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1.
Rev. enferm. Inst. Mex. Seguro Soc ; 31(3): 77-82, 10-jul-2023. tab, graf
Artigo em Espanhol | LILACS, BDENF - Enfermagem | ID: biblio-1518833

RESUMO

Introducción: las enfermedades oncológicas son la causa de 9.5 millones de muertes en el mundo y la tercera causa de muerte en México. La aparición de heridas tumorales es una complicación de la progresión de la enfermedad oncológica con síntomas que repercuten en la calidad de vida de los pacientes. Objetivo: evaluar la percepción de calidad de vida de pacientes hospitalizados con diagnóstico primario de cáncer y herida tumoral en un hospital de tercer nivel de la Ciudad de México. Metodología: estudio descriptivo que incluyó a 57 pacientes hospitalizados con diagnóstico de cáncer primario y herida tumoral. La percepción de calidad de vida se evaluó con el cuestionario McGill Quality of Life Questionnaire (MQOL) con 4 dimensiones: de bienestar físico, psicológico, existencial y de apoyo social. La herida tumoral se estadificó con la escala Malignant Cutaneous Wound Stating System. La severidad de la enfermedad se midió con la escala APACHE II. El análisis se hizo con estadística descriptiva. Resultados: de 57 pacientes con edad entre 24 y 81 años de edad, predominó el cáncer de mama en 31.5% de mujeres y cáncer de testículo en 10.5% de hombres. La herida tumoral grado IV se presentó en 72% de los pacientes. La percepción de calidad de vida en general, que se midió con el Single ítem scale, fue buena y regular en 38.6 y 26.3%, respectivamente. Conclusiones: para la práctica de enfermería la evaluación de la calidad de vida en las personas con cáncer significa una diversidad de posibilidades para intervenir y promover el bienestar en la persona y la familia.


Introduction: Oncological diseases are the cause of 9.5 million deaths in the world and the third cause of death in Mexico. The appearance of tumor wounds is a complication of the oncological disease progression with symptoms that affect the quality of life of patients. Objective: To evaluate the perception of quality of life of hospitalized patients with a primary diagnosis of cancer and tumor wound in a tertiary care hospital in Mexico City. Methodology: Descriptive study that included 57 hospitalized patients diagnosed with primary cancer and tumor wound. The perception of quality of life was evaluated with the McGill Quality of Life Questionnaire with 4 dimensions: of physical, psychological, and existential well-being, as well as social support. The tumor wound was staged using the Malignant Cutaneous Wound Stating System scale. The severity of the disease was calculated with the APACHE II scale. The analysis was made with descriptive statistics. Results: Out of 57 patients aged 24 to 81 years, breast cancer predominated in 31.5% of women and testicular cancer in 10.5% of men. Grade IV tumor wound occurred in 72% of patients. The perception of quality of life in general, measured with the Single Item Scale, was good and regular in 38.6 and 26.3%, respectively. Conclusions: For nursing practice, the evaluation of the quality of life in people with cancer means a diversity of possibilities to intervene and promote the well-being of the person and the family.


Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Neoplasias/psicologia , Cuidados de Enfermagem/métodos , Neoplasias Testiculares/psicologia , Neoplasias da Mama/psicologia
2.
Artigo em Português | LILACS | ID: biblio-1410505

RESUMO

Objetivos: relatar um caso raro de sarcoma fibromixoide de baixo grau (SFMBG) em uma localização incomum de modo a reforçar aspectos histopatológicos e imunoistoquímicos relevantes para o reconhecimento desta entidade e o adequado diagnóstico diferencial de massas paratesticulares. Relato de caso: homem de 20 anos, com massa escrotal à direita, cuja análise histopatológica demonstrou a presença de tecido fibroso com áreas mixoides e predominância de células fusiformes. A imunoistoquímica foi positiva para vimentina, com índice de Ki67 de 2%, e negativa para S100, CD-34, beta-catenina, desmina e miogenina. Conclusões: caso raro de SFMBG na região paratesticular que reforça a importância da histopatologia e da imunoistoquímica no diagnóstico desse tumor. Apesar da característica histológica benigna, o SFMBG apresenta altas taxas de recorrência e metástases, sendo essencial o seguimento do paciente.


