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1.
J Cardiothorac Surg ; 19(1): 43, 2024 Feb 03.
Artigo em Inglês | MEDLINE | ID: mdl-38310241

RESUMO

BACKGROUND: Tumor-like lesions of the trachea are rare and challenging in diagnosis and management. Inflammatory myofibroblastoma, also known as Inflammatory pseudo tumors (IPTs), as well as Rosai Dorfman Disease (RDD) are inflammatory lesions that may involve the central airways with variable non-specific clinical features mimicking tumors. CASE PRESENTATION: In this study 2 cases with tumor-like lesions are presented. One case with an inflammatory pseudotumor and the other one with Rosai-Dorfman disease affecting the upper trachea. Both cases were successfully managed with tracheal resection anastomosis. CONCLUSION: Tracheal Inflammatory myofibroblastoma, and Rosai-Dorfman diseases are rare tumor like lesions that present with upper airway obstruction. Despite being benign, these lesions may have features suggestive of malignancy, requiring prompt management. Complete surgical excision by segmental resection and primary anastomosis (if feasible) is the treatment of choice with an optimum outcome.


Assuntos
Histiocitose Sinusal , Neoplasias de Tecido Muscular , Neoplasias , Humanos , Histiocitose Sinusal/diagnóstico , Traqueia/cirurgia , Traqueia/patologia , Anastomose Cirúrgica
2.
Rev Med Interne ; 45(3): 138-141, 2024 Mar.
Artigo em Francês | MEDLINE | ID: mdl-38395714

RESUMO

INTRODUCTION: Lymphadenopathies are a major cause of consultation in internal medicine, with various causes of diagnosis. Unexplained persistent lymphadenopathy must be biopsied to rule out malignant tumor. CASE REPORT: We report the case of a 53-year-old man, with inguinal lymphadenopathy evolving for more than one year. The patient had no associated symptoms and his blood tests were unremarkable. Due to the progression of the adenopathy and its hypermetabolism on PET-CT, an excisional biopsy was performed. Histological analysis revealed an intranodal proliferation of spindle cells with a palisading pattern. ß-catenine and smooth muscle actin labelling were positive, leading to the diagnosis of intranodal palisaded myofibroblastoma, a benign tumour. CONCLUSION: Intranodal palisaded myofibroblastoma is a rare benign cause of adenopathy, with often inguinal lymph node localization and slow growth and without risk of recurrence after surgical removal.


Assuntos
Linfadenopatia , Neoplasias de Tecido Muscular , Masculino , Humanos , Pessoa de Meia-Idade , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada , Linfonodos/patologia , Linfadenopatia/diagnóstico , Linfadenopatia/etiologia , Neoplasias de Tecido Muscular/complicações , Neoplasias de Tecido Muscular/diagnóstico , Neoplasias de Tecido Muscular/patologia , Biópsia
5.
Artigo em Chinês | MEDLINE | ID: mdl-38114319

RESUMO

Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal soft tissue tumor characterized by borderline or low-grade malignancy. It is rare childhood tumor with an average age of onset of 10 years old. It is even rarer in infants and toddlers, and the etiology and pathogenesis of this tumor are still unclear. The clinical presentation of IMT is non-specific and are related to the location of the tumor. When the tumor compresses adjacent organs, it can cause pain and functional impairment. According to the current literature, IMT is most commonly found in the digestive and respiratory systems, but also occasionally occur in the genitourinary system, head and neck, and limbs. At present, there have been no reports of nasopharyngeal IMT involving nasal cavity of infants and toddlers at home and abroad.This article reports a case of a massive inflammatory myofibroblastic tumor involving the nasal cavity and nasopharynx in an infant. Plasma-assisted minimally invasive surgery was performed through multiple surgical approaches and achieved satisfactory therapeutic results. This case report may provide valuable reference for the treatment of similar diseases.


