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1.
Int J Risk Saf Med ; 35(1): 25-36, 2024.
Article in English | MEDLINE | ID: mdl-37302041

ABSTRACT

BACKGROUND: There is currently no widespread implementation of pharmacogenetic testing (PGx) methods in the practice of phthisiology service. OBJECTIVE: The aim of this study is to determine how informed and prepared phthisiologists, residents, and postgraduate students of the Russian Medical Academy of Continuing Professional Education (RMACPE, Moscow) use PGx techniques in their work to improve treatment safety, predict the occurrence of adverse reactions (ADRs), and personalize therapy. METHODS: A survey was conducted among phthisiologists (n = 314) living in different regions of the Russian Federation and studying at RMACPE, such as residents and post-graduate students (n = 185). The survey was developed on the Testograf.ru web platform and had 25 questions for physicians and 22 for residents and post-graduate students. RESULTS: More than 50% of respondents are ready to use PGx in clinical practice and thus are aware of the method's possibilities. At the same time only a small part of participants were aware of the pharmgkb.org resource. The absence of PGx in clinical guidelines and treatment standards, according to 50.95% of phthisiologists and 55.13% of students of RMACPE, the absence of large-scale randomized clinical trials, according to 37.26% of phthisiologists and 43.33% of students, and the lack of physician knowledge on PGx, according to 41.08% of phthisiologists and 57.83% of students, are all factors that prevent the implementation of PGx in Russia. CONCLUSION: According to the survey, the overwhelming majority of participants recognize the importance of PGx and are willing to use the method in practice. However, there is a low level of awareness among all respondents about the possibilities of PGx and the pharmgkb.org resource. The implementation of this service could significantly increase patient compliance, lower ADRs, and enhance anti-tuberculosis (TB) therapy quality.


Subject(s)
Physicians , Tuberculosis , Humans , Pharmacogenetics , Academies and Institutes , Russia , Tuberculosis/drug therapy
2.
Int J Mycobacteriol ; 12(3): 261-266, 2023.
Article in English | MEDLINE | ID: mdl-37721230

ABSTRACT

Background: Human immunodeficiency virus (HIV) and tuberculosis (TB) coinfection represents a serious public health problem that requires new approaches for its prevention and comprehensive management. Therefore, the aim of this study was to analyze the bibliometric profile of the worldwide scientific production on TB and HIV coinfection. Methods: Bibliometric study that retrieved publications indexed in Scopus, from the design of a search strategy based on Medical Subject Heading terms and logical operators. The sample consisted of 219 articles, whose metadata were analyzed with SciVal, VOSviewer, and RStudio. Results: Between 2017 and 2018, there was a notorious interest in the interrelationship between HIV and TB, as well as in the role of Mycobacterium tuberculosis in the context of acquired immunodeficiency syndrome. The United States and South Africa clustered the most publications. On the other hand, the most productive authors have a US Institution affiliation, Brust James CM and Gandhi Neel R had seven publications. The categories of "Infectious Diseases" and "Microbiology (medical)" accumulated 94 and 35 publications. In addition, the most productive journals were PLOS One and the International Journal of TB and Lung Disease, while clinical infectious diseases had the best CiteScore 2021 (17.3). Conclusions: Scientific production has been mainly disseminated in high-impact journals, with a slight increase in recent years. The United States is the leading and most influential country, followed by South Africa; in addition, Brust James CM, an American National, is recognized as the most productive.


