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1.
J. coloproctol. (Rio J., Impr.) ; 43(3): 171-178, July-sept. 2023. tab, graf, ilus
Artigo em Inglês | LILACS | ID: biblio-1521147

RESUMO

Colorectal cancer (CRC) is among the most diagnosed malignancies worldwide, and it is also the second leading cause of cancer-related deaths. Despite recent progress in screening programs, noninvasive accurate biomarkers are still needed in the CRC field. In this study, we evaluated and compared the urinary proteomic profiles of patients with colorectal adenocarcinoma and patients without cancer, aiming to identify potential biomarker proteins. Urine samples were collected from 9 patients with CRC and 9 patients with normal colonoscopy results. Mass spectrometry (label-free LC—MS/MS) was used to characterize the proteomic profile of the groups. Ten proteins that were differentially regulated were identified between patients in the experimental group and in the control group, with statistical significance with a p value ≤ 0.05. The only protein that presented upregulation in the CRC group was beta-2-microglobulin (B2M). Subsequent studies are needed to evaluate patients through different analysis approaches to independently verify and validate these biomarker candidates in a larger cohort sample. (AU)


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Neoplasias Retais/diagnóstico , Biomarcadores Tumorais/urina , Neoplasias do Colo/diagnóstico , Proteômica , Estadiamento de Neoplasias
2.
J. coloproctol. (Rio J., Impr.) ; 43(2): 82-92, Apr.-June 2023. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1514426

RESUMO

Background: Anastomotic leakage (AL) is still the most annoying postsurgery complication after colorectal resection due to its serious complications up to death. Limited data were available regarding differences in AL incidence, management, and consequences for different types of colorectal resection. The aim of the present work was to evaluate differences in incidence of AL, incidence of postoperative complications, and length of hospital stay in a large number of patients who underwent elective colorectal resection for management of colorectal lesions. In addition to detect when and what type of reoperation for management of AL occur after colorectal resection. Patients: All 250 included patients underwent elective surgeries for colorectal resection with performance of primary anastomosis for management of colorectal neoplastic and non-neoplastic diseases in the period between May 2016 and July 31, 2021. We followed the patients for 90 days; we registered the follow-up findings. Results: the rates of AL occurrence were variable after the different procedures. The lowest rate of AL occurrence was found in patients who underwent right hemicolectomy, then in patients who underwent sigmoidectomy, left hemicolectomy, transversectomy and anterior resection (p= 0.004). A stoma was frequently performed during reoperation (79.5%) which was significantly different between different procedures: 65.5% in right hemicolectomy, 75.0% in transversectomy, 85.7% in left hemicolectomy, and 93.0% in sigmoid resection (p< 0.001). Conclusion Rates, types, time of occurrence and severity of AL vary according to the type of colectomy performed and selective construction of stoma during AL reoperation is currently safely applied with comparable mortality rates for patients who did and who did not have a stoma after reoperation. (AU)


Assuntos
Humanos , Masculino , Feminino , Complicações Pós-Operatórias , Neoplasias do Colo/cirurgia , Fístula Anastomótica/epidemiologia , Reoperação , Perfil de Saúde , Fatores de Risco , Resultado do Tratamento , Estadiamento de Neoplasias
3.
J. coloproctol. (Rio J., Impr.) ; 43(2): 126-132, Apr.-June 2023. tab, graf, ilus
Artigo em Inglês | LILACS | ID: biblio-1514430

RESUMO

Background: Due to few sufficient data regarding the comparison between endoscopic and surgical resection of malignant colorectal polyps regarding outcomes and survival benefits, there are no clear guidelines of management strategies of malignant colorectal polyps. The aims of the present study were to compare endoscopic resection alone and surgical resection in patients with malignant polyps in the colon (T1N0M0) readings advantages, disadvantages, recurrence risks, survival benefits, and long-term prognosis to detect how management strategy affects outcome. Patients and methods: we included 350 patients. All included patients were divided into 2 groups; the first group included 100 patients who underwent only endoscopic polypectomy and the second group included 250 patients who underwent endoscopic polypectomy followed by definitive surgical resection after histopathological diagnosis. We followed all patients for about 5 years, ranging from 18 to 55 months. The primarily evaluated parameters are surgical consequences and patients' morbidity. The secondary evaluated parameters are recurrence risks, recurrence free survival, and overall survival rates. Results: The age of patients who underwent polypectomy is usually younger than the surgical group, males have more liability to polypectomy in comparison with females. Patients with tumors in the left colon have more liability to polypectomy in comparison with the right colon (p< 0.0001). Tumor factors associated with more liability to surgical resection are presence of lymphovascular invasion, high grade, and poor tumor differentiation (p< 0.0001). The management strategy was the most significant predictor of overall and recurrence free survival rates in patients with malignant colon polyps (p< 0.001). Conclusions: We found that survival benefits and lower incidence of recurrence are detected in the surgical resection group more than in the polypectomy group. (AU)


Assuntos
Procedimentos Cirúrgicos do Sistema Digestório/métodos , Pólipos do Colo/cirurgia , Neoplasias do Colo/mortalidade , Laparoscopia , Endoscopia , Recidiva Local de Neoplasia , Estadiamento de Neoplasias
4.
Arq. bras. oftalmol ; 86(1): 71-73, Jan.-Feb. 2023. graf
Artigo em Inglês | LILACS | ID: biblio-1403476

