Dysregulated CD46 shedding interferes with Th1-contraction in systemic lupus erythematosus.
Ellinghaus, Ursula; Cortini, Andrea; Pinder, Christopher L; Le Friec, Gaelle; Kemper, Claudia; Vyse, Timothy J.
Eur J Immunol
; 47(7): 1200-1210, 2017 07.
Artigo em Inglês | MEDLINE | ID: mdl-28444759
Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells.
The CD46-Jagged1 interaction is critical for human TH1 immunity.
The complement receptor CD46 tips the scales in T(H)1 self-control.
Monocyte:T-cell interaction regulates human T-cell activation through a CD28/CD46 crosstalk.
Complementing T Cells' Functions: Bringing in Metabolism Matters.
N-glycolylneuraminic acid knockout reduces erythrocyte sequestration and thromboxane elaboration in an ex vivo pig-to-human xenoperfusion model.
Immunization with autologous CD46 generates a strong autoantibody response in rats that targets spermatozoa.
IFN-α and CD46 stimulation are associated with active lupus and skew natural T regulatory cell differentiation to type 1 regulatory T (Tr1) cells.
RNA interference screen in primary human T cells reveals FLT3 as a modulator of IL-10 levels.
CD46 Activation Regulates miR-150-Mediated Control of GLUT1 Expression and Cytokine Secretion in Human CD4+ T Cells.