The APC/C activator FZR1 is essential for meiotic prophase I in mice.
Holt, Janet E; Pye, Victoria; Boon, Evan; Stewart, Jessica L; García-Higuera, Irene; Moreno, Sergio; Rodríguez, Rubén; Jones, Keith T; McLaughlin, Eileen A.
; 141(6): 1354-65, 2014 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-24553289
FZR1 loss increases sensitivity to DNA damage and consequently promotes murine and human B-cell acute leukemia.
Molecular architecture and mechanism of the anaphase-promoting complex.
EMI1 switches from being a substrate to an inhibitor of APC/C to start the cell cycle.
Substrate Recognition by the Cdh1 Destruction Box Receptor Is a General Requirement for APC/CCdh1-mediated Proteolysis.
O-GlcNAcylation Antagonizes Phosphorylation of CDH1 (CDC20 Homologue 1).
Loss of LKB1 leads to impaired epithelial integrity and cell extrusion in the early mouse embryo.
Feedback regulation between atypical E2Fs and APC/CCdh1 coordinates cell cycle progression.
The APC activator fizzy-related-1 (FZR1) is needed for preimplantation mouse embryo development.
The APC/C activator FZR1 coordinates the timing of meiotic resumption during prophase I arrest in mammalian oocytes.
DNA methylation of E-cadherin is a priming mechanism for prostate development.