS | ID: ibc-152442

RESUMO

Tumors are complex tissues that interact in many different ways. Tissue biopsies provide a great amount of information and remain the gold standard for tumor diagnosis. However, they cannot always be performed due to the invasive nature of the procedure and in such circumstances, a liquid biopsy could provide a solution. Liquid biopsy is defined as the search of biomarkers in peripheral blood. To date, there are three main research fields: (1) circulating tumor cells (CTCs); (2) circulating free tumor nucleic acids (cfNA) and (3) exosomes, small vesicles containing various types of signaling molecules capable of modulating a tumor-immune response. In recent years, exosomes have arisen as a powerful tool both to further our understanding of cancer biology and to improve clinical management. We review how the isolation and study of exosomes from liquid biopsies may affect clinical practice (AU)


Las biopsias tisulares, aunque otorgan gran cantidad de información y son el gold standard para el diagnóstico tumoral, no pueden ser realizadas continuamente para monitorizar la evolución tumoral dada su inherente naturaleza invasiva. Por otro lado, la biopsia líquida surge como una herramienta capaz de compensar estas limitaciones. En este momento se han identificado 3 tipos principales de biomarcadores en la biopsia líquida: (1) células tumorales circulantes (CTC); (2) ácidos nucleicos tumorales circulantes libres (cfNA), y (3) exosomas. En los últimos años los exosomas (pequeñas vesículas que contienen moléculas capaces de modular la respuesta inmune-tumoral) han surgido como una potente herramienta para comprender mejor la biología del cáncer así como una manera para intentar mejorar el manejo de los pacientes oncológicos. El objetivo de este artículo es presentar una revisión sobre cómo la caracterización de los exosomas a través de la biopsia líquida podría influir sobre la práctica clínica (AU)


Assuntos
Humanos , Masculino , Feminino , Exossomos/classificação , Exossomos/patologia , Biópsia/instrumentação , Biópsia/métodos , Biópsia , Biomarcadores Tumorais/análise , MicroRNAs/análise , Cetuximab/análise , Tetraspanina 30/administração & dosagem , Tetraspanina 30/análise , MicroRNAs/administração & dosagem , Imuno-Histoquímica/instrumentação , Imuno-Histoquímica/métodos , Imuno-Histoquímica , Citometria de Fluxo
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