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2.
Exp Pathol Jena ; 9(1-2): 59-63, 1974.
Artigo em Inglês | MedCarib | ID: med-7814

RESUMO

The pyrrolizidine alkaloids are naturally-occurring plants toxins which are considered significant in the etiology of certain liver diseases, particularly in some tropical and sub-tropical regions. Fulvine, a hepatotoxic alkloid present in the medicinal herb Crotolaria fulva, was observed to be fetotoxic and highly teratogenic in rats. The occurrence of fetal resorptions showed a dose-effect relationship. The highest incidence of developmental defects was induced by fulvine at a dose-level of 80 mg/kg which in other studies produced significant chromosomal damage. Microscopic examination of fetal liver, following maternal exposure of fulvine, did not reveal hepatic lesions.(Summary)


Assuntos
Ratos , 21003 , Anormalidades Induzidas por Medicamentos/etiologia , Fissura Palatina/induzido quimicamente , Extremidades/anormalidades , Feto/efeitos dos fármacos , Idade Gestacional , Hidrocefalia/induzido quimicamente , Rim/anormalidades , Gravidez
3.
Exp Pathol ; 6(1): 55-8, 1972.
Artigo em Inglês | MedCarib | ID: med-15806

RESUMO

Hypoglycin B, a toxic hypoglycaemic constituent contained in the seed of the plant, Blighia sapida, is highly teratogenic in the rat when administering intra-amniotically on day 14 of gestation. Major foetal abnormalities comprise malformations of the cranio-facial region and of the limbs. (summary)


Assuntos
Ratos , 21003 , Feminino , Anormalidades Induzidas por Medicamentos/epidemiologia , Feto/crescimento & desenvolvimento , Nozes , Propionatos/efeitos adversos , Aminoácidos/administração & dosagem , Aminoácidos/efeitos adversos , Âmnio/efeitos dos fármacos , Feto/efeitos dos fármacos , Extratos Vegetais/administração & dosagem , Extratos Vegetais/efeitos adversos , Plantas , Gravidez , Propionatos/administração & dosagem
5.
Kingston; s.n; Dec. 1969. 166 p. ills, tab.
Tese em Inglês | MedCarib | ID: med-13667

RESUMO

Hypoglycin-A is a toxic, non-proteinogenic amino acid of considerable biochemical interest. It is obtained fron the fruit of Blighia sapida K., and is the causative factor of the Jamaican "vomiting sickness". The toxicity of hypoglycin-A is attributed to the formation of a metabolic methylenecycclopropaneacetic acid which inhibits the oxidation of long-chain fatty acids. Hypoglycin-A induced in pregnant rats a significantly high incidence of congenital abnormalities and reabsorption. It did not reduce the fertility in mice, malformations were absent and only a small increase in reabsorption sites was observed after the adminstration of large doses. Hypoglycin-A administered to pregnant rabbits resulted in a high incidence of foetal reabsorption and overall stunting. Injected into the yolk sac of 24 and 48 hour chick embryos, hypoglycin-A was not teratogenic. Leucine, administered to pregnant rats simutaneously with hypoglycin-A, afforded no protection against the teratogenic action of hypoglycin-A. Leucine was shown to be highly teratogenic and exaggerated the teratogenicity of riboflavin and hypoglycin-A to pregnant rats the occurrence of congenital abnormalities. Inhibition of long-chain fatty acid oxidation may represent a basic cellular mechanism involved in the teratogenicity of hypoglycin-A, because of its influence on oxidative phosphorylation and the electron transport system. Reversal of the hypoglycin-induced teratogenic effects by riboflavin, suggests that inhibition of the acyl dehydrogenase flavin-dependent-oxidation reaction, occurring during the degradation of fatty acids, is the site of action of hypoglycin-A (AU)


Assuntos
Humanos , Gravidez , Recém-Nascido , Embrião de Galinha , Camundongos , Coelhos , Ratos , Feminino , Hipoglicinas/efeitos adversos , Hipoglicinas/farmacologia , Desenvolvimento Embrionário e Fetal/efeitos dos fármacos , Anormalidades Induzidas por Medicamentos/embriologia , Reabsorção do Feto/embriologia , Leucina/farmacologia , Riboflavina/farmacologia , Teratógenos/farmacologia
6.
Arzneimittelforschung ; 19(8): 1309-10, Aug. 1969.
Artigo em Inglês | MedCarib | ID: med-8034

