RESUMO
A 32-year-old Caucasian man presented with a 6 month history of gradual visual loss. He lived alone and consumed large quantities of alcohol. In addition, he smoked heavily and had only one meal per day. Examination revealed poor visual acuities bilaterally, with normal looking optic discs and retina. An MRI brain scan was normal. Visual evoked potentials showed small P100 responses. His mean corpuscular volume was elevated as was the gammaglutamyl transpeptidase. The patient was started on high dose vitamin B. His visual acuities are improving. (AU)
Assuntos
Adulto , Relatos de Casos , Humanos , Masculino , Ambliopia/terapia , Acuidade Visual/efeitos dos fármacos , Riboflavina/uso terapêutico , Tiamina/uso terapêutico , Índices de Eritrócitos/efeitos dos fármacos , gama-Glutamiltransferase/uso terapêuticoAssuntos
Humanos , Dieta , Necessidades Nutricionais , Avaliação Nutricional , Nutrientes , Ingestão de Energia , Cálcio , TiaminaRESUMO
Thiamin status has been measured using the erythrocyte transketolase (EC 2.2.1.1) assay in twenty-eight normal children and in twenty-five severely malnourished children throughout the course of recovery. Subclinical thiamin deficiency was found in 7 percent of the normal children and 36 percent of the malnourished children on admission. There was no significant association between thiamin status and oedema, stunting or wasting, history of breast-feeding, pattern of weaning, age or sex. Five malnourished children, who died, all had a normal thiamin status on admission; however, two developed biochemical evidence of thiamin deficiency preterminally (AU)
Assuntos
Feminino , Humanos , Lactente , Masculino , Distúrbios Nutricionais/sangue , Tiamina/sangue , Eritrócitos/enzimologia , Jamaica , Deficiência de Tiamina/epidemiologia , Transcetolase/sangueRESUMO
Thiamine status has been determined in 22 "normal" adults and 8 adults with alcoholic cirrhosis. The activity of erythrocyte transketolase was measured with and without the addition of exogenous thiamine pyrophospate and expressed as a percentage stimulaion (TTP-E percent). Biochemical evidence of thiamine deficiency was found in 14 percent of normal adults and 38 percent of alcoholics. The most severe deficiency was found in an alcoholic with cardiac involvement (TTP-E of 58 percent). The three deficient alcoholics improved with thiamine therapy, but the response was slow, indicating, perhaps, an apotransketolase deficiency. One patient with Wernicke's encephalopathy had a normal thiamine status. Two of the deficient patients had hepatic encephalopathy, whilst the third had delirium tremens.(AU)
Assuntos
Humanos , Adulto , Pessoa de Meia-Idade , Idoso , Masculino , Feminino , Cirrose Hepática Alcoólica/sangue , Tiamina/sangue , Eritrócitos/enzimologia , Hemoglobinas/análise , Jamaica , Deficiência de Tiamina/sangue , Transcetolase/análiseRESUMO
Cases of hepatitis of unknown aetiology are described. It is possible that they are caused by dietary deficiency, permitting easy damage of the gastric or duodenal mucous membrane, which becomes infected; the toxin absorbed from this focus damages liver cells or the portal vein, or both, resulting in phlebitis and finally cirrhosis, causing obstruction and partial failure to absorb a particular food constituent from a diet already deficient in that respect (Summary)
