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1.
Prensa méd. argent ; 108(5): 262-269, 20220000. fig
Artigo em Espanhol | LILACS, BINACIS | ID: biblio-1392615

RESUMO

La enfermedad de Castleman (EC) es un proceso linfoproliferativo poco frecuente que se caracteriza por hiperplasia de los ganglios linfáticos. Existen dos variedades histológicas bien diferenciadas la hialino-vascular y la plasmocelular, que a su vez pueden ser localizadas o multicéntricas. La forma hialino-vascular suele ser asintomática y localizada en mediastino mientras que la plasmocelular se presenta frecuentemente con signo-sintomatología sistémica y suele ser difusa o multicéntrica. En el contexto de la enfermedad debida al virus de la inmunodeficiencia humana (VIH), la EC se asocia en su patogenia a la infección por el herpes virus humano tipo-8 (HHV-8). La mayoría de los casos corresponden a la variante hialino-vascular (80/90%) en tanto un pequeño porcentaje (10/20%) son de la variante plasmocelular. En algunos pacientes, el patrón histopatológico puede ser mixto. Se describen dos casos de enfermedad de Castleman multicéntrica HHV8- positiva en pacientes con enfermedad HIV/SIDA.


Castleman's disease (CD), is a rare hematological condition of uncertain etiology, involves a massive proliferation of lymphoid tissues and typically presents as mediastinal masses. This is considered as a distinct type of lymphoproliferative disorder associated with inflammatory symptoms. In the context of human immunodeficiency virus (HIV) infection, CD is associated with human herpesvirus-8 (HHV8) infection. Most cases of CD represent either the hyaline vascular variant (80­90% of cases) or the plasma cell variant (10­20%); a small percentage present with a mixed histologic appearance. Two cases of Castleman's disease associated with HHV-8 and HIV/AIDS infection are described


Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Idoso , Hiperplasia do Linfonodo Gigante/patologia , Hiperplasia do Linfonodo Gigante/terapia , Infecções Oportunistas Relacionadas com a AIDS/imunologia , Herpesvirus Humano 8/imunologia , Teste de HIV
2.
Arq. Asma, Alerg. Imunol ; 6(1): 127-133, jan.mar.2022. ilus
Artigo em Inglês, Português | LILACS | ID: biblio-1400122

RESUMO

A doença de Castleman é um distúrbio linfoproliferativo raro, podendo se manifestar sob a forma de massas localizadas ou como doença multicêntrica. A doença de Castleman multicêntrica é caracterizada por adenopatias generalizadas, visceromegalias, manifestações autoimunes e infecções recorrentes. Este artigo apresenta o relato de caso de anemia hemolítica autoimune por anticorpos quentes em paciente com doença de Castleman multicêntrica. Resposta eficaz foi obtida com uso de corticoterapia sistêmica e tocilizumabe.


Castleman disease is a rare lymphoproliferative disorder that can manifest as localized masses or as multicentric disease. Multicentric Castleman disease is characterized by generalized adenopathies, visceromegaly, autoimmune manifestations, and recurrent infections. This article presents the case report of a patient with multicentric Castleman's disease and autoimmune hemolytic anemia by warm antibodies. Effective response was obtained with systemic corticotherapy and tocilizumab.


Assuntos
Humanos , Masculino , Adulto , Hiperplasia do Linfonodo Gigante , Anemia Hemolítica Autoimune , Pacientes , Corticosteroides/uso terapêutico , Anticorpos Monoclonais Humanizados , Transtornos Linfoproliferativos , Anticorpos
4.
Rev. cientif. cienc. med ; 24(2): 167-172, 2021.
Artigo em Espanhol | LILACS | ID: biblio-1391054

RESUMO

La enfermedad de Castleman es un reto diagnóstico que se debe tener presente en pacientes con linfadenopatías, debido a que pertenece a un grupo heterogéneo de trastornos linfoproliferativos, fue descrita por Benjamín Castleman en 1956, es una patología poco frecuente, de etiopatogenia aún no establecida, en el que intervienen varios factores como ser: la estimulación antigénica viral, VHH-8, VIH, inmunodeficiencias, elevados niveles de IL-6 que llevan a un proceso inflamatorio lo que desencadena una sintomatología diversa, el diagnóstico definitivo se realiza mediante biopsia excisional. Se presenta el caso clínico de una paciente femenina de 41 años de edad, que acude al servicio de emergencias con cuadro clínico de aproximadamente 1 año de evolución caracterizado por presentar pérdida de peso progresivo, adenopatías palpables, evidencia de proceso linfoproliferativo y esplenomegalia observados en la tomografía, VIH negativo, anemia y compromiso del estado general.