Objectives: to report a rare case of low-grade fibromyxoid sarcoma (LGFMS) in an unusual location in order to reinforce histopathological and immunohistochemical aspects relevant to the recognition of this entity and the adequate differential diagnosis of paratesticular masses. Case report: 20-year-old man, with a right scrotal mass and histopathological analysis showing the presence of fibrous tissue with myxoid areas and a predominance of spindle cells. Immunohistochemistry was positive for vimentin, with a Ki67 index of 2%, and negative for S100, CD-34, beta-catenin, desmin and myogenin. Conclusions: rare case of LGFMS in the paratesticular region that reinforces the importance of histopathology and immunohistochemistry in the diagnosis of this tumor. Despite the benign histological characteristic, LGFMS has high rates of recurrence and metastasis, and patient follow-up is essential.


Assuntos
Humanos , Masculino , Adulto , Sarcoma/patologia , Neoplasias Testiculares/patologia , Sarcoma/diagnóstico , Neoplasias Testiculares/diagnóstico , Vimentina/análise
3.
In. Graña, Andrea; Calvelo, Estela; Fagúndez, Yohana. Abordaje integral del paciente con cáncer: atención desde la medicina y especialidades. Montevideo, Cuadrado, 2022. p.197-198.
Monografia em Espanhol | LILACS, UY-BNMED, BNUY | ID: biblio-1418020
4.
Artigo em Espanhol | LILACS, CUMED | ID: biblio-1408639

RESUMO

Introducción: El cáncer de testículo es una neoplasia rara a pesar de ser el tumor sólido más frecuente en hombres de 15 a 35 años de edad. Objetivo: Describir la presentación de un caso atendido en el Hospital General de Cienfuegos. Caso clínico: Se trata de un varón de 21 años sin factores de riesgo, que acude con masa escrotal, ginecomastia y adenopatías, los exámenes complementarios demostraron un seminoma clásico con áreas de anaplásico y una diseminación notable que lo clasifica como estadio III. Conclusiones: La mortalidad por cáncer de testículo es en gran medida prevenible, el examen físico constituye la piedra angular del diagnóstico precoz, es imprescindible tener presente su posibilidad diagnóstica sobre todo en adultos jóvenes. A pesar de la disminución de la letalidad por esta enfermedad, el diagnóstico tardío y en etapas avanzadas, como en este caso, ensombrecen el pronóstico(AU)


Introduction: Testicular cancer is a rare neoplasm, despite being the most frequent solid tumor in men aged 15-35 years. Objective: To describe the case of a patient who received attention at the General Hospital of Cienfuegos. Clinical case: This is the case of a 21-year-old man without risk factors who presents with a scrotal mass, gynecomastia and adenopathies. The complementary texts showed a classic seminoma with anaplastic areas and notable spread, which allowed to classify it as a stage-III neoplasm. Conclusions: Mortality from testicular cancer is largely preventable. The physical examination is the cornerstone of early diagnosis. It is essential to bear in mind its diagnostic possibility, particularly in young adults. Despite the decrease in mortality from this disease, late diagnosis or in advanced stages, as in this case, hides prognosis(AU)


Assuntos
Humanos , Masculino , Adulto , Neoplasias Testiculares/epidemiologia , Seminoma/diagnóstico , Neoplasias Testiculares/mortalidade
5.
Rev. Assoc. Méd. Rio Gd. do Sul ; 65(3): 01022105, Jul-Set 2021.
Artigo em Português | LILACS | ID: biblio-1373503

