Design and synthesis of carbazole carboxamides as promising inhibitors of Bruton's tyrosine kinase (BTK) and Janus kinase 2 (JAK2).
Liu, Qingjie; Batt, Douglas G; Lippy, Jonathan S; Surti, Neha; Tebben, Andrew J; Muckelbauer, Jodi K; Chen, Lin; An, Yongmi; Chang, Chiehying; Pokross, Matt; Yang, Zheng; Wang, Haiqing; Burke, James R; Carter, Percy H; Tino, Joseph A.
Bioorg Med Chem Lett
; 25(19): 4265-9, 2015 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-26320619
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Discovery of Subtype Selective Janus Kinase (JAK) Inhibitors by Structure-Based Virtual Screening.
Identification of 4-(2-furanyl)pyrimidin-2-amines as Janus kinase 2 inhibitors.
9H-Carbazole-1-carboxamides as potent and selective JAK2 inhibitors.
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Three dimensional quantitative structure-activity relationship of 5H-Pyrido[4,3-b]indol-4-carboxamide JAK2 inhibitors.
Dual inhibitors of Janus kinase 2 and 3 (JAK2/3): designing by pharmacophore- and docking-based virtual screening approach.
Computer-aided discovery of aminopyridines as novel JAK2 inhibitors.