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1.
West Indian med. j ; 33(Suppl): 30, 1984.
Artigo em Inglês | MedCarib | ID: med-6083

RESUMO

No data have been reported on surface marker studies on haematological malignancies in the Commonwealth Caribbean. Surface marker studies were performed on 14 patients with non-Hodgkin's lymphoma (NHL) and eleven patients with chronic lymphocytic leukaemia (CLL) using rosetting and immunofluorescent techniques on lymphocytes separated by a density gradient flotation method. Twelve of the 14 NHL patients had T-cell disease, indicating that the cell origin of NHL in Jamaica differs from that reported in North America or Europe, where B-cell disease predominates. Nine of 11 were HTLV-antibody-positive, suggesting that they had adult T-cell leukaemia/lymphoma. Ten of the 11 CLL patients had B-Cll, similar to findings elsewhere. However, the frequency of HTLV-antibody-positivity was unexpectedly high in this group (35 percent) and a virus has been isolated from the T-cells of one of the B-CLL patients (AU)


Assuntos
Humanos , Transtornos Linfoproliferativos , Antígenos de Superfície , Jamaica
2.
West Indian med. j ; 32(Suppl): 19, 1983.
Artigo em Inglês | MedCarib | ID: med-6154

RESUMO

The human T-cell leukemia/lymphoma virus (HTLV) is a type-C retrovirus recently isolated from patients with adult T-cell lymphoma. The prevalence of viral infection was determined in patients attending the Hematology Clinic at the University Hospital of the West Indies by using a radioimmunoassay for HTLV antigen and a radioimmune precipitation assay for the viral core antigen (A Antigen). Antibody has been detected in 7 of the first 40 patients tested - 3/8 with non-Hodgkin's lymphoma (NHL); 3/9 with chronic lymphocytic leukemia (CLL); and the only patient in the group who had acute lymphoblastic leukemia (ALL). The tests were negative in 4 patients with myeloma; 4 with pernicious anemia and 14 other patients with a variety of other disorders. The three patients with NHL had lymphadenopathy and hepatomegaly on presentation. Two had splenomegaly and one had skin involvement. Two were hypercalcaemic at presentation and the third became hypercalcaemic soon after admission. Large cells with abundant cytoplasm and convoluted nuclei predominated in the blood of two patients in whom bone marrow infiltration was also demonstrable. The histological appearances varied, but large non-cleave cells predominated. Survival was short (two weeks to one month) and there was poor response to chemotherapy. The HTLV-positive patients who had CLL and ALL showed clinical and hematological features typical of these disorders. Further work is being done to try to define more clearly the role of this viruse in causing lymphoproliferative disorders (AU)


Assuntos
Humanos , Vírus Linfotrópico T Tipo 1 Humano , Leucemia-Linfoma de Células T do Adulto , Transtornos Linfoproliferativos
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