RESUMO
Data are presented on 13 immunocompromised patients with herpes simplex virus (HSV) infection. Eleven patients had recurrent HSV infection. Eight had genital herpes, 3 had disseminated infection and two had localised extragenital infection. Nine patients had confirmed recurrent HSV-type 2 infection. The benefits of recent antiherpetic therapy in the prevention of recurrent HSV infections in immunocompromised Jamaican patients are discussed (AU)
Assuntos
Adolescente , Adulto , Idoso , Criança , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Herpes Simples/etiologia , Síndromes de Imunodeficiência/complicações , Síndrome de Imunodeficiência Adquirida/complicações , Herpes Simples/microbiologia , Simplexvirus/isolamento & purificação , Fatores de Risco , JamaicaRESUMO
Malnourished children have thymic atrophy which is reversed by zinc supplementation. To see if their defect in cell-mediated immunity was also associated with zinc deficiency ten children were skin-tested with Candida antigen on both arms. One test site was covered with local zinc sulphate and the other with placebo ointment. There was a highly significant increase in the typical delayed-hypersensitivity reaction at the site covered with zinc. The magnitude of the difference between the supplemented and unsupplemented arms correlated negatively with the plasma-zinc concentration. These data show that zinc deficiency is a cause of the immunoincompetence seen in malnutrition. The normal reactions of the zinc-supplemented side indicate that, of the many nutritional deficits of malnourished children, zinc deficiency specifically impairs the cell-mediated immune system. Local skin-testing with and without zinc may provide a measure of zinc status. Local application of zinc may enhanc the reliability of tests to diagnose diseases such as tuberculosis in malnourished patients.(AU)
Assuntos
Humanos , Lactente , Formação de Anticorpos , Síndromes de Imunodeficiência/etiologia , Desnutrição Proteico-Calórica/imunologia , Zinco/deficiência , Antígenos de Fungos , Atrofia , Candida/imunologia , Hipersensibilidade Tardia/diagnóstico , Imunidade Celular , Síndromes de Imunodeficiência/diagnóstico , Testes Cutâneos/métodos , Timo/patologia , Zinco/diagnóstico , Zinco/imunologiaRESUMO
A 33-year-old man with overall renal function in the lower normal range had daily excretion in the urine of between 31 and 70 g. of protein composed entirely of fre monoclonal kappa light chains. Kappa light chains were also present in the serum. Serum protein electrophoresis and findings on bone marrow and lymph node biopsy were diagnostic of light chain disease. Amyloid was absent from renal tissue. General clinical improvement and almost total disappearance of protein from the urine followed treatment with phenylalanine mustard. (AU)