Castleman's disease is a diagnostic challenge that must be taken into account in patients with lymphadenopathy, because it belongs to a heterogeneous group of lymphoproliferative disorders, it was described by Benjamin Castleman in 1956, it is a rare pathology, of still unknown etiopathogenesis, In which several factors intervene such as viral antigenic stimulation, HHV-8, HIV, immunodeficiencies, high levels of IL-6 that lead to an inflammatory process that produces diverse symptoms, the definitive diagnosis is made with excisional biopsy. We present the clinical case of a 41-year-old female patient who came to the emergency department with a clinical picture of approximately 1 year of evolution characterized by progressive weight loss, palpable lymphadenopathy, evidence of lymphoproliferative process and splenomegaly in the tomography, HIV negative, anemia and compromise of the general state.


Assuntos
Hiperplasia do Linfonodo Gigante
5.
An. bras. dermatol ; 94(5): 578-581, Sept.-Oct. 2019. graf
Artigo em Inglês | LILACS | ID: biblio-1054871

RESUMO

Abstract The authors have successfully treated and monitored a case of paraneoplastic pemphigus in association with follicular dendritic cell sarcoma aggravated by hyaline-vascular Castleman's disease. The patient was a 56-year-old female who presented with recalcitrant erosive lichen planus of the oral cavity, tongue, and genital mucosa, along with polymorphous eruptions throughout her body. Histological examination of the cutaneous lesions, indirect immunofluorescence on rat bladder epithelium, and western blot of human keratinocyte proteins identified anti-epidermal antibodies in the patient's serum. Positron emission tomography and computed tomography scans found a mass in her retroperitoneal region. Pathology and immunohistochemistry investigation further corroborated the diagnosis of follicular dendritic cell sarcoma originated from hyaline-vascular Castleman's disease. Complete remission was achieved and the patient has been monitored for four years.


Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Hiperplasia do Linfonodo Gigante/complicações , Hiperplasia do Linfonodo Gigante/patologia , Pênfigo/etiologia , Pênfigo/patologia , Sarcoma de Células Dendríticas Foliculares/etiologia , Sarcoma de Células Dendríticas Foliculares/patologia , Biópsia , Tomografia Computadorizada por Raios X , Western Blotting , Resultado do Tratamento , Técnica Indireta de Fluorescência para Anticorpo , Tomografia por Emissão de Pósitrons , Sarcoma de Células Dendríticas Foliculares/cirurgia , Hialina
6.
Int. j. med. surg. sci. (Print) ; 6(1): 14-17, mar. 2019. ilus
Artigo em Inglês | LILACS | ID: biblio-1254180

RESUMO

Castleman's disease (CD) or angiofollicular lymph node hyperplasia includes a heterogeneous mix of reactive lymphoproliferative processes with well-defined histological features. However, they differ in their localization patterns, clinical expression and etiopathogenesis. There are 4 types, one of them is the multicentric CD that is not associated with any viruses and has re-cently been called idiopathic MCD (iMCD). iMCD is a lymphoproliferative disorder with specific histopathological characteristics, more than one region of affected lymph nodes and absence of infection associated to human herpesvirus 8 and human immunodeficiency virus (HIV). iMCD covers multiple differential diagnoses and might simulate autoimmune diseases such as syste-mic lupus erythematosus. The aim of this article is to report the case of a patient with Castle-man's disease and lupus-like presentation. We present the case of a 38-year-old man without morbid history, who presented lumbago, fever, diaphoresis and asthenia with two months of evolution, associated to bilateral cervical adenopathies. General examinations result negative, antinuclear antibodies at a dilution of 1/640 were positive, and extractable nuclear antigens were positive suggesting moderate Systemic Lupus Erythematosus (SLE) plus secondary Sjö-gren's. Methylprednisolone and Hydroxycloroquine boli were thus initiated. The patient evolved with anasarca, severe anemia, acidosis, polyserositis and multiple mediastinal adenopathies. Immunoglobulin and cyclophosphamide were thus initiated. He later presented fever, throm-bocytopenia and nephrotic syndrome. Biopsy of cervical lymph node reported lymphadenitis with polyclonal plasmacytosis and concentric lymphoid hyperplasia, in agreement with iMCD. Treatment with Rituximab was initiated, which led to the favorable evolution of the patient. iMCD is a systemic inflammatory disease, its presentation corresponds to a constitutional syndrome resulting in a wide differential diagnosis. Every time suspicious adenopathies appear, they must be biopsied since this might lead to a definitive diagnosis


Assuntos
Humanos , Masculino , Adulto , Hiperplasia do Linfonodo Gigante/diagnóstico , Lúpus Eritematoso Sistêmico/diagnóstico , Biópsia , Radiografia Torácica
7.
Rev. Soc. Bras. Clín. Méd ; 16(4): 235-237, out.-dez. 2018. ilus.
Artigo em Português | LILACS | ID: biblio-1025924

