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2.
West Indian med. j ; 44(Suppl. 3): 15, Nov. 1995.
Artigo em Inglês | MedCarib | ID: med-5078

RESUMO

Lymphadenopathy is a common clinical problem with an often diverse differential diagnosis. To determine if fine needle aspiration cytology (FNAC) can provide an accurate and reliable diagnosis of malignancy related lymphadenopathy, the records of 328 patients examined by a single cytopathologist were retrieved for analysis. One hundred and seventy-seven (54 percent) were deemed "reactive," 14 (4.3 percent) were unsatisfactory and 91 (27.7 percent) were positive for malignancy. Of the positives, 35 (38.5 percent) were malignant lymphomas. The diagnosis of malignancy was confirmed in 88 (95.7 percent) ofaspirates; 3 (4.5 percent) were deemed false positive using strict criteria. Typing accuracy of malignant lymphomas was 71 percent and for other forms of malignancy the accuracy was 98 percent. The positive predictive value was 97 percent. The results demonstrate that FNAC can provide a reliable diagnosis of malignancy and malignant lymphomas can be fairly reliably typed by this technique (AU)


Assuntos
Humanos , Linfonodos , Biópsia por Agulha , Excisão de Linfonodo , Linfoma
3.
Br J Haematol ; 89(3): 615, Mar. 1995.
Artigo em Inglês | MedCarib | ID: med-5892

RESUMO

We describe two siblings who developed adult T-cell leukaemia lymphoma (ATLL) within 4 years. Both were black of Afro-Caribbean extraction, but one had been born in the United Kingdom and had visited the Caribbean only once. Both patients were HTLV-1 seropositive, as was their mother; their father and brother were negative. The older siblings had the lymphoma form of ATLL, whilst the younger had chronic ATLL. The former was unresponsive to chemotherapy and died of progressive disease; the latter chemotherapy and died of progressive disease; the latter experienced transient responses to various treatments and is alive 5 years after presentation. Immunophenotyping showed a CD4+, CD25+ phenotype; Southern blot demonstrated a monoclonal integration of HTLV-I in the tissues involved. This report, of the first familial ATLL in the U.K., supports the suggestion of transmission of HTLV-I from mother to child and documents and the development of ATLL in second-generation Caribbean immigrants (AU)


Assuntos
Relatos de Casos , Humanos , Masculino , Feminino , Leucemia-Linfoma de Células T do Adulto/transmissão , Transmissão Vertical de Doenças Infecciosas , Antígenos CD4/sangue , Negro ou Afro-Americano , Saúde da Família , Leucemia-Linfoma de Células T do Adulto/etnologia , Leucemia-Linfoma de Células T do Adulto/patologia , Linfonodos/patologia , Linhagem , Receptores de Interleucina-2/análise , Trinidad e Tobago/etnologia
4.
Hum Pathol ; 25(10): 1101-6, Oct. 1994.
Artigo em Inglês | MedCarib | ID: med-2085

RESUMO

We studied a 58 year old black women from Barbados who simultaneously developed myelopathy and lymphoma with human T-lymphotropic virus type I (HTLV-I) antibodies in serum and cerebrospinal fluid and died 3 years after onset. Neuropathological examination showed typical tropical spastic paraparesis (TSP). The polymerase chain reaction (PCR) demonstrated defective proviral genome retaining the HTLV-I pX and env regions in thoracic spinal cord, the level most severely affected. Defective HTLV-I in the nervous system retaining the pX region may be relevant to pathogenesis because circulating CD8+ cytotoxic lymphocytes specific for HTLV-I pX occur in HTLV-I myelopathy. This patient's lymph node biopsy specimen was consistent with Hodgkin's disease (HD), nodular sclerosis subtype, of B-cell origin. The PCR in the paraffin-embedded lymph node involved by HD failed to amplify HTLV-I proviral sequences. Complete HTLV-I proviral amplification was obtained in paraffin-embedded lymph node form positive controls (adults T-cells leukemia). To our knowledge the association of TSP and HD has not been reported previously. Despite claims the HD may be associated with HTLV-I, we demonstrated absence of HTLV-I infected T-cell in the lymphoid infiltrate of HD in this case, positive HTLV-I serology notwithstanding.(AU)


Assuntos
Feminino , Humanos , Pessoa de Meia-Idade , Relatos de Casos , Doença de Hodgkin/virologia , Vírus Linfotrópico T Tipo 1 Humano/isolamento & purificação , Paraparesia Espástica Tropical/virologia , Medula Espinal/virologia , DNA Viral/genética , DNA Viral/isolamento & purificação , Doença de Hodgkin/complicações , Doença de Hodgkin/patologia , Vírus Linfotrópico T Tipo 1 Humano/genética , Linfonodos/patologia , Paraparesia Espástica Tropical/complicações , Paraparesia Espástica Tropical/patologia , Medula Espinal/patologia
5.
West Indian med. j ; 41(3): 101-2, Sept. 1992.
Artigo em Inglês | MedCarib | ID: med-15672

