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1.
Acta cir. bras ; 36(2): e360205, 2021. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1152697

RESUMO

ABSTRACT Purpose To evaluate the influence of autonomic vagal and splenic activities on renal histomorphometric aspects in obese rats. Methods Thirty male Wistar rats were used, of which, 24 received subcutaneous injections of monosodium glutamate (MSG) during the first 5 days of life (4 g/kg body weight) and six control animals received injections of saline solution (CON). Five experimental groups were organized (n = 6/group): falsely-operated control (CON-FO); falsely-operated obese (MSG-FO); vagotomized obese (MSG-VAG); splenectomized obese (MSG-SPL); vagotomized and splenectomized obese (MSG-VAG-SPL). Results The MSG-FO group animals showed a significant reduction in body weight and nasal-anal length when compared to CON-FO group animals (p < 0.05). The MSG-VAG-SPL group showed significant reduced in most biometric parameters associated with obesity. Falsely-operated obese animals showed a significant reduction in renal weight, glomerular diameters, glomerular tuff and capsule areas and Bowman's space compared to CON-FO group animals (p < 0.05). There was a significant reduction in diameter, glomerular tuft and capsule areas, and Bowman's space in MSG-VAG, MSG-SPL, MSG-VAG-SPL groups when compared to the MSG-FO group. Conclusions Vagotomy associated with splenectomy induces a reduction in the adiposity and causes histological changes in the kidney of obese rats.


Assuntos
Animais , Masculino , Ratos , Esplenectomia , Vagotomia , Ratos Wistar , Rim , Lipídeos , Obesidade
2.
ABCD (São Paulo, Impr.) ; 33(3): e1548, 2020. graf
Artigo em Inglês | LILACS | ID: biblio-1152623

RESUMO

ABSTRACT Background: Gastrointestinal disorders are frequently reported in patients with Parkinson's disease whose disorders reduce the absorption of nutrients and drugs, worsening the clinical condition of patients. However, the mechanisms involved in modifying gastrointestinal pathophysiology have not yet been fully explained. Aim: To evaluate its effects on gastrointestinal motility and the involvement of the vagal and splanchnic pathways. Methods: Male Wistar rats (250-300 g, n = 84) were used and divided into two groups. Group I (6-OHDA) received an intrastriatal injection of 6-hydroxydopamine (21 µg/animal). Group II (control) received a saline solution (NaCl, 0.9%) under the same conditions. The study of gastric emptying, intestinal transit, gastric compliance and operations (vagotomy and splanchnotomy) were performed 14 days after inducing neurodegeneration. Test meal (phenol red 5% glucose) was used to assess the rate of gastric emptying and intestinal transit. Results: Parkinson's disease delayed gastric emptying and intestinal transit at all time periods studied; however, changes in gastric compliance were not observed. The delay in gastric emptying was reversed by pretreatment with vagotomy and splanchnotomy+celiac gangliectomy, thus suggesting the involvement of such pathways in the observed motor disorders. Conclusion: Parkinson's disease compromises gastric emptying, as well as intestinal transit, but does not alter gastric compliance. The delay in gastric emptying was reversed by truncal vagotomy, splanchnotomy and celiac ganglionectomy, suggesting the involvement of such pathways in delaying gastric emptying.


RESUMO Racional: Distúrbios gastrintestinais são frequentemente relatados em pacientes com doença de Parkinson cujos distúrbios reduzem a absorção de nutrientes e fármacos, agravando o quadro clínico dos pacientes. No entanto, os mecanismos envolvidos na alteração da fisiopatologia gastrintestinal ainda não foram totalmente elucidados. Objetivo: Avaliar os seus efeitos sobre a motilidade gastrintestinal e o envolvimento das vias vagal e esplâncnica. Métodos: Ratos Wistar machos (250-300 g, n=84) foram utilizados e divididos em dois grupos. O grupo I (6-OHDA) recebeu injeção intraestriatal de 6-hidroxidopamina (21 µg/animal). O grupo II (controle) recebeu solução salina (NaCl, 0,9%) nas mesmas condições. O estudo do esvaziamento gástrico, trânsito intestinal, complacência gástrica e operações (vagotomia e esplancnotomia) foram realizadas 14 dias após a indução da neurodegeneração. Refeição teste (vermelho de fenol+glicose 5%) foi utilizada para avaliar a taxa de esvaziamento gástrico e o trânsito intestinal. Resultados: A doença de Parkinson retardou o esvaziamento gástrico e o trânsito intestinal em todos os tempos estudados; porém, alterações da complacência gástrica não foram observadas. O retardo do esvaziamento gástrico foi revertido por pré-tratamento com vagotomia e esplancnotomia+gangliectomia celíaca, sugerindo assim, o envolvimento de tais vias nos distúrbios motores observados. Conclusão: A doença de Parkinson compromete o esvaziamento gástrico, bem como o trânsito intestinal, mas não altera a complacência gástrica. O retardo do esvaziamento gástrico foi revertido pela vagotomia troncular, esplancnotomia e gangliectomia celíaca, sugerindo o envolvimento de tais vias no retardo do esvaziamento gástrico.


Assuntos
Humanos , Animais , Masculino , Ratos , Doença de Parkinson , Vagotomia/efeitos adversos , Esvaziamento Gástrico/fisiologia , Motilidade Gastrointestinal/fisiologia , Trânsito Gastrointestinal/fisiologia , Ratos Wistar
3.
Acta cir. bras ; 34(9): e201900902, 2019. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1054698

RESUMO

Abstract Purpose: To investigate the role of vagus nerve activation in the protective effects of hypercapnia in ventilator-induced lung injury (VILI) rats. Methods: Male Sprague-Dawley rats were randomized to either high-tidal volume or low-tidal volume ventilation (control) and monitored for 4h. The high-tidal volume group was further divided into either a vagotomy or sham-operated group and each surgery group was further divided into two subgroups: normocapnia and hypercapnia. Injuries were assessed hourly through hemodynamics, respiratory mechanics and gas exchange. Protein concentration, cell count and cytokines (TNF-α and IL-8) in bronchoalveolar lavage fluid (BALF), lung wet-to-dry weight and pathological changes were examined. Vagus nerve activity was recorded for 1h. Results: Compared to the control group, injurious ventilation resulted in a decrease in PaO2/FiO2 and greater lung static compliance, MPO activity, enhanced BALF cytokines, protein concentration, cell count, and histology injury score. Conversely, hypercapnia significantly improved VILI by decreasing the above injury parameters. However, vagotomy abolished the protective effect of hypercapnia on VILI. In addition, hypercapnia enhanced efferent vagus nerve activity compared to normocapnia. Conclusion: These results indicate that the vagus nerve plays an important role in mediating the anti-inflammatory effect of hypercapnia on VILI.


