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3.
J Dent Res ; 100(10): 1039-1046, 2021 09.
Artigo em Inglês | MEDLINE | ID: mdl-33906502

RESUMO

Few university-based regenerative medicine innovations in the dental, oral, and craniofacial (DOC) space have been commercialized and affected clinical practice in the United States. An analysis of the commercial translation literature and National Institute for Dental and Craniofacial Research's (NIDCR's) portfolio identified barriers to commercial translation of university-based DOC innovations. To overcome these barriers, the NIDCR established the Dental Oral Craniofacial Tissue Regeneration Consortium. We provide generalized strategies to inform readers how to bridge the "valley of death" and more effectively translate DOC technologies from the research laboratory or early stage company environment to clinical trials and bring needed innovations to the clinic. Three valleys of death are covered: 1) from basic science to translational development, 2) from translational technology validation to new company formation (or licensing to an existing company), and 3) from new company formation to scaling toward commercialization. An adapted phase-gate model is presented to inform DOC regenerative medicine teams how to involve regulatory, manufacturability, intellectual property, competitive assessments, business models, and commercially oriented funding mechanisms earlier in the translational development process. An Industrial Partners Program describes how to conduct market assessments, industry maps, business development processes, and industry relationship management methods to sustain commercial translation through the later-stage valley of death. Paramount to successfully implementing these methods is the coordination and collaboration of interdisciplinary teams around specific commercial translation goals and objectives. We also provide several case studies for translational projects with an emphasis on how they addressed DOC biomaterials for tissue regeneration within a rigorous commercial translation development environment. These generalized strategies and methods support innovations within a university-based and early stage company-based translational development process, traversing the many funding gaps in dental, oral, and craniofacial regenerative medicine innovations. Although the focus is on shepherding technologies through the US Food and Drug Administration, the approaches are applicable worldwide.


Assuntos
Indústrias , Medicina Regenerativa , Humanos , National Institute of Dental and Craniofacial Research (U.S.) , Estados Unidos , Universidades
4.
5.
J Dent Educ ; 81(9): eS108-eS127, 2017 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-28864811

RESUMO

Scientific inquiry and discovery are the fuel for education, research, technology, and health care in all the health professions: dentistry, medicine, nursing, pharmacy, and allied health sciences. The progression of discoveries from basic or fundamental to clinical research is followed by the progression from clinical to implementation and improved health outcomes and processes. Generally, implementation science is the scientific study of methods to promote the systematic uptake of research findings (e.g., basic, translational, behavioral, socioeconomic, and clinical) as well as other related evidence-based practices into standards of care, thereby improving the quality, effectiveness, and cost benefits of health care services. There is little doubt that science has and will continue to provide the essential fuel for innovations that lead to new and improved technologies for risk assessment, prevention, diagnosis, treatments and therapeutics, and implementation for addressing oral and craniofacial diseases and disorders. The history of the U.S. dental profession reviewed in this article gives testimony to the continued need for investments in scientific inquiry that accelerate progress in comprehensive health care for all people. This article was written as part of the project "Advancing Dental Education in the 21st Century."


Assuntos
Pesquisa Biomédica , Odontologia/tendências , Invenções , Pesquisa em Odontologia , Educação em Odontologia/tendências , Fluoretos , Previsões , Genômica , História do Século XX , Humanos , National Institute of Dental and Craniofacial Research (U.S.)/história , Doenças Periodontais/genética , Parcerias Público-Privadas , Estados Unidos
7.
J Dent Res ; 96(1): 10-16, 2017 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-28033063

RESUMO

This study examines funding from the National Institutes of Health (NIH) to US dental institutions between 2005 and 2014 based on publicly available data from the NIH Research Portfolio Online Reporting Tools. Over the 10-y span, 56 US dental institutions received approximately $2.2 billion from 20 Institutes, Centers, and Offices at the NIH. The National Institute of Dental and Craniofacial Research (NIDCR) is the largest NIH supporter of dental institutions, having invested 70% of the NIH total, about $1.5 billion. The NIDCR is also the primary supporter of research training and career development, as it has invested $177 million, which represents 92% of the total NIH investment of $192 million. Over the past 10 y, about half of the NIDCR's extramural award dollars have gone to dental schools, while the NIH has invested about 1%. There has been an approximately 10% net decrease in extramural dollars awarded to dental institutions over the past decade; however, given the year-to-year variability in support to dental institutions, it is unclear if this net decline reflects a long-term trend. In addition, there was an overall reduction in the extramural dollars awarded by the NIDCR and by the NIH. For example, from 2005 to 2014, the total NIDCR budget for extramural research decreased by roughly 4%, which represents a decrease of $20 million to dental institutions. After adjusting for inflation, the decline in funding to dental institutions from the NIDCR and NIH was approximately 30%. Although the NIDCR and NIH continue to invest in dental institutions, if the current decline were to continue, it could negatively affect the research conducted at dental institutions. Therefore, we discuss opportunities for dental institutions to increase NIDCR and NIH support and improve their capacity for research, research training, and career development.


