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1.
Sultan Qaboos Univ Med J ; 24(1): 123-126, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-38434467

RESUMO

Dermoid cysts are common benign ovarian tumours arising from totipotent germ cells. We report a rare case of chemical peritonitis and prolonged fever following laparoscopic salpingo-oophorectomy for torsion of a large ovarian dermoid and discuss the management of this patient with prolonged hospital stay, antibiotics and anti-inflammatory use, repeated drainage of the collection as well as re-laparotomy. The occurrence of this rare condition can be extremely distressing for the patient and treating surgeon alike, as the recommendations for management are limited. The management of chemical peritonitis may require one or more surgical procedures along with prolonged anti-inflammatory therapy.


Assuntos
Cisto Dermoide , Laparoscopia , Humanos , Feminino , Cisto Dermoide/complicações , Cisto Dermoide/cirurgia , Laparoscopia/efeitos adversos , Antibacterianos/uso terapêutico , Drenagem , Anti-Inflamatórios
2.
Eur Rev Med Pharmacol Sci ; 28(5): 1970-1975, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-38497890

RESUMO

BACKGROUND: Intracranial dermoid cysts (DCs) represent an infrequent subset of congenital ectodermal inclusion cysts predominantly observed near the midline structures. In spite of their benign nature, they can cause clinical manifestations, necessitating surgical removal as the main therapeutic measure. CASE REPORT: We present here an extremely rare case characterized by a radiologically atypical dermoid cyst located within the corpus callosum, an extremely rare location for such tumors. Successful surgical excision resulted in good clinical outcomes. CONCLUSIONS: This paper underscores the importance of a timely, proper radiological diagnostic process, which sees magnetic resonance imaging (MRI) as the main step, as well as the fact that interpretation of MRI data can sometimes be challenging, as it was in the patient of this report.


Assuntos
Cisto Dermoide , Radiologia , Humanos , Corpo Caloso/diagnóstico por imagem , Cisto Dermoide/diagnóstico por imagem , Cisto Dermoide/cirurgia
3.
BMC Womens Health ; 24(1): 158, 2024 Mar 05.
Artigo em Inglês | MEDLINE | ID: mdl-38443937

RESUMO

BACKGROUND: Malignant Struma Ovarii (MSO) is a rare type of germ cell tumour which is diagnosed postoperatively on surgical pathology specimens by the presence of differentiated thyroid cancer in mature cystic teratomas in the ovaries. Treatment and follow-up procedures are not clearly established due to the paucity of MSO cases. CASE 1: A 44-year-old multiparous female presented with an irregular period. Ultrasound showed a left ovarian lesion mostly a dermoid cyst, however, CT showed a 3.8 × 2.7 × 4 cm complex cystic lesion with thick septation and enhancing soft tissue component. Laparoscopic left salpingo-oophorectomy was performed and histopathology showed a follicular variant of papillary thyroid carcinoma arising in a mature cystic teratoma. Peritoneal cytology was positive for malignancy. A thyroid function test was normal before surgery. Total thyroidectomy was performed followed by radioactive (RAI) iodine therapy. Later, a total laparoscopic hysterectomy and right salpingo-oophorectomy were performed. There is no evidence of recurrent disease during the 26-months follow-up. CASE 2: A 46-year-old single female presented with left lower abdominal pain that had persisted for 2 months. Imaging revealed an 8 × 9 × 9.5 cm left ovarian mass. Laparoscopic left salpingo-oophorectomy was performed and histopathology showed mature cystic teratoma with small papillary thyroid cancer. CT showed no evidence of metastatic disease. Later, the patient had a total thyroidectomy followed by radioactive (RAI) iodine therapy. She was started on thyroxine and later had total abdominal hysterectomy and right salpingo-oophorectomy. CONCLUSION: MSO is a very rare tumour. Preoperative diagnosis is very difficult because of the nonspecific symptoms and the lack of specific features in imaging studies. Also, there is no consensus on the optimal treatment of women with MSO. Our two cases add to the limited number of MSO cases.


