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1.
Placenta ; 19(4): 321-31, May 1998.
Artigo em Inglês | MedCarib | ID: med-1765

RESUMO

The fetus has a substantial demand for glycine, which is satisfied in part by placental formation. The ability to form glycine through the activity of alanine: gloxylate aminotransferase enzyme was measured in placentae from normal term human pregnancies and placentae from rats at day 20 of gestation. There was no detectable enzyme activity in either human or rat placentae, although activity was measured in rat liver. It is concluded that in the placenta glycine is only formed from serine through the activity of serine hydroxymethyl transferase enzyme, which uses folate as a cofactor, because there is no other known metabolic pathways for endogenous glycine production.(AU)


Assuntos
Ratos , Técnicas In Vitro , 21003 , Feminino , Humanos , Recém-Nascido , Gravidez , Glicina/biossíntese , Placenta/metabolismo , Transaminases/metabolismo , Fígado/enzimologia , Troca Materno-Fetal , Placenta/enzimologia , Ácido Pirrolidonocarboxílico/urina
2.
Kingston; s.n; 1989. xiv,156 p. tab.
Tese em Inglês | MedCarib | ID: med-13647

RESUMO

Halothane is a commonly used anaethetic in paediatric practice. However, it is thought to be hepatotoxic. This study was designed to examine the effects of both single and multiple halothane anaesthesia on liver function. Heaptic glutathione S-transferase (GST) was also examined as a possible index of acute liver damage. The study group consisted of ten children who had consumed corrosive substances. This group was subdivided into two groups, depending on the number of halothane exposures, the single and the multiple halothane group. These children were compared with a surgical (n=5) and a ketamine control group (n=5). All children were studied prospectively over a 24hr. period, and the trend of liver enzyme release following anaesthesia measured. In addition, the children in the multiple halothane group were studied longitudinally. Four children from the study group, exhibited dramatic increases in the B1 subunit of liver specific GST, 24 hours after anaethesia. Twelve studies showed an early transient rise in total plasma GST, between the end of anaesthesia and 6 hrs. after. Six studies exhibited marked secondary rise at 24 hrs. after anaesthesia. These data indicate two possible phases of liver dysfunction following halothane anaesthesia. Significant changes in the level of aminotransferases were observed in the multiple halothane group, suggesting that measurement of these liver enzymes are still useful as indices of liver dysfunction following multiple halothane exposure. Cellular antioxidant systems were also measured to examine the relationship between halothane exposure and oxidative stress. A significant increase (p<0.05) in red cell GST was noted in the multiple halothane group, indicating that these children are in fact subjected to chronic oxidant stress. Collectively, these data indicate a transient impairment of hepatocellular integrity following multiple halothane exposures, despite lack of clinical evidence of hepatotoxicity. It is recommended that children undergoing repeated halothane anaesthesia be examined carefully for possible hepatic dysfunction (AU)


Assuntos
Humanos , Lactente , Pré-Escolar , Criança , Masculino , Feminino , Anestesia , Glutationa Transferase/metabolismo , Fígado/patologia , Halotano/efeitos adversos , Plasma/metabolismo , Posologia , Transaminases/metabolismo , Esôfago/lesões , Estudos Longitudinais , Testes de Função Hepática
5.
West Indian med. j ; 11(2): 136, June 1962.
Artigo em Inglês | MedCarib | ID: med-7537

RESUMO

Estimation of glutamic pyruvic transaminase, isocitric dehydrogenase and bilirubin were measured in malnourished children. All children that died showed elevation of all three parameters on admission. The 80 percent of the series that showed no such elevated values all survived (AU)


Assuntos
Humanos , Lactente , Transaminases , Transtornos da Nutrição do Lactente , Alanina Transaminase , Isocitrato Desidrogenase , Bilirrubina
7.
Lancet ; 1(7076): 757-8, Apr. 1959.
Artigo em Inglês | MedCarib | ID: med-14466

RESUMO

Liver glutamic-aspartic transaminase activity was investigated in 19 diabetic patients before and after treatment of the diabetic state. In 15 patients who were passing no sugar in the urine at the time of the second biopsy the mean level of transaminase activity was 0.146+- 0.013 units, whereas before treatment the activity had been 0.213+- 0.011 units. This difference is highly significant statistically. There was no apparent relation between the initial level of transaminase activity or the change in activity and the type or duration of the diabetes or of the treatment given (Summary)


Assuntos
Humanos , Adolescente , Adulto , Pessoa de Meia-Idade , Idoso , Masculino , Feminino , Fígado/metabolismo , Diabetes Mellitus/fisiopatologia , Transaminases/fisiologia , Biópsia , Gluconeogênese/fisiologia , Diabetes Mellitus/terapia , Glicemia
8.
West Indian med. j ; 8(1): 73, Mar. 1959.
Artigo em Inglês | MedCarib | ID: med-7481

RESUMO

Liver glutamic-aspartic transaminase activity has been investigated in 19 diabetic subjects before and after treatment of the diabetic state. In 15 patients who were passing no sugar in the urine at the time of the second biopsy the mean level of transaminase activity was 0.146 ñ 0.013 units whereas before treatment the activity had been 0.0213 ñ 0.011 units. This difference is highly significant statistically. There was no apparent relation between the initial level of transaminase activity or the change in activity and the type or duration of the diabetes or of the treatment given (AU)


Assuntos
Humanos , Fígado/metabolismo , Diabetes Mellitus/fisiopatologia , Transaminases/fisiologia , Biópsia , Gluconeogênese/fisiologia , Diabetes Mellitus/terapia , Glicemia
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