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1.
Rev. colomb. cancerol ; 24(3): 130-139, jul.-set. 2020. graf
Artigo em Espanhol | LILACS | ID: biblio-1144332

RESUMO

Resumen El tumor desmoplásico de célula redonda y pequeña (TDCRP) es una patología neoplásica maligna agresiva y poco común. Afecta predominantemente a hombres entre la segunda y tercera década de la vida. Los pacientes que la padecen tienen un pronóstico pobre, con una supervivencia global a 5 años de hasta el 30%. Por lo general se presenta como una masa en la cavidad abdominal, frecuentemente multifocal. Para su tratamiento se recomienda un enfoque multimodal con cirugía, quimioterapia y radioterapia. Poco más de 20 casos de TDCRP a nivel testicular/paratesticular se han reportado en la literatura. A continuación, se presenta un caso ilustrativo en esta localización, se discute el caso y se realiza revisión de la literatura.


Abstract Desmoplastic small round cell tumor (DSRCT) is an aggressive and rare malignant neoplasm. It mainly affects young men in their twenties and thirties. Patients with it have a poor prognosis, with a 5-year survival rate of up to 30%. It generally presents as a mass in the abdominal cavity, often multifocal. A multimodal approach is recommended for its treatment, with surgery, chemotherapy, and radiotherapy. Just over 20 cases of testicular/paratesticular DSRCT have been reported in the literature. Below, we present an illustrative case in this location, we discuss the case and review the literature.


Assuntos
Humanos , Masculino , Adulto , Neoplasias Retroperitoneais/diagnóstico , Neoplasias Retroperitoneais/terapia , Tumor Desmoplásico de Pequenas Células Redondas/diagnóstico , Tumor Desmoplásico de Pequenas Células Redondas/terapia , Neoplasias dos Genitais Masculinos/diagnóstico , Neoplasias dos Genitais Masculinos/terapia , Neoplasias Testiculares/diagnóstico , Neoplasias Testiculares/terapia , Gânglios
2.
An. bras. dermatol ; 94(6): 721-723, Nov.-Dec. 2019. graf
Artigo em Inglês | LILACS | ID: biblio-1054886

RESUMO

Abstract Primary male genital melanomas are very rare; they are associated with high mortality and late detection. Scrotal melanoma is the least common presentation and only 23 cases have been reported. Herein, the authors present a 30-year-old patient with stage IIIC (T4b, N2a, M0) scrotal melanoma in order to report the characteristics, treatment, and outcome, as well as to emphasize the importance of examination of the genitals, education of patients about self-examination and destigmatizing genital lesions to increase the likelihood of earlier detection.


Assuntos
Humanos , Masculino , Adulto , Escroto/patologia , Neoplasias Cutâneas/patologia , Neoplasias dos Genitais Masculinos/patologia , Melanoma/patologia , Neoplasias Cutâneas/tratamento farmacológico , Biópsia , Interferon alfa-2/administração & dosagem , Neoplasias dos Genitais Masculinos/tratamento farmacológico , Melanoma/tratamento farmacológico , Estadiamento de Neoplasias , Antineoplásicos/administração & dosagem
3.
Rev. chil. radiol ; 24(3): 117-124, jul. 2018. tab, ilus
Artigo em Espanhol | LILACS | ID: biblio-978165

RESUMO

Presentamos un caso de Angiomiofibroblastoma-like (AML), en el que la ecografía fue importante para determinar la detección, localización y extensión local. Hallazgos: La ecografía demostró una lesión paratesticular sólida hipoecogénica de bordes bien definidos lo que sugirió lesión benigna extratesticular. La histología evidenció una neoplasia mesenquimal benigna tipo mixoide en cuyo diagnóstico diferencial se incluyen el Angiomixoma superficial (AMS), Angiomixoma agresivo (AMA), Angiomiofibroblastoma (AMF) y el AML. En base a estos hallazgos se realizó una revisión de tumores de similares características en la literatura, llegando finalmente al diagnóstico de AML cuya localización paratesticular sólo ha sido descrita en muy pocos casos hasta la fecha. Conclusión: La ecografía es útil para localizar los tumores paratesticulares y determinar su extensión local. No obstante, para llegar al diagnóstico definitivo es necesario realizar un estudio histológico e inmunohistoquímico de la tumoración.