Assuntos
Cisto Dermoide , Iodo , Neoplasias Ovarianas , Estruma Ovariano , Feminino , Humanos , Adulto , Pessoa de Meia-Idade , Estruma Ovariano/diagnóstico , Estruma Ovariano/cirurgia , Neoplasias Ovarianas/diagnóstico por imagem , Neoplasias Ovarianas/cirurgia
4.
Int J Mol Sci ; 25(4)2024 Feb 06.
Artigo em Inglês | MEDLINE | ID: mdl-38396644

RESUMO

Germline variants in the FOXE1 transcription factor have been associated with thyroid ectopy, cleft palate (CP) and thyroid cancer (TC). Here, we aimed to clarify the role of FOXE1 in Portuguese families (F1 and F2) with members diagnosed with malignant struma ovarii (MSO), an ovarian teratoma with ectopic malignant thyroid tissue, papillary TC (PTC) and CP. Two rare germline heterozygous variants in the FOXE1 promoter were identified: F1) c.-522G>C, in the proband (MSO) and her mother (asymptomatic); F2) c.9C>T, in the proband (PTC), her sister and her mother (CP). Functional studies using rat normal thyroid (PCCL3) and human PTC (TPC-1) cells revealed that c.9C>T decreased FOXE1 promoter transcriptional activity in both cell models, while c.-522G>C led to opposing activities in the two models, when compared to the wild type. Immunohistochemistry and RT-qPCR analyses of patients' thyroid tumours revealed lower FOXE1 expression compared to adjacent normal and hyperplastic thyroid tissues. The patient with MSO also harboured a novel germline AXIN1 variant, presenting a loss of heterozygosity in its benign and malignant teratoma tissues and observable ß-catenin cytoplasmic accumulation. The sequencing of the F1 (MSO) and F2 (PTC) probands' tumours unveiled somatic BRAF and HRAS variants, respectively. Germline FOXE1 and AXIN1 variants might have a role in thyroid ectopy and cleft palate, which, together with MAPK pathway activation, may contribute to tumours' malignant transformation.


Assuntos
Fissura Palatina , Cisto Dermoide , Fatores de Transcrição Forkhead , Neoplasias Ovarianas , Estruma Ovariano , Neoplasias da Glândula Tireoide , Animais , Feminino , Humanos , Ratos , Fissura Palatina/genética , Cisto Dermoide/genética , Fatores de Transcrição Forkhead/genética , Neoplasias Ovarianas/metabolismo , Estruma Ovariano/genética , Estruma Ovariano/metabolismo , Estruma Ovariano/patologia , Neoplasias da Glândula Tireoide/patologia
5.
Stomatologiia (Mosk) ; 103(1): 48-54, 2024.
Artigo em Russo | MEDLINE | ID: mdl-38372607

RESUMO

The article presents a case of a surgical treatment of removing a dermoid cyst of the floor of the oral cavity in a patient with severe hemophilia A. A detailed analysis was carried out of the surgical operation, postoperative management, coagulation factor replacement therapy and accompanying therapy, as well as the features of anesthesia, which allowed a surgical intervention without any hemorrhagic and infectious complications.


Assuntos
Anestesia Dentária , Cisto Dermoide , Hemofilia A , Neoplasias Bucais , Humanos , Neoplasias Bucais/complicações , Neoplasias Bucais/cirurgia , Cisto Dermoide/complicações , Cisto Dermoide/cirurgia , Hemofilia A/complicações , Soalho Bucal/cirurgia
6.
Int J Pediatr Otorhinolaryngol ; 176: 111842, 2024 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-38168651

RESUMO

INTRODUCTION: Midline neck lumps in children are mostly found to be thyroglossal duct cysts or dermoid cysts. Thyroglossal duct cysts often have an associated sinus tract which may connect all the way to the foramen caecum on the tongue, while dermoids have no such connection. This study aims to estimate the annual infection risk for midline neck cysts based on our patient series, and to see if this differs between thyroglossal duct cysts and dermoid cysts. METHODS: All children seen at the Royal Hospital for Children, Glasgow who underwent surgical excision of a midline neck cyst between 1st January 2017 and 31st December 2021 were identified. In those whose cyst had been infected prior to surgical excision, the age at which the first episode of infection occurred was recorded and used to calculate a survival curve. RESULTS: We identified 53 children (29 male, 24 female) aged 1-16 years (median 4) at the time of surgical excision. There were 26 thyroglossal and 24 dermoid cysts, plus 2 with indeterminate histology and 1 lymph node. Of the 24 dermoids, 4 suffered infection prior to surgery (17%), and 2 of these recurred after surgery (8%). Of the 26 thyroglossal cysts, 16 suffered infection prior to surgery (62%) and 5 of these recurred (19%). 78% of thyroglossal and dermoid cysts had at least 1 episode of infection by age 10 years. DISCUSSION: In a child with a congenital midline neck cyst that has never been infected, deferring surgery for a year comes with a 7.8% risk that the cyst will get infected.