RESUMO

A síndrome POEMS é um distúrbio multissistêmico. Sua patogênese não está totalmente estabelecida, mas sabe-se que tem relação com fator de crescimento vascular endotelial, interleucinas e fator de necrose tumoral alfa. A idade média de incidência é 50 anos, com maior prevalência em homens. Neuropatia periférica e gamopatia monoclonal estão presentes em todos os pacientes e são consideradas critérios maiores; quando associadas a pelo menos um critério menor, estabelecem diagnóstico da síndrome. As opções de tratamento são radioterapia, corticosteroides e quimioterapia, além de transplante autólogo de células-tronco hematopoiéticas. (AU)


POEMS syndrome is a multisystem disorder. Its pathogenesis isn't fully established, but it is known to be related to endothelial vascular growth factor, interleukins, and tumoral necrosis factor alpha (TNF-α). The mean age at incidence is 50 years, with a higher prevalence in men. Peripheral neuropathy and monoclonal gammopathy are present in all patients, and are considered major criteria; when associated with at least one minor criterium, they establish the diagnosis of the syndrome. Treatment options are radiotherapy, corticosteroids, chemotherapy, as well as autologous hematopoietic stem cell transplantation. (AU)


Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Síndrome POEMS/diagnóstico , Osteosclerose/etiologia , Paraproteinemias/etiologia , Polineuropatias/diagnóstico , Esplenomegalia/diagnóstico por imagem , Doenças da Glândula Tireoide/diagnóstico por imagem , Dexametasona/uso terapêutico , Hiperplasia do Linfonodo Gigante , Síndrome POEMS/complicações , Síndrome POEMS/tratamento farmacológico , Corticosteroides/uso terapêutico , Vasculite Leucocitoclástica Cutânea/diagnóstico , Polirradiculoneuropatia Desmielinizante Inflamatória Crônica , Inibidores da Angiogênese/uso terapêutico , Ciclofosfamida/uso terapêutico , Diagnóstico Diferencial , Eletromiografia , Imunossupressores/uso terapêutico , Antibióticos Antineoplásicos/uso terapêutico , Mieloma Múltiplo , Antineoplásicos/uso terapêutico
8.
Autops. Case Rep ; 8(3): e2018033, July-Sept. 2018. ilus
Artigo em Inglês | LILACS | ID: biblio-911974

RESUMO

Simultaneous calcified fibrous pseudotumor (CFT) and Castleman disease (CD) is an extremely rare association. CD is an uncommon lymphoproliferative disease that can arise in various sites of the body, while CFT is a rare type of benign fibrous lesion that frequently affects children and young adults, occurring as solitary or multiple lesions throughout the human body. Both entities are rare and exhibit typical and diverse histomorphological features. We report the case of a 15-year-old female patient, who, at the age of 13 had a biopsy performed at an external medical center; however, after 4 months the lesion had regrown. This lesion was removed with a surgical operation; however, it regrew 2 years later and was removed a third time. The results of the latter two biopsies were the same: CFT accompanying CD. The histologic examination of the excised lymph node and the surrounding tissue showed hyalinized fibrous tissue containing dystrophic and psammomatous calcification. In this case, the hyaline vascular type of CD was found to be intertwined with a CFT, which hampered the differentiation of whether both entities emerged within the lymph node or if the CFT developed from the soft tissue and then involved the lymph node. Future studies involving larger case series will provide a more precise insight, which should serve to resolve the current uncertainty.


Assuntos
Humanos , Feminino , Adolescente , Hiperplasia do Linfonodo Gigante/diagnóstico , Clavícula/patologia , Linfonodos/patologia
9.
Rev. habanera cienc. méd ; 17(4): 579-590, jul.-ago. 2018. tab
Artigo em Espanhol | LILACS, CUMED | ID: biblio-978553

RESUMO

Introducción: La Hiperplasia nodular linfoide gastrointestinal constituye una entidad infrecuente con manifestaciones clínicas diversas y con mayor frecuencia en la edad pediátrica. Objetivo: Caracterizar clínica, endoscópica e histológicamente a los pacientes pediátricos con hiperplasia linfoide de colon e íleon terminal diagnosticados en el Instituto de Gastroenterología. Material y Métodos: Se realizó un estudio descriptivo, transversal, en el periodo comprendido entre 2014 y 2016 en el Instituto de Gastroenterología. La muestra estuvo constituida por 50 pacientes, quienes cumplieron los criterios de inclusión y exclusión. Se evaluaron variables demográficas, clínicas, endoscópicas e histológicas, así como el comportamiento de la comorbilidad con enfermedades malignas, enfermedades inflamatorias intestinales, giardiosis, trastornos de la respuesta inmunohumoral y alergias alimentarias. Resultados: El sexo masculino, entre 7-10 años y el color de la piel blanca fueron los más frecuentes. El sangrado rectal fue el síntoma principal (62 por ciento) y la localización a nivel del íleon terminal en 69 por ciento, no se relacionó con enfermedad maligna, hubo tres pacientes con diagnóstico de hiperplasia linfoide de íleon terminal y colitis ulcerosa. El 74 por ciento presentó aspecto nodular por histología y 60 por ciento se le diagnosticó Giardia lamblia, en la evaluación inmunohumoral predominó los pacientes sin inmunocompromiso (78 por ciento), el Prick Test fue positivo en 60 por ciento, sobre todo, a la leche de vaca. Conclusiones: La manifestación clínica que predominó fue el sangrado rectal, endoscópicamente la localización en íleon y la forma nodular por histología. No encontramos comorbilidades con enfermedades malignas y fueron más frecuentes los trastornos alérgicos y parasitarios que las alteraciones inmunológicas(AU)