RESUMO

ABSTRACT We report an unusual case of fulminant endogenous Clostridium septicum panophthalmitis. A 74-year-old male patient presented with sudden amaurosis in the right eye, which in a few hours, evolved into an orbital cellulitis, endophthalmitis, anterior segment ischemia, and secondary perforation of the eye. A complete diagnostic study, which included cranial and orbital contrast-enhanced computed tomography scan, contrast-enhanced magnetic resonance imaging, blood cultures, and complete blood work, were performed. No causal agent was identified. Clostridium septicum infection caused fulminant gaseous panophthalmitis. Despite broad-spectrum antibiotic treatment, evisceration of the eyeball was necessary. The extension study showed a colon adenocarcinoma as the origin of the infection. Clostridium septicum panophthalmitis is a rare but aggressive orbital infection. This infection warrants the identification of a neoplastic process in the gastrointestinal tract in many cases not previously described.


RESUMO Este é o relato de um caso incomum de panoftalmite endógena fulminante por Clostridium septicum. Um paciente do sexo masculino, 74 anos, apresentou amaurose súbita no olho direito, que em poucas horas evoluiu para celulite orbitária, endoftalmite, isquemia do segmento anterior e perfuração secundária do olho. Foi realizado um estudo diagnóstico completo, que incluiu uma tomografia computadorizada com contraste cranial e orbital, um exame de ressonância magnética, hemocultura e hemograma completo. Nenhum agente causal foi identificado. A infecção por Clostridium septicum causou uma panoftalmite gasosa fulminante. Apesar do tratamento com antibióticos de amplo espectro, foi necessário eviscerar o globo ocular. O estudo de seguimento mostrou um adenocarcinoma de cólon como a origem da infecção. A panoftalmite por Clostridium septicum é um tipo raro, mas muito agressivo de infecção orbitária. Essa infecção deve sugerir a busca por um processo neoplásico no trato gastrointestinal, em muitos casos não diagnosticado anteriormente.


Assuntos
Humanos , Idoso , Adenocarcinoma , Neoplasias do Colo , Clostridium septicum , Adenocarcinoma/complicações , Adenocarcinoma/diagnóstico por imagem
5.
Aquichan ; 23(1): e2317, 13 ene 2023.
Artigo em Inglês, Espanhol | LILACS, BDENF - Enfermagem, COLNAL | ID: biblio-1436430

RESUMO

Objective: To design and validate a nursing intervention and its effect on improving self-management behaviors in patients with colorectal cancer following surgery within eight weeks after discharge. Method: Pilot study using Sidane and Braden's intervention design proposal, which included determining the guiding theoretical model, characterization of the intervention, validation with eight experts through content validity, and a pilot test with ten patients during the second semester of 2020. Results: The intervention obtained, called the Program for Self-Management Training in Colorectal Cancer (PEACCR, by its acronym in Spanish), is based on the theory of individual and family self-management in the dimensions proposed by Ryan and Sawin. The validity with experts indicates that it meets the criteria of clarity, precision, comprehension, relevance, and pertinence. The pilot reports an increase in self-management behaviors and the dimensions of knowledge, coping, and health personnel-patient alliance in months 1 and 2, with statistical significance. Conclusions: The designed and validated intervention increases the self-management behaviors of patients with colorectal cancer. The proposed scheme is highly acceptable to participants.


Objetivo: diseñar y validar una intervención de enfermería y su efecto para mejorar los comportamientos de automanejo en pacientes con cáncer colorrectal, después de una intervención quirúrgica dentro de las ocho semanas posteriores al alta. Método: estudio piloto que acoge la propuesta de diseño de intervenciones de Sidane y Braden, lo que incluyó determinar el modelo teórico orientador, la caracterización de la intervención, la validación con ocho expertos a través de la validez de contenido, y una prueba piloto con diez pacientes, durante el segundo semestre del año 2020. Resultados: la intervención obtenida, denominada Programa para el Entrenamiento en Automanejo en Cáncer Colorrectal (PEACCR), se basa en la teoría de automanejo individual y familiar en las dimensiones planteadas por Ryan y Sawin. La validez con expertos indica que cumple con los criterios de claridad, precisión, comprensión, relevancia y pertinencia. El piloto reporta un aumento en los comportamientos de automanejo y en las dimensiones de conocimiento, afrontamiento y alianza personal de salud-paciente en el mes 1 y en el mes 2, con significancia estadística. Conclusiones: la intervención diseñada y validada aumenta los comportamientos de automanejo de pacientes con cáncer colorrectal. El esquema propuesto es de alta aceptabilidad para los participantes.