Assuntos
Animais , Masculino , Ratos , Nervo Vago/cirurgia , Líquido da Lavagem Broncoalveolar/química , Lesão Pulmonar Induzida por Ventilação Mecânica/prevenção & controle , Hipercapnia , Vagotomia , Distribuição Aleatória , Citocinas/análise , Interleucina-8/análise , Fator de Necrose Tumoral alfa/análise , Ratos Sprague-Dawley , Modelos Animais de Doenças
4.
Biol. Res ; 51: 57, 2018. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1011401

RESUMO

BACKGROUND: chronic hypoxia increases basal ventilation and pulmonary vascular resistance, with variable changes in arterial blood pressure and heart rate, but it's impact on heart rate variability and autonomic regulation have been less well examined. We studied changes in arterial blood pressure, heart rate and heart rate variability (HRV) in rabbits subjected to chronic normobaric hypoxia (CNH; PB ~ 719 mmHg; FIO2 ~ 9.2%) for 14 days and assess the effect of autonomic control by acute bilateral vagal denervation. RESULTS: exposure to CNH stalled animal weight gain and increased the hematocrit, without affecting heart rate or arterial blood pressure. Nevertheless, Poincaré plots of the electrocardiographic R-R intervals showed a reduced distribution parallel to the line of identity, which interpreted as reduced long-term HRV. In the frequency domain, CNH reduced the very-low- (< 0.2 Hz) and high-frequency components (> 0.8 Hz) of the R-R spectrograms and produced a prominent component in the low-frequency component (0.2-0.5 Hz) of the power spectrum. In control and CNH exposed rabbits, bilateral vagotomy had no apparent effect on the short- and long-term HRV in the Poincaré plots. However, bilateral vagotomy differentially affected higher-frequency components (> 0.8 Hz); reducing it in control animals without modifying it in CNH-exposed rabbits. CONCLUSIONS: These results suggest that CNH exposure shifts the autonomic balance of heart rate towards a sympathetic predominance without modifying resting heart rate or arterial blood pressure.


Assuntos
Animais , Masculino , Coelhos , Vagotomia , Pressão Sanguínea/fisiologia , Frequência Cardíaca/fisiologia , Hipóxia/fisiopatologia , Glicemia/fisiologia , Peso Corporal/fisiologia , Doença Crônica , Modelos Animais de Doenças , Hematócrito
5.
Rev. cuba. ortop. traumatol ; 31(2): 1-13, jul.-dic. 2017. ilus, tab
Artigo em Espanhol | LILACS, CUMED | ID: biblio-960645

RESUMO

Introducción: La tendovaginitis estenosante de los dedos de la mano o dedo en resorte es una patología relativamente frecuente que puede afectar a personas durante su vida laboral. Existen diversos métodos para solucionar esta afección. Objetivo: Evaluar el empleo durante ocho años de la vaginotomía percutánea en la tendovaginitis estenosante de los dedos largos de las manos. Métodos: Se realizó un estudio de intervención longitudinal prospectivo con adultos mayores de 65 años de edad. La muestra estuvo constituida por 468 pacientes diagnosticados con tendovaginitis estenosante (dedo en resorte). Fueron intervenidos quirúrgicamente 532 dedos con la vagotomía percutánea entre el 1 de enero de 2008 y el 31 de octubre de 2015, en el Centro de Investigaciones en Longevidad, Envejecimiento y Salud. Se evaluaron los pacientes seis meses después del tratamiento. Las variables empleadas fueron: edad, sexo, tiempo de padecimiento, dedo afectado, tiempo quirúrgico, complicaciones perioperatorias, duración del dolor. Se utilizó la clasificación de Newport según el cuadro clínico y el método de Strickland para evaluar los resultados. Resultado: Hubo un predomino del sexo femenino en la sexta década de vida. Las mayores incidencias estuvieron en la mano dominante. Se obtuvo un 98,3 por ciento de resultados satisfactorios. Los tiempos promedios de las variables descritas fueron significativamente cortos. No se mostraron complicaciones serias. Los dedos más afectados fueron el cuarto y el tercero. Hubo predominio de los estadios II y III. Conclusión: La vaginotomía percutánea solucionó satisfactoriamente la morbilidad que produce el dedo en resorte(AU)


Introduction: Stenosing tendovaginitis of hand fingers or spring finger is a relatively frequent pathology that can affect people during their working life. There are several methods to solve this condition. Objective: To evaluate the used of percutaneous vaginotomy in stenosing tendovaginitis of the long fingers for eight years. Methods: A prospective longitudinal intervention was conducted with adults over 65 years of age. 468 patients formed the sample. They were diagnosed with stenosing tendovaginitis (spring finger). Surgery was performed on 532 fingers with percutaneous vagotomy from January 1, 2008 to October 31, 2015, at the Research Center on Longevity, Aging and Health. Patients were assessed six months after treatment. The variables used were age, sex, time of suffering, affected finger, surgical time, perioperative complications, and duration of pain. Newport classification was used according to the symptoms and Strickland method to assess the results. Result: There was predominance of the female sex in their sixth decade of life. The highest incidences were in the dominant hand. Satisfactory results were 98.3 percent. The average times of the variables described were significantly short. No serious complications were shown. The most affected fingers were the fourth and the third. There was predominance of stages II and III. Conclusion: Percutaneous vaginotomy satisfactorily resolved the morbidity produced by the spring finger(AU)


