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1.
Braz. j. med. biol. res ; 52(2): e8103, 2019.
Artigo em Inglês | LILACS | ID: biblio-974278

RESUMO

Dipyrone (metamizole), acting through its main metabolites 4-methyl-amino-antipyrine and 4-amino-antipyrine, has established analgesic, antipyretic, and spasmolytic pharmacological effects, which are mediated by poorly known mechanisms. In rats, intravenously administered dipyrone delays gastric emptying (GE) of liquids with the participation of capsaicin-sensitive afferent fibers. This effect seems to be mediated by norepinephrine originating from the sympathetic nervous system but not from the superior celiac-mesenteric ganglion complex, which activates β2-adrenoceptors. In rats, in contrast to nonselective non-hormonal anti-inflammatory drugs, dipyrone protects the gastric mucosa attenuating the development of gastric ulcers induced by a number of agents. Clinically, it has been demonstrated that dipyrone is effective in the control of colic-like abdominal pain originating from the biliary and intestinal tracts. Since studies in humans and animals have demonstrated the presence of β2-adrenoceptors in biliary tract smooth muscle and β2-adrenoceptor activation has been shown to occur in dipyrone-induced delayed GE, it is likely that this kind of receptors may participate in the reduction of smooth muscle spasm of the sphincter of Oddi induced by dipyrone. There is no evidence that dipyrone may interfere with small bowel and colon motility, and the clinical results of its therapeutic use in intestinal colic appear to be due to its analgesic effect.


Assuntos
Animais , Ratos , Anti-Inflamatórios não Esteroides/farmacologia , Ampirona/farmacologia , Antipirina/farmacologia , Dipirona/farmacologia , Esvaziamento Gástrico/efeitos dos fármacos , Bloqueio Nervoso Autônomo , Dipirona/administração & dosagem , Ratos Wistar
2.
Braz. j. med. biol. res ; 49(3): e5011, Mar. 2016. graf
Artigo em Inglês | LILACS | ID: lil-771943

RESUMO

There is evidence for participation of peripheral β-adrenoceptors in delayed liquid gastric emptying (GE) induced in rats by dipyrone (Dp), 4-aminoantipyrine (AA), and antipyrine (At). The present study aimed to determine whether β-adrenoceptors are involved in delayed GE induced by phenylpyrazole derivatives and the role of the prevertebral sympathetic nervous system in this condition. Male Wistar rats weighing 220-280 g were used in the study. In the first experiment rats were intravenously pretreated with vehicle (V), atenolol 30 mg/kg (ATE, β1-adrenergic antagonist), or butoxamine 25 mg/kg (BUT, β2-adrenergic antagonist). In the second experiment, rats were pretreated with V or SR59230A 2 mg/kg (SRA, β3-adrenergic antagonist). In the third experiment, rats were subjected to surgical resection of the celiac-superior mesenteric ganglion complex or to sham surgery. The groups were intravenously treated with saline (S), 240 µmol/kg Dp, AA, or At, 15 min after pretreatment with the antagonists or V and nine days after surgery. GE was determined 10 min later by measuring the percentage of gastric retention (%GR) of saline labeled with phenol red 10 min after gavage. The %GR (means±SE, n=6) values indicated that BUT abolished the effect of Dp (BUT+Dp vs V+Dp: 35.0%±5.1% vs 56.4%±2.7%) and At (BUT+At vs V+At: 33.5%±4.7% vs 52.9%±2.6%) on GE, and significantly reduced (P<0.05) the effect of AA (BUT+AA vs V+AA: 48.0%±5.0% vs 65.2%±3.8%). ATE, SRA, and sympathectomy did not modify the effects of treatments. These results suggest that β2-adrenoceptor activation occurred in delayed liquid gastric emptying induced by the phenylpyrazole derivatives dipyrone, 4-aminoantipyrine, and antipyrine. Additionally, the released neurotransmitter did not originate in the celiac-superior mesenteric ganglion complex.


