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1.
Bone ; 43(1): 156-161, Jul. 2008. tabgraf
Artigo em Inglês | MedCarib | ID: med-17700

RESUMO

Population dynamics predict a drastic growth in the number of older minority women, and resultant increases in the number of fractures. Low bone mineral density (BMD) is an important risk factor for fracture. Many studies have identified the lifestyle and health-related factors that correlate with BMD in Whites. Few studies have focused on non-Whites. The objective of the current analyses is to examine the lifestyle, anthropometric and health-related factors that are correlated with BMD in a population based cohort of Caribbean women of West African ancestry. We enrolled 340 postmenopausal women residing on the Caribbean Island of Tobago. Participants completed a questionnaire and had anthropometric measures taken. Hip BMD was measured by DXA. We estimated volumetric BMD by calculating bone mineral apparent density (BMAD). BMD was >10% and >25% higher across all age groups in Tobagonian women compared to US non-Hispanic Black and White women, respectively. In multiple linear regression models, 35-36% of the variability in femoral neck and total hip BMD respectively was predicted. Each 16-kg (one standard deviation (SD)) increase in weight was associated with 5% higher BMD; and weight explained over 10% of the variability of BMD. Each 8-year (1 SD) increase in age was associated with 5% lower BMD. Current use of both thiazide diuretics and oral hypoglycemic medication were associated with 4-5% higher BMD. For femoral neck BMAD, 26% of the variability was explained by a multiple linear regression model. Current statin use was associated with 5% higher BMAD and a history of breast feeding or coronary heart disease was associated with 1-1.5% of higher BMAD. In conclusion, African Caribbean women have the highest BMD on a population level reported to date for women. This may reflect low European admixture. Correlates of BMD among Caribbean women of West African ancestry were similar to those reported for U.S. Black and White women.


Assuntos
Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Humanos , Feminino , Research Support, Non-U.S. Gov't , Densidade Óssea , Inquéritos Epidemiológicos , Estilo de Vida , Pós-Menopausa , Inquéritos e Questionários , Trinidad e Tobago/epidemiologia , Saúde da Mulher , População Negra , Osteoporose Pós-Menopausa
2.
West Indian med. j ; 43(suppl.1): 31, Apr. 1994.
Artigo em Inglês | MedCarib | ID: med-5404

RESUMO

Pre- and post-menopausal white women living in The Netherlands in late winter/early spring and black and white post-menopausal women living in Curacao were supplemented with either 400,800 and 2x400 IU vitamin D (3)/day or placebo for 4, 5, or 9 weeks. Baseline plasma 25-hydroxyvitamin D [25(OH)D] of Dutch women was lower than that of Curacao women. Post-menopausal Dutch women had higher parathyroid hormone (PTH) than pre-menopausal Dutch and post-menopausal Curacao women. There were no differences in 1,25-dihydroxyvitamin D [1,25(OH)2D]. Vitamin D supplementation increased 25(OH)D levels in all groups, PTH and 1,25(OH)2D in post-menopausal Curacao women, and PTH in pre-menopausal Dutch women. Serum and urinary calcium and phosphate did not change. There were no response differences between 400 and 800 IU daily doses, or 800 and 2x400 IU doses. Oral vitamin D supplementation raises late winter/early spring plasma 25(OH)D of women living at high latitudes to baseline levels encountered in the tropics (AU)


Assuntos
Estudo Comparativo , Humanos , Feminino , Deficiência de Vitamina D , Pré-Menopausa , Pós-Menopausa , Curaçao , Estações do Ano , Clima Tropical
3.
West Indian med. j ; 37(suppl): 32, 1988.
Artigo em Inglês | MedCarib | ID: med-6608

RESUMO

One hundred and nine patients with postmenopausal bleeding who underwent a fractional dilation and curettage were studied over a 52-year period. Malignancies were found in 20.2 percent of the study group; 11.9 percent were endometrial carcinoma and 7.3 percent squamous carcinoma of the cervix. Forty-five per cent of the patients were discovered to have some form of organic pathology. Compared with the 30 patients who had an atrophic endometrium, those with endometrial carcinoma had an increased mean age of menopause (64 vs 49 yrs), a lower parity (4.2 vs 7.5), a lower haemoglobin level (11.5 vs 13.2g/dl) and a larger uterine size (85 percent vs 10 percent>6wk size). Bleeding was for more than 1 month in 85 percent compared with 15 percent in the atrophic group and it was more frequently heavy, resembling menses (77 percent vs 37 percent). This study points to a low haemoglobin level, heavy menses like bleeding and bleeding for more than one month as clinical features indicative of the presence of advanced endometrial pathology (AU)


Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Neoplasias do Endométrio/diagnóstico , Pós-Menopausa , Hemorragia , Trinidad e Tobago , Dilatação e Curetagem
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