Subject(s)
Acquired Immunodeficiency Syndrome , Coinfection , Tuberculosis , Humans , HIV , Bibliometrics
3.
Int J Mycobacteriol ; 12(2): 111-116, 2023.
Article in English | MEDLINE | ID: mdl-37338469

ABSTRACT

Background: The increase in the number of pregnant women with tuberculosis is an important factor that should be analyzed at present. Thus, It is important to evaluate the bibliometric characteristics of the scientific production indexed in Scopus on complications of pregnancy and childbirth in pregnant women with tuberculosis. Methods: A cross-sectional bibliometric study was carried out analyzing the publications of journals indexed in Scopus between January 2016 and May 2022. A search strategy was developed using MESH terms and Boolean operators. The SciVal program (Elsevier) was used for bibliometric analysis of the information in the documents. Results: Of the 287 publications analyzed, 13 were in the International Journal of Tuberculosis and Lung Disease and BJOG: An International Journal of Obstetrics and Gynaecology presented 11.9 citations per publication. Gupta Amita, from the United States, presented the most published papers; however, Myer London, from South Africa, had the highest impact, with 17.8 citations per publication. Johns Hopkins University was the institution with the highest number of publications (34). 51.9% of the publications were in journals in the Q1 quartile while 41.8% were international collaborations. Conclusions: In each year analyzed, scientific production was similar, with the highest proportion of publications in journals located in the Q1 and Q2 quartile. The institutions with the highest production were from the United States and South Africa. Therefore, there is a need to promote collaborative production in countries with greater presence of this disease.


Subject(s)
Pregnant Women , Tuberculosis , Pregnancy , Female , Humans , Cross-Sectional Studies , Bibliometrics , South Africa
4.
Lima; Perú. Ministerio de Salud. Dirección General de Intervenciones Estratégicas en Salud Pública. Dirección de Prevención y Control de Tuberculosis; 1 ed; Jun. 2023. 170 p. ilus.
Monography in Spanish | LILACS, MINSAPERÚ, LIPECS | ID: biblio-1437365

ABSTRACT

La presente publicación describe los criterios clínicos y programáticos, así como los procedimientos técnicos de las intervenciones sanitarias en el cuidado integral por curso de vida de la prevención y control de la tuberculosis en la población afectada o con factores de riesgo. Asimismo, incorpora importantes avances e innovaciones para la prevención y control de la tuberculosis, basadas en las recomendaciones brindadas por los organismos internacionales de salud y evidencias científicas, aplicadas a la realidad nacional. Así, incluye la introducción de metodología molecular en el diagnóstico de esta enfermedad, el uso de nuevos medicamentos para la terapia preventiva, esquemas totalmente orales y acortados para el tratamiento de la tuberculosis resistente, un mayor involucramiento de los actores comunitarios en la prevención y la detección de la tuberculosis, así como su participación activa en las diversas intervenciones estratégicas


Subject(s)
Tuberculosis , Tuberculosis, Pulmonary , Health Surveillance , Health Care Levels , Comprehensive Health Care , Research Promotion , Moving and Lifting Patients
5.
PLoS One ; 18(2): e0281591, 2023.
Article in English | MEDLINE | ID: mdl-36758064

ABSTRACT

Ranked second in global tuberculosis (TB) incidence, Indonesia has developed a National Strategy for TB Prevention and Control 2020-2024 to accelerate the TB elimination program. Research and innovation are key pillars to support the program and need to be prioritised. This study aimed to develop updated national TB research priorities in Indonesia. This study was a mixed-methods study consisting of an open survey, a published literature survey, and Delphi survey. The open survey invited all related TB stakeholders to answer (a) the main barriers of the TB program and (b) the need for studies to support TB elimination. The published literature survey retrieved scientific articles published in national and international journals between 2015 and 2020 to identify gaps between published research and the current national strategy for TB control. The online survey and literature survey informed a panel of TB experts in a two-phase Delphi Survey to select the top 10 priority research topics. We identified 322 articles and analysed 1143 open survey responses. Through two-phases Delphi surveys, top ten research categories were listed: early TB detection; diagnosis and treatment of DR-TB; contact investigation; case detection and treatment of child TB; TB preventive therapy; government policy; laboratory for drug-sensitive- and drug-resistant-TB diagnosis; treatment adherence; diagnostic tool development; and community empowerment. This study also found the gap between stakeholders' interests and the importance of translating research into policy and practice. TB research priorities have been identified through the involvement of various stakeholders. The combination of an online survey, a published literature survey, and a Delphi survey was a rigorous methodology and was fit to build a systematic consensus about the priority of TB research.