RESUMO

RESUMO Introdução: Os tumores de células de Leydig são tumores testiculares raros e geralmente benignos. É mais comumente encontrado em pré-púberes e entre 30-60 anos. São bem delimitados, apresentando-se como massa ou nódulo testicular palpável e indolor. Apresentação do Caso: É relatado caso de paciente masculino, 56 anos, com achado ocasional de nódulo em região testicular esquerda, com realização de ultrassom e biópsia excisional para diagnóstico e posterior orquiectomia parcial e imuno-histoquímica com comprovação etiológica. Comentários: Tais tumores correspondem de 1 a 3% dos tumor testiculares em adultos, apenas e aproximadamente 10% são malignos. Em 80% são associados a distúrbios hormonais. Com tratamento de primeira linha a cirurgia. PALAVRA-CHAVE: Tumor de células de Leydig, neoplasias testiculares, testículo


ABSTRACT Introduction: Leydig cell tumors are rare and generally benign testicular tumors. They are most commonly found in prepubescent and 30-60-year-olds. They are well delimited, presenting as a painless, palpable testicular mass or nodule. Case Presentation: We report the case of a 56-year-old male patient with occasional finding of a nodule in the left testicular region, with ultrasound and excisional biopsy for diagnosis and subsequent partial orchiectomy and immunohistochemistry with etiological confirmation. Comments: Such tumors account for 1 to 3% of testicular tumors in adults, and only approximately 10% are malignant. In 80% of cases they are associated with hormonal disorders. With surgery as first-line treatment. KEYWORDS: Leydig cell tumor, testicular neoplasms, testis


Assuntos
Humanos , Masculino , Neoplasias Testiculares , Testículo , Tumor de Células de Leydig
6.
Med. UIS ; 34(2): 97-102, mayo-ago. 2021. graf
Artigo em Espanhol | LILACS | ID: biblio-1375824

RESUMO

RESUMEN El lipogranuloma esclerosante es una condición extraña y benigna que puede afectar cualquier órgano, especialmente los genitales externos masculinos. Se suele presentar como masas subcutáneas en escroto, periné y pene. Aunque la mayoría de los casos son secundarios a aplicación de cuerpos extraños como parafina, vaselina o silicona con propósitos estéticos para aumentar el tamaño del pene, también puede deberse a degeneración lipídica endógena, secundaria a trauma, infecciones o reacciones alérgicas. No existe consenso en cuanto a su manejo ni datos sobre su prevalencia al ser una entidad poco reportada; se ha descrito el manejo con ciclos cortos de corticoides sistémicos, y cirugía en los casos recidivantes. El objetivo de este trabajo es reportar el caso de un paciente que acudió con induración y eritema en pene y escroto, quien negaba la aplicación de sustancias exógenas y que fue llevado a biopsia de la lesión, con diagnóstico de lipogranuloma esclerosante. MÉD.UIS.2021;34(2): 97-102.


ABSTRACT Sclerosing lipogranuloma is a noncommon and benign disease that could affect any system in the body, especially the male external genitalia. It is usually presented as a subcutaneous mass in scrotum, perineum and penis. Although, most cases are secondary to the injection of foreign bodies such as paraffin, petrolatum or silicone for cosmetic purposes to increase penis size, it could also be due to endogenous lipid degeneration, secondary to trauma, infections or allergic reactions. There is no unanimity regarding its management or data on its prevalence as it is a poorly reported entity. Management with short cycles of systemic corticosteroids and surgery in relapsing cases have been described. The purpose of this article is to present a case of a patient with induration and erythema in penis and scrotum, who denied the application of exogenous substances and has a reported biopsy of the lesion with diagnosis of sclerosing lipogranuloma. MÉD.UIS.2021;34(2): 97-102.