Assuntos
Cisto Dermoide , Fístula , Cisto Tireoglosso , Criança , Humanos , Masculino , Feminino , Cisto Tireoglosso/cirurgia , Cisto Tireoglosso/patologia , Cisto Dermoide/complicações , Cisto Dermoide/cirurgia , Cisto Dermoide/patologia , Recidiva Local de Neoplasia , Pescoço/cirurgia , Pescoço/patologia , Fístula/cirurgia
7.
J Med Case Rep ; 18(1): 9, 2024 Jan 08.
Artigo em Inglês | MEDLINE | ID: mdl-38185668

RESUMO

BACKGROUND: Dermoid cysts are developmental abnormalities occurring between the third and fifth week of embryogenesis. These lesions can initially develop as intracranial or extracranial and persist throughout the patient's lifetime. While generally benign, their symptoms can be due to mass effect or local irritation secondary to rupture and release of contents, typically presenting as headaches and seizures. Intracranial dermoid cysts are rare and comprise less than 1% of all intracranial lesions, with rupture occurring approximately 0.18% of the time. CASE PRESENTATION: Our case describes a 42-year-old Hispanic female with a late-onset rupture of an intracranial dermoid cyst with associated new onset seizures. She underwent uncomplicated neurosurgical resection with mesh placement and was scheduled to follow-up as an outpatient. CONCLUSION: To avoid rupture and associated sequelae in future patients, we recommend considering a more invasive approach as the initial strategy if internal cysts are relatively accessible.


Assuntos
Cisto Dermoide , Humanos , Feminino , Adulto , Cisto Dermoide/complicações , Cisto Dermoide/cirurgia , Progressão da Doença , Cefaleia , Hispânico ou Latino , Convulsões/etiologia
8.
Vet Med Sci ; 10(1): e1319, 2024 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-37965842

RESUMO

A 6-month-old female Labrador Retriever mix rescued by a local shelter developed respiratory distress and later became tetraplegic. After transferring to a specialty centre, diagnostic imaging (CT and MRI) revealed spina bifida at C3 and dermoid sinuses at the level of C3 and T1. Surgery was performed to remove the dermoid sinuses. The dog was placed on broad-spectrum antibiotics and a tapering anti-inflammatory dose of prednisone, postoperatively. Independent ambulation was regained within 14 days with no recurrence of neurologic clinical signs.


Assuntos
Cisto Dermoide , Doenças do Cão , Disrafismo Espinal , Animais , Cães , Feminino , Cisto Dermoide/complicações , Cisto Dermoide/diagnóstico por imagem , Cisto Dermoide/cirurgia , Cisto Dermoide/veterinária , Disrafismo Espinal/complicações , Disrafismo Espinal/veterinária , Imageamento por Ressonância Magnética , Antibacterianos , Doenças do Cão/diagnóstico por imagem , Doenças do Cão/cirurgia
9.
J Plast Reconstr Aesthet Surg ; 88: 171-181, 2024 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-37983980

RESUMO

BACKGROUND: Nasal dermoid cysts are surgically treated using external incision, open rhinoplasty, transnasal endoscopy, or combined approaches. It is unclear how these approaches differ with regard to the incidence of adverse events. METHODS: We conducted a systematic review of studies on the surgical management of midline nasal dermoids. Following data abstraction, we carried out a series of single-arm meta-analyses to estimate summary risks of recurrence and combined adverse events (recurrence, revision, infection, or readmission) according to the surgical approach. RESULTS: Forty-three eligible studies published between 1958 and 2020 reported on 439 cases of nasal dermoid cysts. Treatment approaches included external incision (25 studies), rhinoplasty (15 studies), and transnasal endoscopy (5 studies). To our knowledge, no study has compared outcome incidence between the surgical approaches. External incision had the lowest summary incidence of both recurrence (1.78% [95% CI: 0.57%, 3.65%]) and combined adverse events (4.94% [95% CI: 2.72%, 7.77%]). Rhinoplasty had a higher incidence of recurrence (4.81% [95% CI: 0.91%, 11.6%]) and combined adverse events (8.32% [95% CI: 2.77%, 16.5%]), and transnasal endoscopy had the highest incidence of recurrence (the only reported adverse event; 7.89% [95% CI: 0%, 28.9%]). CONCLUSION: Our results suggest that the incidence of adverse events was lowest among patients who were subjected to external incision for nasal dermoid removal. Incidence was higher for patients who underwent rhinoplasty and the highest for patients who underwent transnasal endoscopy. Future work on this topic should include well-designed prospective studies that compare rates of adverse events and cosmetic outcomes between surgical approaches.