Subject(s)
Tuberculosis, Multidrug-Resistant , Tuberculosis , Child , Humans , Indonesia/epidemiology , Tuberculosis/diagnosis , Tuberculosis/epidemiology , Tuberculosis/prevention & control , Research , Surveys and Questionnaires
10.
Nurse Pract ; 47(11): 32-39, 2022 11 01.
Article in English | MEDLINE | ID: mdl-36287735

ABSTRACT

ABSTRACT: It is critical to detect latent tuberculosis infection through screening and testing individuals at high risk of progression to active tuberculosis, including patients who are immunocompromised. NPs should be familiar with available testing for accurate diagnosis in order to expedite treatment.


Subject(s)
Latent Tuberculosis , Tuberculosis , Humans , Latent Tuberculosis/diagnosis , Tuberculin Test , Mass Screening , Research
11.
Int J Mycobacteriol ; 11(3): 249-255, 2022.
Article in English | MEDLINE | ID: mdl-36260442

ABSTRACT

Background: Nowadays, tuberculosis and COVID-19 are the principal infections around the world. This study aimed to determine the global scientific production on COVID-19 associated to tuberculosis during the period 2019-2020. Methods: For the collection of metadata on COVID-19 associated to tuberculosis, the Scopus database was used, considering the period 2019-2020, with the last day of update being September 13, 2021. The main authors, countries, institutions, journal metrics, and documents were extracted. The Scival tool was used for the scientometric analysis of the data. Results: A total of 464 papers were retrieved where it was found that universities in South Africa, the United States, and England led the world's scientific production. The International Journal of Tuberculosis and Lung Disease was the journal with the highest production and The Lancet Global Health was the journal with the most citations per publication. On the other hand, most papers were published in Q1 journals, with infectious diseases within the area of medicine being the most addressed. Conclusion: South African universities lead the world in scientific output. Most of the research on this topic has been published in Q1 journals, with collaboration being largely national. Further analysis is needed in the aftermath of the pandemic.


Subject(s)
COVID-19 , Tuberculosis , Humans , Bibliometrics , Tuberculosis/epidemiology , South Africa/epidemiology
12.
Lima; Perú. Ministerio de Salud; Set. 2022. 5 p.
Monography in Spanish | MINSAPERÚ | ID: biblio-1395506

ABSTRACT

El documento contiene los objetivos estratégicos en cuanto a las prioridades nacionales de Investigación en Tuberculosis en el Perú del 2022 al 2025.


Subject(s)
Research , Tuberculosis , Goals
13.
Article in English | MEDLINE | ID: mdl-35954664

ABSTRACT

Contact tracing is a monitoring process including contact identification, listing, and follow-up, which is a key to slowing down pandemics of infectious diseases, such as COVID-19. In this study, we use the scientific collaboration network technique to explore the evolving history and scientific collaboration patterns of contact tracing. It is observed that the number of articles on the subject remained at a low level before 2020, probably because the practical significance of the contact tracing model was not widely accepted by the academic community. The COVID-19 pandemic has brought an unprecedented research boom to contact tracing, as evidenced by the explosion of the literature after 2020. Tuberculosis, HIV, and other sexually transmitted diseases were common types of diseases studied in contact tracing before 2020. In contrast, research on contact tracing regarding COVID-19 occupies a significantly large proportion after 2000. It is also found from the collaboration networks that academic teams in the field tend to conduct independent research, rather than cross-team collaboration, which is not conducive to knowledge dissemination and information flow.