We present a case of a paratesticular Angiomiofibroblastoma-like (AML) tumor in which ultrasound was important to give the specific location and local extension of the lesion. Findings: Ultrasound revealed a hypoechoic paratesticular lesion with well-defined borders, suggesting an extratesticular benign lesion. The histology showed a benign mesenchymal myxoid-type neoplasm. The differential diagnosis included superficial Angiomyxoma (AMS), Aggressive angiomyxoma (AMA), Angiomyofibroblastoma (AMF) and AML. Based on these findings, a review of similar tumors was carried out and ultimately led to the diagnosis of paratesticular AML. This location has been described only in a few cases in the literature. Conclusion: Ultrasound is useful to locate paratesticular tumors and determine their local extension. However, a definitive diagnosis still requires a histological and immunohistochemical study.


Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Angiofibroma/cirurgia , Angiofibroma/diagnóstico por imagem , Neoplasias dos Genitais Masculinos/cirurgia , Neoplasias dos Genitais Masculinos/patologia , Imuno-Histoquímica , Tomografia Computadorizada por Raios X , Ultrassonografia , Angiofibroma/patologia , Diagnóstico Diferencial
4.
Clinics ; 73(supl.1): e551s, 2018. graf
Artigo em Inglês | LILACS | ID: biblio-952836

RESUMO

Infection with human papillomaviruses is associated with a series of benign and malignant hyperproliferative diseases that impose a heavy burden on human populations. A subgroup of mucosal human papillomavirus types are associated with the majority of cervical cancers and a relevant fraction of vulvar, vaginal, anal, penile and head and neck carcinomas. Human papillomaviruses mediate cell transformation by the expression of two pleiotropic oncoproteins that alter major cellular regulatory pathways. However, these viruses are not complete carcinogens, and further alterations within the infected cells and in their microenvironment are necessary for tumor establishment and progression. Alterations in components of the extracellular matrix for instance, matrix metalloproteinases and some of their regulators such as tissue inhibitors of metalloproteinases, have been consistently reported in human papillomaviruses-associated diseases. Matrix metalloproteinases function by remodeling the extracellular matrix and alterations in their expression levels and/or activity are associated with pathological processes and clinical variables including local tumor invasion, metastasis, tumor relapse and overall patient prognosis and survival. In this review we present a summarized discussion on the current data concerning the impact of human papillomavirus infection on the activity and expression of extracellular matrix components. We further comment on the possibility of targeting extracellular matrix molecules in experimental treatment protocols.


Assuntos
Humanos , Masculino , Feminino , Transformação Celular Neoplásica/metabolismo , Infecções por Papillomavirus/metabolismo , Matriz Extracelular/metabolismo , Infecções por Papillomavirus/virologia , Neoplasias dos Genitais Femininos/virologia , Neoplasias dos Genitais Masculinos/virologia , Neoplasias de Cabeça e Pescoço/virologia
6.
Appl. cancer res ; 36: 1-11, 2016. ilus
Artigo em Inglês | LILACS, Inca | ID: biblio-910951

RESUMO

The recently published 2016 World Health Organization (WHO) Classification of Tumors of the Urinary System and Male Genital Organs stems from the accumulated knowledge and data collected during the last 12 years, since the previous edition of the WHO "blue book" 2004. The major changes in prostate pathology include the introduction of a novel grading system for prostate cancer (Grade Groups/International Society of Urological Pathology (ISUP) grades 1­5), the recognition of intraductal carcinoma as a new entity, and the terminological changes regarding the neuroendocrine prostatic neoplasms. In bladder and urothelial tract, within the spectrum of flat and non-invasive lesions, a newly introduced term "urothelial proliferation of uncertain malignant potential" replaced the term "urothelial hyperplasia", and the term "urothelial dysplasia" was better defined. A category of "invasive urothelial carcinoma with divergent differentiation" was introduced for tumors showing a component of "usual type" urothelial carcinoma combined with other morphologies. A new WHO/ISUP renal tumor grading system was recommended (Grade 1­4). The definition of renal papillary adenoma was modified and expanded to include papillary neoplasms measuring up to 1.5 cm. Several new epithelial renal tumors were recognized as new entities including: hereditary leiomyomatosis and renal cell carcinoma (RCC) syndrome­associated RCC, succinate dehydrogenase­deficient RCC, tubulocystic RCC, acquired cystic disease­associated RCC, and clear cell papillary RCC. In testis pathology, intratubular proliferations of testicular germ cell tumors were renamed as "germ cell neoplasia in-situ" (GCNIS), and the testicular neoplasms were divided into two main groups: derived from or unrelated to GCNIS. A major change in penile pathology was the introduction of a new classification of penile squamous cell carcinoma, based on the presence of human papillomavirus (HPV), which characterizes penile tumor subtypes as HPV-related or non-HPV-related. A similar distinction was introduced for the preneoplastic penile intraepithelial precursor lesion (PeIN) into non-HPV related (differentiated PeIN) and HPV-related types (undifferentiated PeIN). In this review, we provide a summary and highlight the changes in the genitourinary pathology introduced by the 2016 WHO blue book, and we also discuss some recent developments that may impact the practice of genitourinary pathology in the near future (AU)


