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1.
J. physiol. biochem ; 78(1): 1-8, feb. 2022.
Artigo em Inglês | IBECS | ID: ibc-215868

RESUMO

Stroke, also known as cerebral stroke or cerebrovascular accident, refers to acute ischemic or hemorrhagic encephalopathy caused by a disturbance to cerebral blood flow. Ischemic stroke is the most common type of cerebral stroke, accounting for approximately 80% of the total incidence of clinical stroke. High morbidity, disability, and mortality rates place heavy burdens on the families of patients and society. An increasing number of studies have shown that histone modification plays an important role in the pathogenesis of ischemic stroke, but most studies on histone modification focus on acetylation, and studies on the role of histone methylation in the pathogenesis of ischemic stroke are limited. Here, we review the role of histone methylation and related histone methyltransferase (HMT) inhibitors in the pathogenesis of ischemic stroke and related HMT inhibitors in the treatment of ischemic stroke, which may open up a new avenue to the study of ischemic stroke. (AU)


Assuntos
Humanos , Isquemia Encefálica/patologia , Acidente Vascular Cerebral/etiologia , Acidente Vascular Cerebral/genética , Histonas/metabolismo , Metilação , Modificação Traducional de Proteínas
2.
Rev. neurol. (Ed. impr.) ; 50(10): 607-609, 16 mayo, 2010. ilus
Artigo em Espanhol | IBECS | ID: ibc-86668

RESUMO

Introducción. Consideradas tradicionalmente como células de soporte, las células gliales constituyen la inmensa mayoría de las células cerebrales al superar en número a las neuronas por un factor de diez. Poco se conoce de su participación en la fisiología cerebral, a pesar de su ubicación privilegiada, envolviendo las sinapsis. Las células de la estirpe glial participan en la formación de la denominada barrera hematoencefálica y representan una conexión entre la concentración de metabolitos en el compartimiento sistémico y el líquido cefalorraquídeo. Desarrollo. En este artículo analizamos los fenómenos moleculares desencadenados por el ácido glutámico en las células gliales y su participación en el acople metabólico establecido entre estas células y las neuronas. Conclusiones. El control de la traducción selectiva de ARN mensajero constituye la base molecular del acople entre la liberación sostenida de glutamato, la captura de este neurotransmisor y la producción y liberación de glutamina por las células gliales (AU)


Introduction. Traditionally regarded as supportive cells, glial cells have been barely studied in the context of brain physiology. No attention has been paid to the fact that these cells outcome neurons by an estimated factor of ten, and more importantly that they surround synapses. Moreover, cells of glial linage influence the formation of the so-called brain blood barrier representing a link between the concentration of metabolites in the systemic compartment and thecerebrospinal fluid. Development. Using as a model system the cerebellar glutamatergic synapses, in this contribution, we analyze the molecular transactions triggered by glutamate within glial cells that are involved neuronal-glia metabolic coupling. Conclusions. A tight coupling between sustained neuronal glutamate release, glial glutamate uptake, glial glutamine production and release is based on the control of the translation of selective mRNAs (AU)


Assuntos
Humanos , Receptores de Neurotransmissores/fisiologia , Moléculas de Adesão Celular Neurônio-Glia/fisiologia , Ácido Glutâmico/metabolismo , Modificação Traducional de Proteínas/fisiologia , Sistemas de Transporte de Aminoácidos/fisiologia
3.
Int. microbiol ; 12(3): 187-192, sept. 2009. ilus
Artigo em Inglês | IBECS | ID: ibc-72379

RESUMO

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a multifunctional housekeeping protein reported to be a target of several covalent modifications in many organisms. In a previous study, enterohemorrhagic (EHEC) and enteropathogenic (EPEC) Escherichia coli strains were shown to secrete GAPDH and the protein to bind human plasminogen and fibrinogen. Here we report that GAPDH of these pathogens is ADP-ribosylated either in the cytoplasm or in the extracellular medium. GAPDH catalyzes its own modification, which involves Cys-149 at the active site. ADP-ribosylation of extracellular GAPDH may play an important role in the host-pathogen interaction, as also proposed in other pathogens (AU)


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Assuntos
Escherichia coli/metabolismo , Gliceraldeído 3-Fosfato Desidrogenase (NADP+)/análise , Fatores de Ribosilação do ADP/análise , Modificação Traducional de Proteínas
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