Subject(s)
COVID-19 , Sexually Transmitted Diseases , Tuberculosis , COVID-19/epidemiology , Contact Tracing/methods , Humans , Pandemics
14.
Rev. Enferm. Atual In Derme ; 96(39): 1-17, Jul-Set. 2022.
Article in English, Portuguese | BDENF - Nursing | ID: biblio-1417239

ABSTRACT

Objetivo: analisar o perfil bibliométrico da produção científica sobre a infecção latente da tuberculose, disponível na base de dados Web of Science. Métodos: estudo bibliométrico, com abordagem quantitativa. Organizou-se estratégia de busca com termos do vocabulário Medical Subject Headings, incluindo publicações de janeiro de 2016 a agosto de 2021. Realizou-se análise estatística descritiva e aplicou-se as Leis de Bradford e Zipf. Resultados: a amostra se constituiu por 2.460 publicações, com predomínio de artigos originais, no idioma inglês, dos anos de 2018 a 2020. Destacaram-se 10 autores e 25 instituições norte-americanas e britânicas. Estados Unidos da América e Inglaterra foram os países que mais publicaram. A principal área de pesquisa foi a de doenças infecciosas. Identificaram-se 25 periódicos mais influentes e 10 palavras-chave com maior representatividade. Conclusões: constatou-se que a produção científica sobre a infecção latente da tuberculose é extensa e diversificada, e apresentou tendência de aumento no período estudado.


Objective:to analyze the bibliometric profile of scientific production on latent tuberculosis infection, available in the Web of Science database. Methods:bibliometric study, with a quantitative approach. A search strategy was organized with terms from the Medical Subject Headings vocabulary, including publications from January 2016 to August 2021. Descriptive statistical analysis was performed and the Bradford and Zipf Laws were applied. Results:the sample consisted of 2,460 publications, with a predominance of original articles, in English, from the years 2018 to 2020. 10authors and 25 North American and British institutions stood out. The United States of Americaand England were the countries that published the most. The main area of research was that of infectious diseases. 25 most influential journals and 10 keywords with greater representation were identified. Conclusions:it was found that the scientific production on latent tuberculosis infection is extensive and diverse, and showed a tendency to increase in the period studied.


Objetivo:analizar el perfil bibliométrico de la producción científica sobre la infección tuberculosa latente, disponible en la base de datos Web of Science. Métodos:estudio bibliométrico, con enfoque cuantitativo. Se organizó una estrategia de búsqueda con términos del vocabulario Medical Subject Headings, incluyendo publicaciones de enero de 2016 a agosto de 2021. Se realizó análisis estadístico descriptivo y se aplicaron las Leyes de Bradford y Zipf. Resultados:la muestra estuvo conformada por 2.460 publicaciones, con predominio de artículos originales, en inglés, de los años 2018 a 2020. Se destacaron 10 autores y 25 instituciones norteamericanas y británicas. Estados Unidos de América e Inglaterra fueron los países que más publicaron. La principal área de investigación fue la de las enfermedades infecciosas. Se identificaron las 25 revistas más influyentes y las 10 palabras clave con mayor representación. Conclusiones:se constató que la producción científica sobre la infección tuberculosa latente es extensa y diversa, y mostró tendencia a aumentar en el período estudiado.


Subject(s)
Humans , Male , Female , Clinical Nursing Research , Bibliometrics , Scientific Publication Indicators , Latent Tuberculosis
15.
Internet resource in Portuguese | LIS -Health Information Locator | ID: lis-48798

ABSTRACT

Um kit de fácil manipulação para o diagnóstico molecular da tuberculose em ambientes com pouca infraestrutura poderá em breve estar disponível para uso nas unidades do Sistema Único de Saúde (SUS).