Assuntos
Humanos , Masculino , Neoplasias Penianas/classificação , Neoplasias da Próstata/classificação , Neoplasias Testiculares/classificação , Neoplasias da Bexiga Urinária/classificação , Classificações em Saúde , Neoplasias Urogenitais/patologia , Neoplasias Urológicas/classificação , Neoplasias dos Genitais Masculinos/classificação , Neoplasias Renais/classificação
7.
An. bras. dermatol ; 90(2): 225-231, Mar-Apr/2015. tab, graf
Artigo em Inglês | LILACS | ID: lil-741083

RESUMO

Paget's disease, described by Sir James Paget in 1874, is classified as mammary and extramammary. The mammary type is rare and often associated with intraductal cancer (93-100% of cases). It is more prevalent in postmenopausal women and it appears as an eczematoid, erythematous, moist or crusted lesion, with or without fine scaling, infiltration and inversion of the nipple. It must be distinguished from erosive adenomatosis of the nipple, cutaneous extension of breast carcinoma, psoriasis, atopic dermatitis, contact dermatitis, chronic eczema, lactiferous ducts ectasia, Bowen's disease, basal cell carcinoma, melanoma and intraductal papilloma. Diagnosis is histological and prognosis and treatment depend on the type of underlying breast cancer. Extramammary Paget's disease is considered an adenocarcinoma originating from the skin or skin appendages in areas with apocrine glands. The primary location is the vulvar area, followed by the perianal region, scrotum, penis and axillae. It starts as an erythematous plaque of indolent growth, with well-defined edges, fine scaling, excoriations, exulcerations and lichenification. In most cases it is not associated with cancer, although there are publications linking it to tumors of the vulva, vagina, cervix and corpus uteri, bladder, ovary, gallbladder, liver, breast, colon and rectum. Differential diagnoses are candidiasis, psoriasis and chronic lichen simplex. Histopathology confirms the diagnosis. Before treatment begins, associated malignancies should be investigated. Surgical excision and micrographic surgery are the best treatment options, although recurrences are frequent.


Assuntos
Feminino , Humanos , Masculino , Neoplasias da Mama/patologia , Doença de Paget Extramamária/patologia , Doença de Paget Mamária/patologia , Neoplasias Cutâneas/patologia , Neoplasias da Mama/terapia , Carcinoma/patologia , Carcinoma/terapia , Diagnóstico Diferencial , Neoplasias dos Genitais Masculinos/patologia , Neoplasias dos Genitais Masculinos/terapia , Mamilos/patologia , Doença de Paget Extramamária/terapia , Doença de Paget Mamária/terapia , Neoplasias Cutâneas/terapia , Neoplasias Vulvares/patologia , Neoplasias Vulvares/terapia
8.
Rev. bras. ciênc. vet ; 21(1): 12-18, 2014. ilus
Artigo em Português | LILACS, VETINDEX | ID: biblio-1491555