Assuntos
Pesquisa em Odontologia/economia , National Institutes of Health (U.S.) , Apoio à Pesquisa como Assunto/estatística & dados numéricos , Pesquisa em Odontologia/educação , Pesquisa em Odontologia/organização & administração , Pesquisa em Odontologia/estatística & dados numéricos , Educação em Odontologia/economia , Educação em Odontologia/organização & administração , Humanos , National Institute of Dental and Craniofacial Research (U.S.)/economia , National Institute of Dental and Craniofacial Research (U.S.)/organização & administração , National Institutes of Health (U.S.)/economia , National Institutes of Health (U.S.)/organização & administração , Apoio à Pesquisa como Assunto/economia , Apoio à Pesquisa como Assunto/organização & administração , Estados Unidos
8.
J Dent Res ; 96(1): 17-22, 2017 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-28033064

RESUMO

The objectives were to characterize oral cavity cancer (OCC) funding from the National Institutes of Health (NIH) with a secondary aim of comparing NIH support provided to OCC and other malignancies. NIH awards supporting OCC inquiry from 2000 to 2014 were accessed from the NIH RePORTER database. These data were used to evaluate temporal trends and the role of human papilloma virus and to determine the academic training and professional profiles of the principal investigators. Comparison of 2014 funding levels with other malignancies was also performed, controlling for incidence. Overall funding totals decreased considerably after 2009. Funding administered through the National Institute of Dental and Craniofacial Research (NIDCR) was 6.5 times greater than dollars awarded by the National Cancer Institute in 2000. During the period evaluated, NIDCR support decreased in most years, while National Cancer Institute support increased and approached NIDCR funding levels. Funding for human papilloma virus-related projects gradually rose, from 3.4% of dollars in 2000 to 2004 to 6.2% from 2010 to 2014 ( P < 0.05). A majority of principal investigators had a PhD omnia solus (57%), and 13% possessed dual PhD/clinical degrees. Among clinicians with specialty training, otolaryngologists and oral/maxillofacial pathologists garnered the most funding. OCC had a 2014 funding:incidence ratio of $785, much lower than for other malignancies. There has been increased volatility in funding support in recent years possibly due to budget cuts and sequestration. The National Cancer Institute has played an increasingly important role in supporting OCC research, concomitant with decreasing NIDCR support. Our findings suggest that OCC is underfunded relative to other non-oral cavity malignancies, indicating a need to increase the focus on rectifying the disparity.


Assuntos
Pesquisa Biomédica/economia , Neoplasias Bucais/economia , Apoio à Pesquisa como Assunto/economia , Pesquisa Biomédica/estatística & dados numéricos , Humanos , National Cancer Institute (U.S.)/economia , National Cancer Institute (U.S.)/organização & administração , National Cancer Institute (U.S.)/estatística & dados numéricos , National Institute of Dental and Craniofacial Research (U.S.)/economia , National Institute of Dental and Craniofacial Research (U.S.)/organização & administração , National Institute of Dental and Craniofacial Research (U.S.)/estatística & dados numéricos , National Institutes of Health (U.S.)/economia , National Institutes of Health (U.S.)/organização & administração , National Institutes of Health (U.S.)/estatística & dados numéricos , Apoio à Pesquisa como Assunto/estatística & dados numéricos , Estados Unidos
9.
J Public Health Dent ; 77(1): 63-77, 2017 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-27759164

RESUMO

OBJECTIVES: To identify successful strategies for retention of participants in multiyear, community-based randomized controlled trials (RCTs) aiming to reduce early childhood caries in health disparities populations from diverse racial/ethnic backgrounds and across diverse geographic settings. METHODS: Four RCTs conducted by the Early Childhood Caries Collaborating Centers (EC4), an initiative of the National Institute of Dental and Craniofacial Research, systematically collected information on the success of various strategies implemented to promote participant retention in each RCT. The observational findings from this case series of four RCTs were tabulated and the strategies rated by study staff. RESULTS: Participant retention at 12 months of follow-up ranged from 52.8 percent to 91.7 percent, and at 24 months ranged from 53.6 percent to 85.9, across the four RCTs. For the three RCTs that had a 36-month follow-up, retention ranged from 53.6 percent to 85.1 percent. Effectiveness of different participant retention strategies varied widely across the RCTs. CONCLUSIONS: Findings from this case series study may help to guide the design of future RCTs to maximize retention of study participants and yield needed data on effective interventions to reduce oral health disparities.


