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1.
West Indian med. j ; 50(3): 17, July, 2001.
Artigo em Inglês | MedCarib | ID: med-246

RESUMO

A 32-year-old Caucasian man presented with a 6 month history of gradual visual loss. He lived alone and consumed large quantities of alcohol. In addition, he smoked heavily and had only one meal per day. Examination revealed poor visual acuities bilaterally, with normal looking optic discs and retina. An MRI brain scan was normal. Visual evoked potentials showed small P100 responses. His mean corpuscular volume was elevated as was the gammaglutamyl transpeptidase. The patient was started on high dose vitamin B. His visual acuities are improving. (AU)


Assuntos
Adulto , Relatos de Casos , Humanos , Masculino , Ambliopia/terapia , Acuidade Visual/efeitos dos fármacos , Riboflavina/uso terapêutico , Tiamina/uso terapêutico , Índices de Eritrócitos/efeitos dos fármacos , gama-Glutamiltransferase/uso terapêutico
2.
Arch Dis Child ; 72(3): 227-9, March 1995.
Artigo em Inglês | MedCarib | ID: med-5894

RESUMO

Chronic hypersplenism in homozygous sickle cell (SS) disease markedly increases haemolysis and the resulting erythropoietic expansion is likely to have a high metabolic cost. Splenectomy for hypersplenism in SS disease is followed by highly significant changes in haematological indices and an increase in height, but not weight, velocity. This pattern is similar to that observed in the trichuris dysentery syndrome after treatment, and differs from the increase in both height and weight velocity that follow nutritional supplementation of severely malnourished children. It is postulated that accelerated linear growth after the reduction in erythropoietic stress may implicate a specific nutrient deficiency in hypersplenic children with SS (AU)


Assuntos
Humanos , Masculino , Feminino , Pré-Escolar , Criança , Crescimento , Hiperesplenismo/cirurgia , Traço Falciforme/complicações , Peso Corporal , Estatura , Índices de Eritrócitos , Testes Hematológicos , Hiperesplenismo/sangue , Hiperesplenismo/fisiopatologia , Traço Falciforme/sangue , Traço Falciforme/fisiopatologia , Traço Falciforme/cirurgia , Esplenectomia
3.
Clin Lab Haematol ; 13: 229-37, 1991. tab, gra
Artigo em Inglês | MedCarib | ID: med-3596

RESUMO

The red cell distribution width (RDW) has been studied during the clinical steady state in 1121 patients with homozygous sickle cell (SS) disease, 344 with sickle cell-haemoglobin C (SC) disease, 68 with sickle cell-beta+ thalassaemia, 49 with cell beta§ thalassaemia and in 130 control subjects with a normal (AA) genotype. The mean RDW was moderately increased in Sbeta+ thalassaemia and SC disease and markedly increased in Sbeta§ thalassaemia and SS disease. In SS, SC and Sbeta§ thalassaemia genotypes, lower RDW values occurred in females and with alpha thalassaemia. The RDW correlated negatively with total haemoglobin, mean cell haemoglobin concentration, mean cell volume and fetal haemoglobin (HbF) and positively with reticulocyte count in SS disease. A low RDW was associated with higher weight and less frequent dactylitis, painful crisis, acute chest syndrome, acute splenic sequestration and hospital admissions. A low RDW in SS disease is consistent with a high total haemoglobin, high HbF, low reticulocyte count, alpha thalassaemia and a more mild clinical course. (AU)


Assuntos
Adolescente , Adulto , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Idoso , Lactente , Anemia Falciforme/sangue , Índices de Eritrócitos , Eritrócitos Anormais/ultraestrutura , Traço Falciforme/sangue , Fatores Etários , Anemia Falciforme/patologia , Estudos de Coortes , Globinas/genética , Doença da Hemoglobina C/sangue , Doença da Hemoglobina C/complicações , Deficiências de Ferro , Índice de Gravidade de Doença , Fatores Sexuais , Traço Falciforme
4.
Lancet ; 335(8690): 637-40, Mar. 17, 1990.
Artigo em Inglês | MedCarib | ID: med-10011

