Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 2 de 2
Filtrar
Mais filtros










Filtros aplicados
Base de dados
Intervalo de ano de publicação
1.
West Indian med. j ; 44(3): 78-80, Sept. 1995.
Artigo em Inglês | MedCarib | ID: med-5889

RESUMO

Guinea-pig tracheal strips were used to investigate whether activation of guanylate cyclase in the trachea can reduce the contractile response of the smooth muscle. Guanylate cyclase was activated by glyceryl trinitrate and a combination of sodium nitrite and ascorbic acid. These activators inhibited tracheal smooth muscle contractions produced by acetylcholine histamine and electrical field stimulation. However, in the presence of methylene blue, a guanylate cyclase inhibitor, tracheal smooth muscle contractions were not inhibited by the activators. But, in the presence of propranolol, which blocked inhibition mediated by beta-adrenoceptor, both glyceryl trinitrate and the sodium nitrite/ascorbic acid combination were still capable of inhibiting tracheal smooth muscle contractions. Additionally, methylene blue inhibited tracheal smooth muscle relaxation that was electrically induced. These results suggest that the inhibitory action mediated by activated guanylate cyclase may be a mechanism for regulating tracheal smooth muscle contractile reponses (AU)


Assuntos
21003 , Cobaias , Músculo Liso/fisiologia , Guanilato Ciclase/fisiologia , Contração Muscular/efeitos dos fármacos , Traqueia/fisiologia , Azul de Metileno , Nitroglicerina/administração & dosagem , Propranolol/administração & dosagem
2.
West Indian med. j ; 36(Suppl): 47, April 1987.
Artigo em Inglês | MedCarib | ID: med-5981

RESUMO

Low dose, transdermal nitroglycerine (TD-NTG) in a "nitropatch" formulation was used in an attempt to ameliorate the hypertensive, tachycardiac response to tracheal intubation. Observations were also made to elucidate whether TD-NTG 5 mg has any effect on the subsequent period of general anaesthesia and recovery. TD-NTG 5 mg patches were applied to ten young, healthy patients with ten similar patients as controls. Premedication, induction and the first four minutes of anaesthesia were standardized. Systolic (SBP), diastolic (DBP) and mean (MAP) arterial pressures along with heart rate (HR) were measured at constant intervals. Rate-pressure product (RPP), as an indicator of myocardial oxygen consumption, was derived for each set of measurements. There was a short-lived, significant (p<0.05) rise in all variables in both groups, during intubation. This rise was significantly lower for all variables (except HR) between the two groups. The increase in HR was similar between the groups. There were no significant differences in the pre-induction or recovery-room measurements between the groups. No gross differences were noted during the course of anaesthesia after intubation. The only side-effect noted was slight headache in TD-NTG patients. TD-NTG patches are a useful addition to the anaesthetic armoury of drugs to control blood pressure during intubation. Their removal before induction from patients using them for the control of angina must be carefully considered in the light of the present study's findings of no adverse effects during general anaesthesia (AU)


Assuntos
Humanos , Nitroglicerina/uso terapêutico , Taquicardia/terapia , Intubação Intratraqueal/efeitos adversos
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...