Assuntos
Humanos , Masculino , Genitália Masculina , Pênis , Escroto , Pele , Neoplasias Testiculares , Urologia
7.
Int. braz. j. urol ; 47(3): 495-502, May-June 2021. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1154505

RESUMO

ABSTRACT Testicular cancer is considered a rare disease affecting approximately 1% to 2% of the male population. This neoplasm has a cure rate of over 95%; as a result, a major concern is the future of fertility of carriers from this disease. There are several histological subtypes of testicular tumors; however, the Testicular Germ Cell Tumors (TGCTs), comprising both seminoma and non-seminoma tumors, are considered the main subtypes of testicular neoplasms. TGCT are characterized by being a solid tumor that mostly affects young men aged between 15 and 40 years old. While TGCT subtypes may have an invasive potential, seminoma subtype does not affect other cells rather than germ cells, while non-seminomas have more invasive properties and can achieve somatic cells; thus, having a more aggressive nature. This research intends to review the literature regarding information about sperm parameters, correlating the data found in those studies to the subfertility and infertility of patients with TCGTs. Furthermore, it will also correlate the data to the non-seminoma and seminoma histological subtypes from pre- and post-cancer therapy. PubMed databases were used. Searched keywords included: seminoma AND non-seminoma; male infertility; germ cell tumor; chemotherapy AND radiotherapy. Only articles published in English were considered. Current studies demonstrate that both TGCT subtypes promote deleterious effects on semen quality resulting in decreased sperm concentration, declined sperm total motility and an increase in the morphology alterations. However, findings suggest that the non-seminoma subtype effects are more pronounced and deleterious. More studies will be necessary to clarify the behavior of seminoma and non-seminoma tumors implicating the reproductive health of male patients.


Assuntos
Humanos , Masculino , Adolescente , Adulto , Adulto Jovem , Neoplasias Testiculares/terapia , Seminoma , Neoplasias Embrionárias de Células Germinativas/terapia , Espermatozoides , Análise do Sêmen
8.
Rev. Assoc. Med. Bras. (1992) ; 67(4): 577-584, Apr. 2021. tab
Artigo em Inglês | LILACS | ID: biblio-1340637

RESUMO

SUMMARY OBJECTIVE: Testicular tumor constitutes 1% of male neoplasms. Infertility can be determined in patients with testicular tumors before orchiectomy due to the deterioration of spermatogenesis. The aim of this study was to show the clinical, radiological, and pathological characteristics and spermiogram results of patients with testicular tumor and their relationship with each other. METHODS: The data of patients who underwent orchiectomy due to testicular tumor between 2016 and 2019 were reviewed retrospectively. These data included sociodemographic data of the patients, pretreatment spermiogram characteristics, level of serum tumor markers, characteristics of the ultrasonography, type of orchiectomy, and histopathological examination. RESULTS: This study included 53 male patients, with a mean age of 33.51±12.86 years. The mean levels of all tumor markers were above the reference levels. The mean tumor size was 34.68±23.32 mm. Multiple localizations and microlithiasis were detected in 11.3 and 13.2% of the tumors, respectively. The most common masses were hypoechoic (n=37; 69.8%) and hypervascular (n=47; 81%). Spermiogram and cryopreservation were performed in 29 (54.7%) of 53 patients preoperatively. The mean sperm concentration before orchiectomy was 24.21×106 /mL and group A sperm motility 0.79%, group B sperm motility 39.10%, group C sperm motility 9.83%, and group D sperm motility 22.69% in testicular tumors. CONCLUSION: Spermatogenesis adversely affected before the treatment due to local and systemic effects of testicular cancer. Fertility expectations can be increased in the subsequent years by semen analysis and referral to cryopreservation.


Assuntos
Humanos , Masculino , Adulto , Adulto Jovem , Neoplasias Testiculares/cirurgia , Contagem de Espermatozoides , Motilidade dos Espermatozoides , Orquiectomia , Estudos Retrospectivos , Análise do Sêmen , Pessoa de Meia-Idade
11.
Autops. Case Rep ; 11: e2020198, 2021. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1142401

