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1.
WEST INDIAN MED. J ; 46(Suppl 2): 30, Apr. 1997.
Artigo em Inglês | MedCarib | ID: med-2290

RESUMO

Gonadotrophin releasing hormone agonist (Goserelin) was used to induce amenorrhea in 27 women who were anaemic as a result of menorrhage due to uterine myomas (fibroids). The aim was to produce a three-month period of amenorrhoea which would be enough time for them to recover from the anaemic status and thus be fit for surgery. GnRH agonists supresses gonadotrophin release from the pituitary, thus inhibiting ovarian steroid secretion, resulting in amenorrhoea. Between March 1993 and May 1996, 27 women were injected with goserelin acetate (zoladex), 3.6 mg in the subcutaneous tissue of the anterior abdominal wall on a monthly basis for 3 months. Twenty three went on to have myomectomy. Haemoglobin (Hb) concentration and packed cell volume (PCV) were determined before initiation of treatment. Haemoglobin levels ranged from 4.7 g/dlto 9.9 g/dl and PCV ranged from 0.14 to 0.30 l/l. Three women did not have amenorrhea after the first injection and reported heavier periods, while three had prolonged light bleeding. All six, plus the other seventeen, had amenorrhoea after the second injection. All experienced hot flushed during the course of treatment and 5 (21.7 percent) had vaginal dryness by the third injection. Demineralization of done which is associated with these agents was not assessed. (Au)


Assuntos
Feminino , Humanos , Hormônio Liberador de Gonadotropina/agonistas , Amenorreia/induzido quimicamente , Menorragia/complicações , Leiomioma/cirurgia , Neoplasias Vaginais/cirurgia
2.
Artigo em Inglês | MedCarib | ID: med-16857

RESUMO

Quartered pituitaries obtained from intact males or gonadectomized males and females (72h) +/- estradiol (24h) and/or testosterone (72h) implants were perfused at .25 ml/minute with Ca++ -free medium at 37 degree Celsius, and sequential effluent fractions collected every 10 minutes, in an attempt to determine if the steroidal conditions known to induce or prevent GnRH self-potentiation would activate or inhibit the extracellular Ca++ -independent component of luteinizing hormone (LH) secretion. COntinuous infusions (4h) of 1 nmol GnRH or 1 umol of phorbol 12-myristate 13-acetate (PMA) did not stimulate LH secretion from pituitaries of castrated males, intact males, estradiol-treated intact males or ovariectomized females. In contrast, estradiol induced delayed (20-30 minutes), protein synthesis-dependent components of LH secretion in response to both GnRH and PMA from pituitaries of gonadectomized males and females. Implantation of testosterone capsules immediately following gonadectomy resulted in an inhibition of the estradiol-induced GnRH- and PMA-stimulated responses from pituitaries of castrated or ovariectomized animals. These results suggest that estradiol can induce extracellular Ca++ -independent components of LH secretion from pituitaries of gonadectomized animals; responses which depend on de novo protein synthesis and which could involve protein kinase C. Additionally, the effects of estradiol are prevented by testosterone, indicating that this component of LH secretion is only apparent under steroidal conditions known to facilitate GnRH self-potentiation (AU)


Assuntos
Ratos , Animais , Cálcio/análise , Cálcio , Hormônio Luteinizante , Hormônio Liberador de Gonadotropina/análise
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