Assuntos
Animais , Masculino , Antagonistas Adrenérgicos beta/farmacologia , Anti-Inflamatórios não Esteroides/farmacologia , Antipirina/administração & dosagem , Ganglionectomia , Esvaziamento Gástrico/efeitos dos fármacos , Receptores Adrenérgicos beta/metabolismo , Antagonistas Adrenérgicos beta/administração & dosagem , Ampirona/farmacologia , Atenolol/farmacologia , Butoxamina/farmacologia , Dipirona/farmacologia , Relação Dose-Resposta a Droga , Gânglios Simpáticos/cirurgia , Modelos Animais , Propanolaminas/farmacologia , Ratos Wistar , Sistema Nervoso Simpático/efeitos dos fármacos
3.
Braz. j. med. biol. res ; 47(3): 231-236, 03/2014. graf
Artigo em Inglês | LILACS | ID: lil-704623

RESUMO

Studies have shown that edaravone may prevent liver injury. This study aimed to investigate the effects of edaravone on the liver injury induced by D-galactosamine (GalN) and lipopolysaccharide (LPS) in female BALB/c mice. Edaravone was injected into mice 30 min before and 4 h after GalN/LPS injection. The survival rate was determined within the first 24 h. Animals were killed 8 h after GalN/LPS injection, and liver injury was biochemically and histologically assessed. Hepatocyte apoptosis was measured by TUNEL staining; proinflammatory cytokines [tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6)] in the liver were assayed by ELISA; expression of caspase-8 and caspase-3 proteins was detected by Western blot assay; and caspase-3 activity was also determined. Results showed that GalN/LPS induced marked elevations in serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Edaravone significantly inhibited elevation of serum AST and ALT, accompanied by an improvement in histological findings. Edaravone lowered the levels of TNF-α and IL-6 and reduced the number of TUNEL-positive cells. In addition, 24 h after edaravone treatment, caspase-3 activity and mortality were reduced. Edaravone may effectively ameliorate GalN/LPS-induced liver injury in mice by reducing proinflammatory cytokines and inhibiting apoptosis.


Assuntos
Animais , Feminino , Antipirina/análogos & derivados , Apoptose/efeitos dos fármacos , Citocinas/efeitos dos fármacos , Doença Hepática Induzida por Substâncias e Drogas/prevenção & controle , Sequestradores de Radicais Livres/farmacologia , Alanina Transaminase/sangue , Antipirina/farmacologia , Aspartato Aminotransferases/sangue , /análise , /metabolismo , /análise , Doença Hepática Induzida por Substâncias e Drogas/fisiopatologia , Ensaio de Imunoadsorção Enzimática , Endotoxinas/toxicidade , Galactosamina/toxicidade , Hepatócitos/efeitos dos fármacos , Marcação In Situ das Extremidades Cortadas , /análise , Lipopolissacarídeos/toxicidade , Camundongos Endogâmicos BALB C , Distribuição Aleatória , Fator de Necrose Tumoral alfa/análise
4.
Braz. j. med. biol. res ; 46(9): 735-738, 19/set. 2013. tab, graf
Artigo em Inglês | LILACS | ID: lil-686572

RESUMO

Dipyrone (Dp), 4-aminoantipyrine (AA), and antipyrine (At) delay liquid gastric emptying (GE) in rats. We evaluated adrenergic participation in this phenomenon in a study in male Wistar rats (250-300 g) pretreated subcutaneously with guanethidine (GUA), 100 mg·kg−1·day−1, or vehicle (V) for 2 days before experimental treatments. Other groups of animals were pretreated intravenously (iv) 15 min before treatment with V, prazosin (PRA; 1 mg/kg), yohimbine (YOH; 3 mg/kg), or propranolol (PRO; 4 mg/kg), or with intracerebroventricular (icv) administration of 25 µg PRO or V. The groups were treated iv with saline or with 240 µmol/kg Dp, AA, or At. GE was determined 10 min later by measuring the percentage of gastric retention (%GR) of saline labeled with phenol red 10 min after gavage. %GR (mean±SE, n=8) indicated that GUA abolished the effect of Dp (GUA vs V=31.7±1.6 vs 47.1±2.3%) and of At (33.2±2.3 vs 54.7±3.6%) on GE and significantly reduced the effect of AA (48.1±3.2 vs 67.2±3.1%). PRA and YOH did not modify the effect of the drugs. %GR (mean±SE, n=8) indicated that iv, but not icv, PRO abolished the effect of Dp (PRO vs V=29.1±1.7 vs 46.9±2.7%) and At (30.5±1.7 vs 49±3.2%) and significantly reduced the effect of AA (48.4±2.6 vs 59.5±3.1%). These data suggest activation of peripheral β-adrenoceptors in the delayed GE induced by phenylpyrazolone derivatives.