RESUMO

The clinical and hematological features of homozygous sickle cell (SS) disease were compared in 30 Greek and 310 Jamaican patients. Deletional O-thallassaemia, which modifies SS disease, is rare among Greek patients, so only Jamaican patients with four O-globin genes were included in the control group. Greek patients had higher total haemoglobin concentration and red cell counts, and lower mean cell haemoglobin concentration (MCHC) and reticulocyte counts. They also had a more normal body build and more adults had persistent splenomegaly. Fewer had a history of leg ulceration or priapism but more reported acute chest syndrome. The comparitively mild disease in Greek patients is consistent with less haemolysis and sickling and therefore less bone marrow expansion. In the absence of amelioriating factors such as high HbF concentration or O-thalassaemia, these findings may be explained by the low MCHC. (AU)


Assuntos
Humanos , Criança , Adolescente , Adulto , Masculino , Feminino , Anemia Falciforme/genética , Homozigoto , Anemia Falciforme/sangue , Anemia Falciforme/complicações , Estudos Transversais , Contagem de Eritrócitos , Índices de Eritrócitos/genética , Hemoglobina Fetal/análise , Genótipo , Grécia , Hemoglobina A2/análise , Hemoglobina Falciforme/análise , Jamaica , Fenótipo , Reticulócitos , Estudos Retrospectivos , Talassemia/sangue , Talassemia/complicações , Talassemia/genética
5.
Arch Intern Med ; 147(7): 1231-4, July 1987.
Artigo em Inglês | MedCarib | ID: med-15882

RESUMO

Some epidemiologic features of the painful crisis in homozygous sickle cell disease were examined in a retrospective study of 995 painful crises. Previously reported associations with cold weather and pregnancy were confirmed. There was a striking increase in painful crises in male patients between the ages of 15 and 25 years, whereas female patients showed little age-related change. The frequency of painful crises correlated positively with hemoglobin levels and reticulocyte counts in female patients. There was a striking increase in painful crises in male patients with hemoglobin levels above 8.5 g/dL (>85 g/L). High hemoglobin levels appear to be an important risk factor for painful crises.(AU)


Assuntos
Humanos , Gravidez , Adolescente , Adulto , Masculino , Feminino , Anemia Falciforme , Homozigoto , Dor/etiologia , Doença Aguda , Fatores Etários , Anemia Falciforme/epidemiologia , Temperatura Baixa , Contagem de Eritrócitos , Índices de Eritrócitos , Hemoglobina Falciforme/análise , Jamaica , Complicações Hematológicas na Gravidez/sangue , Reticulócitos , Estudos Retrospectivos , Risco , Fatores Sexuais
6.
Lancet ; 2(8517): 1198-201, Nov. 1986.
Artigo em Inglês | MedCarib | ID: med-13188

RESUMO

A study of 131 patients with homozygous sickle cell (SS) disease in Orissa State, India, indicated that, compared with Jamaican patients, Indian patients have higher frequencies of alpha thalassaemia, higher fetal haemoglobin, total haemoglobin, and red cell counts, and lower mean cell volume, mean cell haemoglobin concentration, and reticulocyte counts. Indian patients have a greater frequency and later peak incidence of splenomegaly, and hypersplenism is common. Painful crises and dactylitis are not uncommon in Indian patients but chronic leg ulceration is rare. Homozygous sickle cell disease in Orissa is similar to that in the Eastern Province of Saudi Arabia and is very different from that in populations of West Africa origin.(Summary)


Assuntos
Humanos , Pré-Escolar , Criança , Adolescente , Adulto , Pessoa de Meia-Idade , Masculino , Feminino , Anemia Falciforme/epidemiologia , Anemia Falciforme/sangue , Anemia Falciforme/genética , Estudo Comparativo , Contagem de Eritrócitos , Índices de Eritrócitos , Hemoglobina Fetal/análise , Hemoglobina A2/análise , Índia , Jamaica , Reticulócitos/patologia , Talassemia/sangue , Talassemia/epidemiologia , Talassemia/genética
7.
West Indian med. j ; 35(1): 63-5, Mar. 1986.
Artigo em Inglês | MedCarib | ID: med-11612

RESUMO

Changes in mean cell volume in sickle cell disease must be judged against the patient's own steady state values. Two cases are reported in which megaloblastic erythropoiesis was overlooked because of genetically determined microcytosis. The effect of megaloblastic change was to increase the mean cell volume(MCV) but values remained in the range normal for other patients (AU)