RESUMO

The factors surrounding patients subjected to radical vulvectomy were examined. Most patients were over the age of 40 years. The standard butterfly incision was used in all but 2 cases. The histology in all cases was invasive squamous cell carcinoma. The main complications were primary haemorrhage, urinary tract infection and wound dehiscence. The mean hospital stay was 50 days and the mortality rate was 4 percent. (AU)


Assuntos
Humanos , Adulto , Pessoa de Meia-Idade , Feminino , Vulva/cirurgia , Carcinoma de Células Escamosas/cirurgia , Neoplasias Vulvares/cirurgia , Complicações Pós-Operatórias , Linfonodos/cirurgia
6.
West Indian med. j ; 41(Suppl. 1): 23, Apr. 1992.
Artigo em Inglês | MedCarib | ID: med-6470

RESUMO

In a cohort of seronegative mother-infant pairs being studied for perinatal transmission of the human T-lymphotropic virus type (HTLV-I), it was noticed that some infants developed persistent lymphadenopathy for which no specific cause was apparent. In order to determine whether this lymphadenopathy reflected a specific lymphoreticular abnormality, the lymph node pathology was studied, using morphological and immunohistochemical methods. Of 17 infants with lymphadenopathy, 16 were from seropositive mothers. Twenty-four infants (7.0 percent) in the cohort group seroconverted. Only 4 of these were infants with lymphadenopathy. Seroconversion in these tended to occur later than in infants without lymphadenopathy (mean 12 months; range 10 - 18 months). The lymph node histology showed non-specific reactive hyperplasia with a predominance (14/15) of mixed and paracortical hyperplasia. On immunohistochemistry, CD25 staining, characteristic of neoplastic transformation by HTLV-I, was positive in 6/11 cases but without correlation with seropositivity in these infants. This pattern of hyperplasia is unusual in infancy. As in HIV-induced lymphodenopathy, although the changes are not specific, they are sufficiently distinctive, particularly in HTLV-I endemic areas, to warrant serological testing of infants and mothers. The immune reponse without seroconversion appears aberrant. (AU)


Assuntos
Recém-Nascido , Humanos , Gravidez , Feminino , Infecções por HTLV-I/transmissão , Linfonodos/patologia , Troca Materno-Fetal
7.
West Indian med. j ; 39(Suppl. 1): 48, Apr. 1990.
Artigo em Inglês | MedCarib | ID: med-5267

RESUMO

The most common adverse effect of BCG vaccination is regional lymphadenitis, but the treatment of this complication is controversial. A group of 69 patients, with BCG adenitis following vaccination were randomly assigned to receive either "no therapy" or oral erythromycin for one month. Systemic erythromycin therapy caused earlier resolution of the lymph node but failed to prevent progression to abscess formation. Patients who developed subsequent abscesses (36) and another group who had abscess at the time of presentation (27) showed more rapid resolution when treated with single instillation of isoniazid (50mg) into the abscess cavity, compared to oral erythromycin therapy (AU)


Assuntos
Humanos , Criança , Adulto , Vacina BCG , Linfadenite/complicações , Linfonodos/anormalidades , Abscesso
9.
West Indian med. j ; 36(2): 104-7, June 1987.
Artigo em Inglês | MedCarib | ID: med-11650

RESUMO

Multicentric angiofollicular lymph node hyperplasia (MAFH) is a variant of Castleman's disease, localized angiofollicular lymph node hyperplasia. Unlike Castleman's disease, MAFH sometimes runs an aggressive clinical course culminating in death, mainly from infection and rarely from malignant lymphoma. The lymphoma may develop months or years after the onset of MAFH but may be present at the time of diagnosis. In this paper, we present a case of MAFH with co-existing peripheral T-cell lymphoma, in a 59 year-old man who died from disseminated disease. This adds another to the list of five such cases recorded in the literature since the recognition of MAFH (AU)


Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Hiperplasia do Linfonodo Gigante/complicações , Linfonodos/patologia , Linfoma/complicações , Hiperplasia do Linfonodo Gigante/patologia , Linfoma/patologia , Linfócitos T
10.
Scand J Urol Nephrol ; 13(2): 177-83, 1979.
Artigo em Inglês | MedCarib | ID: med-9514

