Assuntos
Adulto , Relatos de Casos , Humanos , Masculino , Doenças da Unha/etnologia , Doenças da Unha/etiologia , Unhas/patologia , Transtornos de Fotossensibilidade/complicações , Queratinócitos/patologia , Melanócitos/patologia , Doenças da Unha/patologia , Recidiva , Pele/patologia , Índias OcidentaisRESUMO
Of 105 patients diagnosed as lupus erythematosus at the Port-of-Spain General Hospital between 1981 and 1986, 86 satisfied the ARA criteria for the classification of SLE, whilst 19 were clinically and histologically DLE. Fifty-eight SLE patients were of African origin, 24 of Asian origin and 4 were mixed. The ages of onset varied from 14 to 64 years, the majority presented in the 15 to 24-year age group. Of the SLE group, 55 percent had malar rash and 21 percent discoid lesions; this is higher than in the Jamaican study (32 percent and 14 percent respectively). Photosensitivity in the Trinidadian patients (20 percent) and the Jamaican patients (12 percent) was lower than that reported in temperate zones. These differences may be due to genetic and environmental factors. Direct immunofluorrescence (DIF) on 32 biopsies of non-sun esxposed (NSE) skin was characteristic of SLE in 80 percent cases compared to 30 percent by histology. Deposits of IgG, IgA and complement in the NSE skin are associated with a poor prognosis. IgM deposits were found in the NSE skin of 4 DLE patients; this probably represents a transitional phase to SLE, a benign state or a distinct subset of lupus erythematosus. This study confirms that DIF is a far more reliable and sensitive diagnostic tool than histology in the differential diagnosis of SLE and DLE, and in the early detection of SLE (AU)
Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto , Lúpus Eritematoso Sistêmico/complicações , Lúpus Eritematoso Sistêmico/imunologia , Manifestações Cutâneas , Trinidad e Tobago , Transtornos de FotossensibilidadeRESUMO
Photo-allergic dermatitis appeared in the course of a chloroquinized salt anti-malaria campaign (1961-1965), conducted in the least accessible parts of the interior of Guyana, over an area of 42,000 square miles and a population of 48,500. This paper deals with the study of 161 cases. This dermatitis was indentical with thah described in the course of high dose, long term, daily chloroquine treatment of rheumatoid arthritis and lupus erythematosus. The disease disappeared with the conclusion of the campaign (December 1965). During 1966, 2 cases were seen in subjects who were still using chloroquinized salt from hoards accumulated from free issues during 1965. (Summary)