Subject(s)
Tuberculosis/diagnosis , Health Research Plans and Programs
16.
BMJ Glob Health ; 7(4)2022 04.
Article in English | MEDLINE | ID: mdl-35440441

ABSTRACT

Two drugs with novel mechanisms of action, the diarylquinoline bedaquiline and the nitroimidazole delamanid-as well as pretomanid from the same class of drugs as delamanid-have recently become available to treat drug-resistant tuberculosis (DR-TB) after many decades of little innovation in the field of DR-TB treatment. Despite evidence of improved efficacy and reduced toxicity of multidrug regimens including the two agents, access to bedaquiline and delamanid has been limited in many settings with a high burden of DR-TB and consistently poor treatment outcomes. Aside from regulatory, logistic and cost barriers at country level, uptake of the novel agents was complicated by gaps in knowledge for optimal use in clinical practice after initial market approval. The main incentives of the current pharmaceutical research and development paradigm are structured around obtaining regulatory approval, which in turn requires efficacy and safety data generated by clinical trials. Recently completed and ongoing clinical trials did not answer critical questions of how to provide shorter, less toxic treatment DR-TB treatment regimens containing bedaquiline and delamanid and improve patient outcomes. Voluntary generation of evidence that is not part of this process-yet essential from a clinical or policy perspective-has been left to non-sponsor partners and researchers, often without collaborative efforts to improve post-regulatory approval access to life-saving drugs. Additionally, these efforts are currently not recognised in the value chain of the research and development process, and there are no incentives to make this critical research happen in a coordinated way.


Subject(s)
Antitubercular Agents , Tuberculosis, Multidrug-Resistant , Antitubercular Agents/therapeutic use , Humans , Oxazoles/therapeutic use , Research , Treatment Outcome , Tuberculosis, Multidrug-Resistant/drug therapy
18.
Lancet Infect Dis ; 22(4): e108-e120, 2022 04.
Article in English | MEDLINE | ID: mdl-35240041

ABSTRACT

To eliminate tuberculosis globally, a new, effective, and affordable vaccine is urgently needed, particularly for use in adults and adolescents in low-income and middle-income countries. We have created a roadmap that lists the actions needed to accelerate tuberculosis vaccine research and development using a participatory process. The vaccine pipeline needs more diverse immunological approaches, antigens, and platforms. Clinical development can be accelerated by validated preclinical models, agreed laboratory correlates of protection, efficient trial designs, and validated endpoints. Determining the public health impact of new tuberculosis vaccines requires understanding of a country's demand for a new tuberculosis vaccine, how to integrate vaccine implementation with ongoing tuberculosis prevention efforts, cost, and national and global demand to stimulate vaccine production. Investments in tuberculosis vaccine research and development need to be increased, with more diversity of funding sources and coordination between these funders. Open science is important to enhance the efficiency of tuberculosis vaccine research and development including early and freely available publication of study findings and effective mechanisms for sharing datasets and specimens. There is a need for increased engagement of industry vaccine developers, for increased political commitment for new tuberculosis vaccines, and to address stigma and vaccine hesitancy. The unprecedented speed by which COVID-19 vaccines have been developed and introduced provides important insight for tuberculosis vaccine research and development.


Subject(s)
COVID-19 , Tuberculosis Vaccines , Tuberculosis , Vaccines , Adolescent , Adult , COVID-19 Vaccines , Humans , Research , Tuberculosis/prevention & control
19.
Article in English | LILACS | ID: biblio-1420487

ABSTRACT

Abstract Recently, the world has coped with the challenge of the novel SARS-CoV-2 rapid spreading, causing COVID-19. This scenario has overburdened health systems, forced social isolation, and interrupted some services, changing the way how health assistance is provided. The management of chronic infectious diseases such as tuberculosis is a sensitive matter in times when the control strategies are at risk. In this sense, how could a high burden disease such as tuberculosis affect or be affected when combined with the COVID-19 pandemic? Patients with tuberculosis have a social background and lung impairment that represent risks in the pandemic scenario of another widely transmitted respiratory disease. Thus, even with several questions remaining unanswered, research and public policies should be addressed to control the effects of the current highly contagious COVID-19 without forgetting how it will affect the natural progression of patients suffering from tuberculosis.


Subject(s)
Tuberculosis/pathology , Health Systems/organization & administration , COVID-19/pathology , Patients/classification , Research/classification , Pandemics/prevention & control , SARS-CoV-2/pathogenicity
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