Assuntos
Cárie Dentária/prevenção & controle , Cooperação do Paciente/estatística & dados numéricos , Criança , Pré-Escolar , Pesquisa Participativa Baseada na Comunidade , Cárie Dentária/epidemiologia , Cárie Dentária/etnologia , Etnicidade , Feminino , Disparidades nos Níveis de Saúde , Humanos , Lactente , Masculino , National Institute of Dental and Craniofacial Research (U.S.) , Seleção de Pacientes , Ensaios Clínicos Controlados Aleatórios como Assunto , Estados Unidos/epidemiologia
15.
Prev Chronic Dis ; 11: E133, 2014 Aug 07.
Artigo em Inglês | MEDLINE | ID: mdl-25101490

RESUMO

BACKGROUND: Four trials of interventions designed to prevent early childhood caries are using community-engagement strategies to improve recruitment of low-income, racial/ethnic minority participants. The trials are being implemented by 3 centers funded by the National Institute of Dental and Craniofacial Research and known as the Early Childhood Caries Collaborating Centers (EC4): the Center for Native Oral Health Research at the University of Colorado, the Center to Address Disparities in Children's Oral Health at the University of California San Francisco, and the Center for Research to Evaluate and Eliminate Dental Disparities at Boston University. COMMUNITY CONTEXT: The community contexts for the EC4 trials include urban public housing developments, Hispanic communities near the US-Mexican border, and rural American Indian reservations. These communities have a high prevalence of early childhood caries, suggesting the need for effective, culturally acceptable interventions. METHODS: Each center's intervention(s) used community-based participatory research approaches, identified community partners, engaged the community through various means, and developed communication strategies to enhance recruitment. OUTCOME: All 3 centers have completed recruitment. Each center implemented several new strategies and approaches to enhance recruitment efforts, such as introducing new communication techniques, using media such as radio and newspapers to spread awareness about the studies, and hosting community gatherings. INTERPRETATION: Using multiple strategies that build trust in the community, are sensitive to cultural norms, and are adaptable to the community environment can enhance recruitment in underserved communities.


Assuntos
Ensaios Clínicos como Assunto , Cárie Dentária/prevenção & controle , Disparidades em Assistência à Saúde , Seleção de Pacientes , Centros Médicos Acadêmicos , Boston , Criança , Pré-Escolar , Colorado , Pesquisa Participativa Baseada na Comunidade , Relações Comunidade-Instituição , Comportamento Cooperativo , Cárie Dentária/diagnóstico , Cárie Dentária/epidemiologia , Pesquisa em Odontologia/organização & administração , Etnicidade , Feminino , Acesso aos Serviços de Saúde , Disparidades nos Níveis de Saúde , Humanos , Masculino , Grupos Minoritários , National Institute of Dental and Craniofacial Research (U.S.) , São Francisco , Estados Unidos
17.
J Mass Dent Soc ; 62(4): 14-23, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24624585

RESUMO

Over the last century and a half, the Massachusetts Dental Society (MDS) has evolved from a small group of dentists meeting to share knowledge into a complex, well-functioning organization of nearly 5,000 dentists that meets the needs of its members, as well as those of the general population. Its mission is dedicated to "improving the oral health of the public and professional development of its membership through initiatives in education, advocacy and promotion of the highest professional standards." What began as a small group of dentists has evolved into a large, effective body that has endeavored to better the practice of dentistry and improve the oral health of residents in the Commonwealth. And in 2014, the MDS is celebrating its Sesquicentennial.


Assuntos
Sociedades Odontológicas/história , Odontólogas/história , Educação em Odontologia/história , História do Século XIX , História do Século XX , História do Século XXI , Humanos , Massachusetts , National Institute of Dental and Craniofacial Research (U.S.)/história , Sociedades Odontológicas/organização & administração , Estados Unidos
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