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1.
Br J Nutr ; 31(1): 109-12, 1974.
Artigo em Inglês | MedCarib | ID: med-12984

RESUMO

Ten severly malnourished children were studied. During recovery the mean energy intake was 916kj (219kcal)/kg per d when the children were fed ad lib. on a high-energy milk preparation. When a lower-energy milk preparation was given ad lib. the children voluntarily increased the volume consumed but the mean energy intake fell to 703 kj (168 kcal)/kg per d. After recovery the children no longer consumed an increased volume when the lower-energy milk preparation was offered. The results provide further evidence of the importance of feeding with a high-energy preparation for the treatment of malnutrition, and demonstrate that additional benefits can be obtained by offering such mixtures ad lib. (AU)


Assuntos
Humanos , Lactente , 21003 , Dietoterapia , Transtornos da Nutrição do Lactente/terapia , Metabolismo Energético , Maltose/metabolismo , Polissacarídeos/metabolismo , Proteínas/metabolismo , Sacarose/metabolismo
2.
Clin Sci ; 39(2): 305-18, Aug. 1970.
Artigo em Inglês | MedCarib | ID: med-8772

RESUMO

The ability of malnourished children to absorb lactose, sucrose and glucose was tested by perfusing the jejunum. Intestinal motility was measured simultaneously in a perfused segment by a dye dilution technique. These tests were repeated on the same children after 6-16 weeks of treatment. There was a significant correlation between the rate of hydrolysis of disaccharide perfusing the jejunum and the level of disaccharidase activity within the jejunal mucosa. All ten malnourished children had dimished glucose absorption, eight had reduced lactose and six had impaired sucrose hydrolysis and absorption. Children with the most severe mucosal damage had the lowest rate of sugar absorption. The malabsorption of disaccharide was related to the impairment of hydrolysis and not to the malabsorption of the monosaccharide products. Primary hypermotility of the intestine was not a feature of the malnourished group. Water absorption from all infusions occurred only in the treated group. Water entry into the intestinal lumen in the malnourished group was greatest with the most poorly absorbed sugars. The mean transit time of fluid passing down the intestine was inversely correlated with the sugar remaining unabsorbed within the lumen. Treating the malnourished child in hospital produced an increase in glucose, lactose and sucrose absorption. The generalized nature of the malabsorption and the reversibility of the defects suggests that lactose intolerance in these children is related to the nutritional state and not to a genetic predisposition to lactase deficiency. (Summary)


Assuntos
Humanos , Lactente , Carboidratos/metabolismo , Motilidade Gastrointestinal , Transtornos da Nutrição do Lactente/metabolismo , Intestino Delgado , Síndromes de Malabsorção/etiologia , Biópsia , Diarreia/etiologia , Glucose/metabolismo , Intubação Gastrointestinal , Jejuno , Intolerância à Lactose , Matemática , Métodos , Perfusão , Potássio/análise , Sacarose/metabolismo , Fatores de Tempo , Água/metabolismo , Jamaica
4.
Lancet ; 1(538): 333-5, Feb. 1968.
Artigo em Inglês | MedCarib | ID: med-14626

RESUMO

Sugar absorption was studied by jejunal perfusion in five malnourished children both on admission and after at least 2 months' high-protein feeding. All children initially had poor glucose absorption, four had defective lactose hydrolysis and two a defect in sucrose hydrolysis. The hydrolytic defects were related to low disaccharidase activities in jejunal mucosal tissue. Mean transit-times of fluid in the jejunal test segment were correlated with the amount of unabsorbed sugar in the lumen. Abnormal intestinal motility was not a primary feature of the diarrhoea in these children. After treatment glucose absorption, lactose and sucrose hydrolysis all improved and disaccharidase activities increased, showing that these intestinal defects in malnutrition can be reversed (Summary)


Assuntos
Humanos , Lactente , Masculino , Feminino , Absorção Intestinal , Desnutrição Proteico-Calórica/fisiopatologia , Jejuno/metabolismo , Glucose/metabolismo , Lactose/metabolismo , Dissacarídeos/metabolismo , Sacarose/metabolismo , Biópsia/instrumentação , Perfusão/instrumentação , Diarreia , Jamaica
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