Assuntos
Cisto Dermoide , Neoplasias Nasais , Rinoplastia , Humanos , Cisto Dermoide/cirurgia , Estudos Prospectivos , Neoplasias Nasais/cirurgia , Rinoplastia/métodos , Endoscopia
10.
J Vet Med Sci ; 86(1): 116-119, 2024 Jan 26.
Artigo em Inglês | MEDLINE | ID: mdl-38072438

RESUMO

A 5-year-old neutered female mixed cat presented with reduced activity and ataxia of the hind limbs. Computed tomography and magnetic resonance imaging revealed an extradural mass compressing the spinal cord on the dorsal aspects from the 7th to 8th thoracic vertebra. Dorsal laminectomy was performed on the 7-8th thoracic vertebra and the cyst was totally removed, giving full resolution of the clinical signs. The cyst was diagnosed as a dermoid cyst. To our knowledge, this is the first report of feline dermoid cyst compressing the spinal cord that was diagnosed antemortem. The prognosis is favorable when the cyst is completely resected.


Assuntos
Doenças do Gato , Cisto Dermoide , Neoplasias da Medula Espinal , Gatos , Animais , Feminino , Cisto Dermoide/diagnóstico por imagem , Cisto Dermoide/cirurgia , Cisto Dermoide/veterinária , Neoplasias da Medula Espinal/diagnóstico por imagem , Neoplasias da Medula Espinal/cirurgia , Neoplasias da Medula Espinal/veterinária , Laminectomia/veterinária , Imageamento por Ressonância Magnética/veterinária , Imageamento por Ressonância Magnética/métodos , Doenças do Gato/diagnóstico por imagem , Doenças do Gato/cirurgia
11.
Am J Emerg Med ; 76: 273.e1-273.e3, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-38072734

RESUMO

BACKGROUND: Abdominal pain is the most common complaint within the emergency department (ED) and has many varied etiologies. Some of these conditions can be medical emergencies, including ovarian torsion. While representing just 3% of gynecologic emergencies, ovarian torsion should be considered in all females presenting to the ED with abdominal or pelvic complaints. CASE: A 38-year-old G5P5 female with a past medical history significant for ureterolithiasis presented to a freestanding ED with abdominal pain, nausea, and vomiting. She developed sudden onset of right sided abdominal pain radiating to her right flank upon awakening. The initial differential diagnosis was for ureterolithiasis or appendicitis. Her complete blood count (CBC) was normal, and testing for pregnancy, infection, and hematuria was negative. Computed topography (CT) imaging of the abdomen and pelvis revealed a 9 cm adnexal mass, consistent with a possible dermoid cyst. A pelvic ultrasound was ordered which showed a possible ovarian torsion. She was transferred to a tertiary care hospital where she had a laparoscopy with right-sided oophorectomy and salpingectomy performed. DISCUSSION: This patient presented with abdominal pain, nausea, and vomiting and was first suspected to have ureterolithiasis or appendicitis. She was found to have an ovarian torsion with a dermoid cyst, which resulted in the loss of her ovary and fallopian tube. This case demonstrates the importance of including gynecologic emergencies in the differential on all female patients presenting with abdominal pain.


Assuntos
Apendicite , Cisto Dermoide , Cálculos Ureterais , Humanos , Gravidez , Feminino , Adulto , Torção Ovariana/complicações , Cisto Dermoide/complicações , Apendicite/complicações , Emergências , Anormalidade Torcional/diagnóstico , Anormalidade Torcional/cirurgia , Dor Abdominal/etiologia , Cálculos Ureterais/complicações , Náusea , Vômito/complicações
13.
J Neurosurg ; 140(3): 677-687, 2024 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-37657097