Assuntos
Granuloma de Células Plasmáticas , Neoplasias de Tecido Muscular , Neoplasias de Tecidos Moles , Humanos , Lactente , Granuloma de Células Plasmáticas/patologia , Nasofaringe/patologia
6.
BMJ Case Rep ; 16(11)2023 Nov 30.
Artigo em Inglês | MEDLINE | ID: mdl-38035683

RESUMO

We present the case of a vulval superficial myofibroblastoma with a lymphocytic and eosinophilic rim in a woman in her late 20s. The tumour presented in pregnancy as a cystic lesion with pain and increasing size. While the histopathology of superficial myofibroblastomas has been well defined in the literature, to our knowledge, there has been no documentation of the presence of an inflammatory infiltrate of lymphocytes and eosinophils surrounding and within the tumour. This may potentially act as a diagnostic or prognostic reference.


Assuntos
Eosinofilia , Neoplasias de Tecido Muscular , Neoplasias Vulvares , Feminino , Humanos , Eosinofilia/patologia , Eosinófilos/patologia , Linfócitos/patologia , Neoplasias de Tecido Muscular/diagnóstico , Neoplasias de Tecido Muscular/cirurgia , Neoplasias de Tecido Muscular/patologia , Neoplasias Vulvares/diagnóstico , Neoplasias Vulvares/cirurgia , Neoplasias Vulvares/patologia , Adulto
7.
Rev Esp Patol ; 56(4): 279-283, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37879826

RESUMO

Intranodal palisaded myofibroblastoma (IPM) is a rare stroma-derived spindle-cell neoplasm of the lymph node with myofibroblastic differentiation and CTNNB1 (ß-catenin gene) somatic mutations. We present a case of IPM found incidentally in the staging of lung adenocarcinoma. We describe the major histopathological and phenotypic features, including a palisaded bland spindle cell proliferation with myofibroblastic differentiation and Wnt pathway activation by immunohistochemistry, including ß-catenin expression. Production of osteoid-like collagen directly from tumor cells was observed. We confirmed p.Gly34Arg CTNNB1 mutation by direct sequencing. We also reviewed the literature for similar cases.


Assuntos
Neoplasias de Tecido Muscular , beta Catenina , Humanos , beta Catenina/genética , beta Catenina/metabolismo , Via de Sinalização Wnt/genética , Linfonodos/patologia , Neoplasias de Tecido Muscular/genética , Neoplasias de Tecido Muscular/metabolismo , Neoplasias de Tecido Muscular/patologia , Mutação
8.
Clin Nucl Med ; 48(12): e614-e616, 2023 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-37883213

RESUMO

ABSTRACT: A 31-year-old man with multiple intrahepatic inflammatory myofibroblastoma tumor was referred to nuclear medicine department to assess its malignant potential. Multiple lesions in the liver exhibited 68 Ga-FAPI uptake at different degrees. Instead, there was no abnormal 18 F-FDG activity in the other hepatic lesions under the normal liver background except for the puncture site. This case reflects tumor heterogeneity of the disease and shows the potential value of 68 Ga-FAPI PET/CT for the evaluation of hepatic inflammatory myofibroblastoma tumor.


Assuntos
Neoplasias Hepáticas , Neoplasias de Tecido Muscular , Masculino , Humanos , Adulto , Fluordesoxiglucose F18 , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada , Tomografia por Emissão de Pósitrons
9.
Urology ; 182: e249-e252, 2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-37696306

RESUMO

This report describes a 14-year-old male with a rare paratesticular inflammatory myofibroblastic tumor that presented atypically with acute unilateral scrotal pain and swelling. This presentation, which raised suspicion for testicular torsion, contrasts with the typical presentation of a slow-growing scrotal mass. Scrotal exploration revealed an infarcted right testis, demonstrating this locally aggressive tumor can undergo vascular invasion and occlude testicular blood supply. Thus, inflammatory myofibroblastic tumor should be considered in the differential diagnosis when evaluating patients with acute scrotal pain suspicious for testicular infarction.