Assuntos
Adolescente , Criança , Humanos , Masculino , Anemia Falciforme/sangue , Eritrócitos Anormais/patologia , Eritropoese , Anemia Falciforme , Índices de Eritrócitos , Jamaica
8.
Br J Haematol ; 60(2): 279-92, June 1985.
Artigo em Inglês | MedCarib | ID: med-9502

RESUMO

The haematological changes in early years following neonatal diagnosis have been observed in representative groups of children with sickle cell-haemoglobin C (SC) disease, sickle cell-á+ thalassaemia, and in sickle cell-á Thalassaemia. Most haematological indices in SC disease were intermediate between previously published values in SS disease and in AA controls, generally being closer to values in normal children, Eceptions were microcytosis which may be genetically determined and a striking elevation of mean cell haemoglobin cocentration from age 2 months to 4 years. The combination of a raised MCHC and a lowered MCV is unusual and may be characteristic of SC disease. Features in sickle cell-á thalassaemaia generally differed accordingly to the type of á thalassaemia gene. Sickle cell-B degree thalassaemia had lower levels of haemoglobin, MCHC, red cell count, MCV, and higher reticulocytes, most differences being significant before 1 year. No differences between SB degree thalassaemia and Sá+ thalassaemia were apparent in HbF levels (which resembled those in SS disease) or in HbA2 levels (which exceeded those in SS disease by 1 year of age).(AU)


Assuntos
Humanos , Recém-Nascido , Lactente , Pré-Escolar , Criança , Masculino , Feminino , Anemia Falciforme/sangue , Doença da Hemoglobina SC/sangue , Talassemia/sangue , Contagem de Células Sanguíneas , Índices de Eritrócitos , Sangue Fetal/análise , Hematócrito , Ferro/sangue , Jamaica , Talassemia/genética
10.
Br J Haematol ; 55(3): 479-86, Nov. 1983.
Artigo em Inglês | MedCarib | ID: med-14722

RESUMO

A study of rheological determinants (plasma viscosity, whole-blood viscosity, and erythrocyte deformability) was made in 24 matched pairs of patients with homozygous sickle cell disease, with and without homozygous x-thalassaemia. Patients with coexisting x-thalassaemia showed a significant increase in erythrocyte deformability measured as filtration of washed erythrocytes through 5 um diameter pores and also as viscosity of whole blood at high shear rate (230s-1) and standard haematocrit (0.45). This rheological advantage may explain the beneficial effect of x-thalassaemia 2 on haematological parameters and clinical events in homozygous sickle cell disease (AU)


Assuntos
Humanos , Criança , Adolescente , Adulto , Pessoa de Meia-Idade , Idoso , Masculino , Anemia Falciforme/sangue , Doença da Hemoglobina SC/sangue , Talassemia/sangue , Viscosidade Sanguínea , Contagem de Eritrócitos , Índices de Eritrócitos , Eritrócitos/fisiologia , Filtração , Hematócrito , Doença da Hemoglobina SC/complicações , Homozigoto , Pressão , Reologia , Talassemia/complicações , Fatores de Tempo
11.
Kingston; s.n.; 1983. ix,127 p. tabs, graphs, map.
Tese em Inglês | MedCarib | ID: med-8697

RESUMO

Weights and heights of 2,408 Grenadian school-children aged 6-11 years were measured between September 1981 to March 1982, in 7 schools representing the 6 parishes of the island. The nutritional status of these children was assessed using WHO standards which indicated that their full growth potential was not attained. Although severe malnutrition was rare, many of the children were mildly to moderately underweight, wasted and stunted. Children in St. David's were among the shortest. However, when weight for height was considered their measurements more closely approached the WHO standard values than any other group. Children in St. Patrick's were the tallest while those in St. Andrew's were the thinnest. Children in St. George's, St. John's and St. Mark's were in relatively poor condition with St. Mark's and St. John's having the highest proportion of stunting. A comparison with Jamaican children of similar ages showed that the Grenadians were taller but of similar weight. In Grade 5 of St. Patrick's Roman Catholic School the relationship between school achievement, nutritional status, attendance and haemoglobin levels was examined. The Wide Rang Achievement Test (W.R.A.T.) which comprised reading, spelling and arithmetic was used to determine school achievement. Nutritional status was assessed using weight and height measurements. Attendance was obtained from the schools' registers. Of the 3 classes studied only 1 attained Grade 5 level and the students of this class were younger and attended school more regularly than the other 2 classes. Attendance and height were observed to affect school achievement, with attendance related to arithmetic and height, to a lesser extent, related to reading and arithmetic. The children studied had good haemoglobin levels and were therefore not anaemic. Since the contributions made by height and attendance were not large enough to account for the observed deficits in school achievement further research is required.