RESUMO

OBJECTIVE: The lateral transorbital approach (LTOA) is a relatively new minimal access skull base approach suited for addressing paramedian pathology of the anterior and middle fossa. The authors define target zones for this approach and describe a series of cases with detailed measurements of visual outcomes, including those obtained with exophthalmometry. METHODS: The authors performed a retrospective analysis of a consecutive series of LTOA patients. Seven target zones were identified: 1) the orbit, 2) the lesser sphenoid wing and anterior clinoid, 3) the middle fossa, 4) the lateral wall of the cavernous sinus and Meckel's cave, 5) the infratemporal fossa, 6) the petrous apex, and 7) the anterior fossa. The authors used volumetric analyses of preoperative and postoperative MR and CT imaging data to calculate the volume of bone and tumor removed and to provide detailed ophthalmological, neurological, and cosmetic outcomes. RESULTS: Of the 20 patients in this cohort, pathology was in zone 2 (n = 10), zone 4 (n = 6), zone 3 (n = 2), zone 1 (n = 1), and zone 5 (n = 1). Pathology was meningioma (n = 10), schwannoma (n = 2), metastasis (n = 2), epidermoid (n = 1), dermoid (n = 1), encephalocele (n = 1), adenoma (n = 1), glioblastoma (n = 1), and inflammatory lesion (n = 1). The goal was gross-total resection (GTR) in 9 patients, all of whom achieved GTR. Subtotal resection (STR) was the goal in 8 patients (5 spheno-orbital meningiomas, 1 giant cavernous sinus/Meckel's cave schwannoma, 1 cavernous sinus prolactinoma, and 1 cavernous sinus dermoid), 7 of whom achieved STR and 1 of whom achieved GTR. The goal was biopsy in 2 patient and repair of encephalocele in 1. Visual acuity was stable or improved in 18 patients and worse in 2. Transient early postoperative diplopia, ptosis, eyelid swelling, and peri-orbital numbness were common. All 9 patients with preoperative diplopia improved at their last follow-up. Seven of 8 patients with preoperative exophthalmos improved after surgery (average correction of 64%). There were no cases of clinically significant (> 2 mm) postoperative enophthalmos. The most frequent postoperative complaint was peri-orbital numbness (40%). There was 1 CSF leak. Most patients were satisfied with their ocular (84%-100% of patients provided positive satisfaction-related responses) and cosmetic (75%-100%) outcomes. CONCLUSIONS: The LTOA is a safe minimal access approach to a variety of paramedian anterior skull base pathologies in several locations. Early follow-up revealed excellent resolution of exophthalmos with little risk of clinically significant enophthalmos. Transient diplopia, ptosis, and peri-orbital numbness were common but improved. Careful case selection is critical to ensure good outcome.


Assuntos
Seio Cavernoso , Cisto Dermoide , Enoftalmia , Exoftalmia , Neurilemoma , Humanos , Diplopia , Seio Cavernoso/diagnóstico por imagem , Seio Cavernoso/cirurgia , Encefalocele , Hipestesia , Estudos Retrospectivos , Exoftalmia/etiologia , Exoftalmia/cirurgia
14.
World Neurosurg ; 182: 83-90, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-37995988

RESUMO

OBJECTIVE: Intracranial dermoid cyst (DC) is a rare benign, slow-growing lesion, most commonly arising along the midline. They can occur in the supratentorial compartment, very rarely involve the sellar region and only exceptionally are intrasellar. The aim of our study is to address the challenges in the diagnosis and management of sellar DCs. METHODS: We performed a systematic review of sellar DCs, in keeping with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, and described an intrasellar DC in a 32-year-old female who presented with bilateral blurring vision. RESULTS: The review identified 4 intrasellar, 29 suprasellar, and 28 parasellar cases. Intrasellar DCs more likely present with progressive visual impairment and pituitary hormone dysfunctions during the fifth decade of life. Suprasellar and parasellar DCs are typically diagnosed during the third decade of life because of diplopia, ptosis, trigeminal hypoaesthesia/para-esthesia or cyst's rupture. Sellar DCs are typically hypodense on computed tomography scans and contain calcifications. Magnetic resonance imaging features include T1 hyperintensity, T2 heterogeneous intensity, no restriction on diffusion-weighted images, and no contrast enhancement. Surgery is the treatment of choice. Gross total resection is achieved in 60% of intrasellar and 61.9% of suprasellar and parasellar DCs. Early postoperative complications are reported in 40.0%, 16.7%, and 23.8% of intrasellar, suprasellar, and parasellar DCs, respectively. CONCLUSIONS: Intrasellar DCs are rare lesions typically diagnosed later than suprasellar and parasellar DCs due to their different clinical presentations. However, they should be considered in the differential diagnosis of cystic lesions of the sella, including epidermoid cysts, craniopharyngiomas, Rathke's cleft cysts, and teratomas.


