RESUMO
An attempt was made to indicate the neuropharmalogical relationship between Parkinson's disease, Huntington's chorea, tardive dyskinesia and Attentional Deficit Disorder. In the case of the latter, an experimental model has been prersented indicating cholinergic dysfunction in the nigro-striatal pathway. Postulates are proposed which will enable us to understand the many factors responsible for these clinical states. (AU)
Assuntos
Humanos , Animais , Ratos , Doença de Huntington/fisiopatologia , Transtornos Motores/fisiopatologia , Doenças do Sistema Nervoso/fisiopatologia , Anfetamina/administração & dosagem , Transtorno do Deficit de Atenção com Hiperatividade/fisiopatologia , Aprendizagem da Esquiva/efeitos dos fármacos , Cérebro/efeitos dos fármacos , Inibidores da Colinesterase/efeitos adversos , Discinesia Induzida por Medicamentos/fisiopatologia , Ácido gama-Aminobutírico/fisiologia , Hipercinese/etiologia , Modelos Neurológicos , Neurotransmissores/fisiologia , Doença de Parkinson/fisiopatologia , Fisostigmina/administração & dosagem , Jamaica , Antipsicóticos/efeitos adversosRESUMO
Huntington's Chorea is a distressing and fatal hereditary condition which is more prevalent in the Caribbean than we have been wont to think. Its hereditary associations are mental deficiency, aggressive psychopathy, alcoholism and other mental illnesses. Patients are of high fecundity and, with widespread promiscuity, it may pose an ever-increasing problem in our islands. It is desirable that the condition be recognised early when it occurs and that steps be taken to prevent its spread by eugenic advice to members of afflicted families and admissions of advanced cases to a mental hospital or other institutions. Three families have been presented, one East Indian and the other two of mixed Negro and White ancestry, showing an unbroken line of transmission, in two instances through four generations. One of the families has been traced to the poor-white settlement of Mt. Moritz in Grenada. Cases are to be found in Trinidad in Patna Valley, Diego Martin; in St. James; and in Bourg Mulatresse, Santa Cruz. There are offshoots of the Santa Cruz family also in Rio Claro (AU)
Assuntos
Humanos , Adulto , Masculino , Feminino , Doença de Huntington/diagnóstico , Doença de Huntington/tratamento farmacológico , Doença de Huntington/epidemiologia , Doença de Huntington/etiologia , Doença de Huntington/genética , Trinidad e TobagoRESUMO
This distressing and fatal hereditary condition is more prevalent in the Caribbean than is thought. Its hereditary associations are mental deficiency, aggressive psychopathy, alcoholism and other mental illnesses. There is a high fecundity rate and steps to prevent its spread should include eugenic advice and admission of advanced cases to hospital. Data on 3 family pedigrees is presented, one East Indian and the other two of mixed negro and white ancestry, showing an unbroken line of transmission, in 2 instances through 4 generations (AU)