Assuntos
Animais , Masculino , Antagonistas Adrenérgicos/administração & dosagem , Ampirona/administração & dosagem , Anti-Inflamatórios não Esteroides/administração & dosagem , Antipirina/administração & dosagem , Dipirona/administração & dosagem , Esvaziamento Gástrico/efeitos dos fármacos , Receptores Adrenérgicos beta/metabolismo , Infusões Intraventriculares , Fenolsulfonaftaleína , Prazosina/administração & dosagem , Propranolol/administração & dosagem , Ratos Wistar , Ioimbina/administração & dosagem
5.
Braz. j. med. biol. res ; 42(11): 1086-1089, Nov. 2009. ilus
Artigo em Inglês | LILACS | ID: lil-529097

RESUMO

Dipyrone (Dp), 4-aminoantipyrine (AA) and antipyrine (At) administered iv and Dp administered icv delay gastric emptying (GE) in rats. The participation of capsaicin (Cps)-sensitive afferent fibers in this phenomenon was evaluated. Male Wistar rats were pretreated sc with Cps (50 mg/kg) or vehicle between the first and second day of life and both groups were submitted to the eye-wiping test. GE was determined in these animals at the age of 8/9 weeks (weight: 200-300 g). Ten minutes before the study, the animals of both groups were treated iv with Dp, AA or At (240 μmol/kg), or saline; or treated icv with Dp (4 μmol/animal) or saline. GE was determined 10 min after treatment by measuring percent gastric retention (GR) of saline labeled with phenol red 10 min after orogastric administration. Percent GR (mean ± SEM, N = 8) in animals pretreated with Cps and treated with Dp, AA or At (35.8 ± 3.2, 35.4 ± 2.2, and 35.6 ± 2 percent, respectively) did not differ from the GR of saline-treated animals pretreated with vehicle (36.8 ± 2.8 percent) and was significantly lower than in animals pretreated with vehicle and treated with the drugs (52.1 ± 2.8, 66.2 ± 4, and 55.8 ± 3 percent, respectively). The effect of icv administration of Dp (N = 6) was not modified by pretreatment with Cps (63.3 ± 5.7 percent) compared to Dp-treated animals pretreated with vehicle (62.3 ± 2.4 percent). The results suggest the participation of capsaicin-sensitive afferent fibers in the delayed GE induced by iv administration of Dp, AA and At, but not of icv Dp.


Assuntos
Animais , Masculino , Ratos , Vias Aferentes/efeitos dos fármacos , Ampirona/farmacologia , Anti-Inflamatórios não Esteroides/farmacologia , Antipirina/farmacologia , Dipirona/farmacologia , Ampirona/administração & dosagem , Animais Recém-Nascidos , Anti-Inflamatórios não Esteroides/administração & dosagem , Antipirina/administração & dosagem , Capsaicina , Dipirona/administração & dosagem , Relação Dose-Resposta a Droga , Esvaziamento Gástrico/efeitos dos fármacos , Ratos Wistar
6.
Braz. j. med. biol. res ; 39(11): 1507-1512, Nov. 2006. ilus
Artigo em Inglês | LILACS | ID: lil-437825

