RESUMO
BACKGROUND: Many studies have been performed during the past decade to find an effective topical therapy for cutaneous leishmaniasis (CL). OBJECTIVE: Our purpose was to evaluate the effect of paromomycin ointment (P-ointment) containing 15 percent paromomycin sulfate and 12 percent methylbenzethonium chloride on Belizean patients with New World CL. METHODS: Fifty-three patients were treated twice daily for 14 to 21 days with P-ointment. RESULTS: Sixty-eight percent of the patients healed, 6 percent had a delayed cure, and 26 percent did not respond. No toxic effects from the ointment were observed. CONCLUSION: Topical paromomycin is as efficacious in the treatment of New World CL as other currently accepted modalities that are potentially more toxic (AU)
Assuntos
Adolescente , Adulto , Humanos , Masculino , Feminino , Leishmaniose/tratamento farmacológico , Paromomicina/administração & dosagem , Administração Tópica , Belize , Criança , Esquema de Medicação , Leishmaniose/parasitologia , Pessoa de Meia-Idade , PomadasRESUMO
Humatin was well tolerated, and eliminated E. histolytica infection as determined by stool examination in sixty percent of cases. The drug appeared to be more effective in older individuals than in those under eight years of age. It eliminated abdominal cramps, fever, nausea, vomiting and weakness in most cases in which these symptoms were present before treatment (AU)
