Assuntos
Relatos de Casos , Humanos , Masculino , Adolescente , Assimetria Facial/diagnóstico , Hipertricose/diagnóstico , Nevo Pigmentado/diagnóstico , Anormalidades Dentárias/diagnóstico , Anormalidades Múltiplas/diagnóstico , Neoplasias Cutâneas/diagnóstico , Anormalidades Múltiplas/patologia , Biópsia por Agulha , Diagnóstico Diferencial , Assimetria Facial/patologia , Hipertricose/patologia , Nevo Pigmentado/patologia , Pele/patologia , Neoplasias Cutâneas/patologia , Síndrome , Terminologia , Anormalidades Dentárias/patologia , Trinidad e Tobago/etnologiaRESUMO
A 48-year-old West Indian woman with hypertension sued the district health authority and doctors at the district hospital for negligence in not warning her about adverse effects of minoxidil. The drug had led to excessive hair growth and darkening of the face, causing great distress and limiting her social life.(AU)
Assuntos
Humanos , Pessoa de Meia-Idade , Feminino , Imperícia/legislação & jurisprudência , Minoxidil/efeitos adversos , Educação de Pacientes como Assunto , Hipertensão/tratamento farmacológico , Hipertricose/induzido quimicamente , Minoxidil/administração & dosagem , Transtornos da Pigmentação/induzido quimicamente , Fatores de Risco , Índias OcidentaisRESUMO
We evaluated the antihypertensive efficacy of "once-a-day" minoxidil, given in conjunction with a diuretic and sympatholytic, and the effect of this simple regimen on patient compliance. Twenty-one severely hypertensive patients and their existing antihypertensive regimens changed to a single daily dose of chlorthalidone (50-100mg) and either nadolol (160 mg) or reserpine (.25mg) for a 3-week period. After stabilization on these two drugs, a single daily dose of minoxidil (2.5 mg) was added to each patient's regimen. Doses were titrated as necessary to achieve diastolic blood pressures of <90 mmHg. After 3 and 6 months of maintenance therapy, blood pressures were measured 24 hours after the previous day's dosing to evaluate the persistence of the antihypertensive effect. Twenty-four-hour blood pressure control was achieved on 76 percent of these occasions, and on at least one occasion in 90 percent of the patients. In addition, compliance was excellent (AU)