RESUMO

O carcinoma de células escamosas (CCE) tem importância relevante na rotina clínica e cirúrgica de equinos e o diagnóstico dessa neoplasia é baseado nos exames clínico e histopatológico. Como a terapia conservativa raramente apresenta resultados satisfatórios,a intervenção cirúrgica tem-se mostrado mais vantajosa, constituindo, em algumas situações, como única alternativa para evitar o comprometimento morfofuncional da estrutura anatômica ou mesmo o óbito do paciente. Este estudo objetivou estabelecer o diagnóstico clínico e laboratorial de CCE genital em equinos, descrever o tratamento cirúrgico empregando sutura captonada como alteração da técnica convencional e avaliar os procedimentos pós-operatórios. Foram utilizados dois animais do sexo masculino,com cerca de 20 anos, um mestiço Apaloosa e outro pônei. Após o diagnóstico clínico foram submetidos ao tratamento cirúrgico mediante anestesia geral e colheita de material para exames citológico e histopatológico. O resultado do exame histopatológico confirmou a suspeita diagnóstica de CCE. Concluiu-se que os exames clínicos e histopatológicos são fundamentais para se estabelecer o diagnóstico do CCE genital em equinos do sexo masculino, porém, para evitar dois procedimentos anestésicos subsequentes e minimizar possíveis complicações decorrentes da anestesia, a colheita de material para avaliação laboratorial deve ser realizada durante o tratamento cirúrgico.


Squamous cell carcinoma (SCC) has relevant importance in the clinical and surgery of equines and the diagnosis is based on clinical and histopathological exams. The conservative therapy rarely gives satisfactory results while the surgical intervention is more advantageous, constituting, in some situations, the only alternative to avoid compromising anatomical structure or eventhe death of the patient. This study aimed to establish the clinical and laboratory diagnosis of genital SCC, describing the quilled suture as changing the conventional technique and evaluating post operative procedures. Were used two male animals, about 20 years old, a half-breed appaloosa and other pony. After the clinical diagnosis, underwent surgery under general anesthesia and collection of material for histopathological examination. The results of this examination confirmed the suspected diagnosis. It was concluded that the clinical and histopathological tests are essential to establish the diagnosis of genital SCC in male horses, however. To avoid two subsequent anesthesia and minimize possible complications during the proceeding, material for laboratoryevaluation should be collected during surgery.


Assuntos
Masculino , Animais , Carcinoma/diagnóstico , Carcinoma/veterinária , Doenças dos Cavalos/diagnóstico , Neoplasias dos Genitais Masculinos/veterinária , Técnicas Citológicas/veterinária , Técnicas de Sutura/veterinária
9.
West Indian med. j ; 62(9): 859-860, Dec. 2013. ilus
Artigo em Inglês | LILACS | ID: biblio-1045771

RESUMO

Metastatic tumour of spermatic cords, epididymis and seminiferous duct from gastric carcinoma has been recently reported but rarely seen. A case of metastatic tumour from gastric carcinoma in a 50-year old man is herein reported. The initial diagnosis was thickening of both spermatic cords. Needle biopsy of the spermatic cord, testicle and epididymis was performed. Pathological findings showed a gastric signet ring cell carcinoma. Thus, double radical orchiectomy was performed and metastatic signet ring cell carcinoma of the spermatic cord and testis was diagnosed through histological examination and immunohistochemistry. Physicians should be aware that gastric carcinoma is one of the possibilities for metastasis to the seminal duct.


El tumor metastásico de los cordones espermáticos, el epidídimo y el conducto seminífero a partir de un carcinoma gástrico ha sido reportado recientemente, pero pocas veces visto. En este trabajo se reporta el caso de un tumor metastásico a partir de un carcinoma gástrico en un hombre de 50 año de edad. El diagnóstico inicial fue el engrosamiento de los dos cordones espermáticos. Se realizó una biopsia con aguja del cordón espermático, testículos y epidídimo. Los resultados patológicos mostraron un carcinoma de células en anillo de sello. Por consiguiente, se realizó una orquiectomía radical doble, y el carcinoma metastásico en anillo de sello del cordón espermático y el testículo, fue diagnosticado mediante examen histológico e inmunohistoquímico. Los médicos deben tener presente que el carcinoma gástrico es una de las posibilidades de metástasis en los conductos seminales.