RESUMO

Antipyrine (At) and dipyrone (Dp) delay gastric emptying (GE) in rats. The objective of the present study was to assess the effects of intravenous (iv) and intracerebroventricular (icv) administration of At and Dp on the GE of liquid by rats. GE was assessed in male Wistar rats (5-10 in each group) 10 min after the icv or iv drug injection by measuring percent gastric retention ( percentGR) of a saline test meal labeled with phenol red 10 min after administration by gavage. The At iv group was significantly higher (64.4 ± 2.6 percent) compared to control (33.4 ± 1.5 percent) but did not differ from the Dp group (54.3 ± 3.8 percent). After icv administration of At, percentGR (34.2 ± 2 percent) did not differ from control (32.6 ± 1.9 percent), but was significantly higher after Dp (54.5 ± 2.3 percent). Subdiaphragmatic vagotomy significantly reduced percentGR in the At group (30.2 ± 0.7 percent) compared to the sham group, but was significantly higher than in the controls (23.0 ± 0.5 percent). In the animals treated with At iv, baclofen significantly reduced percentGR (28.3 ± 2.4 percent) compared to vehicle-treated animals (55.2 ± 3.2 percent). The same occurred in the animals treated iv with vehicle and icv with baclofen. Although vagotomy and baclofen reduced percentGR per se, the reduction was twice more marked in the animals treated with At. The results suggest that At administered iv, but not icv, delays GE of liquid in rats with the participation, at least in part, of the vagus nerve and that this phenomenon is blocked by the activation of GABA B receptors in the central nervous system.


Assuntos
Animais , Masculino , Ratos , Anti-Inflamatórios não Esteroides/farmacologia , Antipirina/farmacologia , Dipirona/farmacologia , Esvaziamento Gástrico/efeitos dos fármacos , Baclofeno/farmacologia , Relação Dose-Resposta a Droga , Agonistas GABAérgicos/farmacologia , Injeções Intraventriculares , Ratos Wistar , Fatores de Tempo , Nervo Vago/efeitos dos fármacos
7.
Braz. j. med. biol. res ; 35(2): 261-269, Feb. 2002. ilus, tab, graf
Artigo em Inglês | LILACS | ID: lil-303551

RESUMO

The present study investigates the isoform(s) of cytochrome P450 (CYP) involved in the metabolism of albendazole sulfoxide (ASOX) to albendazole sulfone (ASON) in patients with neurocysticercosis using antipyrine as a multifunctional marker drug. The study was conducted on 11 patients with neurocysticercosis treated with a multiple dose regimen of albendazole for 8 days (5 mg/kg every 8 h). On the 5th day of albendazole treatment, 500 mg antipyrine was administered po. Blood and urine samples were collected up to 72 h after antipyrine administration. Plasma concentrations of (+)-ASOX, (-)-ASOX and ASON were determined by HPLC using a chiral phase column and detection by fluorescence. The apparent clearance (CL/f) of ASON and of the (+) and (-)-ASOX enantiomers were calculated and compared to total antipyrine clearance (CL T) and the clearance for the production of the three major antipyrine metabolites (CLm). A correlation (P<=0.05) was obtained only between the CL T of antipyrine and the CL/f of ASON (r = 0.67). The existence of a correlation suggests the involvement of CYP isoforms common to the metabolism of antipyrine and of ASOX to ASON. Since the CL T of antipyrine is a general measure of CYP enzymes but with a slight to moderate weight toward CYP1A2, we suggest the involvement of this enzyme in ASOX to ASON metabolism in man. The study supports the establishment of a specific marker drug of CYP1A2 in the study of the in vivo metabolism of ASOX to ASON


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Albendazol , Anti-Helmínticos , Anti-Inflamatórios não Esteroides , Antipirina , Sistema Enzimático do Citocromo P-450 , Neurocisticercose , Albendazol , Anti-Helmínticos , Anti-Inflamatórios não Esteroides , Antipirina , Biomarcadores , Sistema Enzimático do Citocromo P-450 , Interações Medicamentosas , Isoenzimas , Neurocisticercose
8.
Rev. farm. bioquim. Univ. Säo Paulo ; 32(2): 71-6, jul.-dez. 1996. ilus, graf
Artigo em Inglês | LILACS | ID: lil-187720