Introduction: Lymphoid nodular hyperplasia of the gastrointestinal tract is an uncommon entity with diverse clinical manifestations, which is more frequent in the pediatric age. Objective: To characterize clinically, endoscopically, and histologically, those pediatric patients with lymphoid hyperplasia of the colon and terminal ileum diagnosed in the Institute of Gastroenterology. Material and Methods: A descriptive, cross-sectional study was carried out during the period between 2014 and 2016 in the Institute of Gastroenterology. The sample consisted of 50 patients who met the inclusion and exclusion criteria. Demographic, clinical, endoscopic and histological variables were evaluated, as well as the behavior of comorbidity with malignant diseases, inflammatory bowel diseases, giardiasis, disorders of the humoral immune response and food allergies. Results: The male sex, the age group between 7-10 years, and the white skin color were the most frequent. Rectal bleeding was the main symptom (62 percent), and the location of the lesions in the terminal ileum was observed in 69 percent of the patients. There was no relationship between lymphoid hyperplasia and malignant disease, but three patients were diagnosed with lymphoid hyperplasia of the terminal ileum, and ulcerative colitis. 74 percent of the biopsies presented a nodular variety, and 60 percent of the patients were diagnosed with Giardia lamblia; the cases that were not immunocompromised prevailed in the evaluation of humoral immune response (78 percent); the Prick Test was positive in 60 percent of children, especially to cow's milk. Conclusions: The predominant clinical manifestation was rectal bleeding; the localization was in the ileum, which was seen by endoscopic procedure; and the nodular form was demonstrated by histology. We did not find comorbidities with malignant diseases, and allergic and parasitic disorders were more frequently diagnosed than immunological alterations(AU)


Assuntos
Humanos , Criança , Adolescente , Hiperplasia do Linfonodo Gigante/complicações , Hiperplasia do Linfonodo Gigante/epidemiologia , Epidemiologia Descritiva , Estudos Transversais
10.
Rev. méd. Chile ; 145(7): 945-949, jul. 2017. graf
Artigo em Espanhol | LILACS | ID: biblio-902568

RESUMO

We report a 73-year-old female patient with Castleman's disease coexistent with large B cell type non-Hodgkin's lymphoma in a right axillary lymphadenopathy. An excisional biopsy was performed: microscopically, the lymph node revealed the presence of numerous plasma cells and small lymphoid cells characteristic of Castleman's disease. An analysis of another portion of the specimen revealed lymphoid cells with large abnormal nuclei gathered locally that were CDD 79+, CD 38+ and MUM-1+ as well as positive for Kaposi sarcoma-associated herpesvirus and negative for Epstein Barr virus encoded RNA-1 (EBER).


Assuntos
Humanos , Feminino , Idoso , Linfoma Difuso de Grandes Células B/complicações , Hiperplasia do Linfonodo Gigante/complicações , Linfonodos/patologia , Linfoma Difuso de Grandes Células B/patologia , Hiperplasia do Linfonodo Gigante/patologia
11.
Actual. SIDA. infectol ; 25(94): 10-16, 20170000. tab
Artigo em Espanhol | LILACS, BINACIS | ID: biblio-1530910

RESUMO

La enfermedad de Castleman (ECM) es un desorden linfoproliferativo y con un pronóstico desfavorable, que se lo ha asociado a la infección por el virus herpes humano tipo 8 (HHV-8). El mecanismo supuesto de ac-ción del HHV-8 sería la secreción de interleuquinas (IL) virales, homólo-gas a IL humanas tales como IL-6 e IL-10. La coinfección por HHV-8 y vi-rus Epstein Barr (EBV) es bien conocida en pacientes con infección por el virus de la inmunodeficiencia humana tipo 1 (HIV-1). Estos gamma-herpesvirus se asocian a trastornos linfoproliferativos que son favore-cidos por la inmunosupresión. Puede presentarse en el contexto de un buen estado inmunológico y su tratamiento se basa en el uso de quimioterapia. La reactivación del EBV latente es favorecida por la infección por HIV-1 y el uso de drogas inmunosupresoras, determinando un potencial riesgo para el desarrollo de nuevos desór-denes linfoproliferativos. Se presenta el caso de un paciente con enferme-dad de Castleman asociado a la infección por HIV-1 y HHV-8, que presentó como complicación post-qui-mioterapia reactivación de infección EBV. Se realizó una revisión del concepto de ECM y la relación pato-génica entre los virus HIV-1, HHV-8 y EBV