Assuntos
Humanos , Pessoa de Meia-Idade , Cordão Espermático/patologia , Neoplasias Gástricas/patologia , Carcinoma/patologia , Neoplasias dos Genitais Masculinos/secundário , Biópsia por Agulha , Orquiectomia , Neoplasias dos Genitais Masculinos/cirurgia , Neoplasias dos Genitais Masculinos/diagnóstico
11.
São Paulo med. j ; 130(1): 57-60, 2012. ilus, tab
Artigo em Inglês | LILACS | ID: lil-614940

RESUMO

CONTEXT: Extra-adrenal paragangliomas are rare tumors that have been reported in many locations, including the kidney, urethra, urinary bladder, prostate, spermatic cord, gallbladder, uterus and vagina. CASE REPORT: This report describes, for the first time to the best of our knowledge, a primary paraganglioma of the seminal vesicle occurring in a 61-year-old male. The patient presented persistent arterial hypertension and a previous diagnosis of chromophobe renal cell carcinoma. It was hypothesized that the seminal vesicle tumor could be a metastasis from the chromophobe renal cell carcinoma. Immunohistochemical characterization revealed expression of synaptophysin and chromogranin in tumor cell nests and peripheral S100 protein expression in sustentacular cells. Succinate dehydrogenase A and B-related (SDHA and SDHB) expression was present in both tumors. CONCLUSIONS: No genetic alterations to the VHL and SDHB genes were detected in either the tumor tissue or tissues adjacent to the tumor, which led us to rule out a hereditary syndrome that could explain the association between paraganglioma and chromophobe renal cell carcinoma in a patient with arterial hypertension.


CONTEXTO: Paragangliomas extra-adrenais são tumores raros que têm sido relatados em muitas localizações, incluindo rim, uretra, bexiga, próstata, cordão espermático, vesícula biliar, útero e vagina. RELATO DE CASO: Este relato descreve, pela primeira vez em nosso conhecimento, um paraganglioma primário da vesícula seminal ocorrendo em um paciente do sexo masculino de 61 anos de idade. O paciente apresentou hipertensão arterial persistente e um diagnóstico prévio de carcinoma de células renais cromófobo (CCRC). Foi pensado que o tumor de vesícula seminal poderia ser uma metástase do CCRC. A caracterização imunoistoquímica revelou expressão de sinaptofisina e cromogranina nos ninhos de células tumorais e expressão de proteína S100 nas células sustentaculares. Expressão de succinato de-hidrogenase A e B relacionada (SDHA e SDHB) estiveram presentes em ambos os tumores CONCLUSÕES: Nenhuma alteração genética dos genes VHL e SDHB foi detectada nos tecidos tumorais e adjacentes ao tumor, o que nos levou a afastar uma síndrome hereditária que poderia explicar a associação entre o paraganglioma e o CCRC em um paciente com hipertensão arterial.


Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Carcinoma de Células Renais/patologia , Neoplasias dos Genitais Masculinos/patologia , Neoplasias Renais/patologia , Neoplasias Primárias Múltiplas/patologia , Paraganglioma/patologia , Glândulas Seminais/patologia , Diagnóstico Diferencial , Neoplasias dos Genitais Masculinos/genética , Hipertensão/etiologia , Neoplasias Primárias Múltiplas/genética , Paraganglioma/genética , Succinato Desidrogenase/genética , Proteína Supressora de Tumor Von Hippel-Lindau/genética
12.
Rev. chil. urol ; 77(2): 111-114, 2012. ilus, tab
Artigo em Espanhol | LILACS | ID: lil-783395

RESUMO

El Tumor Adenomatoide es la neoplasia paratesticular más frecuente y localizada principalmente en el epidídimo. Material y método: Se presenta una serie clínico-patológica de 14 tumores adenomatoides urológicos diagnosticados entre 1975-2011. Resultados: La edad media de presentación fue de 46 años (rango 32-67 años). La mayoría de los casos se presentó como un nódulo firme indoloro en el epidídimo. No hubo casos de localización intratesticular. Se realizó tumorectomía en 13 casos y además orquiectomía en uno. Los tumores midieron una media de 1.9 cm (rango 0.3-5 cm) y macroscópicamente fueron sólidos, blanquecinos y bien delimitados. A la histología estaban formados por estructuras adenomatoides irregulares rodeadas por tejido fibroso. La inmunotinción para Queratina y Calretinina fueron positivas, lo que apoya el origen mesotelial del tumor. El curso clínico fue benigno en todos los casos, sin presentar recurrencias. Conclusión: Corresponde a una neoplasia benigna urogenital rara de origen mesotelial y que compromete con frecuencia el epidídimo. Se presentaron en hombres de edad media y que en la mayoría fueron tratados con tumorectomía, mostrando un curso clínico benigno...