Assuntos
Doenças dos Genitais Masculinos , Escroto , Torção do Cordão Espermático , Adolescente , Humanos , Masculino , Doenças dos Genitais Masculinos/patologia , Infarto/diagnóstico , Infarto/patologia , Dor , Escroto/patologia , Torção do Cordão Espermático/diagnóstico , Torção do Cordão Espermático/patologia , Testículo/patologia , Neoplasias de Tecido Muscular
11.
Zhonghua Bing Li Xue Za Zhi ; 52(7): 683-689, 2023 Jul 08.
Artigo em Chinês | MEDLINE | ID: mdl-37408398

RESUMO

Objective: To investigate the clinicopathological features, diagnosis and differential diagnosis of breast myofibroblastoma. Methods: The clinicopathological data and prognostic information of 15 patients with breast myofibroblastoma diagnosed at the Department of Pathology of the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China from 2014 to 2022 were collected. Their clinical characteristics, histological subtypes, immunophenotypes and molecular characteristics were analyzed. Results: There were 12 female and 3 male patients, ranging in age from 18 to 78 years, with a median and average age of 52 years. There were 6 cases in the left breast and 9 cases in the right breast, including 12 cases in outer upper quadrant, 2 cases in inner upper quadrant and 1 case in outer lower quadrant. Most of the cases showed a well-defined nodule grossly, including pushing growth under the microscope in 13 cases, being completely separated from the surrounding breast tissue in 1 case, and infiltrating growth in 1 case. Among them, 12 cases were classic subtype and composed of occasional spindle cells with varying intervals of collagen fiber bundles; eight cases had a small amount of fat; one case had focal cartilage differentiation; one case was epithelioid subtype, in which epithelioid tumor cells were scattered in single filing or small clusters; one case was schwannoma-like subtype, and the tumor cells were arranged in a significant palisade shape, resembling schwannoma, and one case was invasive leiomyoma-like subtype, in which the tumor cells had eosinophilic cytoplasm and were arranged in bundles, and infiltrating into the surrounding mammary lobules like leiomyoma. Immunohistochemical studies showed that the tumor cells expressed desmin (14/15) and CD34 (14/15), as well as ER (15/15) and PR (15/15). Three cases with histologic subtypes of epithelioid subtype, schwannoma-like subtype and infiltrating leiomyoma-like subtype showed RB1 negative immunohistochemistry. Then FISH was performed to detect RB1/13q14 gene deletion, and identified RB1 gene deletion in all three cases. Fifteen cases were followed up for 2-100 months, and no recurrence was noted. Conclusions: Myofibroblastoma is a rare benign mesenchymal tumor of the breast. In addition to the classic type, there are many histological variants, among which the epithelioid subtype is easily confused with invasive lobular carcinoma. The schwannoma-like subtype is similar to schwannoma, while the invasive subtype is easily misdiagnosed as fibromatosis-like or spindle cell metaplastic carcinoma. Therefore, it is important to recognize the various histological subtypes and clinicopathological features of the tumor for making correct pathological diagnosis and rational clinical treatment.


Assuntos
Leiomioma , Neoplasias de Tecido Muscular , Neurilemoma , Feminino , Humanos , Masculino , Antígenos CD34 , Biomarcadores Tumorais/análise , Leiomioma/patologia , Neoplasias de Tecido Muscular/química , Neoplasias de Tecido Muscular/genética , Neoplasias de Tecido Muscular/patologia , Adolescente , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Idoso
13.
Diagn Cytopathol ; 51(8): E248-E254, 2023 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-37243568

RESUMO

INTRODUCTION: Intranodal palisaded myofibroblastoma (IPM) is an exceedingly rare benign mesenchymal tumor of the lymph nodes. Magnetic resonance imaging (MRI) findings are unspecific, which may present diagnostic challenges to fine-needle aspiration cytology (FNAC). The histological and immunohistochemical features of IPM are unique. CASE REPORT: A previously healthy 40-year-old male patient presented a slow-growing solitary left inguinal mass. FNAC revealed clustered cells within a metachromatic stroma, single spindle cells without atypia, hemosiderin pigment, and siderophages. An MRI showed a central hyperintense septum in fat-suppressed, T2-weighted sequences. The excised lymph node contained central haphazard fascicles of spindle cells with focal nuclear palisading, hemosiderin pigment, extravasated erythrocytes, and hemorrhagic areas. Vimentin and smooth muscle actin were diffusely positive. Amianthoid collagen fibers were not clearly observed. CONCLUSION: IPM is an extremely rare mesenchymal benign intranodal tumor that should be included in the differential diagnosis of spindle cell lesions in the inguinal region.


