Small Molecule Reversible Inhibitors of Bruton's Tyrosine Kinase (BTK): Structure-Activity Relationships Leading to the Identification of 7-(2-Hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]-9H-carbazole-1-carboxamide (BMS-935177).

De Lucca, George V; Shi, Qing; Liu, Qingjie; Batt, Douglas G; Beaudoin Bertrand, Myra; Rampulla, Rick; Mathur, Arvind; Discenza, Lorell; D'Arienzo, Celia; Dai, Jun; Obermeier, Mary; Vickery, Rodney; Zhang, Yingru; Yang, Zheng; Marathe, Punit; Tebben, Andrew J; Muckelbauer, Jodi K; Chang, ChiehYing J; Zhang, Huiping; Gillooly, Kathleen; Taylor, Tracy; Pattoli, Mark A; Skala, Stacey; Kukral, Daniel W; McIntyre, Kim W; Salter-Cid, Luisa; Fura, Aberra; Burke, James R; Barrish, Joel C; Carter, Percy H; Tino, Joseph A.
J Med Chem; 59(17): 7915-35, 2016 09 08.
Artigo em Inglês | MEDLINE | ID: mdl-27531604