Castleman's disease (CD) is a lymphoproliferative disorder with an unfavorable prognosis, which has been associated with human herpes virus 8 (HHV-8) infection. The presumed mechanism of action of HHV-8 would be the secretion of viral interleukin (IL), homologous to human IL such as IL-6 and IL-10. The co-HHV8 infection and Epstein Barr virus (EBV) is well known in patients infected with the HIV type 1 (HIV-1). These gamma-herpesvirus were associated with lymphoproliferative disorders that are favored by immunosuppression. It can occur in the context of a patient's good immune system and its treatment is based on the use of chemotherapy. Reactivation of latent EBV is favored by HIV-1 and the use of immunosuppressive drugs, determining a potential risk for the development of new lymphoproliferative disorders.We report here a patient with Castleman's disease associated with HIV-1 and HHV-8, who presented, as a complication of the chemotherapy, the reactivation of EBV infection. A review of the concept of CD and the pathogenic relationship between HIV-1, HHV-8 and EBV virus was performed


Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Infecções por HIV/terapia , Hiperplasia do Linfonodo Gigante/terapia , Herpesvirus Humano 8 , Infecções por Vírus Epstein-Barr/terapia
12.
Rev. argent. cir ; 108(4): 1-10, dic. 2016. ilus, tab
Artigo em Espanhol | LILACS, BINACIS | ID: biblio-957888

RESUMO

Antecedentes: la enfermedad de Castleman es conocida como hiperplasia linfática angiofolicular y se caracteriza por crecimiento masivo del tejido linfático. Histológicamente hay tres categorías: hialino-vascular, tipo células plasmáticas y mixto. Se describen dos variantes clínicas: monocéntrica (localizada) y multicéntrica. Objetivo: presentar nuestra experiencia en el manejo de esta enfermedad haciendo énfasis en su compromiso mediastinal y pulmonar. Material y métodos: revisión de historias clínicas e informes patológicos. Resultados: se identificaron 5 pacientes, 1 mujer y 4 hombres, con edad promedio de 58,5 años. Tres pacientes presentaron la forma localizada y dos la multicéntrica. Los síntomas fueron: dolor torácico en dos casos, astenia en 1 caso y síndrome POEMS (polineuropata, organomegalia, endocrinopata y pico monoclo-nal) en 2 casos. Se realizó toracotomía y resección en 2 casos, lobectomía superior derecha en bloque con la lesión mediastinal en 1 caso, biopsia de masa apical en 1 caso y biopsia ganglionar por mediastinoscopia en 1 caso. Se realizó reoperación por sangrado en 1 caso. Tres pacientes presentaron la forma hialino-vascular y 2 la variante de células plasmáticas. Un paciente resecado se perdió de seguimiento. Los pacientes con síndrome POEMS fallecieron, uno al 8° día por neumonía intrahospitalaria y otro al 6° mes por sepsis. Los enfermos resecados restantes cursan buena evolución. Conclusiones: se recomienda la resección quirúrgica en pacientes con enfermedad de Castleman variedad localizada, la cual es curativa. Los pacientes con la variedad multicéntrica no se benefician con esta terapéu-tica, pero son pasibles de quimioterapia o radioterapia o combinación de ambas.


Background: Castleman's disease, known as angio follicular lymph node hyperplasia, is characterized by the massive growth of lymphoid tissue. Histollogically there are three categories: hyaline-vascular, plasm cell type and mixed type. Two clinical variantis have been described: monocentric (localized) and multicentric. Objective: to describe our experience in the treatment of this disease, focusing on itis mediastinal and pulmonary afecton. Method: review of clinical records and pathological reportis. Resultis: 5 patentis (1 female and 4 male), within an age -range of 58, 5 years were screened. Three patentis were afected by the localized type and two by the multicentric type. The symptoms were: thoracic pain in two of the cases, asthenia in one and POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy and monoclonal changes) in 2 cases. We performed thoracotomy and resecton in two cases, upper right side lobectomy in block with the mediastinal lesion in 1 case, apical mass biopsy in 1 case and lymph node biopsy by mediastinoscopy in one case. We performed reoperaton by bleeding in one case. Three patentis presented the hyaline vascular type and two, the plasma-cell type. We lost track of a resectoned patent. Those patentis with POEMS syndrome died, one of them of intra-hospital pneumonia on the eighth day, and another of sepsis on the sixth month. The remaining resectoned patentis are evolving well. Conclusions: on patentis presenting localized type Castleman's disease, we recommend surgical resecton, which is a curative therapy. Patentis presenting the monocentric type do not beneft from this therapy and are passible of chemotherapy and /or radiotherapy.


Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Idoso , Tórax/patologia , Hiperplasia do Linfonodo Gigante/cirurgia , Toracotomia , Radiografia Torácica , Tomografia Computadorizada por Raios X , Estudos Retrospectivos , Hiperplasia do Linfonodo Gigante/diagnóstico por imagem , Biópsia por Agulha Fina/métodos
13.
Rev. colomb. gastroenterol ; 31(3): 283-287, jul.-set. 2016. ilus
Artigo em Espanhol | LILACS | ID: biblio-830339

RESUMO

La hiperplasia nodular linfoide es una patología del aparato gastrointestinal, poco frecuente en adultos. Se caracteriza por un crecimiento del tejido linfoide mucoso y submucoso como respuesta a diferentes tipos de estímulos nocivos. Se ha descrito asociada con otras patologías como infección por VIH/ Síndrome de Inmunodeficiencia Adquirida, giardiasis, infección por Helicobacter Pylori, enfermedad celíaca, y en pocos casos con enfermedad inflamatoria intestinal. No tiene una presentación clínica específica y su manejo aún no está claro


Lymphoid nodular hyperplasia is a pathology of the gastrointestinal tract that rarely occurs among adults. It is characterized by growth of submucosal lymphoid tissue and mucosal response to different types of noxious stimuli. It has been described in association with other diseases such as HIV/AIDS, giardiasis, Helicobacter pylori infections, celiac disease, and very rarely with inflammatory bowel disease. At present, there is no specific clinical presentation or treatment


Assuntos
Humanos , Masculino , Adulto , Colite Ulcerativa , Endoscopia Gastrointestinal , Hiperplasia do Linfonodo Gigante
14.
Rev. Soc. Bras. Clín. Méd ; 14(3): 163-165, jul. 2016. Ilus
Artigo em Português | LILACS | ID: biblio-2130

RESUMO

A doença de Castleman é um distúrbio linfoproliferativo raro. Há três tipos histológicos: hialino-vascular (mais comum), variante de células plasmáticas e forma mista. A forma hialino-vascular é caracterizada tipicamente por apresentar uma evolução clínica benigna e localizada, sem sintomas constitucionais. É geralmente tratada com cirurgia e/ou radioterapia. A doença multicêntrica apresenta sintomas sistêmicos. Ainda não há um consenso sobre qual a melhor abordagem terapêutica. Reportamos o caso da doença em um homem de 47 anos com diagnóstico de doença de Castleman variante hialino-vascular e anemia hemolítica autoimune associada, com presença de CD-20, CD-10, CD3 e Ki67 positivos. Foi tratado com protocolo quimioterápico esquema CHOP e corticoterapia com prednisona, evoluindo com melhora do quadro.


Castleman's disease is a rare lymphoproliferative disorder. There are three histological types: hyaline-vascular (most common), plasma cell variant, and mixed form. The hyaline-vascular form is typically characterized by a benign and localized clinical course without constitutional symptoms. It is usually treated with surgery and/or radiotherapy. The multicentric disease has systemic symptoms. There is still no consensus on the best therapy approach. We report a case of the disease in a 47-year-old man diagnosed with hyaline-vascular variant of Castleman's disease, and associated Autoimmune Hemolytic Anemia, with the presence of CD20-positive, CD10-positive, CD3-positive and Ki67-positive cells. He was treated with chemotherapy protocol of CHOP regimen and corticotherapy with Prednisone, and evolved with improvement.


Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Anemia Hemolítica Autoimune/diagnóstico , Hiperplasia do Linfonodo Gigante/tratamento farmacológico , Diagnóstico Diferencial , Imuno-Histoquímica , Transtornos Linfoproliferativos
15.
Rev. Hosp. Ital. B. Aires (2004) ; 35(3): 86-89, sept. 2015. ilus
Artigo em Espanhol | LILACS, UNISALUD, BINACIS | ID: biblio-1401132

RESUMO

La enfermedad de Castleman (EC) es una rara entidad linfoproliferativa benigna caracterizada por el crecimiento no neoplásico progresivo de los ganglios linfáticos en cualquier parte del cuerpo, aunque en la mayoría de los casos (60%) afecta el mediastino y, con una muy baja frecuencia, compromete la región de la cabeza y el cuello, incluidas las glándulas salivales. Representa un desafío diagnóstico para el médico porque se presenta con síntomas y signos inespecíficos. Existen dos subtipos: uno localizado en forma de adenopatía sin síntomas generales y otro multicéntrico con compromiso de varios grupos ganglionares y con manifestaciones clínicas sistémicas y alteraciones del laboratorio. El diagnóstico requiere un examen físico completo y exámenes complementarios (laboratorio, ecografía, tomografía computarizada o resonancia magnética nuclear o ambas, punción aspiración con aguja fina) y se confirma a través del análisis histopatológico. El tratamiento es quirúrgico, pero la forma multicéntrica requiere además un tratamiento adyuvante. A pesar de su localización inusual en las glándulas salivales, la EC debería ser considerada entre los diagnósticos diferenciales, sobre todo ante la sospecha de procesos linfoproliferativos. Se describe en este trabajo el caso de una paciente pediátrica con diagnóstico de EC localizada en la glándula submaxilar, y se realizó una revisión de la literatura. (AU)