RESUMO

A method which permits the simultaneous HPLC analysis of antipyrine (A), 3-hydroxymethylantipyrine (HMA), 4-hydroxyantipyrine (HOA) and norantiopyrine (NORA) using a single extraction step in a five minute chromatographic run is described. Only 500 micraLitro of urine were necessary for the quantitation of all compounds investigated. An analog derivative, 4-aminoantipyrine, was used as internal standard (IS). Urine samples were hydrolyzed with Limpet acetone powder, 37 graus centigrados, pH 5.0 for 2 h. Sodium chloride was added and urine samples were extracted with diclhormethane-isopropyl alcohol (90:10, v/v) in acidic medium. The residue was dissolved with mobile phase, washed with n-hexane and 20 micralitro of the lower phase were injected into a 4-micron Nova-Pak (R) 'C IND. 18' column. Peaks monitored at 254 nm were eluted with 0.75 M sodium acetate buffer, pH 5.0: methanol, (70:30, v/v) as mobile phase. The method, validated on the basis of the confidence limits for antipyrine and its metabolites, presented good stability, sensitivity, linearity, and intra or interassay precisions lower than 5 percente for all commpounds were investigated. This assay was applied for drug metabolism study carried out in ten healthy volunteers: 23 about 5 yr and 63 about 10 kg(mean about SD) after p.o. single dose of antipyrine, 500 mg/capsule. Diuresis of 24 h up to 72 h of drug administration was preserved with sodium metabisulfite, 4 mg/mL. Biological fluids were stored at -20 centigrade degree until assay. The main hydroxy-metabolites (HMA + HOA) and NORA, minor N-demethylated metabolite of antipyrine, were excreted: 60 percent and 20 percente as percentage of the given dose, respectively. Clearances for production of metabolites expressed as mL/min, were: 8.61 about 4.28 (7.24) for HMA, 13.91 about 6.20(12.67) for HOA, and 8.08 about 4.01(5.93) for NORA, mean about SD (median).


Assuntos
Humanos , Pré-Escolar , Criança , Adolescente , Adulto , Antipirina/análise , Antipirina/metabolismo , Cromatografia , Farmacologia
9.
Braz. j. med. biol. res ; 26(9): 989-98, Sept. 1993. tab
Artigo em Inglês | LILACS | ID: lil-148773

RESUMO

1. The objective of the present investigation was to study some of the possible mechanisms involved in the protective effect of sucrose ingestion against liver necrosis induced by acetaminophen. Three groups of male Wistar rats (220-260 g) were submitted to the following experimental conditions for a period of 42 h: free access to a balanced commercial diet (Group I), an exclusive sucrose diet (Group II) and fasting (Group III). At the end of the experiment, hepatic cytochrome P450 levels were measured in 11 rats from each group, plasma antipyrine half-life (t1/2) was determined in 40 rats from each group, and hepatic glutathione (GSH) concentration in 10 rats from each group. GSH consumption elicited by a high dose of acetaminophen (ACP, 1.0 g/kg, by gavage) was also determined in 30 rats each from Groups II and III. 2. The liver of Group II rats presented a significant reduction of cytochrome P450 levels in the microsome fraction (range 0.31-0.46, median, 0.37 nmol/mg vs range 0.60-0.93, median 0.74 for group I, and range 0.63-1.22, median 0.91 for group III, reported as nmol/mg microsome protein; range 23.8-48.4, median 40.4 vs 66.6-130, median 81.8 for group I and range 59.0-117.1, median 77.1 for group III, reported as nmol/100 g body weight), and a prolongation of antipyrine half-life (146.4 vs 83.4 min for group I and 93.6 for group III) when compared with the rats of the two other groups. 3. Since the toxicity of acetaminophen depends on the production of a reactive metabolite by the cytochrome P450 system in the liver, we conclude that changes in this system brought about by exclusive sucrose ingestion for 42 h may explain the liver protection against the toxicity of a high dose of the drug even in the presence of a significant concomitant reduction in liver GSH levels


Assuntos
Animais , Masculino , Ratos , Acetaminofen/toxicidade , Enzima de Clivagem da Cadeia Lateral do Colesterol/metabolismo , Fígado , Glutationa/metabolismo , Sacarose/administração & dosagem , Antipirina/sangue , Peso Corporal , Jejum , Fígado/metabolismo , Fígado/patologia , Microssomos Hepáticos , Microssomos Hepáticos/metabolismo , Necrose , Ratos Wistar , Fatores de Tempo
10.
Sao Paulo; s.n; 1993. 190 p. ilus, tab.
Tese em Português | LILACS | ID: lil-135301

