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2.
Diabetes;35(3): 324-7, Mar. 1986.
Preprint em Inglês | MedCarib | ID: med-14078

RESUMO

The effect of morphine (0.1 mg/kg) on insulin secretion stimulated by oral, intraduodenal, or intravenous administration of glucose was studied in seven healthy volunteers. When glucose was given intravenously, morphine had no effect on plasma glucose, insulin, glucose-dependent insulinotropic polypeptide (GIP), or pancreatic glucagon. Following oral glucose, morphine slowed gastric emptying and reduced plasma concentrations of glucose, insulin, and GIP. During intraduodenal infusion of glucose, insulin concentrations of plasma were also decreased by morphine, an effect best explained by decreased small intestinal transit with delayed absorption of glucose and delayed release of GIP. We conclude that clinically relevant doses of morphine have no direct effect on insulin secretion and that the changes observed were secondary to slowed gastric emptying and small intestinal transit (AU)


Assuntos
Humanos , Adolescente , Adulto , Masculino , Feminino , Motilidade Gastrointestinal/efeitos dos fármacos , Insulina/metabolismo , Morfina/farmacologia , Glicemia/análise , Duodeno , Peptídeos Semelhantes ao Glucagon/sangue , Esvaziamento Gástrico/efeitos dos fármacos , Polipeptídeo Inibidor Gástrico/sangue , Glucose/administração & dosagem , Glucose/farmacologia , Infusões Parenterais , Insulina/sangue , Neurotensina/sangue
3.
West Indian med. j ; 24(3): 165-8, Sept. 1975.
Artigo em Inglês | MedCarib | ID: med-11122

RESUMO

Successful therapeutic abortion was achieved during the second trimester of pregnancy using intra-amniotic urevert and simultaneous intravenous syntocinon infusion in 19 patients with severe hypertension, severe pre-eclampsia or eclampsia. The mean induction-abortion interval was 24.25 hours, and side-effects were minimal (AU)


Assuntos
Feminino , Humanos , Aborto Terapêutico , Ureia/administração & dosagem , Eclampsia , Infusões Parenterais , Ocitocina/administração & dosagem , Pré-Eclâmpsia , Gravidez , Complicações Cardiovasculares na Gravidez , Segundo Trimestre da Gravidez
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