Abundant pleiotropy in human complex diseases and traits.
Sivakumaran, Shanya; Agakov, Felix; Theodoratou, Evropi; Prendergast, James G; Zgaga, Lina; Manolio, Teri; Rudan, Igor; McKeigue, Paul; Wilson, James F; Campbell, Harry.
Am J Hum Genet
; 89(5): 607-18, 2011 Nov 11.
Artigo em Inglês | MEDLINE | ID: mdl-22077970
Human genetics: pleiotropic mutations.
Estimating and testing pleiotropy of single genetic variant for two quantitative traits.
The many faces of pleiotropy.
A quadratically regularized functional canonical correlation analysis for identifying the global structure of pleiotropy with NGS data.
Polygenic risk score: use in migraine research.
Progress and promise in understanding the genetic basis of common diseases.
A combined large-scale meta-analysis identifies COG6 as a novel shared risk locus for rheumatoid arthritis and systemic lupus erythematosus.
Phenotypes, pleiotropy, and phylogeny.
Fisher's method of combining dependent statistics using generalizations of the gamma distribution with applications to genetic pleiotropic associations.
A general approach to testing for pleiotropy with rare and common variants.