RESUMO
Four cases of sinus histiocytosis fulfilling the clinico-pathological requirements laid down by Rosai and Dorfman are reported. This benign disease is characterized by massive lymphadenopathy especially in the cervical region and pathologically by enlargement of lymph node sinuses by phagocytic histiocytes. The disease is self-limiting, regressing over a variable period of time from months to years. These four cases and the six reported by Rosai and Dorfman are, to our knowledge, the total number of cases reported in the West Indies to date (AU)
Assuntos
Adolescente , Adulto , Pré-Escolar , Feminino , Humanos , Masculino , Histiócitos/patologia , Linfadenite/patologia , Doenças Linfáticas/patologia , Diagnóstico Diferencial , Linfadenite/diagnóstico , Doenças Linfáticas/diagnóstico , JamaicaRESUMO
The clinical, radiological and pathological features of fibroxanthomatous pseudotumour of the lung in a 17-year-old Jamaican female Negro are described. The patient was symptom-free 4 years after treatment by conservative surgery. The condition is extremely rare. Its aetiology and pathogenesis are discussed. (Summary)
Assuntos
Humanos , Adolescente , Feminino , Fibroma , Neoplasias Pulmonares , Peso Corporal , Brônquios/patologia , Broncografia , Núcleo Celular , Colágeno/análise , Tosse/etiologia , Citoplasma , Eosinófilos , Fibroma/diagnóstico , Fibroma/patologia , Fibroma/cirurgia , Hemoptise/etiologia , Histiócitos , Pulmão/patologia , Pulmão/diagnóstico por imagem , Neoplasias Pulmonares/cirurgia , Linfócitos , Plasmócitos , TomografiaRESUMO
Nine patients had a syndrome characterized by the presence of a sea-blue histiocyte and splenomegaly. Lipid analysis of liver from the most recent patient revealed accumulations of specific glycosphingolipids and phospholipids. Urinary mucopolysaccharide excretion was increased, and there was a suggestion of mucopolysaccharide storage in the hepatic parenchymal cells. Clinically, patients with the disease may have a relatively benign course, with mild purpura secondary to thrombocytopenia, or may have progressive hepatic cirrhosis, hepatic failure and death. The name "syndrome of the sea-blue histiocyte," the striking morphologic feature of the disease, is suggested for these cases (AU)
Assuntos
Humanos , Adulto , Masculino , Feminino , Histiócitos , Doenças Linfáticas , Grânulos Citoplasmáticos/análise , Manifestações Oculares , Fundo de Olho , Glicolipídeos/análise , Histiócitos/análise , Fígado/patologia , Linfonodos/patologia , Glicosaminoglicanos/urina , Fosfolipídeos/análise , Doenças Linfáticas/diagnóstico , Doenças Linfáticas/genética , Baço/patologiaRESUMO
Two young Jamaican women of Chinese descent with idiopathic thrombocytopenic purpura were found to have lipid-laden histiocytes in their spleens; their condition has improved following splenectomy. The electron microscopic appearances of the spleens suggest that platelet destruction contributed to the accumulation of lipid (AU)