Assuntos
Humanos , Estado Nutricional , Escolaridade , Índices de Eritrócitos , Criança , Granada
12.
N Engl J Med ; 306(24): 1441-6, 1982.
Artigo em Inglês | MedCarib | ID: med-14410

RESUMO

Patients with homozygous sickle-cell disease may be homozygous for alpha-thalassemia 2 (O-/O-), may be heterozygous for alpha-thalessemia 2 (O-/OO), or may have a normal alpha-globin-gene complement (OO/OO). We compared the clinical and hematologic features of 44 patients who had sickle-cell disease and homozygous alpha-thalassemia 2 with those of controls with the two hematologic conditions. The patients with homozygous alpha-thalassemia 2 had significantly higher red-cell counts and levels of hemoglobin and hemoglobin Aý, as well as significantly lower hemoglobin F, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, mean corpuscular volume, reticulocyte counts, irreversibly-sickled-cell counts, and serum total billirubin levels, than those with a normal alpha-globin-gene complement. Heterozygotes (O-/OO) had intermediate values. In the group with homozygous alpha-thalassemia 2, fewer patients had episodes of acute chest syndrome and chronic leg ulceration and more patients had splenomegaly, as compared with patients in the other two subgroups. These data confirmed previous suggestions that alpha-thalassemia inhibits in vivo sickling in homozygous sickle-cell disease and may be an important genetic determinant of its hematologic severity.


Assuntos
Humanos , Adolescente , Adulto , Masculino , Feminino , Anemia Falciforme/complicações , Talassemia/complicações , Anemia Falciforme/sangue , Anemia Falciforme/genética , Bilirrubina/análise , Contagem de Eritrócitos , Índices de Eritrócitos , Hemoglobina Fetal/análise , Hemoglobina A2/análise , Hemoglobinas/análise , Hematócrito , Globinas/genética , Heterozigoto , Homozigoto , Esplenomegalia/complicações , Talassemia/sangue , Talassemia/genética
13.
Br J Haematol ; 50(1): 29-34, Jan. 1982.
Artigo em Inglês | MedCarib | ID: med-12240

RESUMO

The haematological indices in 50 patients with homozygous sickle cell (SS) disease and avascular necrosis of the femoral head and in 180 patients with SS disease without this complication have been compared. Avascular necrosis of the femoral head was significantly associated with high total levels and with low fetal haemoglobin levels. Low fetal haemoglobin levels are associated with increased intravascular sickling. These results suggest that both intravascular sickling and the increased viscosity associated with high haemoglobin levels are related to the development of avascular necrosis of the femoral head in SS disease. (AU)


Assuntos
Adulto , Feminino , Masculino , Humanos , Anemia Falciforme/sangue , Necrose da Cabeça do Fêmur/sangue , Anemia Falciforme/complicações , Contagem de Eritrócitos , Índices de Eritrócitos , Hemoglobina Fetal/análise , Hemoglobina A2/análise
14.
Br J Ophthalmol ; 65(10): 712-7, Oct. 1981.
Artigo em Inglês | MedCarib | ID: med-14818

RESUMO

In a selected sample of patients with sickle cell-haemoglobin C (SC) disease, proliferative retinopathy (PSR) occurred in 90/243 (37 percent) patients, developed most frequently between the ages of 20 and 30 years, and affected 68 percent patients aged 45 years or over. Comparison of haematological indices in patients with and without PSR, after age-related effects were allowed for, indicated significant relationships with high mean cell volume in males and with low fetal haemoglobin in both sexes. A highly significant relationship with total haemoglobin level in males (as previously reported in SS disease) was shown in SC disease to be entirely secondary to a strong age-related trend in haemoglobin level (AU)