RESUMO

Merkel cell carcinoma is an aggressive malignancy that frequently recurs/disseminates, but metastases to the genitourinary tract are rare. Only eight cases of Merkel cell carcinoma metastatic to the testis are reported. We describe the ninth case of this event and provide a review of the literature. A 58-year-old man diagnosed with Merkel cell carcinoma of the wrist, presented, 37 months later, a recurrence in the form of a testicular metastasis. The tumor consisted of a monotonous proliferation of small, blue, round cells, with immunoexpression of neuroendocrine markers and the typical dot-like paranuclear immunostaining for cytokeratin 20, in the absence of immunostaining for cytokeratin 7. The patient is alive with no evidence of disease. Clinicians should be aware of the possibility of metastatic dissemination to the testis since genital examination/imaging is not part of routine follow-up for these patients, but timely orchiectomy may be curative.


Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Testiculares/complicações , Carcinoma de Célula de Merkel/complicações , Tumores Neuroendócrinos/patologia , Metástase Neoplásica
12.
Int. braz. j. urol ; 46(5): 725-740, Sept.-Oct. 2020. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1134221

RESUMO

ABSTRACT Purpose: To evaluate whether components of Testicular Dysgenesis Syndrome (TDS) affect testicular germ cell tumor (TGCT) prognosis and oncological outcomes. According to the hypothesis called TDS; undescended testis, hypospadias, testicular cancer and spermatogenic disorders share the same risk factors and have a combined fetal origin. Materials and Methods: We retrospectively evaluated the stages and oncological outcomes of 69 patients who underwent radical orchiectomy between January 2010 and December 2014 due to TGCT in our department. The presence of undescended testis, hypospadias and semen parameters disorders were recorded according to anamnesis of patients. Results: Among 69 patients with TGCT, only 16 (23.1%) had TDS. Significantly higher rate of TDS (36.1% vs. 9.1%) was observed at the advanced stages of TGCT(p=0.008). In the TDS group, the rates of local recurrence (50% vs. 11.3%, p<0.001), distant metastasis (93.6% vs. 3.8%, p<0.001) and cancer-spesific mortality (87.5% vs. 3.8%, p<0.001) were found significantly higher than those without TDS. The predicted time for recurrence-free survival (13.70±5.13 vs. 100.96±2.83 months, p<0.001) metastasis-free survival (13.12±4.21 vs. 102.79±2.21 months, p <0.001) and cancer-specific survival (13.68±5.38 vs. 102.80±2.19 months, p<0.001) were also statistically lower in this group. Conclusions: According to our preliminary results, there is an apparent relationship between TDS and tumor prognosis. Even if the components of TDS alone did not contain poor prognostic features for TGCT, the presence of TDS was found as the most important independent predictive factor for oncological outcomes in both seminomas and nonseminomas as well as all patients with TGCT.


Assuntos
Humanos , Masculino , Doenças Testiculares/etiologia , Neoplasias Testiculares/terapia , Neoplasias Embrionárias de Células Germinativas/terapia , Prognóstico , Testículo , Estudos Retrospectivos , Resultado do Tratamento , Recidiva Local de Neoplasia
14.
Rev. colomb. cancerol ; 24(3): 130-139, jul.-set. 2020. graf
Artigo em Espanhol | LILACS | ID: biblio-1144332

RESUMO

Resumen El tumor desmoplásico de célula redonda y pequeña (TDCRP) es una patología neoplásica maligna agresiva y poco común. Afecta predominantemente a hombres entre la segunda y tercera década de la vida. Los pacientes que la padecen tienen un pronóstico pobre, con una supervivencia global a 5 años de hasta el 30%. Por lo general se presenta como una masa en la cavidad abdominal, frecuentemente multifocal. Para su tratamiento se recomienda un enfoque multimodal con cirugía, quimioterapia y radioterapia. Poco más de 20 casos de TDCRP a nivel testicular/paratesticular se han reportado en la literatura. A continuación, se presenta un caso ilustrativo en esta localización, se discute el caso y se realiza revisión de la literatura.