Introduction: La ténosynovite sténosante des doigts de la main, ou doigt à ressort, est une pathologie assez fréquente pouvant affecter les personnes tout au long de leur vie. Il y a plusieurs méthodes pour corriger cette affection. Objectif: Évaluer l'utilisation pendant huit ans de la ténotomie percutanée pour corriger la ténosynovite sténosante des doigts longs de la main. Méthodes: Une étude interventionnelle, longitudinale et prospective des personnes âgées de plus de 65 ans a été effectuée. L'échantillon a été composée de 468 patients diagnostiqués de ténosynovite sténosante (doigt à ressort). Un nombre significatif d'interventions chirurgicales (532 doigts) ont été effectuées entre le 1 janvier 2008 et le 31 octobre 2015 au Centre de recherches sur la longévité, le vieillissement et la santé. Les patients ont été évalués six mois après le traitement. On a utilisé des variables telles que l'âge, le sexe, la durée de l'affection, le doigt affecté, le temps chirurgical, les complications péri-opératoires, et la durée de la douleur. Afin d'évaluer les résultats, on a appliqué la classification de Newport, selon le tableau clinique et la méthode de Strickland. Résultats: On a trouvé que les femmes dans les soixante ans étaient les plus souvent touchées par cette affection, étant la main dominante la plus affectée. Il y a eu de très bons résultats (98.3 pourcent). Les temps moyens des variables décrites ont été notamment courts. Il n'y a pas eu de complications graves. Le troisième et le quatrième doigt ont été les plus fréquemment touchés. Dans la classification, le stade II et III ont été en prédominance. Conclusions: La ténotomie percutanée a réussi à corriger de manière satisfaisante la morbidité provoquée par le doigt à ressort(AU)


Assuntos
Humanos , Masculino , Feminino , Idoso , Vagotomia/métodos , Falanges dos Dedos da Mão/cirurgia , Encarceramento do Tendão/cirurgia , Estudos Longitudinais
6.
Arq. bras. cardiol ; 104(2): 144-151, 02/2015. graf
Artigo em Inglês | LILACS | ID: lil-741140

RESUMO

Background: In pathological situations, such as acute myocardial infarction, disorders of motility of the proximal gut can trigger symptoms like nausea and vomiting. Acute myocardial infarction delays gastric emptying (GE) of liquid in rats. Objective: Investigate the involvement of the vagus nerve, α 1-adrenoceptors, central nervous system GABAB receptors and also participation of paraventricular nucleus (PVN) of the hypothalamus in GE and gastric compliance (GC) in infarcted rats. Methods: Wistar rats, N = 8-15 in each group, were divided as INF group and sham (SH) group and subdivided. The infarction was performed through ligation of the left anterior descending coronary artery. GC was estimated with pressure-volume curves. Vagotomy was performed by sectioning the dorsal and ventral branches. To verify the action of GABAB receptors, baclofen was injected via icv (intracerebroventricular). Intravenous prazosin was used to produce chemical sympathectomy. The lesion in the PVN of the hypothalamus was performed using a 1mA/10s electrical current and GE was determined by measuring the percentage of gastric retention (% GR) of a saline meal. Results: No significant differences were observed regarding GC between groups; vagotomy significantly reduced % GR in INF group; icv treatment with baclofen significantly reduced %GR. GABAB receptors were not conclusively involved in delaying GE; intravenous treatment with prazosin significantly reduced GR% in INF group. PVN lesion abolished the effect of myocardial infarction on GE. Conclusion: Gastric emptying of liquids induced through acute myocardial infarction in rats showed the involvement of the vagus nerve, alpha1- adrenergic receptors and PVN. .


Fundamento: Distúrbios da motilidade do intestino proximal no infarto agudo do miocárdio podem desencadear sintomas digestivos como náuseas e vômitos. O infarto do miocárdio ocasiona retardo do esvaziamento gástrico (EG) de líquido em ratos. Objetivo: Investigar se existe a influência do nervo vago (VGX), adrenoreceptores α-1, receptores GABAB do sistema nervoso central e participação do núcleo paraventricular (NPV) do hipotálamo no esvaziamento gástrico (EG) e complacência gástrica (CG) em ratos infartados. Métodos: Ratos Wistar (n = 8-15) foram divididos em: grupo infarto (INF), sham (SH) e subdivididos. O infarto foi realizado por ligadura da artéria coronária descendente anterior. A complacência gástrica foi estimada com curvas pressão-volume. Realizada vagotomia por secção dos ramos dorsal e ventral. Para verificar a ação dos receptores GABAB foi injetado baclofeno por via intra ventrículo-cerebral. Simpatectomia química foi realizada com prazosina intravenosa (iv), e na lesão do núcleo paraventricular do hipotálamo foi utilizada corrente elétrica de 1mA/10s, com esvaziamento gástrico determinado por medição da retenção gástrica (% RG) de uma refeição salina. Resultados: Não houve diferença significativa na CG. A vagotomia (VGX) reduziu significativamente a %RG; no grupo INF, o tratamento intra ventrículo-cerebral (ivc) com baclofeno reduziu significativamente a % RG; não houve conclusivamente envolvimento dos receptores GABAB em retardar o EG; o tratamento intravenoso com prazosina reduziu significativamente a %RG no grupo INF. A lesão do NPV aboliu o efeito do infarto do miocárdio no EG. Conclusão: O nervo vago, receptores α-adrenérgicos e núcleo paraventricular estão envolvidos no retardo do esvaziamento gástrico no infarto agudo do miocárdio em ratos. .


Assuntos
Animais , Masculino , Esvaziamento Gástrico/fisiologia , Infarto do Miocárdio/fisiopatologia , Núcleo Hipotalâmico Paraventricular/fisiopatologia , Receptores Adrenérgicos alfa 1/fisiologia , Receptores de GABA-B/fisiologia , Nervo Vago/fisiopatologia , Antagonistas de Receptores Adrenérgicos alfa 1/farmacologia , Baclofeno/farmacologia , Agonistas dos Receptores de GABA-B/farmacologia , Gastroparesia/fisiopatologia , Infarto do Miocárdio/complicações , Prazosina/farmacologia , Ratos Wistar , Fatores de Tempo , Vagotomia
7.
Acta cir. bras ; 29(2): 99-103, 02/2014. graf
Artigo em Inglês | LILACS | ID: lil-702521

RESUMO

To evaluate morphological changes of the gastric stump and not resected stomach mucosa after the completion of truncal vagotomy. METHODS: Eighty male Wistar rats were divided into four groups: CT, TV, RY and RYTV. In CT group, abdominal viscera were manipulated and the abdominal cavity was closed, in TV vagal trunks were isolated and sectioned, in RY a partial Roux-en-Y gastrectomy was performed and in RYTV the vagal trunks were sectioned and a partial Roux-en-Y gastrectomy was performed. At the 54th week after surgery, the rats were euthanized. The findings were submitted to histological analyses. RESULTS: None macroscopic or histological alterations in groups TV and CT was observed. Specimens from RY and RYTV groups did not show alterations in the gastric stump mucosa. At the jejunal side of the gastroenterostomy we found shallow ulcerative lesions always single, well-defined and with variable diameter 3 to 6 mm, six times in the RY group and none in the RYTV group (RY>RYTV, p=0.008). Neoplastic or preneoplastic lesions were not diagnosed in all groups. CONCLUSION: Truncal vagotomy is a safe and non-carcinogenic method in not resected and partially resected stomach.