Assuntos
Cistos do Sistema Nervoso Central , Cisto Dermoide , Cisto Epidérmico , Neoplasias Hipofisárias , Feminino , Humanos , Adulto , Cisto Dermoide/diagnóstico por imagem , Cisto Dermoide/cirurgia , Cisto Dermoide/complicações , Neoplasias Hipofisárias/diagnóstico por imagem , Neoplasias Hipofisárias/cirurgia , Cistos do Sistema Nervoso Central/diagnóstico por imagem , Cistos do Sistema Nervoso Central/cirurgia , Cistos do Sistema Nervoso Central/complicações , Cisto Epidérmico/complicações , Imageamento por Ressonância Magnética , Sela Túrcica/diagnóstico por imagem , Sela Túrcica/cirurgia , Sela Túrcica/patologia
15.
Braz Oral Res ; 37: e107, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-38055524

RESUMO

Dermoid cysts (DCs) and epidermoid cysts (ECs) are uncommon developmental cysts affecting the oral cavity. This study aims to evaluate patients with oral DCs and ECs and their demographic and clinicopathologic features. A retrospective descriptive cross-sectional study was performed. A total of 105,077 biopsy records of oral and maxillofacial lesions from seven Brazilian oral pathology centers were analyzed. All cases diagnosed as oral DCs and ECs were reviewed, and clinical, demographic, and histopathological data were collected. The series comprised 32 DCs (31.4%) and 70 ECs (68.6%). Most of the DCs occurred on the floor of the mouth (n = 14; 45.2%) of women (n = 17; 53.1%) with a mean age of 34.6 ± 21.6 years. All DCs were lined partially or entirely by stratified squamous epithelium (100%). Chronic inflammatory cells, melanin pigmentation, multinucleated giant cell reaction, and cholesterol clefts were observed in the fibrous capsule . Most of the ECs affected the labial mucosa (n = 20; 31.7%) of men (n = 39; 56.5%) with a mean age of 48.0±19.8 years. Microscopically, most ECs (n = 68; 97.1%) were lined entirely by stratified squamous epithelium. Two cysts (2.9%) showed areas of respiratory metaplasia. Chronic inflammatory cells, melanin pigmentation, multinucleated giant cell reaction, and cholesterol clefts were also observed in the fibrous capsule. Conservative surgical excision was the treatment of choice in all cases. Oral DCs and ECs are uncommon and often clinically misdiagnosed lesions. Clinicians should consider DCs and ECs in the differential diagnosis of soft tissue lesions in the oral cavity, mainly located on the floor of the mouth and labial mucosa.


Assuntos
Cisto Dermoide , Cisto Epidérmico , Neoplasias Bucais , Adolescente , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Adulto Jovem , Brasil/epidemiologia , Colesterol , Estudos Transversais , Cisto Dermoide/epidemiologia , Cisto Dermoide/patologia , Cisto Dermoide/cirurgia , Cisto Epidérmico/epidemiologia , Cisto Epidérmico/patologia , Cisto Epidérmico/cirurgia , Melaninas , Estudos Retrospectivos , Neoplasias Bucais/epidemiologia , Neoplasias Bucais/patologia , Neoplasias Bucais/cirurgia
16.
Indian J Pathol Microbiol ; 66(4): 848-851, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-38084546

RESUMO

Teratomas are germ cell tumors occurring usually in gonadal organs. They are neoplasms composed of one or more of the three germ layers. Extragonadal teratomas are uncommonly reported in the literature. The liver is an extremely rare site for teratoma, constituting < 1% of all teratomas. The majority of the liver teratomas are found in the pediatric population with only a dozen cases reported in adults to the best of our knowledge. We present a case of a 27-year-old male with a history of abdominal pain of 5 months duration. CT scan revealed liver mass suggesting teratoma. The patient underwent cholecystectomy and segmental liver resection. Histopathology revealed mature cystic teratoma. Complete resection remains the best treatment option. Teratomas of the liver are extremely rare, constituting < 1% of all teratomas. An extensive review of the literature yielded < 50 cases of primary hepatic teratomas with only a dozen cases in adults and only two cases in males.


