Discovery of 7-(3-(piperazin-1-yl)phenyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives as highly potent and selective PI3Kδ inhibitors.

Qin, Lan-Ying; Ruan, Zheming; Cherney, Robert J; Dhar, T G Murali; Neels, James; Weigelt, Carolyn A; Sack, John S; Srivastava, Anurag S; Cornelius, Lyndon A M; Tino, Joseph A; Stefanski, Kevin; Gu, Xiaomei; Xie, Jenny; Susulic, Vojkan; Yang, Xiaoxia; Yarde-Chinn, Melissa; Skala, Stacey; Bosnius, Ruth; Goldstein, Christine; Davies, Paul; Ruepp, Stefan; Salter-Cid, Luisa; Bhide, Rajeev S; Poss, Michael A.
Bioorg Med Chem Lett; 27(4): 855-861, 2017 02 15.
Artigo em Inglês | MEDLINE | ID: mdl-28108251