Objetivo: desenhar e validar uma intervenção de enfermagem e seu efeito para melhorar os comportamentos de autogestão em pacientes com câncer colorretal, depois de uma intervenção cirúrgica dentro das oito semanas posteriores à alta. Materiais e método: estudo-piloto que utiliza a proposta de desenho de intervenções de Sidane e Braden, o que inclui determinar o modelo teórico orientador, a caracterização da intervenção, a validação com oitos especialistas por meio da validade de conteúdo e um teste-piloto com dez pacientes, durante o segundo semestre de 2020. Resultados: a intervenção obtida, denominada "Programa para o Treinamento em Autogestão em Câncer Colorretal", está baseada na teoria de autogestão individual e familiar nas dimensões propostas por Ryan e Sawin. A validade com especialistas indica que cumpre com os critérios de clareza, precisão, compreensão, relevância e pertinência. O piloto relata um aumento nos comportamentos de autogestão e nas dimensões de conhecimento, enfrentamento e parceria pessoal de saúde-paciente no mês 1 e no mês 2, com significância estatística. Conclusões: a intervenção desenhada e validada aumenta os comportamentos de autogestão de pacientes com câncer colorretal. O esquema proposto é de alta aceitabilidade para os participantes.


Assuntos
Alta do Paciente , Resultado do Tratamento , Neoplasias do Colo , Avaliação de Eficácia-Efetividade de Intervenções , Autogestão , Enfermagem
6.
Gastroenterol. latinoam ; 34(1): 15-21, 2023. tab
Artigo em Espanhol | LILACS | ID: biblio-1524560

RESUMO

Colorectal Cancer (CRC) is the third most frequent neoplasia worldwide. Despite the significant advances in surgical techniques and the development of new targeted antineoplastic therapies for this type of tumor, primary prevention and early diagnosis of malignant precursor lesions will continue to be the best strategies to reduce their incidence, morbidity, and mortality. Technologies for CRC screening can be classified into two groups, those of an invasive nature, such as colonoscopy and all its different modalities of use, and those of a non-invasive nature, such as laboratory tests and imaging. This review, will focus exclusively on non-invasive screening tests, excluding imaging. Specifically, it will address those that use depositions as a sample. This review will approach the latest international recommendations, regarding the age at which they should be used, their technical-biological bases, the two main types currently used (biochemical and immunological), and we will put into perspective their advantages and their possible disadvantages. Towards the end of this article, the most recent biotechnological developments in relation to molecular tests based on the study of blood samples, will be discussed. Although these tests are not yet in routine clinical use given their high costs, they are promising for the early detection of CRC.


El cáncer colorrectal (CCR) es la tercera neoplasia más común en todo el mundo. A pesar de los avances significativos en las técnicas quirúrgicas y en el desarrollo de nuevas terapias antineoplásicas para este tipo de tumor, la prevención primaria y el diagnóstico precoz de lesiones precursoras malignas siguen siendo las mejores estrategias para reducir la incidencia, morbilidad y mortalidad asociadas al CCR. Existen dos tipos de tecnologías para el tamizaje del CCR: las invasivas, como la colonoscopia, y las no invasivas, como los ensayos de laboratorio y la imagenología. Esta revisión, se centrará exclusivamente en las pruebas de tamizaje no invasivas que utilizan muestras de deposiciones, excluyendo las imágenes. Se abordarán las últimas recomendaciones internacionales sobre el momento etario en que se deben utilizar, sus bases técnico-biológicas, los dos principales tipos utilizados en la actualidad (bioquímico e inmunológico) y pondremos en perspectiva sus ventajas y posibles desventajas. Al final de esta revisión, se discutirá brevemente los últimos avances biotecnológicos relacionados con pruebas moleculares basadas en el estudio de muestras sanguíneas. Aunque estas pruebas aún no son de uso clínico habitual debido a sus altos costos, representan una prometedora innovación para la detección temprana del CCR.


Assuntos
Humanos , Programas de Rastreamento/métodos , Neoplasias do Colo/diagnóstico , Neoplasias Colorretais/diagnóstico , Neoplasias Colorretais/prevenção & controle , Neoplasias do Colo/prevenção & controle , Sangue Oculto
7.
Edumecentro ; 152023.
Artigo em Espanhol | LILACS | ID: biblio-1440043

RESUMO

Fundamento: en la actualidad se observan restricciones epistemológicas y praxiológicas en la formación del residente de Cirugía General. La lógica hermenéutico-dialéctica de dicha formación se expresa en su relación con la práctica quirúrgica contextual; el desarrollo de las habilidades quirúrgicas discurre mediante la educación en el trabajo. Objetivo: diseñar un modelo didáctico de la formación quirúrgico-asistencial en la educación en el trabajo del residente de Cirugía General, para la atención integral de pacientes con cáncer de colon. Métodos: se realizó una investigación de desarrollo en el los hospitales "Saturnino Lora" y "Juan B. Zayas" de Santiago de Cuba durante 2021. Se emplearon métodos teóricos: análisis-síntesis, sistematización y generalización de experiencias, holístico-dialéctico, modelación y enfoque hermenéutico; empíricos: encuesta y entrevista a residentes, especialistas y expertos de ambos hospitales. Resultados: el modelo diseñado se sustenta en la sistematización y generalización de las experiencias de los autores concernientes a los períodos preoperatorio, operatorio y posoperatorio de la cirugía de esta neoplasia. Conclusiones: el modelo didáctico fue validado por expertos como pertinente, factible y aplicable; tiene como contradicción la relación entre la lógica secuencial algorítmica de la práctica quirúrgica y la lógica hermenéutico-dialéctica del proceso de formación del residente en Cirugía General, a fin de contribuir a disminuir las insuficiencias y limitaciones de este profesional durante el proceso formativo.