RESUMO

One hundred and thirty-four lymph nodes from forty-seven patients with renal adenocarcinoma and the same number of regional nodes from sixty-one patients with gastric ulcer were evaluated histologically by using the standardized reporting system introduced by Cottier, Turk & Sobin (1973). Special attention was focused on the morphologic features which correlate with the immunological responses of the antibody response were found to be active more often in the ulcer series than in the cancer series. On the other hand, the constituents of the cell-mediated immune system were depressed more often in the nodes draining renal carcinomas. The significance of the different immune responses evoked by these two diseases is discussed and the conclusion is drawn that there is some degree of derangement of both humorlal and cell-mediated immune systems in the regional lymph nodes of renal adenocarcinoma. The applicability of the reporting system used in assessing the morphology of human lymph nodes is to be emphasized.(AU)


Assuntos
Humanos , Adenocarcinoma/patologia , Neoplasias Renais/patologia , Linfonodos/patologia , Úlcera Gástrica/patologia , Adenocarcinoma/imunologia , Neoplasias Renais/imunologia , Linfonodos/imunologia , Linfócitos/imunologia , Linfócitos/patologia , Estadiamento de Neoplasias , Úlcera Gástrica/imunologia
11.
Bull Pan Am Health Organ ; 12(1): 51-4, 1978.
Artigo em Inglês | MedCarib | ID: med-12666

RESUMO

An unusual outbreak of gastroenteritis among children in Trinidad and Tobago led to the investigation of porcine carcasses at a local abattoir. Salmonella organisms were isolated from 18.4 per cent of the samples taken over a 12-month period (AU)


Assuntos
Humanos , Criança , 21003 , Infecções por Salmonella , Suínos/microbiologia , Doenças dos Suínos/epidemiologia , Surtos de Doenças , Gastroenterite/microbiologia , Gastroenterite/veterinária , Linfonodos/microbiologia , Mesentério/microbiologia , Infecções por Salmonella/transmissão , Salmonella/isolamento & purificação , Sorotipagem , Trinidad e Tobago , Índias Ocidentais
12.
Semin Hematol ; 9(3): 1-4, July 1972.
Artigo em Inglês | MedCarib | ID: med-9557

RESUMO

Nine patients had a syndrome characterized by the presence of a sea-blue histiocyte and splenomegaly. Lipid analysis of liver from the most recent patient revealed accumulations of specific glycosphingolipids and phospholipids. Urinary mucopolysaccharide excretion was increased, and there was a suggestion of mucopolysaccharide storage in the hepatic parenchymal cells. Clinically, patients with the disease may have a relatively benign course, with mild purpura secondary to thrombocytopenia, or may have progressive hepatic cirrhosis, hepatic failure and death. The name "syndrome of the sea-blue histiocyte," the striking morphologic feature of the disease, is suggested for these cases (AU)


Assuntos
Humanos , Adulto , Masculino , Feminino , Histiócitos , Doenças Linfáticas , Grânulos Citoplasmáticos/análise , Manifestações Oculares , Fundo de Olho , Glicolipídeos/análise , Histiócitos/análise , Fígado/patologia , Linfonodos/patologia , Glicosaminoglicanos/urina , Fosfolipídeos/análise , Doenças Linfáticas/diagnóstico , Doenças Linfáticas/genética , Baço/patologia
14.
Am J Clin Pathol ; 48(4): 396-400, Oct. 1967.
Artigo em Inglês | MedCarib | ID: med-12423

RESUMO

A case of histiocytic medullary reticulosis in an 18-year-old East Indian man is presented. To our knowledge, this is the youngest case to have been reported and the first described in an East Indian. The diagnosis was established at autopsy. The patient presented the typical clinical picture of a rapidly progressive illness of 5 weeks' duration, with fever, wasting, hepatosplenomegaly, lymphadenopathy, and pancytopenia. An intresting hematologic finding, hitherto unreported, was erythrophagocytosis by atypical mononuclear cells in the peripheral blood. The histopathologic picture was charecterized by proliferation of erythrophagocytic histiocytes and thier precursors in the spleen, bone marrow, liver, and lymph nodes. The most severe changes were observed in the spleen and the bone marrow. The affected organs demonstrated iron deposits, most marked in the Kupffer cells of the liver. (AU)


Assuntos
Humanos , Adolescente , Masculino , Doenças Linfáticas , Doenças da Medula Óssea , Hepatopatias , Linfonodos , Esplenopatias
15.
Br J Surg ; 46(199): 449-53, 1959.
Artigo em Inglês | MedCarib | ID: med-14543

RESUMO

The seventh case of solitary plasmocytoma of the stomach is reported. It is suggested that in this case and possibly in others the tumor arose as a rare type of malignant change in a chronic peptic ulcer. The literature on extramedullary plasmocytoma of the gastro-intestinal tract is reviewed (Summary)


Assuntos
Humanos , Pessoa de Meia-Idade , Masculino , Plasmocitoma/patologia , Plasmocitoma/cirurgia , Neoplasias Gástricas , Plasmocitoma/sangue , Linfonodos/patologia , Causas de Morte , Mieloma Múltiplo/etiologia , Jamaica
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