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1.
(East. Mediterr. health j).
em Inglês | WHO IRIS | ID: who-117541

RESUMO

This study investigated the association between HLA antigens and inflammatory bowel disease in 65 Iraqi patients [50 ulcerative colitis, 15 Crohn disease] compared with 67 matched controls. At HLA class I region, the patients showed significantly increased frequencies of A9 and B41 and a decrease of A11. Similar results were found when the clinical types were considered separately, except for A11, which was not significant. At HLA class II region, DR8 was significantly increased in the total patients, but the association was not maintained for ulcerative colitis or Crohn disease patients; instead Crohn disease was positively associated with DQ1. Comparing the clinical types revealed a significant difference in the antigen B16, suggesting that B16 is a differentiating marker in the disease


Assuntos
Colite Ulcerativa , Doença de Crohn , Antígenos HLA , Doenças Inflamatórias Intestinais
2.
(East. Mediterr. health j).
em Inglês | WHO IRIS | ID: who-117252

RESUMO

Chronic ulcerative colitis is being encountered with increasing frequency in developing countries. In Amman, Jordan, the records of 372 patients with chronic ulcerative colitis diagnosed between 1994 and 2001 were reviewed. Bloody diarrhoea and crampy abdominal pain were the most common presenting symptoms [84% of patients]. The mean age at onset was 31.8 years. In two thirds of patients the diagnosis was made more than 1 year after the onset of symptoms. The pattern of the disease differed from that in industrialized countries in the mild course of the disease, the absence of skin manifestations, and the rarity of colorectal cancer in our patients. The mortality rate was 6%


Assuntos
Neoplasias Colorretais , Demografia , Colite Ulcerativa
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