RESUMO

A atividade de formas especificas do citocromo P450 foi caracterizada "in vivo", em pacientes portadores de insuficiencia renal cronica moderada, atraves da administracao dos farmacos marcadores antipirina e nifedipina na forma de "coquetel". Foram investigados nove pacientes portadores de hipertensao arterial e insuficiencia renal cronica moderada e dez pacientes portadores de hipertensao arterial com funcao renal normal. Atraves do "clearance" total da nifedipina e do "clearance" de formacao de cada produto de biotransformacao da antipirina, 3-hidroximetilantipirina (HMA), norantipirina (NORA) e 4-hidroxiantipirina (OHA) foram caracterizadas quatro formas distintas do citocromo P450. Mostraram-se induzidas nos pacientes portadores de insuficiencia renal cronica moderada as formas de citocromo P450 associadas com a formacao da NORA e da desidronifedipina (citocromo P450 III A4). O estudo evidencia seletividade nas formas induzidas justificando o aumento da velocidade de biotransformacao oxidativa de alguns medicamentos na insuficiencia renal cronica


Assuntos
Humanos , Masculino , Feminino , Adulto , Antipirina/farmacocinética , Antipirina/uso terapêutico , Sistema Enzimático do Citocromo P-450/metabolismo , Hipertensão/tratamento farmacológico , Insuficiência Renal Crônica/tratamento farmacológico , Nifedipino/farmacocinética , Nifedipino/uso terapêutico , Administração Oral , Biotransformação
11.
Sao Paulo; s.n; 1992. 146 p. ilus, tab.
Tese em Português | LILACS | ID: lil-128255

RESUMO

Avaliaram-se as alteracoes na eliminacao da antipirina e de seus principais produtos de biotransformacao , 3-hidroximetilantipirina (3HMA), 4-hidroxiantipirina (4HOA) e norantipirina (NORA) em pacientes portadores de doencas hepaticas. Investigaram-se onze pacientes com cirrose hepatica confirmada por biopsia, nove pacientes com esquistossomose hepatesplenica e vinte e cinco voluntarios sadios. Os "clearances" total e hepatico da antipirina foram reduziods com prolongamento de sua meia-vida de eliminacao nos pacientes cirroticos. Os "clearances" de formacao da 3HMA, 4HOA e NORA tambem foram reduzidos como consequencia de seu comprometimento hepatico. Os pacientes com esquistossomose hepatesplenica mostraram alteracoes no metabolismo da antipirina, afetando os "clearances" de formacao da 3HMA e da 4HOA, enquanto que para a NORA este parametro manteve-se inalterado. Deste modo, a determinacao do "clearance" total da antipirina e da excrecao urinaria da antipirina e seus principais produtos de biotransformacao mostrou ser teste util para avaliar o metabolismo oxidativo nas doencas hepaticas


Assuntos
Humanos , Antipirina/farmacocinética , Biotransformação , Hepatopatias/metabolismo , Antipirina/sangue , Antipirina/uso terapêutico , Antipirina/urina , Cirrose Hepática/tratamento farmacológico , Hepatopatias/tratamento farmacológico , Esquistossomose/tratamento farmacológico
13.
Rev. ciênc. farm ; 10: 31-9, 1988. tab
Artigo em Português | LILACS | ID: lil-167834

RESUMO

O conteúdo histamínico pulmonar de ratos submetidos ao edema pulmonar agudo adrenalínico näo foi afetado pelos antiinflamatórios tremaril e ácido acetilsalicílico. Porém, os animais previamente tratados com indometacina, na dose única de 50 mg/kg, assim como nas três doses de 25 mg/kg, apresentaram uma variaçäo estatisticamente significativa do conteúdo histamínico pulmonar. O mesmo fato foi observado com os animais pré-tratados com fenazona (10, 40 e 80 mg/kg). Os animais pré-tratados com fenilbutazona, nas doses de 10 e 80 mg/kg e aqueles com oxifenilbutazona (20 mg/kg) apresentaram uma variaçäo estatisticamente significativa do conteúdo histamínico pulmonar


Assuntos
Animais , Masculino , Ratos , Antipirina/farmacologia , Aspirina/farmacologia , Histamina/análise , Indometacina/farmacologia , Oxifenilbutazona/farmacologia , Fenilbutazona/farmacologia , Edema Pulmonar/induzido quimicamente , Anti-Inflamatórios/farmacologia , Epinefrina
14.
Arq. bras. med ; 61(6): 437-40, nov.-dez. 1987. tab
Artigo em Português | LILACS | ID: lil-47655

