The clinical effectiveness of dihydroergocristine - reserpine clopamide combination in the treatment of hypertension - abstract

A clinical trial was undertaken to compare the effectiveness of the combination of dihydroergocristine, reserpine and a thiazide diurectic, with that of another combinatioin without the ergot derivative in the treatment of 25 hypertensive patients. An analysis of the results showed that the addition of dihydroergocristine to rauwolfia alkaloids and a thiazide diurectic produces an effective combination for the lowering of the blood pressure in hypertensive patients. The only side effect observed was postural hypotension. It is postulated that underlying pharmacological action of the combination is due to an "adrenaline reversal" effect on the blood pressure (AU)