RESUMO
A non proteinaceous extract of Bromelia pinguin fruit was examined for activity on the rat uterus in vivo and in vitro. The in vivo experiments involved pregnant rats given the extract intraperitoneally. These rats did not abort nor were any foetal deformities observed. The extract inhibited spontaneous activity of the pregnant rat uterus in vitro. The extract of Bromelia pinguin fruit may have some utero-active compound which inhibits uterine motility.(AU)
Assuntos
Ratos , Técnicas In Vitro , 21003 , Gravidez , Feminino , Contração Uterina/efeitos dos fármacos , Extratos Vegetais , Abortivos , Plantas Medicinais , Prenhez/efeitos dos fármacos , Ratos WistarRESUMO
Dietary protein depletion causes a significant incidence of resorption in pregnant rats when compared to rats fed a complete diet. Histologically, this resorption consists of an extravasation of blood into the implantation crypt on day 9, dilating the crypt and causing necrosis and sloughing of the embryo and decidua. Embryonic death and fragmentation appears subsequent to the appearance of blood and debris in the crypt on day 9 1/2 (AU)
Assuntos
Gravidez , Ratos , 21003 , Feminino , Estruturas Embrionárias/crescimento & desenvolvimento , Implantação do Embrião , Prenhez , Deficiência de Proteína/fisiopatologiaRESUMO
The resin of cannabis sativa L. (Ganga) exerts teratogenic effects in the rat when it is administered daily, at a dose level of 4.2 mg./kg. body weight on days 1-6 of gestation. The teratogenic effects are manifested in the following ways: a high incidence of malformed foetuses in the litters of treated animals, an increase in the incidence of foetal resorption, and a decrease in foetal weight and size. These results are of particular interest in relation to recent reports on the teratogenicity of another psychotropic drug, LSD (Alexander et al 1967 and Zellweger et al 1967) (AU)