Assuntos
Animais , Ratos , Estômago/anatomia & histologia , Mucosa Gástrica/anatomia & histologia , Vagotomia , Ratos/classificação
8.
Rev. cuba. cir ; 50(2)abr.-jun. 2011.
Artigo em Espanhol | LILACS | ID: lil-616291

RESUMO

El divertículo epifrénico provocado por el aumento de la presión intraesofágica a causa de alteraciones motoras subyacentes es raro; representa cerca del 10 por ciento de todos los divertículos esofágicos. Se presenta el caso de una paciente de 65 años de edad, que ingresó en el Servicio de Cirugía General con ictericia obstructiva por pancreatitis crónica. Se le realizó una triple derivación de Catell y durante la evolución posoperatoria comenzó a presentar vómitos que contenían alimentos sin digerir, fétidos, ingeridos con horas o días de antelación. Se le realizó una radiografía baritada de esófago, estómago y duodeno, con buen pase de contraste al duodeno, y se observó la presencia de un divertículo epifrénico de gran tamaño, responsable de los síntomas. Fue intervenida quirúrgicamente utilizando como vía de acceso una incisión media previa y vía transhiatal. Se practicó una vagotomía, diverticulectomía, miotomía esofágica extendida, procedimiento antirreflujo y yeyunostomía temporal para la alimentación precoz. La evolución fue favorable y la paciente está hoy asintomática(AU)


The epinephrine diverticulum due to the increase of intraesophageal pressure by underlying motor alterations is a rare entity; it accounts for around the 10% of all esophageal diverticula. This is the case of a female patient aged 65 admitted in the General Surgery Service presenting with obstructive jaundice by chronic pancreatitis. A triple Catell's bypass was carried out and during the postoperative course had vomiting containing non-digested fetid foods, ingested many hours or days ago. Barium radiography of esophagus, stomach and duodenum was obtained with a good contrast passage, verifying the presence of a very large epinephrine diverticulum causing the symptoms. She was operated on using as approach route a previous middle incision and trans-hiatal route. A vagotomy, diverticulectomy, extended esophageal myotomy, anti-reflux procedure and temporary jejunostomy for the early feeding. Course was favorable and patient remains asymptomatic(AU)


Assuntos
Humanos , Feminino , Idoso , Vagotomia/métodos , Divertículo Esofágico/cirurgia , Divertículo Esofágico/patologia , Jejunostomia/efeitos adversos , Miotomia de Heller/métodos
9.
Sci. med ; 21(1)jan.-mar. 2011. tab, ilus
Artigo em Português | LILACS | ID: lil-593781

RESUMO

Objetivos: revisar os principais aspectos históricos da progressão do conhecimento sobre a etiologia da úlcera péptica e das terapêuticas clínicas e cirúrgicas empregadas no tratamento desta enfermidade.Fonte de dados: revisão bibliográfica através do PubMed. Foram analisados artigos selecionados sobre a história da úlcera péptica.Síntese dos dados: durante décadas, cirurgiões acreditaram que a doença da úlcera péptica era causada pelo excesso de ácido. O aforisma ?sem ácido, sem úlcera? foi enraizado em todos os residentes de cirurgia, e todos os esforços foram concentrados em eliminar o ácido através de uma operação. Com o advento da terapêutica farmacológica, houve melhora no sucesso do tratamento clínico e o número de casos cirúrgicos diminuiu. Com a descoberta do Helicobacter pylori, ainda mais pacientes foram tratados clinicamente e o número de casos cirúrgicos diminuiu novamente, persistindo apenas para casos refratários, hemorragia ou perfuração.Conclusões: úlcera péptica é uma doença reconhecida desde a antiguidade. A compreensão da evolução gradual das várias formas de seu tratamento serve de alerta e ensinamento de como evolui o conhecimento científico, onde as certezas efinitivas podem ser alteradas por inovações e resultados de pesquisas metodologicamente bem delineadas e realizadas, bem como elucidar a difícil trajetória que tem sido percorrida para poder solucionar o sofrimento dos pacientes que possuem essa enfermidade.


Aims: To review the main aspects of the historical progression of knowledge about the etiology of peptic ulcer and the clinical and surgical treatment used in the treatment of this disease.Source of data: A search was carried out at PubMed. Selected papers about the history of the peptic ulcer were reviewed.Summary of findings: For decades, surgeons were taught and believed that peptic ulcer disease was caused by acid.The dictum ?no acid, no ulcer? was engrained into every resident of surgery, and all efforts were focused on eliminating acid through operation. With the advent of pharmacological therapy, more ulcers were successfully treated medically and the number of surgical cases decreased. With the discovery of Helicobacter pylori, even more patients were successfully treated medically and the number of surgical cases decreased again, usually only to include refractory cases, hemorrhage or perforation.Conclusions: Peptic ulcer is a disease recognized since ancient times. The understanding of the gradual evolution of several forms of treatment serves as a warning and teaching of how scientific knowledge evolves, where the final certainties can be changed by innovations and research findings methodologically well designed and executed, and to clarify the difficult path that has been traversed in order to solve the suffering of patients who have this disease.


Assuntos
Helicobacter pylori , História da Medicina , Vagotomia , Úlcera Gástrica , Úlcera Péptica/cirurgia , Úlcera Péptica/história , Úlcera Péptica/terapia
10.
Clinics ; 66(6): 1061-1066, 2011. graf, tab
Artigo em Inglês | LILACS | ID: lil-594379

RESUMO

OBJECTIVE: The objective of this study was to evaluate the involvement of peripheral nitric oxide (NO) in vagotomy-induced pulmonary edema by verifying whether the nitric oxide synthases (NOS), constitutive (cNOS) and inducible (iNOS), participate in this mechanism. INTRODUCTION: It has been proposed that vagotomy induces neurogenic pulmonary edema or intensifies the edema of other etiologies. METHODS: Control and vagotomized rats were pretreated with 0.3 mg/kg, 3.0 mg/kg or 39.0 mg/kg of L-NAME, or with 5.0 mg/kg, 10.0 mg/kg or 20.0 mg/kg of aminoguanidine. All animals were observed for 120 minutes. After the animals' death, the trachea was catheterized in order to observe tracheal fluid and to classify the severity of pulmonary edema. The lungs were removed and weighed to evaluate pulmonary weight gain and edema index. RESULTS: Vagotomy promoted pulmonary edema as edema was significantly higher than in the control. This effect was modified by treatment with L-NAME. The highest dose, 39.0 mg/kg, reduced the edema and prolonged the survival of the animals, while at the lowest dose, 0.3 mg/kg, the edema and reduced survival rates were maintained. Aminoguanidine, regardless of the dose inhibited the development of the edema. Its effect was similar to that observed when the highest dose of L-NAME was administered. It may be that the non-selective blockade of cNOS by the highest dose of L-NAME also inhibited the iNOS pathway. CONCLUSION: Our data suggest that iNOS could be directly involved in pulmonary edema induced by vagotomy and cNOS appears to participate as a protector mechanism.