Castleman disease (CD) is a rare lymphoproliferative entity characterized for a non ­ neoplasic progressive growth of the lymph nodes in any part of the body; nevertheless it usually affects the mediastinum (60 %), and with less frequency, it compromises the head and neck region, including the salivary glands. It represents a diagnostic challenge for the doctor, because it has nonspecific symptoms and signs. There are two subtypes: the localized form, that generally is presented through an adenopaty without systemic symptoms, and a multicentric form that compromises several nodal groups and has systemic symptoms and laboratory abnormalities. Diagnosis requires a complete physical examination and complementary exams (blood tests, ultrasonography, computed tomography and/or magnetic resonance, fine needle puncture ­ aspiration), and the final diagnosis is through histopathological analysis. The treatment is surgery, but multicentric form requires adyuvant treatment. Although its unusual presentation in salivary glands, CD should be considered between differential diagnosis, especially when we are thinking of lymphoproliferative entities. In this article, we present a case of a pediatric patient with diagnosis of CD of submaxilar gland and we review the literatura about this disease with special attention in the salivary glands location. (AU)


Assuntos
Humanos , Feminino , Adolescente , Glândulas Salivares/patologia , Hiperplasia do Linfonodo Gigante/patologia , Hiperplasia do Linfonodo Gigante/diagnóstico por imagem , Glândulas Salivares/cirurgia , Biópsia por Agulha , Espectroscopia de Ressonância Magnética , Tomografia Computadorizada por Raios X , Hiperplasia do Linfonodo Gigante/cirurgia , Hiperplasia do Linfonodo Gigante/etiologia , Diagnóstico Diferencial
17.
Actual. SIDA. infectol ; 23(88): 33-41, 20150000. fig, tab
Artigo em Espanhol | LILACS, BINACIS | ID: biblio-1532011

RESUMO

La enfermedad de Castleman es un desorden linfoprolifera-tivo de origen aún incierto pero, en principio, relacionado con una dis-función de las células dendríticas foliculares y con una producción al-terada de distintas citoquinas, la mayor parte de ellas con actividad proinflamatoria y responsable de la sintomatología que presentan los pacientes.La relación con la presencia del HHV8, especialmente de las formas graves, ha sido ampliamente documentada en los últimos años y su desarrollo en el marco de la infección por el HIV permite una evolu-ción desafortunada de esta asociación morbosa presentando una ten-dencia importante hacia el desarrollo de patologías neoplásicas tales como la enfermedad de Kaposi y distintos tipos de linfomas.Se presentan dos casos de enfermedad de Castleman asociados a in-fección por HIV y HHV8 y se describe el contexto patogénico donde se desarrollan


Castleman ́s disease is a lymphoproliferative disorder of uncertain origin but, principally, related to dysfunction of follicular dendritic cells and impaired production of various cytokines, most of which have proinflammatory activity and are responsible for the symptoms that patients present.The relationship between Castleman ́s disease and HHV8, especially in severe forms, has been well documented in the last years. This morbid association is related to an unfortunate evolution in the context of HIV infection, presenting an increased risk of neoplastic disorders such as Kaposi ́s disease and various types of lymphomas.Two cases of Castleman ́s disease associated with HHV8 and HIV infection, and the pathogenic context in which they developed, are presented and described


Assuntos
Humanos , Masculino , Adulto , Pessoa de Meia-Idade , Infecções por HIV/terapia , Hiperplasia do Linfonodo Gigante/diagnóstico , Herpesvirus Humano 8/imunologia
18.
Rev. bras. enferm ; 68(3): 452-459, maio-jun. 2015. tab, ilus
Artigo em Português | LILACS, BDENF - Enfermagem | ID: lil-756529

RESUMO

RESUMOObjetivo:identificar termos relacionados à prática de enfermagem direcionada à criança e ao adolescente em situação de violência doméstica.Método:pesquisa descritiva bibliográfica, que selecionou 40 artigos na base da Biblioteca Virtual em Saúde, no tema da violência doméstica contra a criança e o adolescente, suas manifestações, causas e consequências, articulado com as práticas de enfermagem para enfrentamento e prevenção; e extraiu termos com uso de ferramenta computacional.Resultados:Foram extraídos 17.365 termos que após a normalização e adequação, resultou numa lista de 915 termos.Conclusão:Os termos selecionados focalizam o nexo biopsíquico individual e a face histórica do fenômeno foi, em parte, identificada em termos de menor frequência de aparição nos artigos, explicitando a contradição entre a lógica formal de identificação dos termos e a lógica dialética que reconhece as raízes históricas e a dinamicidade dos fenômenos.