Abstract Desmoplastic small round cell tumor (DSRCT) is an aggressive and rare malignant neoplasm. It mainly affects young men in their twenties and thirties. Patients with it have a poor prognosis, with a 5-year survival rate of up to 30%. It generally presents as a mass in the abdominal cavity, often multifocal. A multimodal approach is recommended for its treatment, with surgery, chemotherapy, and radiotherapy. Just over 20 cases of testicular/paratesticular DSRCT have been reported in the literature. Below, we present an illustrative case in this location, we discuss the case and review the literature.


Assuntos
Humanos , Masculino , Adulto , Neoplasias Retroperitoneais/diagnóstico , Neoplasias Retroperitoneais/terapia , Tumor Desmoplásico de Pequenas Células Redondas/diagnóstico , Tumor Desmoplásico de Pequenas Células Redondas/terapia , Neoplasias dos Genitais Masculinos/diagnóstico , Neoplasias dos Genitais Masculinos/terapia , Neoplasias Testiculares/diagnóstico , Neoplasias Testiculares/terapia , Gânglios
15.
Int. braz. j. urol ; 46(supl.1): 79-85, July 2020. tab
Artigo em Inglês | LILACS | ID: biblio-1134298

RESUMO

ABSTRACT Introduction: There is little information on how to prioritize testis cancer (TC) patients' care during COVID-19 pandemic in order to relieve its pressure on the health care systems. Objective: To describe the recommendations for diagnosis, treatment and follow-up of patients with TC amidst COVID- 19 pandemic. Material and Methods: Pubmed search and review of the main urological association guidelines on TC. Results: The biology of TC requires immediate care of patients during diagnosis, initial surgical therapy and management of recurrent disease. Active surveillance is the first choice of management and should be offered to all compliant clinical stage I TC patients provided they understand the need to self-isolate. Active surveillance may also help decrease the demand for intensive care unit beds, ventilators, personal protective equipment, and other critical hospital and human resources by minimizing surgeries without compromising patient outcomes. Complications of therapy and symptomatic patients represent medical emergencies and should be treated immediately. Telemedicine may be useful during follow-up periods. Conclusions: Most stages of testis cancer require urgent care; however, all recommendations must be adapted to local health care priorities considering that most of these patients are at low risk of severe COVID-19 infection.


Assuntos
Humanos , Masculino , Pneumonia Viral/epidemiologia , Neoplasias Testiculares/terapia , Infecções por Coronavirus/epidemiologia , Pandemias , Betacoronavirus , SARS-CoV-2 , COVID-19
16.
Pesqui. vet. bras ; 40(7): 525-535, July 2020. tab, graf, ilus
Artigo em Inglês | LILACS, VETINDEX | ID: biblio-1135661

RESUMO

This study aimed to characterize the prevalence and clinical, macroscopic and histopathological aspects of dogs affected by testicular tumors based on biopsy specimens from the Laboratório de Patologia Veterinária of the Universidade Federal de Santa Maria (LPV-UFSM) over 19 years. Parameters regarding the age, size, and breed of the affected dogs were also established. Of all dogs with some type of neoplasm submitted to histopathological analysis at the LPV over these 19 years (n=1,900), 213 (11.2%) had at least one testicular neoplasm. The tissues of 190 dogs (with 220 neoplasms) were available for histological reassessment. The dogs in this study had different types of testicular tumors with relatively similar frequencies. In descending order, the most frequent testicular neoplasms were seminomas (88/220), Leydig (interstitial) cell tumor (LCT; 64/220), Sertoli cell tumor (SCT; 61/220), and mixed germ cell-sex cord stromal tumor (MGSCT) (07/220). Among the dogs of defined breed (119 cases), large breeds had the largest number of cases (50/119), followed by small (47/119) and medium-sized (22/119) breeds. The ages of dogs affected by testicular tumors ranged from 10 months to 18 years. Increased testicular volume was the most common clinical manifestation. Eleven dogs presented information about clinical signs suggestive of hyperestrogenism syndrome (feminization). In seminomas, the diffuse pattern predominated over the intratubular pattern. Two sites (luminal and basal compartments) suggestive of the onset of neoplastic transformations in germ cells were observed in intratubular seminomas. They corroborate the hypothesis that canine seminomas possibly have pathogenesis similar to that observed in human spermatocytic seminomas. The SCTs and LCTs presented high cell morphology variation. SCTs had neoplastic cells organized in five different histological arrangements. As for LCT, solid-diffuse and cystic-vascular histological patterns were the most commonly observed. Through this study, it was possible to establish some of the leading clinical, macroscopic, and histopathological aspects of testicular neoplasms diagnosed over 19 years in the area covered by the LPV-UFSM.(AU)


