RESUMO
Patients with sickle-cell anaemia were unable to increase free water reabsorption (TcH2O) in response to intravenous hypertonic sodium chloride solution. Ethacrynic acid caused a brisk natriuresis in patients with sickle-cell anaemia but fractional sodium excretion was lower in these patients. These findings could be explained by abnormal function of the loop of Henle.(AU)
Assuntos
Humanos , Adulto , Anemia Falciforme/metabolismo , Diurese/efeitos dos fármacos , Ácido Etacrínico/farmacologia , Cloreto de Sódio/farmacologia , Natriurese/efeitos dos fármacos , Sódio/urinaRESUMO
The case history of a twenty-one month old boy who presented with congestive cardiac failure in association with chronic tonsillar and adenoidal hypertrophy is presented. This is the first such case to be reported from Jamaica. The aetiology of cardiac failure in association with upper airway obstruction is briefly discussed (AU)
Assuntos
Humanos , Lactente , Masculino , Doenças Nasofaríngeas/complicações , Doença Cardiopulmonar/complicações , Tonsila Faríngea/patologia , Obstrução das Vias Respiratórias/complicações , Anemia/complicações , Diurese , Eletrocardiografia , Hipertrofia , Doença Cardiopulmonar/diagnóstico por imagem , Tonsila Palatina/patologia , JamaicaRESUMO
Rats maintained in a state of chronic water diuresis were given as osmotic loads intraperitoneally, 10 percent of their body weight of either 0.45 percent saline or 10 percent mannitol in water. Faeces-free urines were collected under the following experimental protocols: osmotic diuresis, osmotic diuresis plus ADH and osmotic diuresis plus ADH plus metabolic inhibitors. A number of inhibitors of aerobic and anaerobic metabolism were used. Samples of kidney cortex medulla and papilla were also collected and analysed. The results obtained show that rats maintained in chronic water diuresis excreted a dilute urine and had largely dissipated their cortico-medullary gradients of sodium and urea. Under ADH stimulation, the rats excreted a concentrated urine with marked restoration of the cortico-medullary gradients. These effects were markedly inhibited by iodo-acetate and fluoride, but not by 2-4 dinitrophenol, hydroxylamine HCl or cyanide. The results suggest that a large proportion of the energy required for the creation of a hypertonic medulla, and hence the formation of a concentrated urine, is derived from anaerobic glycolysis (AU)
