RESUMO
The intraoperative control of cardiovascular disturbances associated with the resection of phaeochromocytoma is traditionally achieved by the use of deep anaesthesia in conjunction with A and B blockers, calcium antagonists, nitroglycerine or sodium nitroprusside. We report the successful use of magnesium sulphate as adjunctive therapy in the control of the cardiovascular consequences associated with surgical resection of a phaeochromocytoma in a patient.(Au)
Assuntos
Adulto , Relatos de Casos , Feminino , Humanos , Feocromocitoma/cirurgia , Sulfato de Magnésio/uso terapêutico , Complicações Intraoperatórias/tratamento farmacológico , Hipertensão/tratamento farmacológico , Neoplasias das Glândulas Suprarrenais/cirurgiaRESUMO
Recently magnesium sulphate (MgSO4) has been used as a bronchodilator in adults with asthma not responding favourably to conventional bronchodilator therapy (CBT). In our institution we treated severe asthmatics with continuous infusion of MgSO4 when everything else failed. However, the optimal dose and frequency to maintain adequate magnesium levels for sustained bronchodilation is not known. The objective of this study was to examine the effect of a continuous infusion of MgSO4 on serum magnesium (Mg) levels, Woods Clinical Asthma Scores (CAS) and side effects in severe asthmatics on standard therapy. Six patients were treated with continuous MgSO4 after they did not respond to CBT. All patients received an initial loading dose of MgSO4 (60-70 mg/kg) during 20 minutes, followed by a continuous infusion of 2-3 g/hr (28-52 mg/kg/hr). Patient data included: Woods Clinical Asthma Score (CAS); Mg levels at baseline (0 min), 40 min and 4 hr after starting the loading dose; electrolytes and ionizing calcium at 4 hr. Patients were monitored continuously for evidence of untoward effect (blood pressure, heart rate and rhythm, deep tendon reflexes). All patients showed sustained clinical improvement. MgS04 may be a beneficial adjunctive therapy for severe asthma. A continuous infusion may maintain adequate levels for sustained bronchodilation with no side effect.(AU)
Assuntos
Adulto , Humanos , Sulfato de Magnésio/uso terapêutico , Broncodilatadores/uso terapêutico , Asma/tratamento farmacológico , Sulfato de Magnésio/sangueRESUMO
One hundred and three patients with eclampsia were managed during a period of eleven years. The perinatal mortality rate was 136 per 1000 total births and there were six maternal deaths. The maternal mortality rate was less among eclamptics delivered by Caesarean Section. Liberal use of diazepam and magnesium sulphate and early recourse to Caesarean Section were integral in the care of these women (AU)
Assuntos
Humanos , Gravidez , Recém-Nascido , Adolescente , Adulto , Feminino , Sulfato de Magnésio/uso terapêutico , Eclampsia/epidemiologia , Eclampsia/terapia , Mortalidade Infantil , Mortalidade Materna , Cesárea , Trinidad e Tobago , Resultado da GravidezAssuntos
Feminino , Humanos , Gravidez , Trabalho de Parto Prematuro/prevenção & controle , Agonistas Adrenérgicos beta/uso terapêutico , Etanol/uso terapêutico , Bloqueadores dos Canais de Cálcio/uso terapêutico , Sulfato de Magnésio/uso terapêutico , Progesterona/uso terapêutico , Antagonistas de Prostaglandina/uso terapêuticoRESUMO
Five cases are described of infantile gastroenteritis in which neurological disturbances including tremor, muscle rigidity, twitches and convulsions were associated with low levels of serum magnesium. Three of the cases were frankly malnourished. Serum calcium levels were normal in all, and parental calcium was without therapeutic effect in three cases, whereas magnesium administration in all five cases induced remission of the neurological disorder (AU)