Adenomatoid Tumor is the most frequent paratesticular neoplasia and it is located mainly in the epididymis. Material and methods: A series of 14 cases of Urological Adenomatoid Tumor diagnosed between 1975 - 2011 is presented. Results: Average age at presentation was 46 years (range 32-67 years). The majority of the cases were presented as a painless and firm nodule in the epididymis. No cases involving the testicular parenchyma were seen. The tumors measured an average of 1.9 cm (range 0.3 - 5 cm) and grossly all cases were solid, whitish and fair/y well demarcated. The histology revealed adenomatoid structures surrounded by fibrous tissue. The immunostains were positive for keratin and calretinin which support‘ the mesothelialial origin of the tumor. All cases showed a benign clinical course and no relapses were found. Conclusion: Correspond to a rare benign urogenital/neoplasia that frequently involves the epidermis. They were presented in middle age men and in the majority of the cases were treated by lumpectomy, showing a bening clinical course...


Assuntos
Humanos , Masculino , Adulto , Pessoa de Meia-Idade , Epididimo/patologia , Neoplasias dos Genitais Masculinos/epidemiologia , Neoplasias dos Genitais Masculinos/patologia , Tumor Adenomatoide/epidemiologia , Tumor Adenomatoide/patologia
13.
Rev. Col. Bras. Cir ; 36(5): 466-467, set.-out. 2009. ilus
Artigo em Português | LILACS | ID: lil-535843

RESUMO

Non-Hodgkin´s lymphoma of the spermatic cord are rare. There is the registration of 14 (fourteen) cases of spermatic cord lymphoma in the literature, all treated with radical orchiectomy with or without radiotherapy. The adjuvant chemotherapy still is not a consensus, therefore the therapy must be individualized and applied according to the stage of the disease. The present study report a new case of primary non-Hodgkin´s lymphoma of the spermatic cord treated with radical orchiectomy through inguinal via with precocious ligature of the spermatic cord and adjuvant chemotherapy. Presently found with 2 and a half years of follow-up without recidivation clinical evidence, as the image exams show to be normal.


Assuntos
Idoso , Humanos , Masculino , Neoplasias dos Genitais Masculinos , Linfoma Difuso de Grandes Células B , Cordão Espermático , Neoplasias dos Genitais Masculinos/patologia , Neoplasias dos Genitais Masculinos/cirurgia , Linfoma Difuso de Grandes Células B/patologia , Linfoma Difuso de Grandes Células B/cirurgia
15.
RBM rev. bras. med ; 64(8): 363-368, ago. 2007. tab, graf
Artigo em Inglês | LILACS | ID: lil-469690

RESUMO

Introduction: Squamous cell carcinoma of the penis is a rare disease in the developed world but common in underdeveloped countries. We have evaluated the prognostic factors related to penile carcinoma and assessed the outcome of patients regarding the lymph node status at two institutions. Materials and methods: Between January 1990 and December 2003, 87 patients with a clinical diagnosis of penile carcinoma had been treated at Instituto de Cancer de Londrina and Universidade Estadual de Londrina and were retrospectively reviewed. Patients who were followed for more than 18 months or until death due to penile cancer were evaluated for prognostic factors. Overall survival was calculated according to lymph node status. Results: Overall survival according to lymph node status at presentation, showed a poor outcome for patients with palpable lymph nodes compared with those with clinically negative lymph node (2-year survival of 20 and 68 respectively, p < 0.0005). The same was observed in those who presented delayed lymphadenopathy compared with patients who persisted N0 during follow-up time (2-year-survival of 28 and 90 respectively, p < 0.0005). Forty eight patients were assessed for prognostic factors. Histological grade and pathological stage were all statistically significant at univariate analysis regarding disease-free survival. Conclusion: Patients with positive lymph node had a poor overall survival regardless whether or not an immediate or a delayed lymphadenectomy had been performed. Histological grade and pathological stage were the only variables statistically significant at univariate analysis with respect to disease-free survival.