Assuntos
Animais , Masculino , Ratos , Óxido Nítrico Sintase Tipo II/metabolismo , Óxido Nítrico Sintase Tipo III/metabolismo , Óxido Nítrico/metabolismo , Edema Pulmonar/metabolismo , Vagotomia/efeitos adversos , Inibidores Enzimáticos/uso terapêutico , Guanidinas/uso terapêutico , NG-Nitroarginina Metil Éster/uso terapêutico , Óxido Nítrico Sintase Tipo II/antagonistas & inibidores , Óxido Nítrico Sintase Tipo III/antagonistas & inibidores , Edema Pulmonar/tratamento farmacológico , Edema Pulmonar/etiologia , Edema Pulmonar/prevenção & controle , Ratos Wistar , Índice de Gravidade de Doença , Fatores de Tempo
11.
ABCD (São Paulo, Impr.) ; 23(3): 159-162, jul.-set. 2010.
Artigo em Inglês | LILACS | ID: lil-562777

RESUMO

BACKGROUND: The gastrointestinal disorders have been associated with morphological alterations in the myenteric nervous plexus. AIM: To evaluate, through morphometric studies, the chronic effects of the subdiaphragmatic trunk vagotomy on the nervous plexus. METHODS: Fifteen male exemplars of Wistar Rattus novergicus weighing about 150g, distributed into three groups, have been used: control (n=5), Sham (n=5) and vagotomized (n=5). The animals were sacrificed after 30 and 90 days post surgery. Fragments of duodenum were fixed in Bouin solution, embedded into paraffin and stained with HE and PAS. Morphometric analysis was performed by a Carl Zeiss KM 450 image system. The following aspects were observed: the density of nervous cells per linear micrometer (µm) (ND); the area of perikarya (µm²) (NA); the number of satellite cells per µm (SCD); and the number of satellite cells per neuron (SC/N). The averages were compared with the help of "software" program Sigma Plus through two way - ANOVA and Tuckey post-test. RESULTS: Denervation increased SC/N (p<0,05) and NA (p<0,05), in a time-dependent denervation way (p<0,05). However ND and SCD, decreased, which significantly with the animal's age (p<0,001). CONCLUSION: Vagotomy altered the myenteric plexus morphology in a time-dependent way.


RACIONAL: As disfunções gastrintestinais têm sido associadas à alterações morfológicas no plexo nervoso mioentérico. OBJETIVO: Avaliar através do estudo morfométrico, os efeitos crônicos da vagotomia troncular subdiafragmática sobre esse plexo nervoso. MÉTODOS: Foram utilizados 15 exemplares machos de Rattus novergicus da variedade Wistar, com cerca de 150 g, distribuídos nos grupos controle (n=5), Sham (n=5) e vagotomizados (n=5). Os animais foram sacrificados depois de 30 e 90 dias após as operações. Em seguida, fragmentos do duodeno foram fixados em solução de Bouin, incluídos em parafina e corados por HE e PAS. A análise morfométrica foi realizada por meio do sistema de análise de imagem Carl Zeiss KM 450. Foram observados: a densidade de células nervosas por micrômetro linear (µm); a área dos pericários (µm²); o número de células satélites por µm; e o número de células satélites por neurônio. As médias foram comparadas com o auxílio do programa de "software" Sigma Plus através do Two way - ANOVA e do pós-teste de Tukey. RESULTADOS: A desnervação aumentou o número de células satélites por neurônios (p<0,05) e a área média dos pericários (p<0,05), de maneira dependente do tempo de desnervação (p<0,05), mas diminuiu significativamente a densidade de neurônios (p<0,05) e de células satélites (p<0,05) em função da idade (p<0,001). CONCLUSÃO: A vagotomia alterou a morfologia do plexo mioentérico de maneira dependente do tempo.


Assuntos
Animais , Masculino , Ratos , Duodeno/fisiopatologia , Plexo Mientérico/anatomia & histologia , Vagotomia/efeitos adversos , Denervação Autônoma , Plexo Mientérico/cirurgia , Ratos Wistar
12.
Rev. cuba. cir ; 49(1)ene.-mar. 2010. tab
Artigo em Espanhol | LILACS, CUMED | ID: lil-575487

RESUMO

INTRODUCCIÓN. El objetivo del presente estudio fue analizar los resultados del tratamiento quirúrgico en la enfermedad ulceropéptica crónica gástrica o duodenal complicada, durante un período de 15 años. MÉTODOS. Se realizó un estudio descriptivo y retrospectivo de los pacientes con enfermedad ulceropéptica complicada tratados mediante exéresis. Los pacientes (45 en total) fueron atendidos por alguno de los autores, en el Hospital Provincial Clinicoquirúrgico Amalia Simoni, en Camagüey, entre enero de l989 y diciembre del 2004. RESULTADOS. La enfermedad se presentó con mayor frecuencia en el sexo masculino (82,22 por ciento) y en las edades comprendidas entre 36 y 50 años (46,67 por ciento). El 95,56 por ciento de los pacientes tratados padecían úlcera duodenal, y la principal indicación para la cirugía fue la intratabilidad (62,22 por ciento). La endoscopia (84,44 por ciento) resultó ser muy útil para el diagnóstico de esta afección. A todos los operados se le realizó vagotomía con antrectomía; en el 68,89 por ciento la anastomosis fue de Billroth II, y en el resto de los pacientes (31,11 por ciento) fue del tipo Billroth I. Se observó igual cantidad de complicaciones precoces en las técnicas realizadas, y entre ellas prevalecieron el sangrado de la anastomosis y el retardo de la evacuación. Se detectaron más complicaciones tardías en la anastomosis de tipo Billroth II que en la de Billroth I. Los resultados quirúrgicos fueron excelentes y muy buenos en el 89 por ciento de los casos. La variante antecólica registró el mayor porcentaje de resultados no satisfactorios (9,09 por ciento). Solo en dos pacientes se obtuvieron resultados malos, aunque no hubo mortalidad operatoria. CONCLUSIONES. Este tipo de cirugía tiene indicación solo en casos de úlcera péptica complicada. No es el método de elección en pacientes ulcerosos, pero su uso requiere conocer las diferentes técnicas y saber utilizarlas. No es por tanto un procedimiento que deba olvidarse(AU)