Background: currently epistemological and praxiological restrictions are observed in the training of the General Surgery resident. The hermeneutic-dialectical logic of such training is expressed in its relationship with contextual surgical practice; the development of surgical skills proceeds through the in-service training. Objective: to design a didactic model of surgical-care training in the in-service training of the General Surgery resident, for the comprehensive care of patients with colon cancer. Methods: a development investigation was carried out in the "Saturnino Lora" and "Juan B. Zayas" hospitals in Santiago de Cuba during 2021. Theoretical methods were used: analysis-synthesis, systematization and generalization of experiences, holistic-dialectical, modeling and hermeneutic approach; empirical ones: survey and interview with residents, specialists and experts from both hospitals. Results: the designed model is based on the systematization and generalization of the authors' experiences concerning the preoperative, operative, and postoperative periods of surgery for this neoplasm. Conclusions: the didactic model was validated by experts as pertinent, feasible and applicable; Its contradiction is the relationship between the algorithmic sequential logic of surgical practice and the hermeneutic-dialectical logic of the training process of the resident in General Surgery, in order to help reduce the insufficiencies and limitations of this professional during the training process.


Assuntos
Neoplasias do Colo , Educação Médica , Internato e Residência , Aprendizagem
9.
BioSCIENCE ; 81(2): 120-124, 2023.
Artigo em Português | LILACS | ID: biblio-1524195

RESUMO

Introdução: Imagem endoscópica aprimorada permite o diagnóstico diferencial das lesões colorretais em tempo real através do estudo da microvasculatura. Objetivo: Revisar o uso do Blue Laser Imaging (BLI) na análise do padrão dos capilares para o diagnóstico diferencial entre lesões neoplásicas e não neoplásicas. Métodos: Esta é revisão integrativa da literatura que colheu informações publicadas em plataformas virtuais em português e inglês. A busca para leitura e análise foi realizada nas plataformas SciELO ­ Scientific Electronic Library Online, Google Scholar, Pubmed e Scopus. Os descritores retirados do DeCS/MESH foram: "Blue laser imaging. Endoscopia. Cromoendoscopia, Pólipos colorretais. Magnificação" e seus correspondentes em inglês "Blue laser imaging. Image-enhanced endoscopy. Chromoendoscopy. Colorectal polyps. Magnification" com busca AND ou OR, considerando o título e/ou resumo. Foram incluídos somente os que tivessem maior correlação ao tema, e neles foi baseada a revisão com leitura, na íntegra, dos textos. Resultados: Ao final resultaram 22 artigos que compuseram esta revisão. Conclusão: BLI associada à magnificação mostrou bons resultados no diagnóstico histológico preditivo em tempo real para as lesões de cólon e reto.


Introduction: Improved endoscopic imaging allows the differential diagnosis of colorectal lesions in real time through the study of the microvasculature. Objective: To review the use of Blue Laser Imaging (BLI) in analyzing the capillary patern for the differential diagnosis between neoplastic and nonneoplastic lesions. Methods: This is an integrative review of the literature that collected information published on virtual platforms in Portuguese and English. The search for reading and analysis was carried out on the SciELO ­ Scientific Electronic Library Online, Google Scholar, Pubmed and Scopus platforms. The descriptors taken from DeCS/MESH were: "Blue laser imaging. Endoscopy. Chromoendoscopy, Colorectal polyps. Magnification" and its English counterparts "Blue laser imaging. Image-enhanced endoscopy. Chromoendoscopy. Colorectal polyps. Magnification" with AND or OR search, considering the title and/or abstract. Only those that had the greatest correlation to the topic were included, and the review was based on them, with reading, in full, of the texts. Results: In the end, 22 articles resulted that made up this review. Conclusion: BLI associated with magnification showed good results in real-time predictive histological diagnosis for colon and rectal lesions.


Assuntos
Humanos , Neoplasias do Colo
10.
J. coloproctol. (Rio J., Impr.) ; 43(1): 12-17, Jan.-Mar. 2023. tab, graf, ilus
Artigo em Inglês | LILACS | ID: biblio-1430693

RESUMO

Introduction: The second most common cause of cancer-related mortality is colorectal cancer, and laparoscopic-assisted colectomy (LAC) has gained popularity among surgeons as an alternative to the conventional approach, which is open colecrtomy (OC). The differences between LAC and OC in terms of short-term outcomes have not been well documented, and the aim of the present work is to compare the short-term outcomes of both procedures. Materials and Methods: The present prospective study comprised 164 participants submitted to LAC (n = 82) and OC (n = 82) at the Helwan and Zagazig University hospitals between January 2018 and January 2022. We collected and analyzed demographic data, surgical data, and the short-term outcomes. Results: The LAC group had a significantly lower estimated amount of blood loss, shorter hospital stay, lower rates of incisional surgical site infection, and fewer cases of burst abdomen postoperatively, but with a considerably longer operative time (30.3 minutes) than the OC group. Conclusions: Our findings show that LAC is favorable option to OC, with superior outcomes. (AU)


Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Resultado do Tratamento , Neoplasias do Colo/cirurgia , Complicações Pós-Operatórias , Procedimentos Cirúrgicos do Sistema Digestório/métodos , Perda Sanguínea Cirúrgica , Laparoscopia
11.
Cambios rev med ; 21(2): 886, 30 Diciembre 2022. tabs, grafs.
Artigo em Espanhol | LILACS | ID: biblio-1416079

RESUMO

INTRODUCCIÓN. El cáncer de colon es una neoplasia del tubo digestivo considerada una de las más frecuentes en ambos sexos y que predomina en adultos mayores. OBJETIVO. Describir las características clínicas y epidemiológicas de los pacientes con cáncer de colon. MATERIALES Y MÉTODOS. Estudio observacional, descriptivo, retrospectivo. Población de 1 601 y muestra de 210 datos de Historias Clínicas Electrónicas de pacientes diagnosticados con cáncer de colon, atendidos por la Unidad de Oncología del Hospital de Especialidades Carlos Andrade Marín de la ciudad de Quito en el periodo enero de 2016 a diciembre de 2019. Criterios de inclusión: diagnóstico confirmado de Cáncer de Colon, edad igual o mayor a 18 años, y disponer de todos los datos clínicos requeridos en el estudio. Se utilizó el método de muestreo probabilístico con lo que se estimó una proporción para el estudio con un intervalo de confianza del 95%, un margen de error del 5% y una frecuencia esperada del 3%, de donde se obtuvo una muestra ajustada al 10% de pérdidas. El procesamiento de datos se realizó en los programas Microsoft Excel versión 16 y el Statistical Package for Social Sciences versión 24. RESULTADOS. La mayor presentación fue en adultos mayores de 50 años, con una relación 1:1 en cuanto a sexo, y en la procedencia, se ubicó mayoritariamente en la población de la región Sierra; las personas con una actividad económica de tipo profesional fueron las más afectadas; en lo que se refiere a los antecedentes se encontró mayor relación en los personales y dentro de estos los pólipos; no hubo relación con los antecedentes quirúrgicos ni familiares. El síntoma de debut más prevalente fue el dolor abdominal; la mayoría fueron sometidos a colonoscopia; predominó la lateralidad derecha y el tipo histológico principalmente identificado fue el adenocarcinoma. CONCLUSIÓN. No se observó relación estadísticamente significante entre estadíos, evolución y tratamientos instaurados, lo que pudo estar influenciado por el muestreo al azar; y que el 53,30% de los pacientes aún se encuentra en controles.


INTRODUCTION. Colon cancer is a neoplasm of the digestive tract considered one of the most frequent in both sexes and predominantly in older adults. OBJECTIVE. To describe the clinical and epidemiological characteristics of patients with colon cancer. MATERIALS AND METHODS. Observational, descriptive, retrospective study. Population of 1 601 and sample of 210 data from Electronic Medical Records of patients diagnosed with colon cancer, attended by the Oncology Unit of the Hospital de Especialidades Carlos Andrade Marín of the city of Quito in the period January 2016 to December 2019. Inclusion criteria: confirmed diagnosis of Colon Cancer, age equal to or older than 18 years, and having all the clinical data required in the study. The probability sampling method was used with which a proportion was estimated for the study with a confidence interval of 95%, a margin of error of 5% and an expected frequency of 3%, from which a 10% loss adjusted sample was obtained. Data processing was performed in Microsoft Excel version 16 and Statistical Package for Social Sciences version 24. The greatest presentation was in adults over 50 years of age, with a 1:1 ratio in terms of sex, and in terms of origin, it was mainly located in the population of the Sierra region; people with a professional economic activity were the most affected; in terms of history, a greater relationship was found in personal history and within these, polyps; there was no relationship with surgical or family history. The most prevalent debut symptom was abdominal pain; the majority underwent colonoscopy; right laterality predominated and the histological type mainly identified was adestatistically significant relationship was observed between stages, evolution and treatment, which could be influenced by random sampling; and that 53,30% of the patients are still in controls.


Assuntos
Humanos , Masculino , Feminino , Neoplasias do Colo Sigmoide , Pólipos do Colo , Colo , Doenças do Colo , Neoplasias do Colo , Polipose Adenomatosa do Colo , Colecistectomia , Adenocarcinoma , Dor Abdominal , Colonoscopia , Colectomia , Equador , Hemorragia Gastrointestinal , Neoplasias Intestinais , Oncologia
12.
Oncología (Guayaquil) ; 32(3): 300-309, 2 de diciembre del 2022.
Artigo em Espanhol | LILACS | ID: biblio-1411154

