RESUMO
This paper records for the first time the exocrine pancreatic response to scorpion venom, in this case that of Tityus trinitatia, a scorpion endemic in Trinidad. The crude venom injected intravenously into fasting anaethetised dogs induced a secretion of the exocrine pancreas. The secretion evoked was rich in enzyme (AU)
Assuntos
Cães , 21003 , Escorpiões , Pâncreas/efeitos dos fármacos , Pâncreas/enzimologia , Suco Pancreático/enzimologia , Suco Pancreático/metabolismo , Peçonhas , Amilases/metabolismo , Lipase/metabolismo , Tripsina/metabolismo , Trinidad e TobagoAssuntos
21003 , Feminino , Ratos , Técnicas In Vitro , Pâncreas/efeitos dos fármacos , Escorpiões , Peçonhas , Amilases/metabolismo , Pâncreas/metabolismoRESUMO
This study examined the action of the venom of the scorpion Tityus trinitatis on the pancreas and gastrointestinal tract in anaesthetized dogs, on the isolated extracorporeal haemoperfused canine pancreas and on the isolated canine sphincter of Oddi. The venom induces exocrine secretion in both the isoslated and intact pancreas and causes contraction of the isolated sphincter of Oddi. These results are discussed in relation to the pathogenesis of acute scorpion pancreatitis and possibly of some other forms of acute pancreatitis. (Summary)
Assuntos
21003 , Cães , Humanos , Pancreatite/etiologia , Peçonhas/toxicidade , Doença Aguda , Amilases/sangue , /efeitos dos fármacos , Esfíncter da Ampola Hepatopancreática/efeitos dos fármacos , Pâncreas/metabolismo , Ductos Pancreáticos/efeitos dos fármacos , Secretina/administração & dosagem , Trinidad e TobagoRESUMO
Over a two-month period 30 patients were admitted to hospital following stings of the scorpion of Trinidad, the tityus trinitatis. In 24 cases acute pancreatitis developed soon after the sting, but in nine of these no abdominal pain occurred. All the patients made an uneventful recovery. Although such complications have been reported no pseudocyst formations or acute haemorrhagic pancreatitis occurred in this series (AU)