INTRODUCTION: The aim of present study was to analyze the surgical treatment results in the complicated duodenal or gastric chronic peptic ulcer over 15 years. METHODS: A retrospective and descriptive study was conducted in patients presenting with complicated peptic ulcer by exeresis. Patients (n=45) were seen by some of us in the Amalia Simoni Clinical Surgical of Camaguey province from January, 1989 to December, 2004. RESULTS: Disease was more frequent in male sex (82,22 percent) and in ages from 36 to 50 years (46,67 percent). The 95,56 percent of patients treated suffered from duodenal ulcer and the main criterion for surgery was its unmanageable condition (62,22 percent). Endoscopy was very useful for diagnosis of this entity. All operated on underwent vagotomy with antrectomy; in the 68,89 percent we performed a Billroth's II anastomosis and in remainder (31,11 percent it was of Billroth I type. There was a similar figure of early complications related to techniques used and among them prevails the anastomosis bleeding and delay evacuation. There were more late complications in type Billroth II anastomosis than in the Billroth I. Surgical results were excellent and very good in the 89 percent of cases. The enterocolitis variant has the great percentage of non-satisfactory results (9,09 percent). Only two patients had poor results, although there wasn't operative mortality. CONCLUSIONS: This kind of surgery is indicated only in cases of complicated peptic ulcer. It is not the choice method in ulcer patients, but in its use it is necessary to know about different techniques and its use. Thus, we must to know a lot about this procedure(AU)


Assuntos
Humanos , Masculino , Adulto , Pessoa de Meia-Idade , Úlcera Péptica/cirurgia , Úlcera Péptica/complicações , Vagotomia/métodos , Anastomose Cirúrgica/métodos , Epidemiologia Descritiva , Estudos Retrospectivos
13.
Rev. habanera cienc. méd ; 8(5,supl.5)dic. 2009. ilus, tab, graf
Artigo em Espanhol | LILACS | ID: lil-575754

RESUMO

Aunque en la actualidad la cirugía electiva de la úlcera péptica duodenal se realiza con menos frecuencia, las indicaciones para el tratamiento quirúrgico continúan siendo las mismas y existe un pequeño número de pacientes que aún debe ser operado. Las modalidades de vagotomías laparoscópicas más aceptadas han sido las de Taylor (vagotomía troncular posterior y seromiotomía gástrica anterior) y de Hill-Barker (vagotomía troncular posterior y vagotomía altamente selectiva anterior), debido a su eficacia, seguridad y simplicidad. El objetivo de este estudio es evaluar los resultados a mediano y largo plazos de estas técnicas laparoscópicas. Entre 1994 y 2001, fueron realizadas en el Centro Nacional de Cirugía de Mínimo Acceso 183 vagotomías laparoscópicas (108 vagotomías de Hill-Barker y 75 vagotomías de Taylor). Los pacientes fueron seguidos prospectivamente para evaluar mediante variables como: tiempo quirúrgico, mortalidad, morbilidad, efectos colaterales de la operación y recurrencia de la enfermedad; la practicabilidad de los procedimientos, su seguridad y los resultados funcionales a largo plazo. El tiempo quirúrgico promedio fue 116,3 minutos para la técnica de Hill-Barker, y 149,2 minutos para la técnica de Taylor. No hubo conversión a cirugía convencional y la mortalidad perioperatoria fue nula. La estancia hospitalaria promedio fue 2,1 días. Las principales complicaciones postoperatorias fueron: diarrea (10,9%) y retardo del vaciamiento gástrico (4,4%). El índice global de recidiva fue de 10,4%. Las vagotomías laparoscópicas constituyen la opción de tratamiento ideal para la úlcera péptica duodenal, cuando el tratamiento quirúrgico está indicado, debido a bajos índices de mortalidad, recurrencia y trastornos funcionales colaterales a largo plazo, a lo cual se añaden las ventajas de la cirugía mínimamente invasiva.


Although elective surgery for duodenal ulcer is less frequent today, the indications for surgical treatment remain the same and there is still a small proportion of patients who should be considered for surgical treatment. The Taylor's procedure (posterior truncal vagotomy with anterior gastric seromiotomy) and the Hill-Barker's procedure (posterior truncal vagotomy with anterior highly selective vagotomy) have been the most accepted modalities of vagotomies when they have been performed by laparoscopy because of their efficacy, safety and simplicity. The objective of this study was to evaluate the long-term results of these laparoscopic techniques. 183 consecutive patients receiving either Taylor (n=75) or Hill-Barker (n=103) procedures at National Center for Minimal Access Surgery between 1994 and 2001, were prospectively followed for 1 to 80 (mean, 52) month to assess their outcomes. Factors related to feasibility, safety and long-term functional result, like operative time, mortality, morbidity, side effects of operation and recurrence, were analyzed during the follow-up. The mean operative time was 116,3 minutes for Hill-Barker's procedure and 149,2 minutes for Taylor's procedure. Our results show no operative mortality and no conversion to an open procedure. Hospital stay was 2,1 days. Diarrhoea (10,9%) and delayed gastric emptying (4,4%) were the most frequent complications. The global rate of recurrent ulceration was 10,4%. The low rates of mortality, recurrence and functional disorders at long-term, added to the advantages of minimal invasive surgery confers to laparoscopic vagotomies the condition of ideal treatment for duodenal ulcer, when surgical treatment is indicated.


