Assuntos
21003 , Humanos , Dopamina/efeitos adversos , Esquizofrenia/induzido quimicamente , Anfetamina/efeitos adversos , Anfetamina/antagonistas & inibidores , Clorpromazina/farmacocinética , Corpo Estriado/fisiopatologia , Meio Ambiente , Alucinógenos/efeitos adversos , Haloperidol/farmacocinética , Levalorfano/efeitos adversos , Norepinefrina/efeitos adversos , Estresse Psicológico , Tranquilizantes/efeitos adversos , Tranquilizantes/farmacocinéticaAssuntos
Ratos , 21003 , Amino Álcoois/antagonistas & inibidores , Cortisona/farmacologia , Desoxicorticosterona/farmacologia , Fenoxibenzamina/farmacologia , Propranolol/antagonistas & inibidores , Simpatolíticos/antagonistas & inibidores , Glândulas Suprarrenais , Adrenalectomia , Antagonistas Adrenérgicos beta/antagonistas & inibidores , Pressão Arterial/efeitos dos fármacos , Norepinefrina/farmacologia , Sotalol/antagonistas & inibidoresRESUMO
Adrenaline and Noradrenaline both caused a contraction of the vas deferens. However, adrenaline was a more potent stimulant than noradrenaline. Isoprenaline by itself had no effect on the vas deferens, but it modified the stimulatory effect of subsequent administered adrenaline and noradrenaline. In small doses isoprenaline lessened and in large doses it potentiated the stimulating effect of the other two amines, the degree of inhibition by isoprenaline being greater on noradrenaline than on adrenaline. It was suggested that isoprenaline acted by inhibiting alpha adrenergic receptors in small concentrations, stimulating them in large concentrations and not by stimulating Beta receptors as is presently believed (AU)
Assuntos
21003 , Cobaias , Técnicas In Vitro , Aminas/efeitos adversos , Ducto Deferente/efeitos dos fármacos , Cobaias , Epinefrina , Norepinefrina , IsoproterenolRESUMO
The use of B-thiopropionic acid for the stabilisation of the flourescence of the final solutions in the trihydroxyindole method of analysis of adrenaline and noradrenaline is described. Reliable plasma analysis with a methodological error of about ñ0.1 ng may be achieved using this thio-acid, and the Turner 111 flourometer (AU)