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1.
Veterinary parasitology ; 166(1-2): 119-123, Dec. 2009. tab, graf
Artigo em Inglês | MedCarib | ID: med-17638

RESUMO

Haemonchus contortus is one of the most important parasites that infects sheep and exerts its pathogenic effects by sucking blood, causing disturbances of organ-functions and thus inducing alterations in various normal physiological parameters. Changes in live body weight, faecal egg count, kinetics of circulating eosinophils and PCV value were studied at weekly interval for a period of 84 days in 18 lambs of local breed after infection with a single dose of 5000 H. contortus (L(3)). In the two groups of lambs infected with nematodes both non-treated and treated with ivermectin (HcNT and HcIT), similar egg excretion patterns was observed starting from third week after infection, with a regular increase in FEC. Examination of whole abomasum of each animal revealed no developmental stage of nematode from treated and control lambs on day 84. The total mean number of H. contortus worms recovered at necropsy from abomasa of untreated infected lambs (group HcNT) was 2576.2 (+/-221.0). The significant loss of body weight, development of heavy worm burden and severe anaemia as indicated by reduced PCV in untreated infected lambs indicated high susceptibility of the lambs to H. contortus. On the other hand, complete absence of the parasite, improved PCV value and body weight after treatment of infected animals (HcIT) proved 100% efficacy of ivermectin against H. contortus.


Assuntos
Animais , Eosinófilos , Anemia , Haemonchus , Doenças dos Ovinos/tratamento farmacológico , Doenças dos Ovinos/fisiopatologia , Doenças dos Ovinos/parasitologia , Ovinos
2.
Int J Epidemiol ; 25(5): 1090-7, Oct. 1996.
Artigo em Inglês | MedCarib | ID: med-2088

RESUMO

BACKGROUND: Other than adult T-cell leukaemia (ATL) and HTLV-I associated myelopathy (HAM), the health effects of infection with human T-lymphotropic virus type I (HTLV-I) are not well defined. METHOD: A cohort of 201 confirmed HTLV-I seropositive Jamaican food service workers and 225 seronegative controls of similar age and sex from the same population was examined. A health questionnaire, physical examination, and laboratory tests were performed at enrollment into the cohort in 1987-1988. RESULTS: One of 201 HTLV-I seropositives, but no controls were diagnosed with HAM, for a prevalence of 0.5 percent (95 percent confidence interval) (CI) 0.01-2.7 percent); no cases of ATL were diagnosed. While there was no difference in current symptoms, the HTLV-I seropositive group was more likely to report a past medical history of hepatitis or jaundice (OR = 3.49, 95 percent CI: 0.93-13.08), malaria (OR = 2.13, 95 percent CI: 0.96-4.73), and dengue fever (OR = 1.37, 95 percent CI 0.82-2.29); however, these differences were of borderline statistical significance. Low income HTLV-I seropositive women had lower body weight (P , 0.01) and body mass index (P < 0.009) than their seronegative counterparts; similar differences were seen in the smaller male group. A trend toward higher prevalence of severe anaemia (haemoglobin < 10 g/dl) (12.6 percent verus 7.7 percent, P < 0.105) and a significantly lower prevalence of eosinophilia (1.0 percent verus 6.3 percent, P < 0.004) was seen among HTLV-I seropositives are asymptomatic, HAM may be diagnosed in approximately 0.5 percent of carriers. Chronic HTLV-I infection may also subtle effects on body mass and haematological parameters.(AU)


Assuntos
Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Paraparesia Espástica Tropical/complicações , Anemia/sangue , Anemia/epidemiologia , Anemia/etiologia , Eosinofilia/sangue , Eosinofilia/epidemiologia , Eosinofilia/etiologia , Eosinófilos/imunologia , Jamaica/epidemiologia , Contagem de Leucócitos , Paraparesia Espástica Tropical/sangue , Paraparesia Espástica Tropical/epidemiologia , Prevalência , Estudos Prospectivos , Fatores de Risco
3.
Am J Trop Med Hyg ; 26(5): 909-16, Sept. 1977.
Artigo em Inglês | MedCarib | ID: med-14394

RESUMO

Plasma samples from St. Lucians were tested for the presence of antibodies which cooperate in vitro with normal human luekocytes in causing cytotoxic damage to schistosomula of Schistosoma mansoni. The in vitro antibody activity, which has been previosly shown to depend on eosinophil effector cells was detected in 56 percent of the individuals with known, current S. mansoni infections and in 14 percent of control subjects from the same endemic area. Quantitatively, eosinophil dependent cytoxic antibody (EDCA) activity, when expressed as the maximum amount of damage to schistosomula induced at high plasma concentration, correlated significantly with the intensity of S.mansoni infection as detemined by fecal egg count, the highest levels of activity occuring in patients with stool counts of 60 eggs/ml or greater. In addition, plasma ECDA activity was found to correlate with the in vitro blastogenic responsiveness of patients' lympjocytes to three different parasite antigen preparations. In contrast, titrations of ECDA activity failed to reveal a relationship between ECDA titer and the most recent egg count performned on each subjects. However, a significant correlation was observed when titers were compared to egg counts averaged over a 3-year period. Neither maximal ECDA activity nor titer was found to correlate with the duration of known schistosome infection (AU)


Assuntos
Humanos , Anticorpos/análise , Testes Imunológicos de Citotoxicidade , Eosinófilos/imunologia , Ativação Linfocitária , Schistosoma mansoni , Fatores de Tempo , Santa Lúcia
4.
Br J Dis Chest ; 68: 202-6, July 1974.
Artigo em Inglês | MedCarib | ID: med-8776

RESUMO

The clinical, radiological and pathological features of fibroxanthomatous pseudotumour of the lung in a 17-year-old Jamaican female Negro are described. The patient was symptom-free 4 years after treatment by conservative surgery. The condition is extremely rare. Its aetiology and pathogenesis are discussed. (Summary)


Assuntos
Humanos , Adolescente , Feminino , Fibroma , Neoplasias Pulmonares , Peso Corporal , Brônquios/patologia , Broncografia , Núcleo Celular , Colágeno/análise , Tosse/etiologia , Citoplasma , Eosinófilos , Fibroma/diagnóstico , Fibroma/patologia , Fibroma/cirurgia , Hemoptise/etiologia , Histiócitos , Pulmão/patologia , Pulmão/diagnóstico por imagem , Neoplasias Pulmonares/cirurgia , Linfócitos , Plasmócitos , Tomografia
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