Assuntos
Laparoscopia , Vagotomia , Úlcera Duodenal
14.
Rev. cuba. cir ; 46(3)jul.-sept. 2007. tab, graf
Artigo em Espanhol | LILACS, CUMED | ID: lil-486434

RESUMO

Se realizó un estudio de los pacientes operados por úlcera péptica gastroduodenal perforada en el Hospital Provincial Docente Clinicoquirúrgico Dr. Ambrosio Grillo Portuondo (Santiago de Cuba), entre los años 2000 y 2006. En el estudio predominaron los pacientes en la tercera década de la vida (30,3 por ciento) y el sexo masculino (90 por ciento). En la mayoría de los pacientes (68,7 por ciento) la perforación fue una complicación de enfermedad ulcerosa y predominó entre ellos el nivel medio de escolaridad (67,7 por ciento). Tenían más de un hábito tóxico 72 por ciento de los pacientes. El procedimiento más realizado fue la vagotomía troncular con piloroplastia (82,8 por ciento). No hubo complicaciones posoperatorias en 77,7 por ciento de los operados y la mortalidad global fue de 98 por ciento(AU)


A study was conducted on 99 patients operated from perforated gastroduodenal peptic ulcer at Dr Ambrosio Grillo Portuondo provincial teaching clinical and surgical hospital in Santiago de Cuba province in the period from 2000 to 2006. Thirty years age group (30,3 per cent), males (90 per cent)and intermediate level schooling prevailed. Perforation was a complication of ulcerous disease in most of the patients (68,7 per cent). More than one toxic habit was found in 72 per cent of patients. The most performed procedure was troncular vagotomy with piloroplasty (82,8 per cent). There was no postoperative complication in 77,7 per cent of the operated patients and the global mortality was 98 cent(AU)


Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Úlcera Péptica Perfurada/cirurgia , Vagotomia/métodos
15.
Rev. cuba. cir ; 45(1)ene.-mar. 2006. tab
Artigo em Espanhol | LILACS, CUMED | ID: lil-449774

RESUMO

La úlcera péptica duodenal continúa siendo un problema de salud en nuestros días y su cirugía, un tema muy discutido. Se realizó un estudio analítico, observacional, de casos y controles, en el Centro Nacional de Cirugía Endoscópica, con el propósito de evaluar los resultados del tratamiento quirúrgico laparoscópico de la úlcera péptica duodenal, mediante la técnica de vagotomía altamente selectiva modificada de Hill-Barker. La comparación con igual proceder por la vía convencional fue adoptada como medidor de eficacia entre ambos métodos. La hipótesis planteó que el acceso laparoscópico superaba al convencional. Resultó que los pacientes en estudio necesitaron un menor tiempo quirúrgico y anestésico, la respuesta clínica fue mejor y recidivaron 8 pacientes (13,3 por ciento) por 12 (20 por ciento) de los intervenidos del grupo control. Más del 50 por ciento del total de pacientes con recidiva lograron al menos mejoría clínica. Los factores pronóstico como el hábito de fumar, el uso de antiinflamatorios no esteroideos o la reinfección por Helicobacter pylori se vieron relacionados importantemente con las recidivas, en todos los casos. Las complicaciones posquirúrgicas, relacionadas con la vagotomía o no relacionadas con ella, fueron significativamente menores en los pacientes en estudio. Los costes fueron significativamente menores en aquellos operados por mínimo acceso. Se observó que la técnica endoscópica fue superior a la convencional en cuanto al tiempo quirúrgico y anestésico, la respuesta clínica, las recidivas, las complicaciones y los costes, por lo que se cumplió la hipótesis de la investigación


The ulcer peptic duodenal continues being a problem of health in our days and its surgery, a very discussed topic. He/she was carried out an analytic, observational study, of cases and controls, in the National Center of Surgery Endoscópica, with the purpose of evaluating the results of the treatment surgical laparoscópico of the ulcer peptic duodenal, by means of the technique of modified highly selective vagotomía of Hill-Barker. The comparison with equal to proceed for the conventional road was adopted between both as meter of effectiveness methods. The hypothesis outlined that the access laparoscópico overcame to the conventional one. It was that the patients in study needed a smaller surgical and anesthetic time, the clinical answer was better and recidivaron 8 patients (13,3 percent) for 12 (20 percent) of those intervened of the group control. More than 50 percent of the total of patient with relapse achieved clinical improvement at least. The factors presage like the habit of smoking, the use of antiinflamatorios non esteroideos or the reinfección for Helicobacter pylori were related importantly with the relapses, in all the cases. The complications posquirúrgicas, related with the vagotomía or not related with her, they were significantly smaller in the patients in study. The costs were significantly smaller in those operated by minimum access. It was observed that the technical endoscópica went superior to the conventional one as for the surgical and anesthetic time, the clinical answer, the relapses, the complications and the costs, for what the hypothesis of the investigation was completed(AU)


Assuntos
Humanos , Masculino , Feminino , Úlcera Péptica/complicações , Vagotomia/métodos , Laparoscopia/métodos , Úlcera Duodenal/complicações , Estudos de Casos e Controles , Anti-Inflamatórios não Esteroides/uso terapêutico , Estudos Observacionais como Assunto
16.
Bol. Hosp. San Juan de Dios ; 53(1): 11-15, ene.-feb. 2006. ilus, tab
Artigo em Espanhol | LILACS | ID: lil-430774

RESUMO

Se presenta un trabajo prospectivo de los casos de esófago de Barrett, encontrándose que un termino medio de índice de reflujo de 16,661, (p = 0003) en relación al grupo control, al igual que un índice de DeMeester de 60,015, (p = 0,0002) así como también un largo abdominal del esfínter de 0,641 (p = 0,002) a la manometría, son hechos estadísticamente significativo en la existencia de un esófago de Barrett, en los pacientes con reflujo gastroesofágico. Se encontró, además, la desaparición del 25,4 por ciento y una disminución del 30,3 por ciento de los esófagos de Barrett después de la cirugía, al cabo de tres años de observación. A medida que pasan los años de evaluación, estas cifras van aumentando, razón por la cual se postula efectuar una vagotomía supraselectiva con una fundoplicatura geométricamente simétrica, como tratamiento de los reflujos con esófago Barrett.