Este estudo teve por objetivo caracterizar a prevalência, aspectos clínicos, macroscópicos e histopatológicos dos cães acometidos por neoplasmas testiculares, a partir dos espécimes de biópsias do Laboratório de Patologia Veterinária da Universidade Federal de Santa Maria (LPV-UFSM) em 19 anos. Parâmetros quanto à idade, porte, raça dos cães acometidos também foram estabelecidos. De todos os cães com algum tipo de neoplasma submetido à análise histopatológica no LPV nesses 19 anos (n=1.900), 213 (11,2%) tinham ao menos um neoplasma testicular. Os tecidos de 190 cães (com 220 neoplasmas) estavam disponíveis para reavaliação histológica. Os cães deste estudo apresentaram diferentes tipos de neoplasmas testiculares com frequências relativamente semelhantes. Em ordem decrescente, os neoplasmas testiculares mais frequentes foram: seminomas (88/220), leydigomas (64/220), sertoliomas (61/220) e o tumor misto de células germinativas e do estroma do cordão sexual (MGSCT; 07/220). Dentre os cães com raça definida (119 casos), as raças de grande porte tiveram o maior número de casos (50/119), seguido das raças de pequeno (47/119) e médio porte (22/119). As idades dos cães acometidos por neoplasmas testiculares variaram de 10 meses a 18 anos. Aumento de volume testicular foi a manifestação clínica mais comum. Onze cães tinham informações sobre sinais clínicos sugestivos da síndrome da feminilização. Nos seminomas, houve o predomínio do padrão difuso sobre o intratubular. Dois locais (compartimentos luminal e basal) sugestivos de início das transformações neoplásicas nas células germinativas foram observados nos seminomas intratubulares, corroborando com a hipótese de que os seminomas caninos possivelmente tem patogênese semelhante à observada nos seminomas espermatocíticos humanos. Sertoliomas e leydigomas foram neoplasmas com alta variação na morfologia celular. Os sertoliomas tinham células neoplásicas dispostas em cinco arranjos histológicos distintos. Quanto aos leydigomas, os padrões histológicos sólido-difuso e cístico-vascular foram os mais comumente observados. Através deste estudo foi possível estabelecer alguns dos principais aspectos clínicos, macroscópicos e histopatológicos dos neoplasmas testiculares diagnosticados em 19 anos na área de abrangência do LPV-UFSM.(AU)


Assuntos
Animais , Masculino , Cães , Neoplasias Testiculares/patologia , Neoplasias Testiculares/veterinária , Neoplasias Testiculares/epidemiologia , Seminoma/veterinária , Doenças do Cão/patologia , Tumor de Células de Sertoli/veterinária , Tumor de Células de Leydig/veterinária
18.
Int. braz. j. urol ; 46(3): 353-362, May-June 2020. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1090612