RESUMO

The teratogenic activity of sodium barital in pregnant mice of the Rockfeller strain was investigated. A high incidence of foetal resorption and congenital malformations were observed following the i.p. administration of the barbiturate. (Summary)


Assuntos
21003 , Ratos , Gravidez , Feminino , Anormalidades Induzidas por Medicamentos , Barbitúricos , Morte Fetal/química , Anoftalmia/química , Barbitúricos/administração & dosagem , Fissura Palatina/química , Hidrocefalia/química , Injeções Intraperitoneais , Crânio , Disrafismo Espinal/química
7.
West Indian med. j ; 18(1): 34-9, Mar. 1969.
Artigo em Inglês | MedCarib | ID: med-10753

RESUMO

The amino acid leucine, administered to pregnant rats during early gestation, induced a high incidence of multiple congenital abnormalities and foetal resorptions. These adverse effects may be accounted for by an imbalance in the amino acid pool, which is available for protein synthesis during embryonic development (AU)


Assuntos
Gravidez , 21003 , Feminino , Anormalidades Induzidas por Medicamentos , Feto/efeitos dos fármacos , Leucina/toxicidade , Aminoácidos/toxicidade , Doenças Fetais/induzido quimicamente
10.
West Indian med. j ; 17(4): 232-4, Dec. 1968.
Artigo em Inglês | MedCarib | ID: med-10743

RESUMO

The resin of cannabis sativa L. (Ganga) exerts teratogenic effects in the rat when it is administered daily, at a dose level of 4.2 mg./kg. body weight on days 1-6 of gestation. The teratogenic effects are manifested in the following ways: a high incidence of malformed foetuses in the litters of treated animals, an increase in the incidence of foetal resorption, and a decrease in foetal weight and size. These results are of particular interest in relation to recent reports on the teratogenicity of another psychotropic drug, LSD (Alexander et al 1967 and Zellweger et al 1967) (AU)


Assuntos
Animais , Ratos , Anormalidades Induzidas por Medicamentos , Cannabis/toxicidade , Prenhez/efeitos dos fármacos
11.
West Indian med. j ; 17(4): 247, Dec. 1968.
Artigo em Inglês | MedCarib | ID: med-7612

RESUMO

Hypoglycin-A, the active principle of the fruit of Blighia sapida (called "ackee" in Jamaica), produced a high incidence of foetal abnormalities in the rat. Prenatal treatment of pregnant rats with hypoglycin-A (30 mg/kg.) daily during the first five days of gestation resulted in 95 percent of the foetuses being retarded in development, syndactyly in 87 percent and encephalocoele in 89 percentof the foetuses. Foetal resorption occurred in 5 percent of all implantations. In order to extend the experience reported above, the teratogenic effect of hypoglycin-A was further investigated in the mouse embryo. Hypoglycin-A did not reduce fertility in the mice. No gross malformations were observed, and even in doses as high as 120 mg/kg., there was only a small increase in resorption sites. The differences in species susceptibility to teratogenesis may be due to particular metabolic pathways involving the formation of toxic metabolites in some species but not in others(AU)


Assuntos
Ratos , Hipoglicinas/efeitos adversos , Anormalidades Induzidas por Medicamentos
12.
West Indian Med. j ; 17(3): 163-5, Sept. 1968.
Artigo em Inglês | MedCarib | ID: med-10657

RESUMO

The embryopathic activity of hypoglycin-A was investigated in the mouse. Hypoglycin-A did not reduce fertility. Only a small increase in resorption sites was observed. Because of the species differencies that occurred in the teratogenic testing of hypoglycin-A, these results are reported in order to demonstrate the difficulties involved in predicting human teratogenicity on the basis of animal experiments (AU)


Assuntos
Feminino , Camundongos , Anormalidades Induzidas por Medicamentos
13.
West Indian med. j ; 17(2): 74-82, June 1968.
Artigo em Inglês | MedCarib | ID: med-10671

RESUMO

The thalidomide disaster and the recent epidemic of rubella in the U.S.A. and in Jamaica have given impetus to intense research in the pathogenesis of congenital abnormalities. Some of the problems here involved are discussed. An account of animal experiments and their relation to human teratology is included (AU)


Assuntos
Embrião de Galinha , Cães , Feminino , Humanos , Recém-Nascido , Camundongos , Coelhos , Ratos , Gravidez , Anormalidades Congênitas , Anormalidades Induzidas por Medicamentos
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