Assuntos
Masculino , Adolescente , Adulto , Humanos , Feminino , Pessoa de Meia-Idade , Esôfago de Barrett/etiologia , Esôfago de Barrett/terapia , Refluxo Gastroesofágico/cirurgia , Estudos Prospectivos , Resultado do Tratamento , Vagotomia
17.
Braz. j. med. biol. res ; 36(10): 1375-1382, Oct. 2003. ilus
Artigo em Inglês | LILACS | ID: lil-346487

RESUMO

Dipyrone administered intravenously (iv) delays gastric emptying (GE) in rats. The objectives of the present study were to assess: 1) the effect of the dose of dipyrone and time after its iv administration on GE in rats, 2) the effect of subdiaphragmatic vagotomy (VgX) and bilateral electrolytic lesion of the paraventricular nucleus (PVNX) on the delayed GE induced by the drug, and 3) the intracerebroventricular (icv) action of dipyrone and of one of its metabolites, 4-aminoantipyrine on GE. Male Wistar rats received saline labeled with phenol red intragastrically as a test meal. GE was indirectly assessed by the determination of percent gastric retention (GR) of the test meal 10 min after administration by gavage. Dipyrone delays GE in a dose- and time-dependent manner. Thirty minutes after the iv administration of 80 mg/kg dipyrone, the animals showed significantly higher GR (mean = 62.6 percent) compared to those receiving vehicle (31.5 percent). VgX and PVNX significantly reduced the iv effect of 80 mg/kg dipyrone (mean percentGR: VgX = 28.3 vs Sham = 55.5 and PVNX = 34.5 vs Sham = 52.2). Icv administration of 4 æmol dipyrone caused a significant increase in GR (54.1 percent) of the test meal 10 min later, whereas administration of 4 æmol 4-aminoantipyrine had no effect (34.4 percent). Although the dipyrone dose administered icv was 16 times lower than that applied iv, for the same time of action (10 min), the GR of animals that received the drug icv (54.1 percent) or iv (54.5 percent) did not differ significantly. In conclusion, the present results suggest that the effect of dipyrone in delaying GE is due to the action of the drug on the central nervous system, with the participation of the PVN and of the vagus nerve


Assuntos
Animais , Masculino , Ratos , Ampirona , Anti-Inflamatórios não Esteroides , Sistema Nervoso Central , Dipirona , Esvaziamento Gástrico , Análise de Variância , Relação Dose-Resposta a Droga , Núcleo Hipotalâmico Paraventricular , Ratos Wistar , Fatores de Tempo , Vagotomia , Nervo Vago
18.
Braz. j. med. biol. res ; 34(3): 301-314, Mar. 2001. ilus
Artigo em Inglês | LILACS | ID: lil-281610

RESUMO

The immune and central nervous systems are functionally connected and interacting. The concept that the immune signaling to the brain which induces fever during infection and inflammation is mediated by circulating cytokines has been traditionally accepted. Administration of bacterial lipopolysaccharide (LPS) induces the appearance of a so-termed "cytokine cascade" in the circulation more or less concomitantly to the developing febrile response. Also, LPS-like fever can be induced by systemic administration of key cytokines (IL-1ß, TNF-alpha, and others). However, anti-cytokine strategies against IL-1ß or TNF-alpha along with systemic injections of LPS frequently lead to attenuation of the later stages of the febrile response but not of the initial phase of fever, indicating that cytokines are rather involved in the maintenance than in the early induction of fever. Within the last years experimental evidence has accumulated indicating the existence of neural transport pathways of immune signals to the brain. Because subdiaphragmatic vagotomy prevents or attenuates fever in response to intraperitoneal or intravenous injections of LPS, a role for vagal afferent nerve fibers in fever induction has been proposed. Also other sensory nerves may participate in the manifestation of febrile responses under certain experimental conditions. Thus, injection of a small dose of LPS into an artificial subcutaneous chamber results in fever and formation of cytokines within the inflamed tissue around the site of injection. This febrile response can be blocked in part by injection of a local anesthetic into the subcutaneous chamber, indicating a participation of cutaneous afferent nerve signals in the manifestation of fever in this model. In conclusion, humoral signals and an inflammatory stimulation of afferent sensory nerves can participate in the generation and maintenance of a febrile response


Assuntos
Animais , Encéfalo/fisiologia , Citocinas/biossíntese , Febre/induzido quimicamente , Lipopolissacarídeos/farmacologia , Neurônios Aferentes/fisiologia , Cobaias , Sistema Imunitário/fisiologia , Injeções Intraperitoneais , Injeções Intravenosas , Interleucina-1/farmacologia , Fator de Necrose Tumoral alfa/farmacologia , Vagotomia , Nervo Vago/fisiologia
19.
Acta gastroenterol. latinoam ; 30(4): 253-65, 2000. tab, graf
Artigo em Espanhol | LILACS | ID: lil-272970

RESUMO

The present tests, in male Wistar rsts, center around the trophic and functional changes of the pancreatic gland (R G), both exocrine and endocrine, induced by different types of autonomic nervous interruptions. First Group of Tests: Following one year celiac ganglionectomy (CG), nonpancreatectomized (Non-Pt) rats showed, basally, in blood, adrop of glucose (G), without changes of insulin (I). At autpsy, the CG animals showed an increase of the pancreatic we weight, of the total protein, of the RNA but not DNA. In the Pt. 95 per cent rats, superimposing CG triggered, on the one hand, a drop to control values of the raised G blood levels, and on the other, a rise of I Besides, in feces, a rising of chymotrypsin concentration. At autopsy, in the PG, an increase of total protein and of RNA. Second Group of Tests: CG, after 6 months, induced, in blood, both basally and a 2 h glucose tolerance test, significant opposite enzyme activities changes in respect to C. Indeed, as amylase (A) was increased, that of lipase (L) was depressed. When alcohol feeding (AF) was superimposed to CG rats, a reversal of the L values was observed. The latter reached levels significantly higher those of the C. In in-vitro tests, the isolated islets of CG disclosed to release more I to the bath medium than those of the C animals. Third Group of Tests: Analyzing, in conscious animal, the L excretory changes in the basal bile pancreatic secretion (BB-PS) induced by chronic (2 months interruption of the autonomic nervous innervation of the PG, it was found that CG, truncal vagotomy (V), the association of CG + V, peri-Vaterian duodenotomy (PV-D), but not bilateral splachnicectomy (Spl), inhibit, significantly the L output. It was also shown that superimosing AF to the V or CG + V animals reverted to C values the I depressed levels...


Assuntos
Animais , Masculino , Ratos , Sistema Nervoso Autônomo/fisiologia , Ganglionectomia , Pâncreas/cirurgia , Regeneração , Sistema Nervoso Autônomo/cirurgia , Plexo Celíaco/fisiologia , Plexo Celíaco/cirurgia , Etanol/toxicidade , Insulina/metabolismo , Ilhotas Pancreáticas/metabolismo , Lipase/metabolismo , Pâncreas/inervação , Pâncreas/metabolismo , Pancreatectomia , Ratos Wistar , Vagotomia
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