RESUMO

ABSTRACT Purpose: Testicular germ cells tumor (TGCT) are associated with a high cure rate and are treated with platinum-based chemotherapy. However, a group of testicular cancer patients may have a very unfavorable evolution and insensitivity to the main therapeutic agent chemotherapy (CT) cisplatin. The aim of this study was to evaluate the risk of recurrence and overall survival related to the expression of nuclear factor kappa-B (NF-κB), transglutaminase 2 (TG2) and excision repair cross-complementation group 1 (ERCC1) in patients with TGCT treated with platinum combinations. Patients and Methods: A retrospective study was performed with TGCT patients treated with platinum-based chemotherapy. Immunohistochemical analysis was performed and the expression was correlated with clinical and laboratory data. Results: Fifty patients were included, the mean age was 28.4 years (18 to 45), and 76% were non-seminoma. All patients were treated with standard cisplatin, etoposide and bleomycin or cisplatin, and etoposide. Patient's analyzed immunodetection for NF-κB, TG2, and ERCC1 were positive in 76%, 54% and 42%, respectively. Multivariate analysis identified that positive expressions to ERCC1 and NF-κB are independent risk factors for higher recurrence TGCT after chemotherapy (RR 2.96 and 3.16, respectively). Patients with positive expression of ERCC1 presented a poor overall survival rate for 10-year follow (p=0.001). Conclusions: The expression of ERCC1 and NF-κB give a worse prognosis for relapse, and only ERCC1 had an influence on the overall survival of TGCT patients treated with platinum-based chemotherapy. These may represent markers that predict poor clinical outcome and response to cisplatin.


Assuntos
Humanos , Masculino , Adulto , Neoplasias Testiculares , Transglutaminases/metabolismo , NF-kappa B/metabolismo , Proteínas de Ligação ao GTP/metabolismo , Neoplasias Pulmonares , Prognóstico , Protocolos de Quimioterapia Combinada Antineoplásica , Estudos Retrospectivos , Cisplatino , Resistencia a Medicamentos Antineoplásicos/fisiologia , Proteínas de Ligação a DNA , Reparo do DNA , Endonucleases
20.
Arq. bras. med. vet. zootec. (Online) ; 72(2): 332-338, Mar./Apr. 2020. ilus
Artigo em Português | LILACS, VETINDEX | ID: biblio-1128180

RESUMO

O seminoma é uma neoformação testicular originária de células germinativas de ocorrência comum em cães, com maior prevalência em animais senis. Em geral, o comportamento biológico do seminoma canino é benigno. Relata-se neste trabalho um caso de seminoma com metástase em região orbital em um cão com 14 anos de idade. O animal foi atendido com queixa de aumento de volume em órbita esquerda, com posterior detecção de nódulo testicular. A punção aspirativa por agulha fina da massa orbital sugeriu tratar-se de linfoma de alto grau, contudo o diagnóstico definitivo de seminoma difuso foi estabelecido pela avaliação histopatológica, a qual revelou tratar-se de neoplasia maligna pouco diferenciada, sendo o diagnóstico de seminoma difuso confirmado pelo exame imunoistoquímico. Relatos de seminomas metastáticos em cães são incomuns. Objetivou-se com este trabalho relatar um caso de seminoma anaplásico difuso em cão cujo foco principal de metástase ocorreu em região orbital, além de descrever e discutir as dificuldades diagnósticas encontradas.(AU)


Seminoma is a testicular neoformation originating from germ cells, commonly occurring in dogs. With higher prevalence in senile animals, the biological behavior of canine seminomas generally benign. This case reports seminoma with mestastasis in the orbital region in a 14-year-old dog. The animal was treated with a complaint of increased volume in the left orbit, and later a nodule in the testicle was discovered. Fine-needle aspiration of the orbit mass initially indicated a high-grade lymphoma. The definitive diagnosis of diffused seminoma was established by histopathological examination, resulting in poorly differentiated malignant neoplasia. Finally, the diagnosis was confirmed through immunohistochemistry, being the result compatible with diffused seminoma. Metastatic seminomas reported in dogs are quite uncommon. In this work we report a case of diffused anaplastic seminoma in dogs, where the main focus of metastasis was observed in the orbital region, and we also describe and discuss the difficulties encountered in the diagnostic.(AU)


Assuntos
Animais , Cães , Seminoma/veterinária , Metástase Neoplásica , Neoplasias Testiculares/veterinária , Biópsia por Agulha Fina/veterinária
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