Assuntos
Humanos , Masculino , Neoplasias dos Genitais Masculinos , Neoplasias Penianas , Linfonodos
16.
Int. braz. j. urol ; 33(4): 515-520, July-Aug. 2007.
Artigo em Inglês | LILACS | ID: lil-465788

RESUMO

OBJECTIVE: To analyze how scrotal neoplasias have been managed during the past decade and to question possible factors or professions associated to its presence. MATERIALS AND METHODS: We retrospectively evaluated every case reported from 1995 to 2005 at our hospital. We described the clinical scenario, complementary exams, treatments and outcomes. We also tried to verify if there was any risk, predisposing factors or professions that would explain the cancer origin. RESULTS: Six cases were reviewed. Out of these, three patients were truck drivers. Five of them showed restricted lesions without inguinal lymph nodes enlargement. Histologically, six patients presented squamous carcinoma, with two of them having the verrucous type. The median age of patients was 52 years old (31 to 89). The five patients who are still alive had their lesions completely removed with safety margin and primary closure. CONCLUSIONS: We have noticed that the scrotal carcinoma behavior is similar to that of the penis, where removal of the lesion and study of the regional lymph nodes help to increase the patient survival rate. The outstanding fact was that three out of six patients were truck drivers, raising the hypothesis that such profession, maybe due to the contact or attrition with the diesel exhaust expelled by the engine or to sexual promiscuity, would imply in a larger risk of developing this rare neoplasia.


Assuntos
Adulto , Idoso de 80 Anos ou mais , Humanos , Masculino , Pessoa de Meia-Idade , Condução de Veículo , Carcinoma de Células Escamosas/patologia , Neoplasias dos Genitais Masculinos/patologia , Veículos Automotores , Doenças Profissionais/patologia , Escroto/patologia , Carcinoma de Células Escamosas/etiologia , Carcinoma de Células Escamosas/cirurgia , Neoplasias dos Genitais Masculinos/etiologia , Neoplasias dos Genitais Masculinos/cirurgia , Exposição por Inalação/efeitos adversos , Doenças Profissionais/etiologia , Estudos Retrospectivos , Fatores de Risco , Comportamento Sexual , Escroto/cirurgia , Emissões de Veículos
17.
Rev. chil. dermatol ; 23(3): 197-200, 2007. ilus
Artigo em Espanhol | LILACS | ID: lil-481391

RESUMO

El carcinoma de Verrucous en el área anogenital ha sido reportado bajo una variedad de nombres, incluyendo el condiloma acuminado gigante o tumor de Buschke-Loewenstein. Histológicamente, corresponde a un carcinoma espinocelular bien diferenciado. Se ha descrito una variedad de alternativas terapéuticas, siendo de primera elección la extirpación quirúrgica. El Imiquimod en crema al 5 por ciento representa un modificador tópico de la respuesta inmune. Actualmente está siendo utilizado en el tratamiento de una variedad de enfermedades cutáneas. Objetivo: Revisión del tema y presentación del primer caso de carcinoma verrucous anogenital tratado con cirugía shaving más criocirugía e imiquimod al 5 por ciento en crema con un seguimiento de siete años. Caso clínico: Paciente de sexo masculino, de 55 años, heterosexual, con antecedentes de lesión tumoral inguino-escroto-perineal derecha de 15 años de evolución y de crecimiento lentamente progresivo. Su primera consulta dermatológica se efectúa el 04.02.99. Se extirpa nódulo de tamaño mayor tamaño para examen histopatológico tipificación VPH por PCR (positivo para genotipos 6 y 11) Se diagnostica carcinoma espinocelular de bajo grado de malignidad. Se utilizaron en su tratamiento múltiples técnicas combinadas con métodos citodestructivos e inmunoterapia. Posteriormente se iniciaron ciclos de imiquimod 5 por ciento (una aplicación nocturna tres veces por semana) por seis semanas y luego ciclos de cuatro semanas cada uno, dos-tres veces al año. Se hizo un seguimiento a siete años, logrando erradicar exitosamente la enfermedad clínica y controlando las recidivas de forma satisfactoria.


Verrucous carcinoma of the anogenetal region has been reported under a series of names, including giant condyloma acuminatum or Buschke-Loewenstein tumor. Histologically, it corresponds to a well differentiated squamous carcinoma. A number of therapeutic alternatives have been described, the first choice being surgical removal. Imiquimod cream 5 percent represents a topical modifier of the immune response, and is currently being used in the treatment of a series of skin diseases. Objective: We present a review of the literature and the first case of anogenital verrucous carcinoma treated with a seven-year follow-up. Clinical case: A55-year-old man, with a history of a giant condyloma acuminatum with histological evidence of a low degree multiple techniques combined with cytodestructive methods and immunotherapy. A seven-year follow-up was carried out, success-fully eradicating the clinical disease and controlling recurrence with cycles of imiquimod cream 5 percent treatment (average 3 monthly treatment cycles per year).


Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Antineoplásicos/uso terapêutico , Carcinoma Verrucoso/terapia , Neoplasias dos Genitais Masculinos/terapia , Neoplasias do Ânus/terapia , Administração Tópica , Adjuvantes Imunológicos/uso terapêutico , Aminoquinolinas/uso terapêutico , Seguimentos , Pomadas , Resultado do Tratamento
18.
Int. braz. j. urol ; 32(5): 504-512, Sept.-Oct. 2006. tab
Artigo em Inglês | LILACS | ID: lil-439381

RESUMO

The authors report the experience of a high-volume center with laparoscopic surgery in urological oncology, as well as a review of other relevant series. Laparoscopic outcomes in the treatment of adrenal, kidney, upper tract transitional cell carcinoma, bladder, prostate, and testicular malignancy are described in this review. Specific considerations as complications and port-site recurrence are also addressed. The authors concluded that the intermediate-term oncological data is encouraging and comparable to open surgery.


Assuntos
Humanos , Masculino , Neoplasias das Glândulas Suprarrenais/cirurgia , Neoplasias dos Genitais Masculinos/cirurgia , Laparoscopia , Neoplasias Urológicas/cirurgia , Laparoscopia/efeitos adversos , Laparoscopia/mortalidade , Recidiva Local de Neoplasia , Análise de Sobrevida
19.
Int. braz. j. urol ; 32(5): 566-569, Sept.-Oct. 2006. ilus
Artigo em Inglês | LILACS | ID: lil-439390

RESUMO

Seminal vesicle tumor is a rare disease with unclear origin. Generally, it is presented as a pelvic mass that can be detected by sonography and digital rectal exam. The authors report a 25-year-old patient with a pelvic mass which the magnetic resonance and surgical specimen reveal a seminal vesicle tumor. Immunohistochemical findings favored a primitive neuroectodermal tumor of the seminal vesicle. Herein, the treatment, histological and histochemical findings of this entity are discussed.


Assuntos
Humanos , Masculino , Adulto , Neoplasias dos Genitais Masculinos/diagnóstico , Tumores Neuroectodérmicos Primitivos Periféricos/diagnóstico , Glândulas Seminais/patologia , Protocolos de Quimioterapia Combinada Antineoplásica , Quimioterapia Adjuvante , Seguimentos , Neoplasias dos Genitais Masculinos/tratamento farmacológico , Neoplasias dos Genitais Masculinos/cirurgia , Imuno-Histoquímica , Imageamento por Ressonância Magnética , Tumores Neuroectodérmicos Primitivos Periféricos/tratamento farmacológico , Tumores Neuroectodérmicos Primitivos Periféricos/cirurgia , Glândulas Seminais/cirurgia , Resultado do Tratamento
20.
Int. braz. j. urol ; 32(4): 445-447, July-Aug. 2006. ilus
Artigo em Inglês | LILACS | ID: lil-436889

RESUMO

We report a pelvic liposarcoma originating from the left spermatic cord that recurred following inadequate excision. In our case, the tumor was resected without performing orchiectomy previously. The patient was managed by laparoscopic resection, before undergoing radical orchiectomy in the left inguinal region. To our knowledge, no case of laparoscopic resection for the recurrent liposarcoma has been described. In addition, the present case serves to demonstrate that radical orchiectomy with wide excision is needed for paratesticular tumor.


Assuntos
Idoso , Humanos , Masculino , Neoplasias dos Genitais Masculinos , Laparoscopia , Lipossarcoma/cirurgia , Neoplasias Pélvicas/cirurgia , Cordão Espermático , Neoplasias dos Genitais Masculinos/patologia , Neoplasias dos Genitais Masculinos/cirurgia , Lipossarcoma/secundário , Orquiectomia , Neoplasias Pélvicas/diagnóstico , Neoplasias Pélvicas/secundário , Tomografia Computadorizada por Raios X
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