Assuntos
Hemossiderina , Neoplasias de Tecido Muscular , Masculino , Humanos , Adulto , Linfonodos/patologia , Biópsia por Agulha Fina , Neoplasias de Tecido Muscular/patologia , Citodiagnóstico
14.
Clin Nucl Med ; 48(6): 522-524, 2023 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-37083628

RESUMO

ABSTRACT: Hepatic inflammatory myofibroblastoma is an uncommon borderline tumor. We present 68 Ga-FAPI PET/CT findings of hepatic inflammatory myofibroblastoma in a 58-year-old man. The rare hepatic inflammatory myofibroblastoma demonstrated intense tracer uptake on 68 Ga-FAPI PET/CT. This case demonstrates the potential value of 68 Ga-FAPI PET/CT for the evaluation of hepatic inflammatory myofibroblastoma.


Assuntos
Neoplasias de Tecido Muscular , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada , Masculino , Humanos , Pessoa de Meia-Idade , Transporte Biológico , Radioisótopos de Gálio , Neoplasias de Tecido Muscular/diagnóstico por imagem , Fluordesoxiglucose F18
15.
Int J Surg Pathol ; 31(8): 1559-1564, 2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-36917841

RESUMO

Myofibroblastoma is a rare benign mesenchymal tumor first described in the breast. It is also known as mammary-type myofibroblastoma outside of the breast, more frequently located along the embryonic milk line. Exceptionally, myofibroblastoma can occur at visceral locations. We present a case of myofibroblastoma detected incidentally in the liver. A well-circumscribed mass, grossly measuring 6.2 cm in the liver parenchyma, was found on imaging studies. Histologically, the lesion is characterized by benign spindle cells in a hyalinized collagenous stroma, with positive staining for SMA and ER, focal positivity for CD34, negative for desmin, and loss of RB1. This rare tumor at such an unusual location makes it diagnostically challenging, especially on core biopsy of the lesion. To our knowledge, this is the second case of myofibroblastoma in the liver reported in the English literature and the first such case with a detailed pathology description.


Assuntos
Biomarcadores Tumorais , Neoplasias de Tecido Muscular , Humanos , Imuno-Histoquímica , Neoplasias de Tecido Muscular/diagnóstico , Neoplasias de Tecido Muscular/cirurgia , Neoplasias de Tecido Muscular/patologia , Mama/patologia , Fígado/patologia
16.
Fetal Pediatr Pathol ; 42(1): 123-130, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-35403555

RESUMO

Inflammatory myofibroblastic tumor (IMT) infrequently involves the sigmoid colon, and has not previously been described in an infant sigmoid colon.An inflammatory myofibroblastic tumor arose from the sigmoid colon of an 11-month-old boy, confirmed by anaplastic lymphoma kinase (ALK), smooth muscle actin (SMA) and desmin immunohistochemical staining. The patient recovered well after complete resection of the tumor.Sigmoid IMT can occur in infancy. This eighth case is the youngest so far. The child did well after surgical resection.


Assuntos
Neoplasias de Tecido Muscular , Neoplasias do Colo Sigmoide , Masculino , Criança , Humanos , Lactente , Colo Sigmoide/patologia , Neoplasias do Colo Sigmoide/diagnóstico , Neoplasias do Colo Sigmoide/cirurgia , Neoplasias de Tecido Muscular/diagnóstico , Neoplasias de Tecido Muscular/cirurgia , Neoplasias de Tecido Muscular/patologia , Inflamação/patologia
17.
Ear Nose Throat J ; 102(8): 511-515, 2023 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34006125

RESUMO

This report describes an extremely rare case of a primary inflammatory myofibroblastic tumor of the trachea. The patient underwent surgical resection by a transtracheal approach and reconstruction with esophageal tracheoplasty. This case report highlights the rarity of such tumors and a minimally invasive and safe surgical technique for tumors around the central neck structures.


