Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 2 de 2
Filtrar
Mais filtros










Filtros aplicados
Base de dados
Assunto principal
Intervalo de ano de publicação
1.
West Indian med. j ; 39(Suppl. 1): 40-1, April 1990.
Artigo em Inglês | MedCarib | ID: med-5278

RESUMO

Cellular immune reactions to non-specific mitogen, phytohaemagglutinin in (PHA) and specific blastogenic response to the nephritogenic strain, M55, of the streptococcus were investigated in an East Indian family in which all six siblings exhibited concurrent symptoms of post-streptococcal acute glomerulonephritis (PSAGN) requiring hospitalization. These assays, as well as HLA typing, were done on the entire family to determine whether a specific non-responder status to the M55 antigen was present in the family, and to investigate the possible presence of an immune response gene controlling M55 response. With the exception of one sibling, cellular immune reactions to PHA were similar to control responses, indicating normal overall T cell functions. Specific M55 stimulation revealed a decreased response (30 percent reduction relative to controls) in the cells of the father and 3 of the siblings. The results of HLA typing showed the presence of the B52/DR2 halotype in all siblings due to the homozygous presence of this halotype in the father. The B52 antigen was also present in the mother, resulting in a homozygous condition for this antigen in 4 of the 6 children. While it cannot be concluded from this single family study that the presence of B52 antigen is related to disease susceptibility, the repeated occurrence of this antigen, as well as the B52/DR2 halotype, in this family is noteworthy. The study further illustrates the usefulness of family studies in resolving apparent "blanks" which occur with some frequency in our small inbred island population (AU)


Assuntos
Humanos , Glomerulonefrite/imunologia , Fito-Hemaglutininas , Imunidade Celular , Trinidad e Tobago
2.
West Indian med. j ; 39(Suppl. 1): 40, April 1990.
Artigo em Inglês | MedCarib | ID: med-5279

RESUMO

The objectives of the study were to determine the humoral and cellular immunological profiles of 14 patients with chronic glomerulonephritis (CGN) who were about to be dialyzed. Fourteen healthy subjects matched for age, sex and ethnic origin served as controls. Serum IgG levels showed no significant difference in the two groups. However, serum IgA levels were elevated (p<0.01) but serum IgM levels were suppressed (p<0.001). Immune complexes (IC) were prepared by the polyethylene glycol 6,000 precipitation method and their immunoglobulin content measured. The IgG and IgM levels in IC were markedly depressed (p<0.001, p<0.001 respectively. IgG subclass determinations showed that IgG1 and IgG3 were essentially the same in patients and controls. The IgG2 level, however, was markedly elevated (p<0.02) in patients. Cellular immune responses to the rheumatogenic M41 and to the nephritogenic M55 cell membrane antigens at 3 concentrations (100, 10, 1 ug/ml) as well as to phytohaemagglutinin (PHA) a non-specific mitogen, were measured. In patients, there was depressed cellular sensitivity to the M55 antigen at all 3 concentrations (p<0.01; p§.05; p<0.05, respectively). This suppression was greatly exaggerated when cellular sensitivity to the M55 antigen at the same 3 concentrations was measured (p<0.001, p<0.001, p<0.001 respectively. Patients and controls showed no difference in their response to PHA. These results suggest that both the cellular and humoral immunological factors play a role in the pathogenesis of chronic renal disease (AU)


Assuntos
Humanos , Adulto , Pessoa de Meia-Idade , Glomerulonefrite/imunologia , Fatores Sexuais , Fatores Etários , Etnicidade , Imunoglobulina G , Imunoglobulina M , Fito-Hemaglutininas , Trinidad e Tobago
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...