Identification of 1-{2-[4-chloro-1'-(2,2-dimethylpropyl)-7-hydroxy-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]phenyl}-3-{5-chloro-[1,3]thiazolo[5,4-b]pyridin-2-yl}urea, a potent, efficacious and orally bioavailable P2Y(1) antagonist as an antiplatelet agent.

Jeon, Yoon T; Yang, Wu; Qiao, Jennifer X; Li, Ling; Ruel, Rejean; Thibeault, Carl; Hiebert, Sheldon; Wang, Tammy C; Wang, Yufeng; Liu, Yajun; Clark, Charles G; Wong, Henry S; Zhu, Juliang; Wu, Dauh-Rurng; Sun, Dawn; Chen, Bang-Chi; Mathur, Arvind; Chacko, Silvi A; Malley, Mary; Chen, Xue-Qing; Shen, Hong; Huang, Christine S; Schumacher, William A; Bostwick, Jeffrey S; Stewart, Anne B; Price, Laura A; Hua, Ji; Li, Danshi; Levesque, Paul C; Seiffert, Dietmar A; Rehfuss, Robert; Wexler, Ruth R; Lam, Patrick Y S.
Bioorg Med Chem Lett; 24(5): 1294-8, 2014 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-24513044