Assuntos
Granuloma de Células Plasmáticas , Neoplasias de Tecido Muscular , Humanos , Quinase do Linfoma Anaplásico , Traqueia/cirurgia , Traqueia/patologia , Granuloma de Células Plasmáticas/cirurgia , Granuloma de Células Plasmáticas/patologia , Pescoço/patologia , Neoplasias de Tecido Muscular/cirurgia , Neoplasias de Tecido Muscular/patologia
18.
J Cutan Pathol ; 50(4): 326-329, 2023 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-36271750

RESUMO

Myofibroblastoma is a rare, benign mesenchymal tumor first described as a neoplasm of the breast. Extramammary myofibroblastoma is a histopathologically and genetically identical lesion occurring outside the breast. Herein is presented a case of extramammary myofibroblastoma arising in the oral cavity. A 59-year-old woman presented with a 1.5 cm nodule on the buccal surface of the lower lip. Wide local excision was performed. Histopathologic examination revealed haphazard fascicles of monomorphic spindle cells with hyalinized collagen bundles without fat. The spindled cells were diffusely positive for CD34, and focally for progesterone receptor. Desmin, smooth muscle actin, estrogen receptor, androgen receptor, S100, and STAT6 were negative. Rb1 expression was lost in tumor cells. Thus, the diagnosis of extramammary myofibroblastoma was made. Differential diagnoses include spindle-cell lipoma and angiofibroma. All three tumors are members of the 13q14 deletion/RB1 loss family. Indolent but locally aggressive (solitary fibrous tumor, desmoid fibromatosis) and frankly malignant (low-grade peripheral nerve sheath tumor, dermatofibrosarcoma protuberans) entities can be excluded by immunohistochemistry and careful microscopic examination. Extensive sampling extramammary myofibroblastoma is important to exclude the possibility of malignancy. Clinicians and pathologists alike should be aware of this entity and its potential to arise rarely in unusual locations.


Assuntos
Angiofibroma , Lipoma , Neoplasias de Tecido Muscular , Feminino , Humanos , Pessoa de Meia-Idade , Neoplasias de Tecido Muscular/metabolismo , Mama/patologia , Angiofibroma/patologia , Lipoma/patologia , Lábio/patologia , Biomarcadores Tumorais/metabolismo
20.
Ann Diagn Pathol ; 60: 152010, 2022 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-35907316

RESUMO

OBJECTIVE: To describe the clinicopathological features and differential diagnoses of 15 cases of superficial myofibroblastoma, a rare mesenchymal tumor involving the lower female genital tract. METHODS: The clinicopathological data and immunohistochemical findings were retrospectively analyzed in 15 cases of superficial myofibroblastoma. Meanwhile, a systematic literature review was conducted. RESULTS: The age of patients ranged from 34 to 73 years (median, 49 years). Most patients presented with nodular or polypoid masses ranging in size from 0.4 cm to 6.5 cm. Twelve tumors were located in the vagina, two in the vulva, and one in the cervix. Microscopically, the tumor was located in the subepithelial tissue, with a clear boundary and without capsule on the surface. The tumor cells were spindle, oval, stellate or wavy, and arranged in various architectural patterns of reticular, fascicular, wavy and disorderly patterns. There were no obvious cellular atypia and mitotic figures. Thin collagen fibers and thin-walled vessels could be observed in all cases. Most cases were diffusely and strongly reactive to Vimentin (12/12), Desmin (14/15), ER (15/15) and PR (13/14). Variable immunoreactivity for CD34 (8/15), Caldesmon (2/8), SMA (4/14) and CD99 (4/5) were observed. The tumors showed a low Ki67 proliferative index (≤5 %). Follow-up information was available in 10 patients and there was no evidence of recurrence or metastasis. CONCLUSIONS: Superficial myofibroblastoma is a rare benign tumor that originates from the hormone-sensitive, subepithelial mesenchymal tissue of the lower female genital tract, and should be differentiated from other mesenchymal tumors.


Assuntos
Neoplasias de Tecido Muscular , Adulto , Idoso , Biomarcadores Tumorais/análise , Proteínas de Ligação a Calmodulina , Colágeno , Desmina/metabolismo , Feminino , Hormônios , Humanos , Antígeno Ki-67 , Pessoa de Meia-Idade , Neoplasias de Tecido Muscular/diagnóstico , Estudos Retrospectivos , Vagina/patologia , Vimentina/metabolismo
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