Assuntos
Humanos , Recém-Nascido , Lactente , Pré-Escolar , Criança , Adolescente , Adulto , Pessoa de Meia-Idade , Masculino , Feminino , Anemia Falciforme/complicações , Doença da Hemoglobina C/complicações , Doenças Retinianas/etiologia , Traço Falciforme/complicações , Fatores Etários , Índices de Eritrócitos , Doença da Hemoglobina C/sangue , Hemoglobinas/análise , Doenças Retinianas/sangue , Traço Falciforme/sangue
15.
Br J Haematol ; 48(4): 533-43, Aug. 1981.
Artigo em Inglês | MedCarib | ID: med-14384

RESUMO

A cohort study of sickle cell disease from birth has allowed observations on the disease without the symptomatic selection inherent in previous series. The development of haematological indices from birth to 6 years in male and female infants with homozygous sickle cell (SS) disease is presented and compared with values in age and sex matched controls with a normal haemoglobin (AA) genotype previously presented elsewhere. In SS disease total haemoglobin levels fell rapidly from birth to a plateau at 3-6 months before falling again to 15 months after which no age related change occured. Mean cell haemoglobin concentration fell from birth to lowest values at 15-18 months before increasing to reach the level present at birth by the age of 5 years. Red cell counts fell rapidly after birth to a plateau at 2 months, increased slightly to 2 months and then fell steadily throughout the remaining period of study. The mean cell voloume and mean cell haemoglobin also fell rapidly after birth reaching the lowest values by 6 months and then increased progressively. Female patients showed significantly higher haemoglobin levels from 15 months to 4« years. Compared to AA controls, SS patients manifested significantly lower levels of haemoglobin from 2 weeks, and red cell counts from 1 month, and significantly higher levels of MCHA from 4 months to 3 years, MCV from 8 months to 5 years, and serum iron levels from 1 to 4 years. Children with SS disease were partially protected from iron deficiency in early childhood, perhaps by increased intestinal absorption of iron, and the associated increase in intracellular haemoglobin concentration might be disadvantageous during this high risk period (Summary)


Assuntos
Humanos , Recém-Nascido , Lactente , Pré-Escolar , Criança , Masculino , Feminino , Anemia Falciforme/sangue , Contagem de Eritrócitos , Índices de Eritrócitos , Hemoglobina A/metabolismo , Hemoglobina Falciforme/metabolismo , Doenças do Recém-Nascido/sangue , Ferro/sangue , Reticulócitos , Fatores de Tempo
16.
Br J Haematol ; 48(3): 445-9, July 1981.
Artigo em Inglês | MedCarib | ID: med-14385

RESUMO

The contribution of red cell (mean cell volume) to the clinical and haematological manifestations of homozygous sickle cell (SS) disease has been investigated by comparing the-/* features of two groups of patients with low (<80 fl) and high (>95 fl) MCV values after matching for age, sex, and fetal haemoglobin level. The microcytic group manifested significantly higher Hb, PCV, RBC and HbAý levels and significantly lower reticulocyte and irreversibly sickled-cell counts. Clinical features were not less severe in the microcytic group, splenomegaly persisting for longer and painful crises were more common although the latter difference did not reach significance. The milder haematological picture associated with decreased intravascular sickling was not reflected in a more mild clinical course. It is postulated that the higher vicosity accompanying the higher haemoglobin levels in microcytic patients may offset the rheological advantages of decreased intravascular sickling (Summary)


Assuntos
Humanos , Criança , Adolescente , Adulto , Pessoa de Meia-Idade , Masculino , Feminino , Anemia Falciforme/sangue , Índices de Eritrócitos , Contagem de Eritrócitos , Hemoglobina Fetal/metabolismo , Hematócrito
17.
Clin Lab Haematol ; 2(3): 169-78, Feb. 1980.
Artigo em Inglês | MedCarib | ID: med-13885

RESUMO

Haematological indices, including total haemoglobin, mean cell haemoglobin concentration, red cell count, mean cell volume, mean cell haemoglobin, reticulocytes, and serum iron values, in a cohort of 243 randomly selected Negro children with normal haemoglobin genotype, followed from birth to 5 years, are reported. Total haemoglobin fell rapidly from high levels at birth to a plateau at 2-6 months, a secondary fall occurred after 6 months and a gradual increase after 18 months. The red cell count also fell rapidly, but increased after 2 months to a plateau and then slowly declined from age 1-5. Mean cell volume and mean cell haemoglobin fell continously from birth to the lowest values at 15 months and then progressively increased to the age of 5 years. Serum iron levels were low at one year of age (mean 9.7 mumol/1) increasing slowly by age 4 and sharply by age 5. Mean cell haemoglobin concentration fell gradually to 1-1 1/2 years and then increased progressively to age 5. Values for Hb, MCHC, MCV, and MCH were consistently and often significantly lower in males before the age of 2 years, compatible with greater depletion of iron stores. Serum iron values were generally lower in males but there was no sex difference at one year when highly significant differences in Hb, MCHC, MCV, and MCH occurred. The cause of sex differences in early haematological development is currently unclear (AU)