RESUMO

Introducción: Los pacientes con cáncer de colon tienen un riesgo de obstrucción intestinal maligna (OIM). El objetivo del estudio fue determinar la prevalencia de la OIM en un grupo de pacientes con cáncer de colon en un centro de referencia regional público. Metodología: El presente estudio transversal se realizó en el Hospital General IESS Ceibos de Guayaquil -Ecuador de marzo 2017 a junio del 2020. Se incluyeron pacientes con cáncer de colon incidentes en el período de estudio. Las variables fueron edad, sexo, presencia de OIM. Se utiliza estadística descriptiva en frecuencias y porcentajes. Resultados: Se analizan 90 pacientes, 55 hombres (61.11%). La edad más prevalente fue el grupo de 61 a 70 años 27 casos (30%).La comorbilidad más prevalente fue la hipertensión arterial en el 36%. El tipo histológico predominante fue el adenocarcinoma de colon en el 94.44%. 61.11% tuvieron un tumor en el recto y 15.56% en la unión rectosigmoidea. La prevalencia de OIM fue de 55 casos 61.11% (IC95% 60.77-61.45%). En 15 casos (16.67%) fue obstrucción completa y 36 casos (40%) fue obstrucción parcial. La mortalidad fue de 52 casos (57.78%). La presencia del tumor en la unión rectosigmoidea OR=6.188 (IC95% 1.282-29.86) P=0.0232. Conclusión: La prevalencia de OIM es alta más del 61%. La presencia del tumor en la unión recto-sigmoidea fue un factor de riesgo para el desarrollo de OIM.


Introduction: Patients with colon cancer are at risk of malignant intestinal obstruction (MIO). The study aimed to determine the prevalence of MIO in a group of patients with colon cancer in a public regional reference center. Methodology: This cross-sectional study was carried out at the IESS Ceibos General Hospital in Guayaquil, Ecuador, from March 2017 to June 2020. Patients with incident colon cancer were included in the study period. The variables were age, sex, and the presence of MIO. Descriptive statistics are presented as frequencies and percentages. Results: Ninety patients were analyzed, 55 men (61.11%). The most prevalent age group was 61 to 70, with 27 cases (30%). The most prevalent comorbidity was arterial hypertension (36%). The predominant histological type was colon adenocarcinoma (94.44%). A total of 61.11% had a tumor in the rectum, and 15.56% had a tumor in the rectosigmoid junction. The prevalence of MIO was 55 cases, 61.11% (95% CI 60.77-61.45%). In 15 cases (16.67%), there was complete obstruction; in 36 cases (40%), there was partial obstruction. Mortality was 52 cases (57.78%). The presence of the tumor in the rectosigmoid junction OR=6.188 (95% CI 1.282-29.86) P=0.0232. Conclusion: The prevalence of MIO is high, at more than 61%. The presence of a tumor in the rec-tosigmoid junction was a risk factor for the development of MIO.


Assuntos
Neoplasias do Colo , Neoplasias , Estudos Transversais , Colo , Obstrução Intestinal
13.
Rev. cuba. cir ; 61(4)dic. 2022.
Artigo em Espanhol | LILACS, CUMED | ID: biblio-1441531

RESUMO

Introducción: El modelo interdisciplinario en el ámbito oncológico ha permitido la vinculación entre diferentes disciplinas lo que permite aportar soluciones para elevar la calidad de vida de los enfermos y proporcionan una atención de excelencia. Objetivo: Explorar la evidencia científica sobre la colaboración interdisciplinar en el tratamiento del cáncer de colon. Métodos: Se realizó una investigación de tipo sistemática. Se ejecutó una búsqueda digital en las bases de datos de Web of Science, Lilacs, SciELO, Latindex, Elsevier, PubMed, Medline y Google de publicaciones actualizadas en inglés y español. Desarrollo: El enfoque interdisciplinario en el tratamiento de las enfermedades oncológicas, entre ellas el cáncer de colon, se ha descrito desde hace algún tiempo. El diseño permite vincular diferentes especialidades en las interconsultas y en el propio acto quirúrgico, lo que redunda en la formulación de problemas de investigación que requieren para su solución el intercambio de conocimientos y tecnologías de una especialidad a otra, permite aportar soluciones para elevar la calidad de vida de los enfermos y proporciona una atención de excelencia. Conclusiones: El cáncer es una enfermedad que requiere una atención para el paciente, no solo dentro de la esfera biológica; también psicológica, social y espiritual. Los equipos interdisciplinares, formados por profesionales de distintas disciplinas, son una herramienta que puede ayudar, en gran medida, a conseguir una mejor atención(AU)


Introduction: The interdisciplinary model in the oncological field has permitted connection between different disciplines, allowing to offer solutions for raising the quality of life of patients and provide excellent care. Objective: To explore the scientific evidence on interdisciplinary collaboration in the treatment of colon cancer. Methods: A systematic research was carried out. A digital search was carried out in the Web of Science, Lilacs, SciELO, Latindex, Elsevier, PubMed, Medline and Google databases, in view of identifying updated publications in English and Spanish. Development: The interdisciplinary approach in the treatment of oncologic diseases, including colon cancer, has been described for some time. The design allows connecting different specialties during interconsultation or the surgical act itself, which results in the formulation of research problems that require, for their solution, the exchange of knowledge and technologies from one specialty to another, allowing to offer solutions for raising the quality of life of patients and provide excellent care. Conclusions: Cancer is a disease that requires care for the patient, not only within the biological sphere, but also in the psychological, social and spiritual aspect. Interdisciplinary teams, made up of professionals from different disciplines, are a tool that can help, to a great extent, achieve better care(AU)


Assuntos
Humanos , Neoplasias do Colo/terapia , Literatura de Revisão como Assunto , Bases de Dados Bibliográficas
15.
Rev. colomb. cir ; 37(4): 701-707, 20220906. fig
Artigo em Espanhol | LILACS | ID: biblio-1396511