RESUMO

Os autores realizaram estudo duplo-cego, comparativo, avaliando as eficácia analgésica entre propifenazona (220mg), placebo e a associaçäo ácido acetilsalicílico (200mg)/paracetamol (150mg/cafeína (50mg) no pós-operatório de cirurgias odontológicas. A dor avaliada através de escala analógica visual. Os tratamentos ativos foram significativamente superiores ao placebo, näo havendo diferenças estatisticamente significativas entre propifenazona 220mg e a associaçäo empregada. Näo foram relatados efeitos colaterais no grupo propifenazona


Assuntos
Adolescente , Adulto , Pessoa de Meia-Idade , Humanos , Masculino , Feminino , Acetaminofen/administração & dosagem , Antipirina/administração & dosagem , Aspirina/administração & dosagem , Cafeína/administração & dosagem , Dor Pós-Operatória/tratamento farmacológico , Método Duplo-Cego , Quimioterapia Combinada , Placebos/uso terapêutico
15.
Invest. med. int ; 12(4): 321-5, feb 1986. tab, ilus
Artigo em Espanhol | LILACS | ID: lil-45898

RESUMO

Se estudiaron 20 pacientes de ambos sexos con cefalea de origen diverso a quienes se administró la combinación analgésica dihidroergotamina, propifenazona y cafeína en una solo gragea, en dosis de dos grageas iniciales y cada seis horas hasta alcanzar el efecto terapéutico o la dosis máxima de seis grageas. La edad promedio de los pacientes fue de 31.7 ñ 11.6 años. Se observaron efectos indeseables graves en dos casos; sin embargo no fue necesario suspender el tratamiento en ninguno. Finalmente la combinación analgésica estudiada demostró ser eficaz en el tratamiento de cefalea de origen diverso y fue bien tolerada en dosis terapéuticas


Assuntos
Adolescente , Adulto , Pessoa de Meia-Idade , Humanos , Masculino , Feminino , Antipirina/análogos & derivados , Antipirina/uso terapêutico , Cafeína/uso terapêutico , Di-Hidroergotamina/uso terapêutico , Cefaleia/tratamento farmacológico , Quimioterapia Combinada
16.
Invest. med. int ; 12(4): 254-9, feb 1986. tab, ilus
Artigo em Espanhol | LILACS | ID: lil-46865

RESUMO

En un estudio doble ciego comparativo contra placebo, se incluyó a 37 pacientes con cefalea de origen diverso; 17 de ellos recibieron una combinación analgésica de mesilato de dehidroergotamina (0.5 mg), butalbital (45 mg), propifenazona (125 mg) y cafeína (40 mg) en dosis de dos grageas cada seis horas, hasta un máximo de seus grageas por día, quedando 20 pacientes que recibieron placebo, en presentación idéntica al medicamento estudiado. El origen de la cefalea fue diverso tanto en el grupo que recibió el principio activo como en el grupo placebo; la localización y evolución de las cefaleas fueron similares en ambos grupos. Mediante el tratamiento, que tuvo una duración de cinco días, la intensidad del dolor de acuerdo a una escala de valoración previamente establecida, descendió de 3.23 ñ 0.90 a 0.82 ñ 1.28 en el grupo tratado, mientras que en el grupo placebo el descenso no fue estadísticamente significativo. Se analizó también el número de grageas requeridas, tiempo de instalación del efecto terapéutico y su duración, así como los efectos indeseables que se presentaron en cada grupo. Se concluye que la combinación analgésica demostró ser útil en el tratamiento de la cefalea de diverso origen


Assuntos
Adolescente , Adulto , Pessoa de Meia-Idade , Masculino , Feminino , Antipirina/análogos & derivados , Barbitúricos/uso terapêutico , Cafeína/uso terapêutico , Di-Hidroergotamina/uso terapêutico , Cefaleia/tratamento farmacológico , Ensaios Clínicos como Assunto , Método Duplo-Cego , Quimioterapia Combinada
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