Assuntos
Humanos , Recém-Nascido , Lactente , Pré-Escolar , Masculino , Feminino , Sangue , Anemia Falciforme/diagnóstico , Contagem de Eritrócitos , Índices de Eritrócitos , Hematócrito , Hemoglobinas/análise , Ferro/sangue , Jamaica , Reticulócitos/citologia
18.
Br J Haematol ; 46(1): 39-46, Sept. 1980.
Artigo em Inglês | MedCarib | ID: med-14809

RESUMO

A prospective study of 2191 Negro infants in Jamaica showed that approximately 7 percent of them had detectable levels of Hb Bart's (Y4) in the neonatal period. The red cell indices, globin chain biosynthesis and restriction endonuclease mapping of DNA from these infants were used to determine the significance of Hb Bart's at birth. The results indicate that the genotypes OO/OO, - O/OO and - O/-O are associated with 0 percent, 0.1-2 percent, and greater than 2 percent Hb Bart's respectively. Although trace amounts of Hb Bart's may be associated with the genotype - O/OO this is not always the case and therefore haemoglobin analysis in the neonatal period cannot be used to diagnose this genotype with any certainty (AU)


Assuntos
Humanos , Recém-Nascido , Lactente , Talassemia/diagnóstico , DNA , Índices de Eritrócitos , Genótipo , Globinas/biossíntese , Hemoglobinas Anormais/análise , Jamaica , Estudos Prospectivos , Talassemia/sangue , Talassemia/genética
19.
Br J Haematol ; 22(3): 273-80, March 1972.
Artigo em Inglês | MedCarib | ID: med-14571

RESUMO

Serum iron, iron binding capacity and transferrin saturation were measured in 389 predominantly Negro adults from an agricultural community in Jamaica. The relationships between iron measurements and several other red cell characteristics were investigated and the possible influence of common inhereted red cell defects was examined. Iron deficient erythropoiesis (transferrin saturation <15 percent) occurred in only a third of anaemic subjects. Values of total iron binding capacity were considerable lower than those found in a large random sample from Wales (Jacobs et al, 1969). These findings are considered in relation to the nutritional status of the population (Summary)


Assuntos
Humanos , Adulto , Pessoa de Meia-Idade , Idoso , Masculino , Feminino , Eritropoese , Anemia , Ferro/sangue , Anemia Hipocrômica , Índices de Eritrócitos , População Rural , Estado Nutricional , Transferrina/análise , Negro ou Afro-Americano , Jamaica
20.
Br Med J ; 2(5315): 1283-8, Nov. 17, 1962.
Artigo em Inglês | MedCarib | ID: med-9553

RESUMO

Analyses of diets of St. Kitts negro labourers indicate that they are low in calories, protein, and especially fat, and resemble estimates from other West Indian groups. Serum cholesterol concentrations are lower in men than in women of like age, and those of women do not show a "menopausal" rise. Serum lipoprotein analyses in women yield similar information. Serum totals protein is higher than in North Americans because of high concentrations of gamma-globulin. Blood haemoglobin concentrations are lower than in North Americans, possibly as a result of a marginally adquate protein intake. Prevalence of glycosuria in about 14 per 1,000 at ages 20-49. Ischaemic heart disease attributable to coronary atherosclerosis, or thrombosis, was found in about 1 percent of men aged 40-49 and women aged 45-49. The data again exemplify the concurrence of low subsistence diets, largely of vegetable origin, and of hard work with a low prevalence of ischaemic heart disease.(AU)


Assuntos
Humanos , Doença das Coronárias/epidemiologia , Hipertensão , Inquéritos sobre Dietas , Proteínas Sanguíneas , Colesterol , Glicosúria , Lipoproteínas/sangue , Índices de Eritrócitos
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