Domain-Specific and Stage-Intrinsic Changes in Tcrb Conformation during Thymocyte Development.
Majumder, Kinjal; Rupp, Levi J; Yang-Iott, Katherine S; Koues, Olivia I; Kyle, Katherine E; Bassing, Craig H; Oltz, Eugene M.
; 195(3): 1262-72, 2015 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-26101321
T cell receptor gene recombinations in human tumor specimen exome files: detection of T cell receptor-ß VDJ recombinations associates with a favorable oncologic outcome for bladder cancer.
Initiation of allelic exclusion by stochastic interaction of Tcrb alleles with repressive nuclear compartments.
Differential regulation of proximal and distal Vbeta segments upstream of a functional VDJbeta1 rearrangement upon beta-selection.
Noncore RAG1 regions promote Vß rearrangements and αß T cell development by overcoming inherent inefficiency of Vß recombination signal sequences.
The ataxia telangiectasia mutated and cyclin D3 proteins cooperate to help enforce TCRß and IgH allelic exclusion.
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IL-7 coordinates proliferation, differentiation and Tcra recombination during thymocyte ß-selection.
A discrete chromatin loop in the mouse Tcra-Tcrd locus shapes the TCRÎ´ and TCRα repertoires.
Position-dependent silencing of germline Vß segments on TCRß alleles containing preassembled VßDJßCß1 genes.
Pre-T Cell Receptors (Pre-TCRs) Leverage Vß Complementarity Determining Regions (CDRs) and Hydrophobic Patch in Mechanosensing Thymic Self-ligands.