RESUMENObjetivo:identificar termos relacionados a la práctica del Enfermería direccionada a los niños y a los adolescentes en situación del violencia doméstica.Método:investigación descriptiva bibliográfica, la cuál seleccionó 40 artículos con bases en la Biblioteca Virtual en Salud, en el tema de la violencia doméstica contra los niños y los adolescentes, suya manifestación, causas y consecuencias, articulado con las prácticas del enfermería para el confronto y prevención; y extraer termos con él uso de la herramienta computacional.Resultados:fueron extirpados 17.365 termos los cuales después de la normalización y adecuación resultó en una lista con 915 termos.Conclusión:los termos seleccionados destacan el nexo biopsíquico individual y la face histórica del fenómeno fue, en parte, identificada en termos con menor frecuencia de la aparición en los artículos, demostra la contradicción entre la lógica formal de la identificación de los termos y la lógica dialéctica la cual reconoce las raíces históricas y la dinámica de los fenómenos.


ABSTRACTObjective:Identifi cation of terminology relating to nursing practices aimed at children and adolescents at risk of domestic violence.Methods:bibliographic descriptive research which selected 40 articles from the Virtual Health Library on domestic violence against children and adolescents, its manifestations, causes, and consequences, in association with nursing procedures for its confrontation and prevention, and which also identifi ed terminology via computer tools.Results:17,365 terms that, after standardization and uniformity procedures, resulted in a listing of 915 terms.Conclusion:The terminology selected focused on the individual biopsychic nexus and the historic manifestation of this phenomenon was partially identifi ed in terms that appear less frequently in these articles, thereby explaining the contradiction between the formal identifi cation logic of such terminology and the dialectic logic that recognizes the historic reasons for, and dynamicity of, such phenomena.


Assuntos
Humanos , Masculino , Feminino , Criança , Adolescente , Adulto , Pessoa de Meia-Idade , Hiperplasia do Linfonodo Gigante/patologia , Imageamento por Ressonância Magnética , Pescoço , Tomografia Computadorizada por Raios X , Imageamento por Ressonância Magnética/métodos , Pescoço/patologia , Pescoço , Estudos Retrospectivos , Tomografia Computadorizada por Raios X/métodos
20.
Rev. bras. reumatol ; 54(4): 326-329, Jul-Aug/2014. tab, graf
Artigo em Português | LILACS | ID: lil-722288

RESUMO

A doença de Castleman (DC) é uma desordem linfoproliferativa policlonal, também conhecida como hiperplasia nodular gigante ou hiperplasia angiofolicular linfoide. Esta é uma doença rara que está frequentemente associada ao vírus da imunodeficiência humana (HIV) e ao herpes vírus 8 (HHV-8). Os achados histopatológicos encontrados na DC sugerem uma intensa resposta aos estímulos antigênicos observada em várias doenças associadas com ativação imune, como a artrite reumatoide. Um fator importante implicado na patogênese da DC é a produção autônoma da interleucina-6 (IL-6). Nessa doença, as manifestações clínicas estão relacionadas aos níveis de IL-6, e a remoção cirúrgica dos linfonodos acometidos ou a utilização de anticorpos anti-IL-6 fazem regredir os sintomas. Descrevemos um caso da DC multicêntrica em uma mulher jovem, não associada à infecção pelo vírus HHV-8 ou à imunossupressão. Uma breve revisão da literatura se segue à descrição do caso clínico.


Castleman's disease (CD) is a polyclonal lymphoproliferative disorder also known as giant nodular hyperplasia or angiofollicular lymph node hyperplasia. It is a rare disease often associated to human immunodeficiency virus (HIV) and human herpes virus 8 (HHV-8). Histopathological findings in Castleman's disease suggest an exaggerated response to antigenic stimuli seen in other diseases associated with immune activation, such as rheumatoid arthritis. An important aspect of its pathogenesis is the autonomous production of interleukin-6 (IL-6). In this disease, the clinical manifestations are associated to IL-6 serum levels, and surgical removal of the compromised lymph nodes or use of anti-IL-6 antibodies can slow down the symptoms. We describe a multicentric Castleman's disease in a young woman not associated to HHV-8 virus infection or immunosuppression. A short review of the literature follows the description of this clinical case.


Assuntos
Humanos , Feminino , Adulto , Hiperplasia do Linfonodo Gigante/diagnóstico , HIV-1 , Herpesvirus Humano 8
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