RESUMO

Introducción. La invaginación intestinal o intususcepción es el deslizamiento de una parte del intestino dentro de otra adyacente. Es la causa más común de obstrucción intestinal en niños entre 3 meses y 6 años de edad, con una baja incidencia en adultos, correspondiente al 1 % del total de los cuadros obstructivos en el adulto. Su localización en colon es poco frecuente, pero conviene prestar especial atención por su asociación a lesiones malignas. Caso clínico. Varón de 39 años que acude a Urgencias con cuadro de obstrucción intestinal secundario a una invaginación en sigmoide. Se intenta reducción endoscópica, sin éxito, por lo que se indicó cirugía urgente, realizando sigmoidectomía y anastomosis colorrectal. El resultado anatomopatológico informó un adenoma de gran tamaño como causante de la invaginación. Conclusión. Existen controversias respecto al manejo endoscópico en invaginación intestinal en los adultos, especialmente en el colon, debido al elevado porcentaje de etiología tumoral maligna, recomendándose actualmente la resección en bloque sin reducción, para minimizar el riesgo de potencial siembra tumoral.


Introduction. Intestinal invagination or intussusception is the sliding of one part of the intestine into the adjacent one. It is the most common cause of intestinal obstruction in children between 3 months and 6 years of age, with a low incidence in adults, corresponding to 1% of all obstructive conditions in adults. Its location in the colon is rare, but special attention should be paid due to its association with malignant lesions. Case report. A 39-year-old male admitted to the emergency department with symptoms of intestinal obstruction secondary to a sigmoid intussusception. Endoscopic reduction was attempted, without success, so urgent surgery was indicated, performing sigmoidectomy and colorectal anastomosis. The pathology result reported a large adenoma as the cause of invagination. Conclusion. There are controversies regarding the endoscopic management of intussusception in adults, especially in the colon, due to the high percentage of malignant tumor etiology, currently recommending en bloc resection without reduction, to minimize the risk of potential tumor seeding.


Assuntos
Humanos , Endoscopia do Sistema Digestório , Obstrução Intestinal , Intussuscepção , Colectomia , Neoplasias do Colo
16.
Cir. Urug ; 6(1): e405, jul. 2022. ilus
Artigo em Espanhol | LILACS, UY-BNMED, BNUY | ID: biblio-1384417

RESUMO

La fístula gastrocólica descrita en 1755 por Albrecht von Haller, se define como la comunicación anormal entre el colon generalmente transverso y estómago en su curvatura mayor. Se conocen distintas etiologías, siendo un hallazgo poco frecuente con escasos reportes en la literatura. Se presenta el caso de una paciente de 85 años con historia de anemia y adelgazamiento que consulta por cuadro de vómitos fecaloideos, sin alteraciones de tránsito digestivo bajo, sin dolor ni distensión abdominal con ruidos hidroaéreos normales y sonda nasogástrica con contenido fecaloideo. La Tomografía (fig. 1) confirma una lesión de probable etiología maligna del ángulo esplénico del colon fistulizado a estómago por lo que se decide la realización de una colectomía sectorial con anastomosis primaria y gastrectomía subtotal, evolucionando favorablemente con un alta a los 6 días. La anatomía patológica informa adenocarcinoma de colon moderadamente diferenciado con compromiso gástrico.


Assuntos
Humanos , Feminino , Idoso de 80 Anos ou mais , Fístula Intestinal/cirurgia , Neoplasias do Colo/cirurgia , Neoplasias do Colo/diagnóstico por imagem , Anastomose Cirúrgica , Fístula Intestinal/etiologia , Colectomia , Neoplasias do Colo/complicações , Gastrectomia , Octogenários
17.
J. coloproctol. (Rio J., Impr.) ; 42(3): 273-276, July-Sept. 2022. ilus
Artigo em Inglês | LILACS | ID: biblio-1421984

RESUMO

Introduction: Streptococcus gallolyticus belongs to theStreptococcus bovis complex, and it is a common bacterium colonizing the gastrointestinal tract. Its presence in the blood may suggest an underlying pathology such as a colonic neoplasm. We report herein a case of S. bovis bacteremia in an apheresis platelet donor, review similar cases in the literature, and suggest a flowchart for the management of similar cases in other blood donation centers. Case Presentation: A 61-year-old subject presented to a Hemotherapy Service to make an apheresis platelet donation. On quality control testing, S. gallolyticus was identified in hemoculture, and the donor was called back for follow-up. At first, a new hemoculture was requested, and the patient was referred to the outpatient department of infectious diseases to further investigate pathologies associated with S. gallolyticus. A subsequent colonoscopy investigation evidenced a polypoid structure in the ascending colon. Pathology reported the resected specimen as a low-grade tubular adenoma. Conclusion: Isolation of S. bovis in blood products requires further investigation and should be managed with precision by Hemotherapy Services. A standard protocol for the management of asymptomatic patients with S. bovis positive hemoculture, with the requests of a new blood culture, a colonoscopy, and an echocardiogram is crucial, as it may ensure early diagnosis and reduce morbidity and mortality. (AU)


Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Bacteriemia/complicações , Neoplasias do Colo/diagnóstico , Streptococcus gallolyticus/isolamento & purificação , Adenoma/etiologia , Doação de Sangue
18.
J. coloproctol. (Rio J., Impr.) ; 42(3): 193-202, July-Sept. 2022. tab, graf, ilus
Artigo em Inglês | LILACS | ID: biblio-1421988

RESUMO

Background: It is important to detect novel biomarkers responsible for the progression and spread of colorectal cancer (CRC) to better evaluate the prognosis of the patients, provide better management, and foster the development of therapeutic targets. In humans, pyrroline-5-carboxylate reductase 2 (PYCR2) is encoded on chromosome 1q42.12, and its metabolic activity has been linked to oncogenesis in many cancers. Zinc finger and broad-complex, tramtrack, and bric-à-brac (BTB) domain-containing protein 18 (ZBTB18), a zinc finger transcriptional repressor, has been found to have a tumor-suppressor role and to be methylated in CRCs. To date, the prognostic roles of PYCR2 and ZBTB18 in CRC patients have not been thoroughly studied. Objective: To evaluate the tissue protein expression of PYCR2 and ZBTB18 in CRC and adjacent non-neoplastic intestinal tissues, to detect their roles in CRC carcinogenesis, progression and metastases. Patients and methods: After applying the inclusion criteria, 60 CRC patients were included in the study. Tissue samples from the tumor and the adjacent non-neoplastic tissues were stained with PYCR2 and ZBTB18. The patients were followed up for about 30 months (range: 10 to 36 months). We performed a correlation regarding the expression of the markers, and clinicopathological and prognostic parameters. Results Upregulation of PYCR2 and downregulation of ZBTB18 were found to be higher in CRC tissue than in the adjacent non-neoplastic colonic mucosa (p = 0.026 and p < 0.001 respectively). High expression of PYCR2 and low expression of ZBTB18 were positively correlated with large tumor size, higher tumor grade, advanced tumor stage, presence of spread to lymph nodes, and presence of distant metastases (p < 0.001). High PYCR2 and low ZBTB18 expressions were significantly associated with poor response to therapy (p = 0.008 and 0.0.17 respectively), as well as high incidence of progression and recurrence (p = 0.005), and unfavorable overall survival (OS) rates (p = 0.001). Conclusion: High expression of PYCR2 and low expression of ZBTB18 were independent predictors of CRC, progression, poor prognosis and unfavorable patient OS and progression-free survival (PFS) rates. (AU)


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Pirrolina Carboxilato Redutases , Neoplasias Retais/terapia , Proteínas Repressoras , Neoplasias do Colo/terapia , Prognóstico , Carcinoma , Resultado do Tratamento , Estadiamento de Neoplasias
19.
Cir. Urug ; 6(1): e301, jul. 2022. ilus
Artigo em Espanhol | LILACS, UY-BNMED, BNUY | ID: biblio-1384406

RESUMO

Los abscesos del psoas ilíaco secundarios a un tumor de colon fistulizado son excepcionales y potencialmente graves. La mayoría son adenocarcinomas de tipo mucinoso. Su tratamiento es complejo ya que, para lograr una resección oncológica pretendidamente curativa, es necesario realizar una resección ampliada con mayor morbimortalidad. Presentamos el caso de una paciente con un adenocarcinoma mucinoso de colon izquierdo fistulizado al músculo ilíaco y la pared anterolateral del abdomen en la que se realizó una resección multivisceral que incluyó el colon izquierdo, el músculo y la cresta ilíaca y parte de la pared anterolateral del abdomen.


Iliopsoas abscess secondary to perforation of colon cancer is an extremely rare and potentially life-threatening condition. Most tumors are mucinous adenocarcinomas. Its treatment its complex, as most patients need radical extended resections to achieve good oncological results, which are in turn, graved with higher morbidity and mortality. We present the case of a patient with a left colon mucinous adenocarcinoma penetrating to the iliopsoas muscle and the anterolateral abdominal wall that required a multivisceral resection including left colon, iliac muscle and crest and part of the anterolateral abdominal wall.


Abscessos do iliopsoas secundários a um tumor de cólon fistulizado são raros e potencialmente graves. A maioria são adenocarcinomas do tipo mucinoso. Seu tratamento é complexo, pois, para se obter uma ressecção oncológica supostamente curativa, é necessário realizar uma ressecção ampliada com maior morbimortalidade. Apresentamos o caso de um paciente com adenocarcinoma mucinoso de cólon esquerdo fistulizado para o músculo ilíaco e parede ântero-lateral do abdome no qual foi realizada ressecção multivisceral que incluiu cólon esquerdo, músculo e crista ilíaca e parte do a parede anterolateral do abdome.


Assuntos
Feminino , Pessoa de Meia-Idade , Neoplasias do Colo/cirurgia , Adenocarcinoma Mucinoso/cirurgia , Fístula Intestinal/etiologia , Abscesso do Psoas/etiologia , Colectomia , Neoplasias do Colo/complicações , Neoplasias do Colo/diagnóstico por imagem , Adenocarcinoma Mucinoso/complicações , Parede Abdominal/patologia , Ílio/patologia
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