Assuntos
Cisto Dermoide , Neoplasias Embrionárias de Células Germinativas , Teratoma , Adulto , Humanos , Masculino , Hepatectomia , Fígado/diagnóstico por imagem , Fígado/cirurgia , Fígado/patologia , Neoplasias Embrionárias de Células Germinativas/cirurgia , Teratoma/diagnóstico , Teratoma/cirurgia , Teratoma/patologia
17.
J Int Med Res ; 51(12): 3000605231218634, 2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-38149433

RESUMO

Dermoid cysts are one of the most common benign orbital tumours in children and usually occur unilaterally. Bilateral dermoid cysts in the orbit are rare. We report here, a case of bilateral orbital dermoid cysts, in a 29-month-old baby girl. The patient's prognosis was favourable following surgical resection. Through this case report, we hope to increase the recognition and understanding of this condition.


Assuntos
Cisto Dermoide , Neoplasias Orbitárias , Criança , Lactente , Feminino , Humanos , Pré-Escolar , Cisto Dermoide/diagnóstico por imagem , Cisto Dermoide/cirurgia , Neoplasias Orbitárias/diagnóstico por imagem , Neoplasias Orbitárias/cirurgia , Neoplasias Orbitárias/patologia , Órbita/patologia
18.
J Paediatr Child Health ; 59(11): 1272-1273, 2023 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-37997477
19.
BMC Pediatr ; 23(1): 447, 2023 09 07.
Artigo em Inglês | MEDLINE | ID: mdl-37679697

RESUMO

BACKGROUND: ​Extracranial metastasis can occur in intracranial germ cell tumors (GCTs), but it is very rare. Recurrence or metastasis of non-germinomatous germ cell tumors (NGGCTs) is often accompanied by elevated tumor markers. ​Occult extracranial metastases or recurrences with negative markers are often difficult to detect in time, resulting in a very poor prognosis. CASE PRESENTATION: A 12-year-old boy was admitted to our institution with dizziness, headache, vomiting, and sleepiness. Magnetic resonance imaging (MRI) showed a pineal mass, accompanied by a significant increase in serum alpha-fetoprotein (AFP). The patient subsequently underwent total removal of the tumor. Pathology revealed that the tumor was a mixed GCT, consisting of mature teratoma, germinoma, and yolk sac tumor. Intracranial GCT achieved complete remission after intensive adjuvant chemotherapy and radiotherapy. Regular follow-up MRI revealed no recurrence of the intracranial tumor and continued monitoring of tumor markers revealed no abnormalities. ​Eight months later, the patient was readmitted due to progressive abdominal pain. Imaging and physical examination revealed abdominal occupation and lymphatic mass in the neck. He received salvage chemotherapy, anti-PD-1 immunotherapy, and palliative chemotherapy, but still developed multiple organ dysfunction syndromes (MODS) due to tumor progression and eventually died after one month. CONCLUSIONS: ​This profound case suggests that intracranial NGGCTs may develop occult extracranial malignancy, which can be very severe at the time of clinical symptoms and has an extremely poor prognosis. Therefore, in addition to tumor marker monitoring, regular follow-up with extracranial imaging may be warranted to detect extracranial tumors as early as possible, although perhaps not as frequently as with neuroimaging.


Assuntos
Neoplasias Encefálicas , Cisto Dermoide , Neoplasias Embrionárias de Células Germinativas , Teratoma , Masculino , Humanos , Criança , Neoplasias Embrionárias de Células Germinativas/diagnóstico por imagem , Neoplasias Embrionárias de Células Germinativas/terapia , Neoplasias Encefálicas/diagnóstico por imagem , Neoplasias Encefálicas/terapia , Biomarcadores Tumorais
20.
Ann R Coll Surg Engl ; 105(7): 678-680, 2023 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-37652086

RESUMO

Dermoid cysts of the spermatic cord are rare, with only a few adult cases published in the literature. We report a patient with a 10cm inguinal mass referred to us for a suspected paratesticular sarcoma. Imaging suggested a cyst but, due to the recent increase in size, the cyst contents were evacuated and the cyst wall was biopsied. Histopathology revealed a dermoid cyst, which is a benign variant of cystic teratomas. Histopathological examination was required here due to the uncertainty. Careful interpretation was required, as cystic teratomas very occasionally undergo a malignant transformation.


Assuntos
Cisto Dermoide , Cordão Espermático , Teratoma , Adulto , Masculino , Humanos , Cordão Espermático/diagnóstico por imagem , Cordão Espermático/cirurgia , Cisto Dermoide/diagnóstico por imagem , Cisto Dermoide/cirurgia , Biópsia
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